Clinical trials: Thalidomide
Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes
Thalidomide in Treating Patients With Myelodysplastic Syndrome
Phase II trial to study the effectiveness of thalidomide in treating patients who have myelodysplastic syndrome. Thalidomide may improve the immune system's ability to fight myelodysplastic syndrome
- Conditions
- Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes, Previously Treated Myelodysplastic Syndromes, Refractory Anemia
- Trial name
- NCT00015990
- Testing
- thalidomide, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Refractory Multiple Myeloma, Stage I Multiple Myeloma
Thalidomide, Dexamethasone, and Clarithromycin in Treating Patients With Multiple Myeloma Previously Treated With Transplant
This phase II trial studies the side effects and how well giving thalidomide, dexamethasone, and clarithromycin together works in treating patients with multiple myeloma previously treated with transplant.
- Conditions
- Refractory Multiple Myeloma, Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
- Trial name
- NCT00182663
- Testing
- clarithromycin, thalidomide, dexamethasone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fred Hutchinson Cancer Center
NSCLC
Conmana Combined With Thalidomide to Treat NSCLC
Our study the NSCLC harbors EGFR-mutation with Conmana combined with thalidomide as first-line treatment, is expected to improve further EGFR-Tyrosine kinase inhibitors (TKI) response rate (ORR), prolong time to progression…
- Trial name
- NCT02778893
- Testing
- Conmana, Thalidomide
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Henan Provincial People's Hospital
Multiple Myeloma
UARK 2003-25: A Study of Intravenous (IV) Busulfan (Busulfex®) in Multiple Myeloma Patients
The purpose of this study is to find out if patients with high risk disease because of age or kidney status can be treated more safely with a drug called Busulfex® followed by autologous transplant compared to treatment with the…
- Trial name
- NCT00113919
- Testing
- Busulfan
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Arkansas
Multiple Myeloma
UARK 2005-01 Study of Velcade, Thalidomide, and Dexamethasone (VTD) With or Without Adriamycin® in Relapsed/Refractory Patients
The main goal of this study is to evaluate the effectiveness of the combination of these drugs, and whether they can be given safely together.
- Trial name
- NCT00111748
- Testing
- Velcade, Thalidomide, Dexamethasone
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Arkansas
Multiple Myeloma
Phase II Randomised Trial of Cyclophosphamide & Dexamethasone in Combination With Ixazomib in Relapsed or Refractory Multiple Myeloma.
This study evaluates a new treatment combination of ixazomib with cyclophosphamide and dexamethasone in relapsed or refractory multiple myeloma.
- Trial name
- MUKEight (NCT02461888)
- Testing
- Ixazomib, Cyclophosphamide, Dexamethasone
- Where
- 18 sites in United Kingdom
- Volunteers
- 112 people
- Sponsor
- University of Leeds
High Grade Squamous Intra-epithelial Lesion (HSIL)
Study of Pomalidomide in Anal Cancer Precursors
This is a single centre open label phase II trial to determine the antitumor efficacy of the oral immunomodulatory agent pomalidomide in persistent human papillomavirus (HPV) -associated high grade squamous intra-epithelial…
- Trial name
- SPACE (NCT03113942)
- Testing
- Pomalidomide 2 MG Oral Capsule [Pomalyst]
- Where
- Australia
- Volunteers
- 26 people
- Sponsor
- Kirby Institute
Fallopian Tube Cancer, Primary Peritoneal Cavity Cancer
Tamoxifen Compared With Thalidomide in Treating Women With Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Randomized phase III trial to compare the effectiveness of tamoxifen with that of thalidomide in treating women who have recurrent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer.
- Conditions
- Fallopian Tube Cancer, Primary Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer, Stage III Ovarian Epithelial Cancer
- Trial name
- NCT00041080
- Testing
- tamoxifen citrate, thalidomide, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- National Cancer Institute (NCI)
Dermatomyositis
3T Therapy in the Treatment of MDA5-positive Dermatomyositis
The goal of this clinical trial is to learn if a combination of tacrolimus, tafocitinib and thalidomide (3T therapy) works to treat severe MDA5 positive dermatomyositis in adults.
