Clinical trials: Stereotactic Body Radiation Therapy
Hepatocellular Cancer, Quality of Life
Prospective Observational Trial to Evaluate Quality of Life After Stereotactic Ablative Radiation Therapy in Patients With Hepatocellular Carcinoma
Prospective single arm, single center observational study to evaluate Quality of Life (Qol) after stereotactic body radiotherapy for patients with hepatocellular cancer.
- Conditions
- Hepatocellular Cancer, Quality of Life, Stereotactic Body Radiation Therapy, Observational
- Trial name
- LIVERCARE (NCT03253536)
- Testing
- observational
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ludwig-Maximilians - University of Munich
NSCLC (Non-small Cell Lung Cancer)
Oral Paclitaxel Solution With Immunotherapy and Concurrent SBRT as Neoadjuvant Treatment for Older Adults With NSCLC
his multicenter, open-label, single-arm phase I/II trial will evaluate the safety, tolerability, and preliminary efficacy of oral paclitaxel solution combined with an immune checkpoint inhibitor and concurrent stereotactic body…
- Trial name
- NCT07754812
- Testing
- Oral Paclitaxel Solution, PD-1/PD-L1 inhibitor, Stereotactic Body Radiotherapy (SBRT)
- Where
- 5 sites in China
- Volunteers
- 78 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
HCC
TACE and SBRT Followed by Double Immunotherapy for Downstaging Hepatocellular Carcinoma
This study is a prospective phase II, single arm mono-institutional study conducted in Queen Mary Hospital (Hong Kong) assessing the efficacy and safety of the sequential administration of trans-arterial chemo-embolization (TACE)…
- Trial name
- NCT04988945
- Testing
- TACE, SBRT, Durvalumab
- Where
- 2 sites in Hong Kong
- Volunteers
- 33 people
- Sponsor
- The University of Hong Kong
Pancreatic Cancer
Stereotactic Body Radiotherapy Dose Escalation in Pancreatic Cancer
This study is to determine the maximum tolerated dose (MTD) of five fraction stereotactic radiotherapy (SBRT) in pancreatic cancer.
- Trial name
- SBRT (NCT02454140)
- Testing
- SBRT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Prostatic Neoplasms
Dose Escalation For INtraprostatic LEsions
External beam radiotherapy combined with androgen deprivation therapy is a standard treatment option for localized prostate cancer.
- Trial name
- DEFINE (NCT05851547)
- Testing
- Prostate SBRT with Focal Boost, Triptorelin Injection
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Ottawa Hospital Research Institute
Prostate Cancer
A Study of Definitive Therapy to Treat Prostate Cancer
To assess the safety of treating men with oligometastatic prostate cancer with the following therapy: (1st) Systemic chemo-hormonal therapy with up to 6-months (~24 weeks) of neoadjuvant androgen deprivation and up to 6 cycles of…
- Trial name
- oligo-mets (NCT02716974)
- Testing
- Leuprolide Acetate, Bicalutamide, Docetaxel
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lung Cancer
Investigation of Respiratory-related Tumour Motion in Liver Cancer Patients Undergoing SBRT Using Audiovisual Biofeedback
Investigation of respiratory-related tumour motion in liver cancer patients undergoing stereotactic body radiotherapy treatment (SBRT) using audiovisual (AV) biofeedback.
- Trial name
- LAVA (NCT04323618)
- Testing
- Breathe Well
- Volunteers
- 5 people
- Sponsor
- University of Sydney
Prostate Cancer
A Study of MRI-guided High-dose Radiation Therapy in Prostate Cancer
One of the usual approaches to treating intermediate-risk prostate cancer is a type of radiation therapy called SBRT (stereotactic body radiation therapy).
- Trial name
- NCT04997018
- Testing
- Radiation Therapy
- Where
- 7 sites in United States
- Volunteers
- 91 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Metastatic Castrate- Resistant Prostate Cancer
Idronoxil Suppository Combine With Radiotherapy for Metastatic Prostate Cancer
The aim of the study is to determine the toxicity of Idronoxil (NOX66) when used in combination with palliative radiotherapy for metastatic prostate cancer
- Trial name
- NCT03041285
- Testing
- idronoxil (NOX66) suppository, Stereotactic Body Radiation Therapy
- Where
- Australia
- Volunteers
- 1 people
- Sponsor
- Royal North Shore Hospital
PSA Level Greater Than 0.03, PSA Progression
Stereotactic Body Radiation Therapy in Treating Patients With Localized Prostate Cancer That Have Undergone Surgery
This phase II trial studies how well stereotactic body radiation therapy works in treating patients with prostate cancer that has not spread to other parts of the body and have undergone surgery.
- Conditions
- PSA Level Greater Than 0.03, PSA Progression, Stage I Prostate Adenocarcinoma AJCC (American Joint Committee on Cancer ) v7, Stage II Prostate Adenocarcinoma AJCC v7
- Trial name
- NCT03541850
- Testing
- Antiandrogen Therapy, Quality-of-Life Assessment, Stereotactic Body Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Lung Cancer
Lung SBRT Motion Management (GCC 1619)
Real-time optical surface monitoring data will be acquired from 44 human patients with primary or metastatic lung lesions during and after their 4DCT scan (standard-of-care at our institution).
