Clinical trials: Stereotactic Body Radiation Therapy
Non-small Cell Lung Cancer, Radiation Toxicity
Detecting Radiation-Induced Cardiac Toxicity After Non-Small Cell Lung Cancer Radiotherapy
Lung cancer is the most common cause of cancer death in Canada. For approximately 30% of patients that present with locally-advanced non-small cell lung cancer (NSCLC), the standard treatment is curative-intent concurrent…
- Trial name
- RICT-LUNG (NCT03416972)
- Testing
- Standard platinum-based chemoradiotherapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Advanced Merkel Cell Carcinoma, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Testing the Addition of Radiation Therapy to Immunotherapy for Merkel Cell Carcinoma
This randomized phase II trial studies how well pembrolizumab with or without stereotactic body radiation therapy works in treating patients with Merkel cell cancer that has spread to other places in the body (advanced).
- Conditions
- Advanced Merkel Cell Carcinoma, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8, Metastatic Merkel Cell Carcinoma
- Trial name
- NCT03304639
- Testing
- Pembrolizumab, Stereotactic Body Radiation Therapy
- Where
- 254 sites in United States
- Volunteers
- 9 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer
Trial of Either Surgery or Stereotactic Radiotherapy for Early Stage (IA) Lung Cancer
The standard treatment for an early stage I lung cancer is surgery. However, surgery can be associated with complications and long-term impairment of the quality of life of patients.
- Trial name
- ROSEL (NCT00687986)
- Testing
- stereotactic radiotherapy, primary surgery
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Amsterdam UMC, location VUmc
Inoperable Locally Advanced Non Small Cell Lung Cancer
Combined CFRT and SABR in Stage II and III NSCLC With Peripheral Tumors Smaller Than 5 cm.
A phase I trial is being conducted in patients with inoperable locally advanced NSCLC to treat with a combination of Conventional Fractionated Radiotherapy (CFRT) on the mediastinal lymph nodes and Stereotactic Ablative…
- Trial name
- N12HYB (NCT01933568)
- Testing
- SABR, Cisplatin
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- The Netherlands Cancer Institute
Oligometastatic Prostate Cancer
Phase II Study of SBRT as Treatment for Oligometastases in Prostate Cancer
This study aims to probe the effect of SBRT as a treatment oligometastases of prostate cancer, regardless of basal treatment received, and I know the response, biochemical control, the progression-free survival as well as their…
- Trial name
- NCT02192788
- Testing
- Stereotactic Body Radiation Therapy for Oligometastases
- Where
- 22 sites in Spain
- Volunteers
- 68 people
- Sponsor
- Grupo de Investigación Clínica en Oncología Radioterapia
Prostate Cancer, Prostate Cancer Recurrent
Stereotactic Body Radiotherapy With or Without Darolutamide for OligoRecurrent Prostate Cancer
The current trial will test the combination of darolutamide with SBRT, in oligometastatic recurrent hormone sensitive prostate cancer.
- Conditions
- Prostate Cancer, Prostate Cancer Recurrent, Prostate Cancer Metastatic, Metastatic Cancer
- Trial name
- DART (NCT04641078)
- Testing
- Darolutamide, metastasis-directed treatment
- Where
- 8 sites in Belgium
- Volunteers
- 124 people
- Sponsor
- University Hospital, Ghent
Adrenal Gland Metastases
An Image-guided SBRT for Adrenal Gland Metastasis in Oligometastatic Patients
The study is designed to to assess the efficacy of ablative SBRT delivered with VMAT technique in oligometastatic patients affected by adrenal gland metastases.
- Trial name
- NCT02848196
- Testing
- Stereotactic Body Radiation Therapy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Clinico Humanitas
Liver Metastases, Colorectal Cancer
Oligometastases of the LIVer Treated With Chemotherapy With ou Without Extracranial Stereotactic Body Radiation Therapy in Patients With Colorectal Cancer
The role of radiotherapy in metastatic cancer has historically been limited to palliation while metastasectomy or radiofrequency has emerged as playing a major role in disease control.
- Trial name
- OLIVER (NCT03532204)
- Testing
- SBRT, Chemotherapy
- Sponsor
- UNICANCER
Non-small Cell Lung Cancer Metastatic
Armatinib Alone or in Combination With SRT for Brain Metastases EGFR-mutated Non-small Cell Lung Cancer
Objective:Patients with asymptomatic or minimally symptomatic Stage IV EGFR-positive NSCLC with baseline intracranial metastases.
- Trial name
- NCT05800223
- Testing
- Almonertinib, SBRT
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Cancer Hospital, China
Colorectal Cancer
Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer
This research study is studying a drug in combination with radiation therapy as a possible treatment for hepatic metastases from colorectal cancer.
- Trial name
- NCT03223779
- Testing
- TAS-102, Photon SBRT
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital
Locally Advanced Head and Neck Squamous Cell Carcinoma
Neoadjuvant Radiotherapy Combined With Toripalimab for Locally Advanced Head and Neck Squamous Cell Carcinoma
This is a phase II study. Twenty-three patients with locally advanced head and neck squamous cell carcinoma were planned to be enrolled to assess the efficacy and safety of neoadjuvant immunotherapy combined with radiotherapy.
