Clinical trials: Tranexamic Acid, completed
Intrapartum - Moderate and Severe Anaemia
World Maternal Antifibrinolytic Trial_2
Postpartum haemorrhage (PPH) is responsible for about 100,000 maternal deaths every year, almost all of which occur in low and middle income countries.
- Trial name
- WOMAN-2 (NCT03475342)
- Testing
- Tranexamic Acid
- Where
- 41 sites in Nigeria, Pakistan and 2 more
- Volunteers
- 15,068 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Tranexamic Acid Adverse Reaction
Tranexamic Acid in Sleeve Gastrectomy
The effectiveness of Tranexamic acid use will be measured in cases of sleeve gastrectomy in bariatric surgery and in early postoperative bleeding.
- Trial name
- NCT05696951
- Testing
- Transamine 200mg iv
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Robotic-assisted Radical Prostatectomy
Can the Prophylactic Administration of Tranexamic Acid Reduce Blood Loss After Robotic-assisted Radical Prostatectomy?
The prophylactic administration of tranexamic acid reduces blood loss during procedures at high risk of perioperative bleeding. Several studies in neurosurgery, cardiac surgery, and orthopedics confirm this finding.
- Trial name
- RARPEX (NCT04319614)
- Testing
- Tranexamic Acid Injectable Product
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Hradec Kralove
Osteoarthritis
Efficacy of Intravenous Versus Topical Tranexamic Acid in Primary Total Hip Arthroplasty
Bleeding during and after total hip replacement surgery is a primary concern to the surgical and anaesthetic team. Tranexamic acid is a commonly-used drug that helps blood clotting and decreases surgical bleeding.
- Trial name
- TeACH-R (NCT02056444)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Intraoperative Bleeding, Postoperative Edema
Prevention of Intraoperative Bleeding and Postoperative Swelling in Orthognathic Surgery Through the Use of Tranexamic Acid
Purpose of the study: To evaluate the effect of tranexamic acid (TXA) of intraoperative blood loss in patients subjected to bi-maxillary orthognathic surgery To evaluate the potential effect of TXA on fibrin structure To evaluate…
- Trial name
- TXA2014-15 (NCT02229292)
- Testing
- Tranexamic Acid, Saline
- Where
- Denmark
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Ligamentoplasty, Anterior Cruciate Ligament (ACL)
A Study Aiming to Demonstrate That the Addition of Intravenous (IV) Tranexamic Acid-Compared to Placebo-During Anterior Cruciate Ligament (ACL) Reconstruction Results in Reduced Blood Loss and Postoperative Pain.
Various reconstruction and graft harvesting techniques are used for ACL reconstruction. The most common techniques involve harvesting one or more hamstring tendons.
- Trial name
- EXACYLCA (NCT07753161)
- Testing
- ACL reconstruction
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Knee Arthroplasty, Total
Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Double Blind Randomized Placebo Controlled Clinical Trial
Total Knee Arthroplasty (TKA) is a common orthopedic surgery usually leads to Bleeding. The null hypothesis of this study was that TA has no effect on post surgical bleeding in patients undergoes TKA.
- Trial name
- NCT02327117
- Testing
- Tranexamic Acid, Normal saline
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Isfahan University of Medical Sciences
Surgical Field Quality Improvement in Spine Surgeries
Tranexamic Acid Versus Dexmedetomidine for Improving Surgical Field Quality During Spine Surgeries
The most common procedure said to involve substantial bleeding is spine surgery. There is always a significant danger of bleeding and blood transfusion associated with these procedures, particularly complex and multilevel spine…
- Trial name
- NCT06587620
- Testing
- Tranexamic acid, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Fast Track, Tranexamic Acid Adverse Reaction
Implementation of a Rapid Recovery Protocol in Total Knee Arthroplasty
Patients undergoing total knee arthroplasty will follow two different rehabilitation protocols. In one of them, they will start walking the day of surgery and discharged on a 48 hours basis.
- Conditions
- Fast Track, Tranexamic Acid Adverse Reaction, Knee Osteoarthritis
- Trial name
- NCT03823573
- Testing
- Walk within 24 hours
- Where
- Spain
- Volunteers
- 175 people
- Sponsor
- Ignacio Aguado Maestro
Chronic Rhinosinusitis With Polyposis, Chronic Hyperplastic Sinusitis
Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is an effective treatment of sinus disease. FESS is carried out using cameras to view the surgical field. Bleeding during the surgery can lead to poor surgical field visualization.
