Clinical trials: Tranexamic Acid, completed
Postoperative Pain
Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty
The primary purpose of this study is to evaluate postoperative pain. Secondary outcomes evaluated in this study will include range of motion (ROM), opioid consumption, and ambulation.
- Trial name
- NCT06479161
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Matthew Grosso, MD
Heart Diseases, Vascular Diseases
Goal-directed vs. Empirical Tranexamic Acid Administrationin Cardiovascular Surgery
The present study is a multi-center randomized prospective placebo-controlled non-inferiority trial. The study's primary objective is to compare the amounts of postoperative bleeding using two different TXA administration…
- Conditions
- Heart Diseases, Vascular Diseases, Transfusion Related Complication, Coagulation Disorder, Blood
- Trial name
- NCT05806346
- Testing
- TXA administration
- Where
- 3 sites in South Korea
- Volunteers
- 764 people
- Sponsor
- Konkuk University Medical Center
Tranexamic Acid Administration, Postpartum Hemorrhage
Tranexamic Acid for Reducing Blood Loss in High-Risk Cesarean Delivery
This randomized study evaluated whether prophylactic tranexamic acid (TXA) reduces perioperative blood loss in women at increased risk of postpartum hemorrhage undergoing elective cesarean delivery.
- Conditions
- Tranexamic Acid Administration, Postpartum Hemorrhage, Blood Transfusion, Perioperative Blood Loss
- Trial name
- TXA (NCT07870499)
- Testing
- Tranexamic Acid
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Mert Yetgin
Kidney Calculi, Urologic Diseases
Tranexamic Acid to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP)
This study is designed to assess if there is a significant difference in same day discharge rates after Holmium Laser Enucleation of the Prostate (HoLEP).
- Conditions
- Kidney Calculi, Urologic Diseases, Benign Prostatic Hypertrophy
- Trial name
- NCT05082142
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Northwestern University
Bleeding, Contraceptive Device; Complications
Tranexamic Acid to Reduce Contraceptive-related Bleeding Side Effects
This randomized double blinded trial seeks to determine whether tranexamic acid (TXA) is an efficacious treatment for contraceptive induced menstrual changes (CIMC) including irregular, bothersome bleeding caused by the…
- Trial name
- NCT06000423
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Oregon Health and Science University
Healthy Participants
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Tranexamic acid is a well-established treatment for post-partum hemorrhage. This study aims to examine the effect of tranexamic acid administration rates on blood pressure changes over 1 minute compared to 10 minutes in healthy…
- Trial name
- RateTXA (NCT06356948)
- Testing
- Tranexamic Acid (TXA)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Surgical Blood Loss, Transfusion-dependent Anemia
Tranexamic Acid for Reduction of Transfusion in Abdominal Surgery
The goal of this clinical trial is to learn if the administration of tranexamic acid can reduce the necessity of blood transfusions in adult patients undergoing major abdominal surgery. .
- Conditions
- Surgical Blood Loss, Transfusion-dependent Anemia, Abdomen Disease
- Trial name
- TATRA (NCT06414031)
- Testing
- Tranexamic Acid
- Where
- 2 sites in Germany
- Volunteers
- 892 people
- Sponsor
- Ulrich Ronellenfitsch, MD
Rotator Cuff Tears
Intravenous Versus Intra-articular Tranexamic Acid for Visual Clarity During Arthroscopic Rotator Cuff Repair
This single-center, prospective, randomized, double-blind controlled trial evaluated whether intravenous (IV) or intra-articular (IA) administration of tranexamic acid (TXA) improves intraoperative visual clarity, compared with a…
- Trial name
- NCT07686705
- Testing
- Tranexamic acid (intra-articular), Tranexamic acid (intravenous)
- Where
- South Korea
- Volunteers
- 115 people
- Sponsor
- Konkuk University Medical Center
Patients Receiving Direct Oral Anticoagulants
Effect of Tranexamic Acid-Modified Leukocyte- and Platelet-Rich Fibrin on Hemostasis and Wound Healing After Tooth Extraction in Patients Receiving Direct Oral Anticoagulants
This randomized split-mouth clinical study evaluated the effects of tranexamic acid-modified leukocyte- and platelet-rich fibrin (L-PRF) on hemostasis, postoperative pain, and soft-tissue wound healing after tooth extraction in…
- Trial name
- NCT07830875
- Testing
- Tranexamic Acid-Modified L-PRF, Absorbable Gelatin Sponge
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Cumhuriyet University
Nebulization, Intravenous
Nebulized Versus Intravenous Tranexamic Acid on Surgical Field Quality in Patients Undergoing Endoscopic Sinus Surgeries
Intraoperative bleeding is one of the vital problems for anesthesiologists and surgeons, during endoscopic nasal surgery; where the surgical field is very limited and surrounded by vital structures.
