Clinical trials: Stereotactic Body Radiation Therapy
Stereotactic Body Radiation Therapy, Lung Lesions
Impact of a Hypnotic Recording on Artifacts in 4D CT in the Context of Stereotactic Body Radiation Therapy for Lung Cancer
This is a single-center prospective cohort study evaluating the impact of a simple audio recording hypnosis system on the occurrence of artifacts on 4D CT scans in patients requiring SBRT radiotherapy for lung lesions (peripheral…
- Trial name
- HYPNOCT-4D (NCT07334990)
- Testing
- Hypnotic record
- Volunteers
- 25 people
- Sponsor
- Centre Leon Berard
Hepatocellular Carcinoma, Liver Metastases
Standard Versus Radiobiologically-Guided Dose Selected SBRT in Liver Cancer
Radiation is a standard treatment option for patients with liver cancer. Unfortunately, the tumour grows after radiation in many patients and radiation can harm normal tissues.
- Trial name
- SAVIOR (NCT04745390)
- Testing
- Radiation therapy
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Non Hodgkin Lymphoma
QUILT-3.052: NANT Non-Hodgkin Lymphoma (NHL) Vaccine: Combination Immunotherapy in Subjects With Relapsed CD20-positive NHL
This is a phase 1b/2 study to evaluate the safety and efficacy of metronomic combination therapy in subjects with with CD20-positive NHL who have progressed on or after rituximab therapy.
- Trial name
- NCT03169790
- Testing
- avelumab, bevacizumab, capecitabine
- Sponsor
- ImmunityBio, Inc.
SBRT, Borderline Resectable Pancreatic Cancer
Phase 2b Study of GC4711 in Combination With SBRT for Nonmetastatic Pancreatic Cancer
GTI-4711-201 is designed as a Phase 2b, multicenter, randomized, double-blind, placebo-controlled study to determine the effect to OS by adding GC4711 to SBRT following chemotherapy in patients with unresectable or borderline…
- Conditions
- SBRT, Borderline Resectable Pancreatic Cancer, Unresectable Pancreatic Cancer
- Trial name
- NCT04698915
- Testing
- Drug GC4711
- Where
- 35 sites in United States, Canada and 2 more
- Volunteers
- 177 people
- Sponsor
- Galera Therapeutics, Inc.
Prostate Cancer
A Study of Stereotactic Body Radiation Therapy and Radium (Ra-223) Dichloride in Prostate Cancer That Has Spread to the Bones
Participants will either receive treatment with standard SBRT and the study drug Radium (Ra-223) dichloride, or standard SBRT alone.
- Trial name
- NCT05133440
- Testing
- Radium dichloride, PET Scan
- Where
- 7 sites in United States
- Volunteers
- 12 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Head and Neck Neoplasms, Squamous Cell Carcinoma
A Study of SBRT for Squamous Cell Carcinoma of the Head and Neck
To evaluate the tumour response rate of squamous cell carcinoma of the head and neck following stereotactic body radiotherapy (SBRT) of 45Gy in 5 fractions delivered once every 3-4 days, such that treatment is completed within 15…
- Conditions
- Head and Neck Neoplasms, Squamous Cell Carcinoma, Squamous Skin Carcinoma
- Trial name
- SHINE (NCT04435938)
- Testing
- Stereotactic Body Radiotherapy (SBRT)
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McMaster University
Newly Diagnosed Oligometastatic Prostate Cancer
Systemic and Tumor-Directed Therapy for Oligometastatic Prostate Cancer
This is a trial for patients with newly diagnosed metastatic prostate cancer with 5 or fewer sites of metastases. The trial involves surgery (removal of the prostate) or radiation to the prostate, six months of hormone therapy…
- Trial name
- NCT03298087
- Testing
- radical prostatectomy, stereotactic body radiotherapy, Leuprolide
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Compression, Neoplasm Metastasis
Stereotactic Radiosurgery in Metastatic Spinal Cord Compression
To determine whether stereotactic radiosurgery of metastatic spinal cord compression is equivalent to decompressive surgery followed by external body radiation therapy to maintain ability to walk at 6 weeks.
- Trial name
- Stereocord (NCT02167633)
- Testing
- Decompression surgery, Radiosurgery, Fractionated Radiotherapy
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8
Magnetic Resonance-Guided Stereotactic Body Radiation Therapy for the Treatment of Prostate Cancer
This clinical trial studies the side effects and how well magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) works in treating patients with prostate cancer.
- Conditions
- Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8, Stage IIIB Prostate Cancer AJCC v8
- Trial name
- NCT07769372
- Testing
- Biopsy Procedure, Computed Tomography, Electronic Health Record Review
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Spinal Metastases, Local Control
Evaluate the Efficacy of Radiofrequency Ablation/Vertebroplasty with or Without SBRT for Treating Painful Spinal Vertebral Metastases
This study is a prospective, multicenter, open, practical, randomized controlled, non inferiority effect clinical study initiated by researchers, which aims to evaluate the clinical efficacy and safety of radiofrequency…
- Conditions
- Spinal Metastases, Local Control, Pain Cancer
- Trial name
- NCT06756087
- Testing
- Radiofrequency Ablation (RFA)/Vertebroplasty+Stereotactic Radiotherapy, Experimental
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Colorectal Cancer, Immunotherapy
Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases
Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. Its early clinical manifestations are often subtle, leading to late-stage diagnosis in about 30% of cases with distant metastases.
