Clinical trials: Tranexamic Acid, open to volunteers
Obese Patients, Obese Patients With Bariatric Surgery
Intravenous Tranexamic Acid
Tranexamic acid is a promising option for minimizing blood loss in high-risk bariatric surgery patients, particularly in those with obesity, diabetes, and other comorbidities.
- Conditions
- Obese Patients, Obese Patients With Bariatric Surgery, Bleeding
- Trial name
- TXA (NCT07192640)
- Testing
- After induction of anaesthesia tranexamic acid will be administered at the start of surgery to reduce intraoperative bleeding. loading dose of 10 mg/kg for high BMI patients who are undergoing bariatr
- Where
- Saudi Arabia
- Volunteers
- 128 people
- Sponsor
- Ain Shams University
Post Partum Hemorrhage
ROLE OF PROPHYLACTIC TRANEXAMIC ACID IN PREVENTION OF POST-PARTUM HEMORRHAGE IN ELLSCS
IN THIS STUDY WOMEN UNDER GOING ELLSCS WOULD BE DIVIDED INTO TWO GROUPS , ONE GROUP WOULD BE GIVEN TRANEXAMIC ACID WHILE THE OTHER WOULD BE GETTING PLACEBO PROPHYLACTICALLY TO SEE THE EFFECT OF TRANEXAMIC ACID IN PREVENTING PPH.
- Trial name
- NCT07002749
- Testing
- Tranexamic Acid (TXA)
- Where
- Pakistan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Patel Hospital, Pakistan
Distal Radius Fractures
Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation
The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people…
- Trial name
- TRADR (NCT06384456)
- Testing
- Topical TRanexamic Acid
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University Health Network, Toronto
Surgery, Cardiac, Tranxemic Acid
The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery
The goal of this clinical trial is to the dose effect of tranexamic acid and the level of ACT on bleeding in adult cardiac surgery. The main questions it aims to answer are: 1.
- Conditions
- Surgery, Cardiac, Tranxemic Acid, Activated Clotting Time, Heparin
- Trial name
- NCT06109155
- Testing
- Tranexamic acid
- Where
- 2 sites in Taiwan
- Volunteers
- 150 people
- Sponsor
- Taichung Veterans General Hospital
Post Partum Haemorrhage
Investigating the Efficacy of Tranexamic Acid as a Prophylactic Agent in Reducing Postpartum Hemorrhage Among Patients Undergoing Cesarean Section in SQUH
Investigating the efficacy of tranexamic acid (TXA) as a prophylactic agent in reducing postpartum haemorrhage (PPH) among patients undergoing cesarean section (CS) in SQUH: a prospective randomized controlled trial.
- Trial name
- NCT07474077
- Testing
- tranexamic acid (1 g diluted in 100 mL of 0.9% saline, Normal (0.9%) saline
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Sultan Qaboos University
Melasma
Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma
In this study, the investigators evaluate the potential efficacy of TXA alone and microneedling assisted with glutathione alone versus combination of oral tranexamic acid and glutathione-assisted microneedling in the treatment of…
- Trial name
- NCT07448415
- Testing
- microneedling, Oral tranexamic acid, Glutathione
- Volunteers
- 42 people
- Sponsor
- Assiut University
Orbital Edema, Orbital Ecchymosis
The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery
Tranexamic acid (TXA) is a synthetic reversible competitive inhibitor to plasminogen lysine receptor, which prevents plasmin formation and stabilizes the fibrin matrix, thus reducing bleeding.
- Trial name
- NCT06450392
- Testing
- Tranexamic acid injection, Tranexamic Acid in NaCl,Iso-Os 1,000 Mg/100 mL (10 Mg/mL) INTRAVEN INTRAVENOUS SOLUTION, PIGGYBACK (ML), normal saline - injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Montefiore Medical Center
ACL Reconstruction, Hemarthrosis
Study the Anti-inflammatory Effect of Tranexamic Acid When Used in Anterior Cruciate Ligament Reconstruction.
Tranexamic acid (TXA) is widely used in orthopedic surgery to reduce perioperative blood loss, particularly in total hip and knee arthroplasty, due to its antifibrinolytic mechanism, low cost, broad availability, and established…
- Trial name
- TXA (NCT07332910)
- Testing
- Tranexamic Acid (TXA)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Chirec
Epistaxis Nosebleed
Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid
Nosebleeds are very common, occurring in 60% of the population; in some patients, nosebleeds are a life-threatening emergency. To stop a nosebleed in the emergency department, doctors usually have to burn the nose (called…
- Trial name
- Bloody SIMPLE (NCT06997796)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Dr. Anne Conlin
Pregnant Women Undergoing Cesarean Delivery
Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Pregnant Women Undergoing Cesarean Section
The purpose of this study is to asses the effect of preoperative prophylactic intravenous tranexamic acid on perioperative blood loss in pregnant women undergoing cesarean section
- Trial name
- NCT07078942
- Testing
- Tranexamic Acid
- Where
- Thailand
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Antifibrinolytic Agents
Point-of-care Measurement of the Antifibrinolytic Activity of Tranexamic Acid in Cardiac Surgery
Tranexamic acid (TXA) is a widely used antifibrinolytic agent that can reduce postoperative blood loss and packed red blood cell transfusions during cardiac surgery.