- Conditions
- Nebulization, Intravenous, Surgical Field, Endoscopic Sinus Surgeries
- Trial name
- NCT06777966
- Testing
- nebulized tranexamic acid, intravenous tranexamic acid
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
EFFECT OF TOPICAL APPLICATION OF TRANEXAMIC ACID ON WOUND DRAINAGE POST MODIFIED RADICAL MASTECTOMY
EFFECT OF TOPICAL APPLICATION OF TRANEXAMIC ACID ON WOUND DRAINAGE POST MODIFIED RADICAL MASTECTOMY
Objective: To compare efficacy of topical tranexamic acid versus standard postop care in reducing wound drainage following modified radical mastectomy (MRM). Study Design: Randomized controlled trial.
- Trial name
- NCT07800832
- Testing
- Tranexamic Acid (Topical Application in Mastectomy Wound)
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Gulab Devi Hospital
Endobronchial Bleeding, Hemoptysis
The Efficacy of Tranexamic Acid and Adrenaline to Control Endobronchial Bleeding
During bronchoscopy (a procedure using a thin, flexible camera to look inside the airways), doctors sometimes take small tissue samples (biopsies) to diagnose lung conditions. This can cause bleeding in the airway.
- Trial name
- CATER (NCT07759089)
- Testing
- Adrenaline, Tranexamic Acid
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Postpartum Hemorrhage, Cesarean Section Complications
Comparison of the Efficacy of Misoprostol and Tranexamic Acid for Postpartum Hemorrhage Prophylaxis in Cesarean Delivery
Postpartum hemorrhage (PPH) is an obstetric emergency, with an estimated incidence ranging from 2.8% to 7.9%. Recent studies indicate an increasing trend in the frequency of PPH.Although it is more commonly seen in developing…
- Conditions
- Postpartum Hemorrhage, Cesarean Section Complications, Delivery Complication
- Trial name
- NCT06970483
- Testing
- Tranexamic acid, Misoprostol 200mcg Tab
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Melasma
Efficacy and Safety of a Combined Topical Formula Versus Placebo in Patients With Melasma
The goal of this clinical trial is to learn whether a topical formulation containing 12% azelaic acid and 5% tranexamic acid is effective and safe for treating melasma in adults.
- Trial name
- NCT07727954
- Testing
- Topical azelaic acid 12% plus tranexamic acid 5%
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- University of Guadalajara
Total Blood Loss, Arthropathy of Knee Joint
Kaolin-based Hemostatic Gauze in Total Knee Arthroplasty
This study is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of combination of intravenous TXA and QCG in a primary TKA procedure.
- Trial name
- NCT05504577
- Testing
- Tranexamic acid injection, apply the QCG, apply surgical gauze
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Blood Loss, Surgical, Blood Loss, Postoperative
Tranexamic Acid Versus Misoprostol to Reduce Blood Loss During and After Cesarean Section
Brief Summary The goal of this clinical trial is to compare two medicines, intravenous tranexamic acid and rectal misoprostol, for reducing blood loss in women undergoing cesarean section.
- Conditions
- Blood Loss, Surgical, Blood Loss, Postoperative, Cesarean Section
- Trial name
- NCT07712510
- Testing
- Intravenous Tranexamic Acid, rectal misoprostol
- Where
- Pakistan
- Volunteers
- 214 people
- Sponsor
- Medicare Hospital (Pvt) Limited
Obstetrical Complications, Hemorrhage
Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean
A randomized placebo-controlled trial of 11,000 women to assess whether tranexamic acid as prophylaxis lowers the risk of postpartum hemorrhage in women undergoing a cesarean delivery.
- Conditions
- Obstetrical Complications, Hemorrhage, Labor and Delivery
- Trial name
- TXA (NCT03364491)
- Testing
- Tranexamic Acid
- Where
- 12 sites in United States
- Volunteers
- 11,000 people
- Sponsor
- The George Washington University Biostatistics Center
Bleeding Nose
Nebulized Tranexamic Acid in Sinus Surgery
The results of several recent studies on endoscopic sinus surgery through topical administration of tranexamic acid are encouraging in terms of the efficacy of tranexamic acid for intraoperative bleeding and other pathological…
- Trial name
- NCT04905901
- Testing
- Tranexamic acid
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Plastic Surgery
Usefullness of Peri-operative Tranexamic Acid in Primary Breast Augmentation With Implants.
Tranexamic acid (TXA), as an antifibrinolytic agent, has shown a tremendous interest in surgery by reducing blood loss ; but only few articles have been reported in the plastic surgery scope.
- Trial name
- DRAINAGE (NCT03364569)
- Testing
- Tranexamic acid
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hôpital NOVO
Blood Loss, Postoperative, Blood Loss, Surgical
EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS IN REAMED INTRAMEDULLARY NAILING OF DIAPHYSEAL FEMORAL AND TIBIAL FRACTURES: A PROSPECTIVE COMPARATIVE STUDY
Perioperative blood loss is one of the most frequently encountered and significant complications of spine surgery. Intraoperative and post-operative bleeding cause various complications and negatively affect patient outcomes.
- Conditions
- Blood Loss, Postoperative, Blood Loss, Surgical, Femoral Fracture, Tibial Fracture
- Trial name
- NCT07625709
- Testing
- Intervention with Tranexamic Acid, Control group (Normal Saline)
- Where
- Nepal
- Volunteers
- 54 people
- Sponsor
- Kathmandu University School of Medical Sciences