- Trial name
- NCT01111669
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Osteoarthritis, Knee
Efficacy and Safety of Topical Application of Tranexamic Acid for Saving Blood Losses in Patients Subjected to Prosthetic Knee Surgery
To compare the efficacy and safety of topical tranexamic acid versus placebo in patients diagnosed with severe knee osteoarthritis who will undergo prosthetic knee surgery in terms of saving blood loss (estimated blood loss…
- Trial name
- TRA (NCT03386656)
- Testing
- Amchafibrin, Saline Solution
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Blood Loss, Surgical
Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss After Total Hip Replacement
This study compares two oral medications (tranexamic acid and aminocaproic acid) as hemostatic agent administered in patients undergoing primary total hip replacement
- Trial name
- NCT04187014
- Testing
- Aminocaproic Acid 1000Mg Tab, Tranexamic acid tablets
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Carlos A Acosta-Olivo
Knee Prosthesis
Evaluation of the Pharmacokinetic Profile of Tranexamic Acid, After Injection in a Knee Neo-articulation.
Evaluate the pharmacokinetic profile of tranexamic acid injected intra-articularly with or without adrenaline, in a population of patients undergoing knee replacement.
- Trial name
- NCT02319915
- Testing
- Tranexamic Acid, Adrenalin
- Where
- Belgium
- Volunteers
- 14 people
- Sponsor
- Brugmann University Hospital
Femoral Neck Fractures
Topical (Intra-Articular) Tranexamic Acid and Transfusion Rates Following Hip Hemiarthroplasty
This study is a double-blinded placebo-controlled clinical trial evaluating the efficacy of 1 gram of topically applied tranexamic acid vs. saline placebo for the reduction of transfusion following hip hemiarthroplasty surgery.
- Trial name
- NCT02664909
- Testing
- Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- UConn Health
Knee Osteoarthritis, Total Knee Arthroplasty
Hemoglobin Drop and Need for Blood Transfusion in Primary Knee Arthroplasty With or Without Drain Insertion
Total knee arthroplasty is a common operation performed to relieve pain and improve movement in patients with severe knee joint disease, such as osteoarthritis, rheumatoid arthritis, post-traumatic arthritis, or osteonecrosis.
- Trial name
- NCT07494708
- Testing
- Closed Suction Drain Insertion, No Drain Placement
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- Shifa International Hospital
Hyperfibrinolysis, Haemorrhage
Effects of an Early Prehospital Administration of Tranexamic Acid on Hyperfibrinolysis in Multiple Trauma
Severe external and internal bleedings are common in multiple trauma patients. Uncontrollable blood loss is the cause for about one third of all trauma deaths.
- Conditions
- Hyperfibrinolysis, Haemorrhage, Mortality
- Trial name
- NCT01938768
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University of Göttingen
Knee Osteoarthritis
Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)
The knee osteoarthritis is a frequent degenerative condition that mainly affects subjects over 60, population often weakened by numerous comorbidities and concomitant treatments, justifying the development of new therapies.
- Trial name
- PANDORA2 (NCT05978180)
- Testing
- Medical Device : HO-1, Medical Device : HS-3, Medical Device : SINOVIAL® ONE
- Where
- 35 sites in France, Monaco
- Volunteers
- 252 people
- Sponsor
- Labrha
Bleeding, Hemoptysis
Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy
Endobronchial bleeding is a common complication of bronchoscopy. Major bleeding, although rare, can be life threatening and often requires advanced therapeutic interventional pulmonary procedures which are not widely available.
- Trial name
- TAVA2 (NCT06145191)
- Testing
- Tranexamic acid, Adrenaline
- Where
- Croatia
- Volunteers
- 1,013 people
- Sponsor
- Clinical Hospital Centre Zagreb
Osteoarthritis, Hip Arthropathy
Topical Tranexamic Acid (TXA) in Joint Arthroplasty
The objective of this study is to evaluate the efficacy of topical tranexamic acid (TXA) in decreasing blood loss following both shoulder arthroplasty and primary total hip arthroplasty.
- Conditions
- Osteoarthritis, Hip Arthropathy, Shoulder Arthropathy
- Trial name
- NCT01937559
- Testing
- Tranexamic acid (TXA), Normal saline
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- The Hawkins Foundation
Hemorrhage, Postpartum, Placenta Previa
Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa
Many RCT(randomized controlled trial) studies reported that tranexamic acid reduced blood loss in women who had elective cesareans.
- Trial name
- TRAPP (NCT05811676)
- Testing
- Tranexamic acid, 0.9% sodium chloride
- Where
- 27 sites in China
- Volunteers
- 1,732 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University