Clinical trials: Transcranial Direct Current Stimulation
Healthy Older Adults
tDCS Effects on GABA Concentration and Brain Functional Connectivity in Older Adults Of Working Age
The aim of this study is to investigate whether anodal tDCS over the left M1 leads to a decrease of GABA concentration and alterations of functional brain connectivity in older people, compared to sham tDCS.
- Trial name
- TRAINSTIM1 (NCT02794272)
- Testing
- tDCS
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Dementia; Degenerative, Dementia Mixed
Longitudinal Study to Investigate Different Transcranial Electrical Stimulation
This research investigates the effect of different frequencies of tACS (0 Hz, 30 Hz, 50 Hz, 70 Hz, 90 Hz) and tRNS with cognitive exercises in a regimen protocol of 4 weeks, everyday (Monday to Friday).
- Trial name
- tES (NCT06877312)
- Testing
- Transcranial Direct Current Stimulation (tDCS), 30 Hz Transcranial Alternating Current Stimulation (tACS), 50 Hz Transcranial Alternating Current Stimulation (tACS)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Heart Failure, Reduced Ejection Fraction, Vitamin B12 Deficiency
Heart Failure With Reduced Ejection Fraction: Adjuvant Therapy With Neurostimulation and Chlorella Pyrenoidosa (HD-tDCS)
Reduced ejection fraction heart failure (HFrEF) is a complex and multifactorial condition. It is characterized by a decrease in the ability of the left ventricle to eject blood effectively during systole, resulting in an ejection…
- Trial name
- HD-tDCS (NCT06528366)
- Testing
- Chlorella pyrenoidosa, High Definition Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Federal University of Paraíba
Chronic Pain
Motor System Activation With Transcranial Direct Current Stimulation and Physical Exercise to Reduce Pain in Elderly
Physical exercises are known to reduce chronic pain in elderly individuals by activating the motor system. However, it seems that exercises are not effective for everyone.
- Trial name
- NCT04332939
- Testing
- transcranial direct current stimulation, Physical exercise
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- Université de Sherbrooke
Sleep Disorders, Circadian Rhythm, Cognitive Impairment
High-frequency tRNS for Sleep Disturbances in Neurocognitive Disorders Due to Vascular Disease
The investigators aim to 1) investigate and compare the safety, efficacy and sustainability of hf-tRNS, tACS and sham transcranial current stimulation (tCS) over left inferior parietal lobe (IPL) in mild neurocognitive disorder…
- Conditions
- Sleep Disorders, Circadian Rhythm, Cognitive Impairment, Vascular Dementia
- Trial name
- NCT06169254
- Testing
- Transcranial current stimulation (tCS)
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Autism Spectrum Disorder
Cerebellar tDCS in Children With Autism Spectrum Disorder
The purpose of this research study is to investigate whether tDCS to the cerebellum (specifically, the right crus I/II area of the cerebellum) of children and young adults with autism spectrum disorders (ASD) is safe and to…
- Trial name
- NCT04446442
- Testing
- tDCS
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Depressive Disorder, Major, Depression, Bipolar
The Effects of tDCS on Depressive Symptoms,Neurocognitive Function and HRV in Unipolar Depression and Bipolar Depression
The study aimed to investigate whether transcranial direct current stimulation could improve depressive symptoms, neurocognitive function and modulate heart rate variability in unipolar and bipolar depression.
- Conditions
- Depressive Disorder, Major, Depression, Bipolar, Electricity; Effects
- Trial name
- NCT03287037
- Testing
- tDCS over DLPFC
- Where
- Taiwan
- Volunteers
- 82 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Anxiety Disorders, Social Phobia
Cerebellar Neuromodulation to Enhance Fear Extinction and Predict Response to Exposure Therapy
Emerging neuroimaging studies have shown that the cerebellum contributes to different aspects of timing, prediction, learning, and extinction of conditioned responses to aversive stimuli, factors that may be relevant to the…
- Trial name
- NCT03275337
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Stroke
Transcranial Galvanic Stimulation After Stroke
Transcranial galvanic stimulation (tDCS) seems to promote motor recovery after stroke by stimulating (anodal) or inhibiting (cathodal) neural circuits in the brain.