- Trial name
- PAATICS (NCT06128330)
- Testing
- Tranexamic acid bolus 20 mg/kg, Tranexamic acid bolus 10 mg/kg, Tranexamic acid bolus 1 mg/kg
- Where
- Switzerland
- Volunteers
- 322 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postpartum Hemorrhage
Tranexamic Acid to Prevent Heavy Bleeding After Childbirth in Women at Higher Risk
Heavy bleeding after childbirth, known as a postpartum haemorrhage (PPH), causes about 70,000 maternal deaths every year. Tranexamic acid (TXA) is a lifesaving treatment for women with PPH.
- Trial name
- I'M-WOMAN (NCT05562609)
- Testing
- Tranexamic acid
- Where
- Tanzania
- Volunteers
- 40,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Blood Coagulation Disorder, Postoperative Blood Loss
Comparative Study of Tranexamic Acid Dosing in Cardiac Surgery
Tranexamic axid is routinely used as an antifibrinolytic agent in cardiac surgery to reduce the risk of blood loss and transfusion.
- Conditions
- Blood Coagulation Disorder, Postoperative Blood Loss, Adverse Drug Event, Fibrinolysis; Hemorrhage
- Trial name
- NCT07164300
- Testing
- Tranexamic acid at a dose of 10 mg/kg followed by 1 mg/kg/h, Tranexamic acid at a dose of 20 mg/kg, Tranexamic acid at a dose of 30 mg/kg
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University of Ioannina
Osteo Arthritis Knee, Pain, Postoperative
Extended Oral Tranexamic Acid After Total Knee Arthroplasty
The utilization of intraoperative tranexamic acid (TXA), whether administered intravenously or orally, has become a standard practice in total joint arthroplasty (TJA).
- Trial name
- NCT06618820
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Campbell Clinic
Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children
Clinical Spectrum and Management of Von Willebrand Disease Among Children in Assiut Governorate
Von Willebrand disease (VWD) is the most common inherited bleeding disorder in children. It occurs due to a deficiency or dysfunction of von Willebrand factor, a protein that plays an essential role in blood clotting.
- Conditions
- Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children, Pediatric Hemostatic Disorders
- Trial name
- VWD-ASSIUT (NCT07410130)
- Testing
- Tranexamic Acid, Von Willebrand Factor-Containing Concentrates
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Assiut University
Brain Tumor, Bleeding
The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies
The goal of this clinical trial is to test the effect of a drug called tranexamic acid (TXA) on reducing blood loss in participants undergoing surgery to remove brain tumors. The main questions it aims to answer are: 1.
- Trial name
- NCT06229483
- Testing
- TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS INJECTION, SOLUTION
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Stephen Lownie
Hemorrhage, Surgical, Tonsillar Bleeding
TEAPOT Study Multisite
After a child has their tonsils removed, sometimes they might bleed which can be a problem. There is a special mist medicine called nebulized tranexamic acid (TXA) that might help stop the bleeding without having to touch the…
- Trial name
- TEAPOT (NCT07565753)
- Testing
- Tranexamic Acid Injectable Product, Normal Saline
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Urethral Stricture, Urethral Diseases
REDUCER Trial (TXA in Urethroplasty)
This study will test whether tranexamic acid (TXA), a medication used to reduce bleeding, can decrease blood loss in patients having urethroplasty.
- Trial name
- REDUCER (NCT07501884)
- Testing
- Tranexamic Acid, Urethroplasty
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Amjad Alwaal, MD, MSc, FRCSC, FACS
Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding
Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients
The goal of this randomized controlled clinical trial is to evaluate the efficacy of Tranexamic acid and vitamin K injection versus placebo in control of upper gastrointestinal bleeding (UGIB) in Egyptian cirrhotic patients.
- Conditions
- Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding, Cirrhosis
- Trial name
- NCT06881628
- Testing
- Tranexamic Acid and vitamin K
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Tanta University
Postpartum Hemorrhage, Systemic Autoimmune Diseases
Prophylactic Tranexamic Acid Reduces Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the most significant leading cause of pregnancy-related mortality in high-risk cesarean delivery women.
- Trial name
- NCT06754371
- Testing
- tranexamic acid, normal saline
- Where
- China
- Volunteers
- 276 people
- Sponsor
- RenJi Hospital