Clinical trials: Topotecan, completed
Colon Cancer
Weekly Topotecan in Patients Treated for Metastatic Colorectal Cancer
This non-randomized phase II study is designed to assess the response rate and toxicity of weekly topotecan as second-line treatment in patients with relapsed or refractory metastatic colorectal cancer.
- Trial name
- NCT00193167
- Testing
- Topotecan
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- SCRI Development Innovations, LLC
Leukemia
Chemotherapy in Treating Children With Relapsed Acute Leukemia, Acute Myeloid Leukemia, or Blastic Phase Chronic Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of topotecan in treating children who have relapsed acute…
- Trial name
- NCT00003735
- Testing
- topotecan hydrochloride
- Where
- 38 sites in United States, Australia and 1 more
- Volunteers
- 11 people
- Sponsor
- Children's Oncology Group
Brain and Central Nervous System Tumors
Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy and radiation therapy with peripheral stem cell transplantation may allow the doctor…
- Trial name
- NCT00003211
- Testing
- filgrastim, amifostine trihydrate, cisplatin
- Where
- 4 sites in United States, Australia
- Volunteers
- 94 people
- Sponsor
- St. Jude Children's Research Hospital
Neuroblastoma
Combination Chemotherapy, Monoclonal Antibody, and Natural Killer Cells in Treating Young Patients With Recurrent or Refractory Neuroblastoma
This is a safety / feasibility trial evaluating the combination of a humanized anti-GD2 antibody (HU14.18K322A) manufactured at the Children's GMP, LLC at St.
- Trial name
- NCT01576692
- Testing
- Humanized anti-GD2 antibody, Chemotherapy, Cytokines
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- St. Jude Children's Research Hospital
Neuroblastoma
Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00004188
- Testing
- filgrastim, carboplatin, cisplatin
- Where
- 96 sites in United States, Canada
- Volunteers
- 495 people
- Sponsor
- Children's Oncology Group
Ovarian Cancer
Paclitaxel, Carboplatin, and Topotecan in Patients With Ovarian Cancer
The purpose of this study is to determine whether the triple combination of Carboplatin, Paclitaxel and Topotecan has a superior clinical outcome in the treatment of ovarian cancer compared with the combination of Carboplatin and…
- Trial name
- NCT00102375
- Testing
- Topotecan
- Where
- 18 sites in Germany
- Volunteers
- 900 people
- Sponsor
- AGO Study Group
Fallopian Tube Cancer, Ovarian Cancer
Paclitaxel Plus Carboplatin With or Without Topotecan in Treating Patients With Stage IIB, Stage III, or Stage IV Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00006454
- Testing
- carboplatin, paclitaxel, topotecan hydrochloride
- Where
- 19 sites in Germany
- Sponsor
- AGO Study Group
Malignancies, Acute Lymphoblastic Leukemia (ALL)
A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies
An open-label, global, multi-center study to evaluate the safety and pharmacokinetics of venetoclax monotherapy, to determine the dose limiting toxicity (DLT) and the recommended Phase 2 dose (RPTD), and to assess the preliminary…
- Conditions
- Malignancies, Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Non-Hodgkin's Lymphoma
- Trial name
- NCT03236857
- Testing
- chemotherapy, venetoclax
- Where
- 31 sites in United States, Australia and 6 more
- Volunteers
- 143 people
- Sponsor
- AbbVie
Gynecologic Tumors
Phase I Trial of Oral Metronomic Topotecan and Oral Pazopanib to Treat Recurrent/Persistent Gynecologic Tumors
This is a Phase 1, dose-escalation study in female patients with recurrent or persistent gynecologic tumors.
- Trial name
- NCT00800345
- Testing
- Oral Topotecan, Pazopanib
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Vector Oncology
Leukemia
Combination Chemotherapy in Treating Patients With Recurrent or Refractory Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00002588
- Testing
- etoposide, topotecan hydrochloride
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Tumors
A Study Evaluating BSI-201 in Combination With Chemotherapeutic Regimens in Subjects With Advanced Solid Tumors
The purpose of the study is to assess the safety and establish the maximum tolerated dose (MTD) of the combination of BSI-201 with chemotherapeutic regimens in adult subjects with histologically or cytologically documented…
- Trial name
- NCT00422682
- Testing
- bsi-201 + topotecan, bsi-201 + temozolomide, bsi-201 + gemcitabine
- Where
- 6 sites in United States
- Volunteers
- 136 people
- Sponsor
- Sanofi
Malignant Glioma, Glioblastoma
Avastin/Radiation (XRT)/Temozolomide (Temodar) Followed by Avastin/Temodar/Topotecan for Glioblastoma
This is a phase II study of the combination of radiation therapy, temozolomide and Avastin followed by Avastin, temozolomide, and topotecan in grade IV malignant glioma patients.
