Clinical trials: Stereotactic Body Radiation Therapy
Hepatocellular Carcinoma
Study of Pembrolizumab and Radiotherapy in Liver Cancer
This is a phase 2 study whose purpose is to assess the efficacy of the combination of pembrolizumab and stereotactic body radiotherapy (SBRT) in patients with advanced hepatocellular carcinoma (HCC) who have experienced disease…
- Trial name
- NCT03316872
- Testing
- Pembrolizumab, Stereotactic Body Radiotherapy (SBRT)
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University Health Network, Toronto
Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain
Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases
This phase III trial studies stereotactic radiosurgery (SRS) before surgery to see how well it works compared with SRS after surgery in treating patients with cancer that has spread to the brain (brain metastases).
- Trial name
- NCT03741673
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- M.D. Anderson Cancer Center
Squamous Cell Carcinoma of the Head and Neck, Nasopharyngeal Carcinoma
Stereotactic Body Radiotherapy for Head and Neck Tumors
This study will evaluate the local control rates as well as acute and late toxicity rates of stereotactic body radiotherapy (SBRT) for the treatment of benign and malignant head and neck tumors.
- Conditions
- Squamous Cell Carcinoma of the Head and Neck, Nasopharyngeal Carcinoma, Salivary Gland Cancer, Head and Neck Sarcoma
- Trial name
- NCT01344356
- Testing
- stereotactic body radiotherapy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mercy Research
Heptocellular Cancer
Radioembolization Versus External Radiation Therapy
The proposed study is a single site, prospective, randomized phase 2 study to evaluate the efficacy and tolerability transarterial radioembolization (TARE) versus stereotactic body radiation therapy (SBRT) for hepatocellular…
- Trial name
- REVERT (NCT07530172)
- Testing
- Transarterial Radioembolization, Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Henry Ford Health System
Non Small Cell Lung Cancer
Phase II Study of Upfront SRT Plus Ivonescimab/Chemotherapy vs Ivonescimab/Chemotherapy in NSCLC Brain Mets
This is a randomized, two-arm, comparative Phase II clinical trial designed to evaluate the difference in intracranial progression-free survival (iPFS) between two treatment strategies, assessed locally.
- Trial name
- NCT07234877
- Testing
- Ivonescimab, Carboplatin, Pemetrexed
- Where
- 26 sites in Austria, France and 6 more
- Volunteers
- 158 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Hematopoietic and Lymphoid Cell Neoplasm, Metastatic Malignant Solid Neoplasm
Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic Immunotherapy
This phase II trial studies the side effects and best dose of radiation therapy and to see how well it works in treating patients with cancer that has spread to other places in the body (metastatic) or has increased in size after…
- Trial name
- NCT02710253
- Testing
- External Beam Radiation Therapy, Laboratory Biomarker Analysis, Stereotactic Body Radiation Therapy
- Where
- 5 sites in United States
- Volunteers
- 214 people
- Sponsor
- M.D. Anderson Cancer Center
Treatment
Different Patterns of Target Delineation in SBRT for Locally Advanced Pancreatic Cancer
The purpose of this study is to compare the efficacy and safety of a recurrence-pattern-based-volume versus conventional-volume stereotactic body radiation therapy for locally advanced pancreatic cancer, so as to determine…
- Trial name
- NCT04699539
- Testing
- SBRT, Chemotherapy
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Changhai Hospital
Metastatic Prostate Cancer
Duration of Androgen Receptor Pathway Inhibitor and ADT With Metastasis Directed Therapy in Oligometastatic Cancer of the Prostate (DIRECT)
This is a multi-centre, investigator-initiated, three-arm, randomized trial to investigate the addition on androgen receptor pathway inhibitor and atorvastatin to standard of care radiation and hormone therapy improve quality of…
- Trial name
- DIRECT (NCT05404139)
- Testing
- Abiraterone, Standard of Care SBRT and ADT, Atorvastatin
- Where
- 2 sites in Canada
- Volunteers
- 352 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer
Prostate Boost Irradiation With Stereotactic Body RT (SBRT)
A randomized controlled open-label trial in patients with high risk prostate cancer. Eligible and consenting patients will be randomly allocated to receive stereotactic body radiotherapy (SBRT) boost to prostate or conventional…
- Trial name
- PBS (NCT03380806)
- Testing
- LHRH agonist, Pelvic Radiation, Stereotactic Body Radiotherapy (SBRT)
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Juravinski Cancer Center
Klatskin Tumor
Stereotactic Body Radiation Therapy After Chemotherapy for Unresectable Perihilar Cholangiocarcinoma
The objective of this study is to evaluate the efficacy of stereotactic body radiation therapy (SBRT) as additional treatment after standard chemotherapy regarding tumor local control, toxicity, progression-free survival (PFS)…
- Trial name
- STRONG II (NCT06493734)
- Testing
- Stereotactic body radiation therapy
- Where
- 8 sites in Belgium, Netherlands
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Neuroma, Acoustic
Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy
The investigators study is to investigate safety and efficacy of performing a planned incomplete removal of large acoustic neuroma tumors to decrease surgical morbidity and yet avoid tumor recurrence by post-operative radiation…
- Trial name
- NCT01129687
- Testing
- Microsurgery, Stereotactic radiation therapy
- Where
- 9 sites in United States
- Volunteers
- 157 people
- Sponsor
- Stanford University
Malignant Gliomas
Dose Escalation Study of Vandetanib With Hypofractionated Stereotactic Radiotherapy in Recurrent Malignant Gliomas
The purpose of the study is to find out the highest dose of vandetanib that can be safely given with repeat radiation therapy. This study drug has been designed to block certain chemical pathways that stimulate tumor to grow.