- Trial name
- NCT05861557
- Testing
- Toripalimab, Stereotactic Body Radiation Therapy (SBRT)
- Where
- 2 sites in China
- Volunteers
- 23 people
- Sponsor
- Tianjin Medical University General Hospital
Pancreatic Cancer Non-resectable, Brachytherapy
I125 Seed Implantation vs Stereotactic Radiotherapy for Pancreatic Cancer
Data of 100 patients with locally advanced pancreatic cancer who received stereotactic radiotherapy or ct-guided radioactive 125I seed implantation in the multicenter of the research group from July 2019 to June 2021 were…
- Conditions
- Pancreatic Cancer Non-resectable, Brachytherapy, Radiotherapy
- Trial name
- Ckvssip (NCT03964064)
- Testing
- Stereotactic Radiotherapy, 3D-printing Template-assisted CT-guided I125 Seed Implantation
- Where
- 4 sites in China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Recurrent Glioblastoma Multiforme
Hypofractionated Stereotactic Radiotherapy in Recurrent Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. The treatment comprises maximal safe resection followed by radiotherapy and chemotherapy.
- Trial name
- GBM Hypo RT (NCT01464177)
- Testing
- Stereotactic hypofractionated RT 5x5Gy, Stereotactic hypofractionated RT 5x7Gy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Andre Tsin Chih Chen
Recurrent Gynecologic Cancer, Recurrent Uterine Cancer
Reirradiation and Total Ablative Strategies for Recurrent Gynecologic Cancer
REGYNERA(dia)TION is an international, multicenter, ambispective observational patient registry of adults with recurrent gynecologic malignancies after prior radiotherapy who are treated or planned for reirradiation and/or total…
- Conditions
- Recurrent Gynecologic Cancer, Recurrent Uterine Cancer, Recurrent Cervical Cancer, Recurrent Vaginal Cancer
- Trial name
- Regynera-RT (NCT07667192)
- Testing
- Reirradiation, Total Ablative Strategy
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
HCC
Sequential TACE and SBRT Followed by ImmunoTherapy for Downstaging HCC for Hepatectomy
This study is a prospective phase II, single arm clinical study conducted in Queen Mary Hospital (Hong Kong) assessing the efficacy and safety of the sequential administration of trans-arterial chemo-embolization (TACE) and…
- Trial name
- START-FIT (NCT03817736)
- Testing
- TACE, SBRT, Immune Checkpoint Inhibitor
- Where
- Hong Kong
- Volunteers
- 33 people
- Sponsor
- The University of Hong Kong
Cancer of Pancreas, Unresectable Pancreatic Cancer
Clinical Phase II Clinical Study Evaluating the Toxicity and Efficacy of mFOLFIRINOX Associated With SBRT (Stereotactic Radiotherapy) in Patients With Unresectable Locally Advanced Pancreatic Cancer
Primary goal: Improvement of the therapeutic index by reducing the toxicity of treatment and increasing local control of the cancer process while evaluating the possibility of conversion to the surgical status.
- Conditions
- Cancer of Pancreas, Unresectable Pancreatic Cancer, Chemotherapy Effect, SBRT
- Trial name
- NCT03891472
- Testing
- Patients will receive initial chemotherapy, followed by evaluation of the response to the treatment, followed by SBRT, followed by chemotherapy.
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Silesia
Brain Metastasis
Hypofractionated Stereotactic Radiation Therapy of Brain Metastases: Evaluation of Whole-brain Radiotherapy
The aim is to identify in patients with brain metastases the predictive factors of overall survival, survival without local recurrence and survival with progression-free brain metastases after complementary whole brain…
- Trial name
- NCT02913534
- Testing
- whole brain radiotherapy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut de Cancérologie de Lorraine
Metastatic Malignant Neoplasm in the Brain
Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases
This randomized phase III trial studies stereotactic radiosurgery to see how well it works compared to clinical observation after surgery in treating patients with brain metastases.
- Trial name
- NCT00950001
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- M.D. Anderson Cancer Center
Early Stage Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8
Hotspot Stereotactic Ablative Radiotherapy Versus Traditional Stereotactic Ablative Radiotherapy for the Treatment of Early-Stage Non-Small Cell Lung Cancer
This clinical trial compares stereotactic ablative radiotherapy (SBRT) with hot spots to standard of care SBRT for the treatment of patients with early-stage non-small cell lung cancer.
- Conditions
- Early Stage Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8
- Trial name
- NCT07718672
- Testing
- Biospecimen Collection, Computed Tomography, Lymph Node Biopsy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Roswell Park Cancer Institute
Chordoma
Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent, Advanced, or Metastatic Chordoma
This phase I trial studies the side effects of nivolumab with or without stereotactic radiosurgery (SRS) in treating patients with chordoma that has come back or spread from where it started to other places in the body.
- Trial name
- NCT02989636
- Testing
- Laboratory Biomarker Analysis, Nivolumab, Stereotactic Radiosurgery
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
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