Clinical trials: Stereotactic Body Radiation Therapy
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Sorafenib Tosylate With or Without Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer
This randomized phase III trial studies sorafenib tosylate and stereotactic body radiation therapy to see how well they work compared to sorafenib tosylate alone in treating patients with liver cancer.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT01730937
- Testing
- Sorafenib, stereotactic body radiation therapy
- Where
- 51 sites in United States, Australia and 3 more
- Volunteers
- 193 people
- Sponsor
- Radiation Therapy Oncology Group
Non-small Cell Lung Cancer (NSCLC)
FLT3 Ligand Immunotherapy and Stereotactic Radiotherapy for Advanced Non-small Cell Lung Cancer
Based on promising data from our laboratory demonstrating synergy between ablative local radiotherapy and FLT3 ligand immunotherapy in murine NSCLC models, investigators are performing a phase II study combining FLT3L…
- Trial name
- FLT3 (NCT02839265)
- Testing
- FLT3 Ligand Therapy (CDX-301), Stereotactic Body Radiotherapy (SBRT)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Montefiore Medical Center
Liver Cancer, Hepatocellular Cancer
A Study of Individualized Stereotactic Body Radiation Therapy (SBRT) for Intrahepatic Cancer
This is a Phase II trial to characterize the safety and efficacy of individualized stereotactic body radiation therapy (SRBT) for patients who have had previous liver treatment or who have primary hepatocellular carcinoma (HCC).
- Trial name
- NCT01522937
- Testing
- individualized Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Michigan Rogel Cancer Center
Lung Cancer (NSCLC)
Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Centrally Located Early-stage Non-small Cell Lung Cancer
This study aims to explore the safety and efficacy of eliminating the PTV (planning target volume) margins based on online adaptive stereotactic radiotherapy for patients with centrally located early-stage non-small cell lung…
- Trial name
- NCT06730295
- Testing
- Online adaptive SBRT
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sun Yat-sen University
Stage IV HCC, Immunotherapy
Combination of Sintilimab and Stereotactic Body Radiotherapy in Advanced Metastatic HCC
Hepatocellular carcinoma (HCC) is a common malignancy, and more than 70% of newly diagnosed HCC patients already have advanced disease. Sorafenib and lenvatinib are recommended as first-line options for advanced HCC.
- Conditions
- Stage IV HCC, Immunotherapy, SBRT
- Trial name
- NCT04547452
- Testing
- Stereotactic body radiation therapy, Anti-PD-1 antibody drug named Sintilimab
- Where
- China
- Volunteers
- 84 people
- Sponsor
- West China Hospital
Hepatocellular Carcinoma
CyberKnife Stereotactic Body Radiation Therapy for Small Hepatocellular Carcinoma Patients With Decompensated Cirrhosis
The aim of our research is to evaluate the curative effect and safety of CyberKnife stereotactic body radiation therapy in treating small hepatocellular carcinoma (HCC) patients with decompensated cirrhosis.
- Trial name
- NCT04512833
- Testing
- Cyberknife stereotactic body radiation therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing 302 Hospital
Brain Metastases
Phase I Dose Escalation in Patients With 1-3 Unresectable Brain Metastases
Brain metastases occur in 20-40% of patients with metastatic cancer. The standard treatment is based on whole brain radiation therapy and local treatment of metastases as neurosurgery or radiosurgery.
- Trial name
- NCT02080949
- Testing
- 4fx x 5Gy
- Where
- Brazil
- Sponsor
- Barretos Cancer Hospital
Hepatocellular Carcinoma
Combination Chemoembolization and Stereotactic Body Radiation Therapy in Unresectable Hepatocellular Carcinoma
The purpose of this study is to develop better ways to treat liver cancer, known as hepatocellular carcinoma or HCC, while it is still in the liver.
- Trial name
- NCT02513199
- Testing
- SBRT, TACE
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pancreatic Cancer
Pancreatic Tumor Cell Vaccine (GVAX), Cyclophosphamide, SBRT, and FOLFIRINOX in Patients With Resected Adenocarcinoma of the Pancreas
The purpose of this study is to estimate safety of GVAX Pancreas Vaccine (GVAX) with immune modulating doses of cyclophosphamide (Cy) followed by SBRT and FOLFIRINOX chemotherapy in pancreatic cancer patients after surgery.
- Trial name
- NCT01595321
- Testing
- Cyclophosphamide, GVAX Pancreas Vaccine, Stereotactic Body Radiation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hepatocellular Carcinoma
SBRT With Atezo/Bev for HCC
A phase I dose escalation and pharmacodynamic study of repeated dose stereotactic body radiotherapy (SBRT) administered with concurrent atezolizumab and bevacizumab for patients with advanced hepatocellular carcinoma (HCC)
- Trial name
- NCT05488522
- Testing
- SBRT + atezolizumab and bevacizumab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Locally Advanced Pancreatic Adenocarcinoma
Sequential Treatment With GEMBRAX and Then FOLFIRINOX Followed by Stereotactic MRI-guided Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
The aim of this study is to demonstrate the efficacy of intensified and sequential chemotherapy (Gabrinox) comprising Gembrax regimen (Gemcitabine-Abraxane) followed by the Folfirinox regimen (5FU, Oxaliplatin and Irinotecan) in…
- Trial name
- GABRINOX-ART (NCT04570943)
- Testing
- Gabrinox, MRI-GUIDED STEREOTACTIC RADIOTHERAPY
- Where
- 9 sites in France
- Volunteers
- 103 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Pancreatic Cancer
QUILT-3.060: NANT Pancreatic Cancer Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy
This is a phase 1b/2 study to evaluate the safety and efficacy of metronomic combination therapy in subjects with pancreatic cancer who have progressed on or after previous SoC chemotherapy.