- Trial name
- IRUSZACT0073 (NCT00822887)
- Testing
- Vandetanib, Fractionated Stereotactic Radiotherapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
HER2-positive Metastatic Breast Cancer, Oligometastatic Disease
Stereotactic Radiation Therapy for HE2-positive Oligometastatic Breast Cancer
This study involves two non-randomized groups of patients: the observation group and the comparison group. The comparison group will retrospectively include data on 29 patients with oligometastatic HER2-positive breast cancer who…
- Trial name
- NCT06299852
- Testing
- Trastuzumab emtansine
- Where
- Russia
- Volunteers
- 58 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Lung Neoplasms
Stereotactic Body Radiotherapy (SBRT) Versus Sublobar Resection for High-Risk Patients Non-Small Lung Cancer
This randomized phase II trial is for medically inoperable early stage non-small cell lung cancer (NSCLC) patients. It is designed to compare the number of patients who are disease free and alive at 2 years between Stereotactic…
- Trial name
- NCT01622621
- Testing
- Sublobar Resection, Stereotactic Body Radiotherapy (SBRT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Recurrent Oligometastatic Disease
Radiosurgery for Patients Recurrent Oligometastatic Disease
This study will evaluate the feasibility of radiosurgery for all metastatic sites in patients presenting with oligometastatic disease, defined here as 5 or fewer sites of metastatic disease involving 3 or fewer organ systems.
- Trial name
- NCT01345552
- Testing
- Stereotactic Radiosurgery (SRS)
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- Steven Burton
Liver Metastases
Functional Liver After SBRT
In this study, the investigators aim to determine the dose-effect relationship between radiation dose and liver function by performing a hepatobiliary scintigraphy (HEBIS) before and after stereotactic body radiotherapy (SBRT)…
- Trial name
- FAFOR (NCT07033364)
- Testing
- Functional liver imaging using hepatobiliary scintigraphy (HEBIS)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- The Netherlands Cancer Institute
Acromegaly
Fractionated Stereotactic Radiotherapy in Patients With Acromegaly
Hypothesis: Fractionated stereotactic radiotherapy is a safe therapy for treatment of patients with acromegaly in terms of both tumour control and biochemical remission
- Trial name
- NCT00934271
- Testing
- fractionated stereotactic radiotherapy
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Bendamustine and Radiation Therapy in Treating Patients With Brain Metastases Caused by Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as bendamustine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00837928
- Testing
- bendamustine, laboratory biomarker analysis, Surgical Resection of Brain Metastases
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- John Grecula
Hepatocellular Carcinoma Non-resectable, Portal Vein Tumor Thrombus
Efficacy and Safety of SBRT Combined With Cardonilizumab and Lenvastinib in the Treatment of Unresectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
This study is a single-arm, multicenter clinical study to evaluate the efficacy and safety of SBRT combined with cardonilizumab and lenvastinib in the treatment of unresectable hepatocellular carcinoma with portal vein tumor…
- Conditions
- Hepatocellular Carcinoma Non-resectable, Portal Vein Tumor Thrombus, Immune Checkpoint Inhibitors
- Trial name
- NCT06040177
- Testing
- Cadonilimab, Stereotactic radiotherapy, Renvatinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Prostate Cancer
MRI in Assessing Hypoxia in Patients With Localized Prostate Cancer Undergoing Stereotactic Body Radiation Therapy
RATIONALE: Diagnostic procedures, such as MRI, may help measure oxygen levels in tumor cells. It may also help doctors predict a patient's response to treatment and help plan the best treatment.
- Trial name
- NCT00963300
- Testing
- blood-oxygen-level-dependent functional magnetic resonance imaging, dynamic contrast-enhanced magnetic resonance imaging, magnetic resonance spectroscopic imaging
- Sponsor
- University of Texas Southwestern Medical Center
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