- Trial name
- NCT06438679
- Testing
- Tofacitinib 5 MG
- Where
- China
- Volunteers
- 133 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Multiple Myeloma
UARK 2006-66, Total Therapy 3B: An Extension of UARK 2003-33 Total Therapy
With this study - Total Therapy IIIB - researchers are extending the findings of Total Therapy III based what they have learned from the first two studies (Total Therapy I and II), with new research strategies designed to explore…
- Trial name
- NCT00572169
- Testing
- Velcade, Thalidomide, Dexamethasone
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Arkansas
Liver, Cancer
Trial of Thalidomide, a- Interferon +/- Octreotide in Patients With Unresectable Hepatocellular Carcinoma
Primary Aim Determine the response rate and time to progression of the combination of thalidomide, interferon, and octreotide in patients with unresectable hepatocellular carcinoma (cancer of the liver that can't be treated…
- Trial name
- NCT00250796
- Testing
- Thalidomide, alpha interferon, Thalidomide, interferon, Octreotide
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of New Mexico
Pain
Evaluation of a TNF-Alpha Modulator for Clinical and Molecular Indicators of Analgesic Effect
This study will evaluate the role of thalidomide, a tumor necrosis factor (TNF)-alpha modulator, on severe inflammation and relief of pain following extraction of wisdom teeth.
- Trial name
- NCT00121563
- Testing
- Thalidomide, Ibuprofen or Diazepam
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Nursing Research (NINR)
Transfusion-dependent Thalassemia
Safety & Efficacy of Thalidomide in Children With Transfusion Dependent Thalassemia
Transfusion Dependent Thalassemia (TDT) is emerging as a global public health concern. Hemopoietic stem cell transplantation (HSCT) is the only curative treatment.
- Trial name
- NCT06098014
- Testing
- Thalidomide Capsules
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Multiple Myeloma
Clinical Outcomes and Prognostic Factors in Multiple Myeloma Patients
1. Description of the demographic, clinical, and laboratory characteristics of patients with MM admitted to the hematology unit of Assuit University Hospitals. 2.
- Trial name
- NCT06457464
- Testing
- Chemotherapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Syringomyelia, Thalidomide
The Therapeutic Effect of Thalidomide in Syringomyelia
Purpose: This phase II clinical trial aims to evaluate the indications, therapeutic effects and side effects of thalidomide in refractory syringomyelia.
- Trial name
- NCT06268093
- Testing
- Thalidomide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuanwu Hospital, Beijing
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Thalidomide and Chemoembolization With Doxorubicin in Treating Patients With Liver Cancer That Cannot be Removed by Surgery
This phase II trial is studying the effectiveness of combining thalidomide and chemoembolization in treating patients who have liver cancer that cannot be removed by surgery.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer
- Trial name
- NCT00006016
- Testing
- thalidomide, doxorubicin hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute (NCI)
HIV Infections
A Study of Thalidomide in HIV-Infected Patients Who Are Receiving HAART
To ascertain the effect of thalidomide on immune responses to vaccination with polyvalent pneumococcal polysaccharide vaccine and tetanus toxoid in HIV-infected patients; particularly, on markers of immune activation and…
- Trial name
- NCT00002392
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rockefeller University
Melanoma (Skin)
Thalidomide and SU5416 in Treating Patients With Metastatic Melanoma
Phase II trial to study the effectiveness of combining thalidomide and SU5416 in treating patients who have metastatic melanoma.
- Trial name
- NCT00017316
- Testing
- semaxanib, thalidomide
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Cancer Institute (NCI)
Myelodysplastic Syndrome
Safety and Efficacy of Azacitidine, and Thalidomide in Higher Risk MDS (Myelodysplastic Syndrome)
Study Objectives The aim of the study is to evaluate the safety and efficacy of the combination of 5-Aza-Cytidine + Thalidomide on the course of hrMDS patients.
- Trial name
- IMDS001 (NCT00704704)
- Testing
- 5-aza-cytidine and Thalidomide
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Leukemia
Thalidomide Anti-Angiogenesis Therapy of Relapsed or Refractory Leukemia
The purpose of this study is to evaluate the efficacy and safety of Thalidomide in patients with leukemia.
- Trial name
- NCT00083694
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Arkansas