- Trial name
- TraGAT (NCT00407667)
- Testing
- transcranial galvanic stimulation
- Where
- 3 sites in Germany, Italy
- Volunteers
- 96 people
- Sponsor
- Charite University, Berlin, Germany
Cognitive Impairment, Cognitive Decline
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy…
- Trial name
- AIM (NCT05998031)
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stroke, Ischemic
The Effect of The Five-Session Dual-tDCS On Lower-Limb Performance in Sub-Acute Stroke
The aim of the present study is to determine the effect of the five-session dual-tDCS combine with physical therapy on gait performance, balance and lower limbs muscle strength in patients with subacute stroke.
- Trial name
- NCT04287231
- Testing
- Transcranial direct current stimulation
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Major Depressive Disorder, Bipolar Disorder
Transcranial Direct Current Stimulation (tDCS) Augmentation by D-Cycloserine as a Treatment for Depression
Among antidepressant treatments, Electroconvulsive therapy (ECT) stands as the most effective in treating acute depression. However, patient concerns with the cognitive side effects of ECT have encouraged the development of new…
- Trial name
- NCT00869765
- Testing
- D-Cycloserine, tDCS (Eldith DC-Stimulator (CE certified))
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- The University of New South Wales
Post Traumatic Stress Disorder
tDCS and Inhibitory Control in PTSD
Large samples (~2,000/yr) of adult undergraduate students at a large southern university will be pre-screened via the University of Kentucky SONA System (IRB#43626) to identify and recruit adult female participants who report a…
- Trial name
- NCT06100731
- Testing
- tDCS
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Gopalkumar Rakesh
Epilepsy
Direct Cortical Measurement of the Intensity and Pattern of Current Flow Produced by TDCS
The primary study objective is to measure the electrical fields evoked by tDCS using subjects who have implanted intracranial electrodes as part of their evaluation for epilepsy surgery.
- Trial name
- NCT02263274
- Testing
- Transcranial Direct Current Stimulation (TDCS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Stroke
Stimulating Language in Subacute StrokE
The investigators will study the effects of transcranial direct current (tDCS) stimulation during language therapy for naming in individuals with aphasia in the acute and subacute post stroke period.
- Trial name
- SLISSE (NCT02674490)
- Testing
- A-tDCS (1 mA), SALT
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
Macular Degeneration
Improving Vision in Adults With Macular Degeneration
The purpose of this study is to test whether a kind of brain stimulation called anodal transcranial direct current stimulation (a-tDCS) can improve the ability of people with age-related macular degeneration (AMD) or juvenile…
- Trial name
- NCT04111068
- Testing
- anodal tDCS Active Stimulation
- Where
- 2 sites in Canada, Hong Kong
- Volunteers
- 21 people
- Sponsor
- University of Waterloo
Drug-Resistant Focal Epilepsy
Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring
This study evaluates whether a non-invasive brain stimulation technique called Temporal Interference (TI) can reduce epilepsy-related abnormal brain activity and influence sleep-related brain rhythms in adults with focal…
- Trial name
- NCT07764718
- Testing
- Temporal Interference Stimulation, Direct Electrical Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Idiopathic Parkinson's Disease, Parkinson Disease
Exploring Mechanisms for Neuropsychiatric Symptoms of Parkinson Disease Using Transcranial Direct Current Stimulation
This study evaluates the effect of transcranial direct current stimulation (tDCS) on non-motor symptoms of Parkinson's disease, including depression and cognitive symptoms.
- Conditions
- Idiopathic Parkinson's Disease, Parkinson Disease, Depression
- Trial name
- NCT03074812
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
PARKINSON DISEASE (Disorder)
Treatment of Cognitive and Sensorimotor Deficits in Parkinson's Disease With High Definition Transcranial Direct Current Stimulation
The purpose of this research study is to examine the effects of transcranial Direct Current Stimulation (tDCS) on verbal retrieval and cognition and sensorimotor control and to determine if tDCS can be used as a way to improve…
- Trial name
- NCT07534397
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas at Dallas
Healthy
Cognitive Stimulation Study
This study will evaluate the influence of non-invasive brain stimulation on different elements of cognitive function in healthy persons between the ages of 18-90 years.
- Trial name
- CogStim (NCT02067689)
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Florida
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