- Trial name
- NCT03329248
- Testing
- ALT-803, ETBX-011, GI-4000
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- ImmunityBio, Inc.
Lung Cancer
SRS Study in Patients With Non-Small Cell Lung Cancer
The goal of this clinical research study is to learn if stereotactic body radiotherapy (SBRT) can help to control NSCLC. The safety of SBRT will also be studied.
- Trial name
- NCT00489008
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- M.D. Anderson Cancer Center
Patients Receiving Fractionated Stereotactic Radiotherapy, for Brain Tumors
Comparing Two Forms of Head Immobilization for Stereotactic Radiotherapy
Fractionated stereotactic radiotherapy (SRT) requires extremely precise and reproducible immobilization of the patient's head. This randomized study compares the efficacy of two commonly used forms of immobilization used for SRT.
- Trial name
- NCT00328510
- Testing
- GTC frame, Thermoplastic facemask, Stereotactic radiation therapy
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Non-Small Cell Lung Cancer, Brain Metastases From Non-small Cell Lung Cancer (NSCLC)
Osimertinib Plus Stereotactic Radiosurgery/Radiotherapy for EGFR-Mutant Non-Small Cell Lung Cancer With Symptomatic Brain Metastases
The goal of this clinical trial is to learn whether adding stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (SRT), delivered on a linear accelerator (LINAC), to osimertinib improves control of brain…
- Conditions
- Non-Small Cell Lung Cancer, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), EGFR Activating Mutation
- Trial name
- NCT07911449
- Testing
- Osimertinib, Stereotactic Radiosurgery
- Where
- Vietnam
- Volunteers
- 41 people
- Sponsor
- Cho Ray Hospital
Kidney Neoplasm
Systemic Treatment Alone Versus Systemic Treatment Plus Radiotherapy in Oligometastatic Renal Cell Carcinoma
To evaluate whether incorporating locoregional radiotherapy in the treatment of oligometastatic renal cell carcinoma, including inductive oligometastases, along with standard systemic therapy, contributes to improved…
- Trial name
- SABLOR (NCT06467097)
- Testing
- SBRT(Stereotatic Body Radiation Therapy)
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Samsung Medical Center
Malignant Neoplasm of Prostate, Locally Advanced Prostate Cancer
STereotActic Body Radiotherapy and 177Lutetium PSMA in Locally Advanced Prostate Cancer
The goal of this clinical trial is to is to investigate if it is possible to lower the chance of cancer reoccurrence and also preserve quality of life by using the drug Pluvicto instead of androgen-deprivation therapy to the…
- Trial name
- STARLiT (NCT06574880)
- Testing
- Lu-PSMA-617, 5-fraction Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Angela Y. Jia, MD PhD
Hepatocellular Carcinoma (HCC)
Comparison of SBRT and SIRT With Combination IO for Locally-advanced, Unresectable HCCs (BIIRTH)
The goal of this clinical trial is to compare the safety and efficacy of sequential Transarterial Chemoembolization (TACE) and Stereotactic body radiation therapy (SBRT) versus Y90-radioembolisation (SIRT), followed by systemic…
- Trial name
- BIIRTH (NCT07293468)
- Testing
- Transarterial chemoembolization (TACE), Stereotactic Body Radiation Therapy (SBRT), SIRT Yttrium-90
- Where
- Hong Kong
- Volunteers
- 106 people
- Sponsor
- Tuen Mun Hospital
Metastatic Colorectal Cancer
A Study of IMM-101 in Combination With Radiation Induced Tumour Necrosis in Colorectal Cancer
The purpose of this study is to investigate the safety and effects of IMM 101 in combination with a single targeted dose of radiation in patients with metastatic colorectal cancer in whom chemotherapy or other treatment has not…
- Trial name
- NCT01539824
- Testing
- Mycobacterium obuense, SBRT
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- Immodulon Therapeutics Ltd
Brain Metastases, Adult
A Neurocognitive Study in Patients With Brain Oligometastases Receiving Hypofractionated SRT
Background: For newly-diagnosed patients with brain metastasis, conventional whole-brain radiation therapy (WBRT) might still remain a common palliative management even for those with brain oligometastases.
- Trial name
- HF-SRT (NCT04805255)
- Testing
- Hypofractionated Stereotactic Radiotherapy
- Where
- 2 sites in Taiwan
- Volunteers
- 135 people
- Sponsor
- Chang Gung Memorial Hospital
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