- Trial name
- NCT02695680
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Stage I Non-Small Cell Lung Cancer, Stage II Non-Small Cell Lung Cancer
Feasibility Study of SBRT Plus Chemotherapy for Non-Small Cell Lung Carcinoma
This pilot clinical trial studies stereotactic body radiation therapy followed by combination chemotherapy in treating patients with non-small cell lung cancer.
- Trial name
- NCT02319889
- Testing
- Stereotactic Body Radiotherapy, Carboplatin, Paclitaxel Albumin-Stabilized Nanoparticle Formulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Case Comprehensive Cancer Center
Brain Tumor
Serial CT Scans in Fractionated Stereotactic Radiotherapy
This study aims at providing a quantitative evaluation of the accuracy of two different fixation systems, where one system is also evaluated with two different set-ups.
- Trial name
- NCT00181350
- Testing
- Relocatable fixation system
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht Radiation Oncology
Urothelial Carcinoma
Anti-PD(L)1 and SBRT in the Treatment of Advanced, Platinum-Refractory Urothelial Carcinoma
This is a feasibility trial of anti-PDL1/PD1 (pembrolizumab) and stereotactic body radiation therapy (SBRT) in patients with advanced, platinum-refractory urothelial carcinoma.
- Trial name
- NCT03287050
- Testing
- Pembrolizumab, SBRT
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Michigan Rogel Cancer Center
Prostatic Adenocarcinoma
Hypofractionated Radiotherapy Versus Stereotactic Irradiation With Hyaluronic Acid
The present randomized, open, multicentric Phase II trial, in parallel groups with two arms of treatment, compares the treatment A, moderate hypofractionated radiotherapy of 62Gy, to treatment B, stereotactic irradiation of 37.5…
- Trial name
- RPAH2 (NCT02361515)
- Testing
- Moderate hypofractionated radiotherapy, Stereotactic radiotherapy
- Where
- 7 sites in France
- Volunteers
- 96 people
- Sponsor
- Hospices Civils de Lyon
Pancreatic Cancer
MFOLFIRINOX And Stereotactic Radiotherapy (SBRT) for Pancreatic Cancer With High Risk and Locally Advanced Disease
This is a prospective, multicentre randomised, phase II clinical trial, with randomisation 2:1 by minimisation and stratification by tumour stage, planned chemotherapy and institution.
- Trial name
- MASTERPLAN (NCT04089150)
- Testing
- Stereotactic Radiotherapy (SBRT), mFOLFIRINOX, Gemcitabine + Nab-paclitaxel
- Where
- 11 sites in Australia
- Volunteers
- 120 people
- Sponsor
- Australasian Gastro-Intestinal Trials Group
Pancreatic Cancer
SBRT and Anti-programmed Cell Death Protein 1(Anti-PD-1) in Late Stage or Recurrent Pancreatic Cancer Patients
When gemcitabine based chemo and fluorouracil based chemo regimes are failed in late-stage or recurrent pancreatic cancer patients, there is no alternative options. Anti-PD-1 antibody has became a promising anti-cancer drug.
- Trial name
- CISPD-2 (NCT03716596)
- Testing
- SBRT, anti-PD-1 antibody
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lung Cancer, Stereotactic Body Radiotherapy
Stereotactic Body Radiotherapy for Lung Lesions With Markerless Tracking (MLT) on the VERO® SBRT System
Stereotactic Body Radiotherapy (SBRT) delivers an ablative dose of radiation to tumours, with high precision. This technique offers an alternative to surgery for lung lesions.
- Conditions
- Lung Cancer, Stereotactic Body Radiotherapy, Lung Diseases, Lung Cancer Metastatic
- Trial name
- SBRT_LOV (NCT06722885)
- Testing
- Standard radiotherapy treatment
- Where
- Belgium
- Sponsor
- Universitair Ziekenhuis Brussel
Breast Cancer
Stereotactic Radiation and Immunotherapy in Patients With Advanced Triple Negative Breast Cancer
This is a multi-centre, open label, phase 2, randomised controlled trial of patients with advanced triple negative breast cancer (TNBC) who have received no more than one line of chemotherapy (not including neoadjuvant or…
- Trial name
- AZTEC (NCT03464942)
- Testing
- SABR, Atezolizumab
- Where
- Australia
- Volunteers
- 54 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Brain Metastases, Adult, Cancer Brain
Hypofractionated Brain Radiationcavity
Stereotactic radiosurgery or hypofractionated radiotherapy of the resection cavity after metastasectomy in cancer patients with brain metastases
- Trial name
- NCT03561896
- Testing
- IGRT, SRS
- Where
- 6 sites in Switzerland
- Volunteers
- 56 people
- Sponsor
- Oncology Institute of Southern Switzerland
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