- Conditions
- Malignant Glioma, Glioblastoma, Gliosarcoma
- Trial name
- NCT01004874
- Testing
- Bevacizumab, Temozolomide, Radiation Therapy (XRT)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Fallopian Tube Cancer, Ovarian Cancer
ZD9331 With or Without Topotecan in Treating Patients With Refractory or Recurrent Epithelial Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining two or more drugs may kill more tumor cells.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00014690
- Testing
- plevitrexed, topotecan hydrochloride
- Where
- United States
- Sponsor
- AstraZeneca
Gliomas
Chronic Convection Enhanced Delivery of Topotecan
The primary goal of this study is to establish, for the first time, safety of prolonged intracerebral convection enhanced delivery of chemotherapy in patients with recurrent high grade glioma (HGG).
- Trial name
- NCT03154996
- Testing
- Topotecan, Gadolinium, Synchromed II infusion pumps
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Columbia University
Uterine Cervical Neoplasms
Safety and Tolerability Evaluation Study of BVAC-C in Patients With HPV Type 16 or 18 Positive Cervical Cancer
BVAC-C is an immunotherapeutic vaccine using B-Cell and Monocytes as antigen-presenting cells. This study is consists of 2 parts. Phase I is for safety evaluation, and Phase IIa is for efficacy assessment.
- Trial name
- NCT02866006
- Testing
- BVAC-C, Topotecan
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Cellid Co., Ltd.
Solid Tumors
Treatment Extension Study for Patients Who Have Previously Participated and Have Benefited From Iniparib in a Clinical Trial
The purpose of this study is to assess the safety and tolerability of iniparib administered as monotherapy or in combination regimens in patients previously treated with iniparib in a clinical study and who have derived clinical…
- Trial name
- NCT01593228
- Testing
- Iniparib (SAR240550/BSI-201), Carboplatin, Doxorubicin HCL liposome injection
- Where
- 32 sites in United States, Belgium and 2 more
- Volunteers
- 37 people
- Sponsor
- Sanofi
Small Cell Lung Cancer
A Randomized Study to Compare the Efficacy and Safety of Belotecan and Topotecan as Monotherapy for Sensitive-Relapsed Small Cell Lung Cancer
The purpose of this study is to evaluate the efficacy and safety of Belotecan administered 5 days every 3 weeks in comparison to Topotecan in Patients with relapsed small cell lung cancer.
- Trial name
- NCT01497873
- Testing
- Topotecan, Belotecan
- Where
- 14 sites in South Korea
- Volunteers
- 164 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Ovarian Cancer
Hycamtin Plus Carboplatin Versus Established Regimens for the Treatment of Ovarian Cancer Relapse
Determination of progression free survival after 12 months of FU Determination of total survival, response and quality of life
- Trial name
- HECTOR (NCT00437307)
- Testing
- Topotecan
- Where
- Germany
- Volunteers
- 550 people
- Sponsor
- North Eastern German Society of Gynaecological Oncology
Solid Tumours
Open-label Study of Topotecan and Pazopanib in Advanced Solid Tumors
To determined what dose of topotecan can be safely given with daily pazopanib.
- Trial name
- NCT00732420
- Testing
- topotecan, pazopanib
- Where
- 3 sites in United States, Netherlands
- Volunteers
- 68 people
- Sponsor
- GlaxoSmithKline
Retinoblastoma
Topotecan Episcleral Plaque for Treatment of Retinoblastoma
This single site, single-arm, non-randomized, dose escalation phase I toxicity clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients with active de novo or residual or…
- Trial name
- STEP-RB (NCT04428879)
- Testing
- Topotecan Episcleral Plaque
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- The Hospital for Sick Children