- Conditions
- Colorectal Cancer, Immunotherapy, Radiotherapy, Targeted Therapy
- Trial name
- NCT06356584
- Testing
- Immunotherapy (Sintilimab), Targeted Therapy Agent (Fruquintinib), Radiotherapy (SBRT and LDRT)
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Shandong Cancer Hospital and Institute
Recurrent Prostate Cancer
Trial of Ultrahypofractionated Focal Salvage Radiotherapy for Isolated Prostate Bed Recurrence After Radical Prostatectomy
The main objective of the trial is to explore the efficacy and safety of combining short-term androgen deprivation therapy (ADT) over 6 months to focal ultrahypofractionated salvage radiotherapy (SRT) delivered in 5 fractions to…
- Trial name
- HypoFocal SRT (NCT05746806)
- Testing
- Ultrahypofractionated salvage radiotherapy to a local recurrence after radical prostatectomy, Androgen deprivation therapy
- Where
- 5 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hepatocellular Carcinoma
Combination Chemoembolization and Stereotactic Body Radiation Therapy in Unresectable Hepatocellular Carcinoma
The purpose of this study is to develop better ways to treat liver cancer, known as hepatocellular carcinoma or HCC, while it is still in the liver.
- Trial name
- NCT02513199
- Testing
- SBRT, TACE
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Head and Neck Squamous Cell Carcinoma
3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial
To learn if it is effective to use advanced radiation treatment techniques (stereotactic radiation or "SBRT") to safely deliver a strong dose of radiation to your tumor in a shorter period of time than would typically be feasible…
- Trial name
- NCT05674396
- Testing
- Stereotactic body radiotherapy, Traditional Palliation
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- M.D. Anderson Cancer Center
Clear-cell Metastatic Renal Cell Carcinoma
Pembrolizumab Plus Radiotherapy for Advanced Renal Cancer
This study is designed as a phase-II proof of clinical trial to investigate if a treatment strategy where stereotactic body radiation therapy (SBRT) is given with pembrolizumab is sufficiently active to warrant further…
- Trial name
- NCT05567588
- Testing
- Drug: Pembrolizumab
- Where
- 2 sites in China
- Volunteers
- 66 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Prostate Adenocarcinoma
A Phase I-II Dose Escalation Study of Stereotactic Body Radiation Therapy in Patients With Localized Prostate Cancer
The aim of this study is to test the safety and efficacy of Stereotactic Body Radiation Therapy (SBRT) in localized prostate carcinoma in patients for whom the standard treatment is the irradiation of the entire prostate gland…
- Trial name
- NCT02254746
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- Switzerland
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Thromboembolism, Lung Cancer
Coagulation System In STereotactic Radiotherapy Of NSCLC
The risk of thromboembolism is elevated in lung cancer patients. The present project investigates whether stereotactic body radiation therapy (SBRT) further increases the risk of thromboembolic disease in lung cancer patients.
- Conditions
- Thromboembolism, Lung Cancer, NSCLC, Radiotherapy; Complications
- Trial name
- CISTRON (NCT03893461)
- Testing
- x
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Odense University Hospital
Non-Small Cell Lung Cancer
Efficacy and Safety Study of Stereotactic Body Radiotherapy (SBRT) With or Without Pembrolizumab (MK-3475) in Adults With Unresected Stage I or II Non-Small Cell Lung Cancer (NSCLC) (MK-3475-867/KEYNOTE-867)
The purpose of this study is to assess the efficacy and safety of stereotactic body radiotherapy (SBRT) plus pembrolizumab (MK-3475) in the treatment of adult participants with unresected Stage I or II (Stage IIB N0, M0)…
- Trial name
- NCT03924869
- Testing
- Stereotactic Body Radiotherapy (SBRT), Pembrolizumab
- Where
- 194 sites in United States, Argentina and 22 more
- Volunteers
- 448 people
- Sponsor
- Merck Sharp & Dohme LLC
Non-small Cell Lung Cancer
Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer
The purpose of this trial is to test a deescalated 3-fraction stereotactic body radiotherapy (SBRT) regimen to 45 Gray (Gy) in 3 fractions for centrally located thoracic tumors.
- Trial name
- NCT04210492
- Testing
- 45 Gray (Gy) regimen
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- Yale University
Breast Cancer
Combined Immunotherapies in Metastatic ER+ Breast Cancer
Women with Hormone Receptor (HR)+ Human Epidermal growth factor Receptor (HER)2- metastatic breast cancer are eligible to a randomized trial.
- Trial name
- NCT04563507
- Testing
- Stereotactic Body Radiation Therapy (SBRT) (50GY in 5 fractions), Letrozole 2.5Mg Tab, Palbociclib 125mg
- Where
- 3 sites in United States
- Volunteers
- 102 people
- Sponsor
- Weill Medical College of Cornell University
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