Clinical trials: Treatment as usual
Pharmacogenomics
Effectiveness of an Arabic CPIC-Based Pharmacogenomics Microlearning Program on Community Pharmacists' Clinical Decision-Making in Jordan
Pharmacogenomics (PGx) presents a vital opportunity to optimize medication safety, yet community pharmacists often lack the applied clinical training required to interpret and act upon genetic data.
- Trial name
- NCT07735572
- Testing
- immediate post-intervention clinical decision-making score
- Where
- Jordan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Petra
Attention Deficit Hyperactivity Disorder
A Psychosocial Treatment Program for College Students (ACCESS)
The results of this study are expected to provide important and new information regarding the treatment of academic impairment among college students with ADHD.
- Trial name
- ACCESS (NCT04186312)
- Testing
- ACCESS - Accessing Campus Connections & Empowering Student Success
- Volunteers
- 280 people
- Sponsor
- University of North Carolina, Greensboro
Stroke
Implementation of a HABIT-ILE Intervention at Home for Chronic Stroke
This study will use a randomized controlled trial design to assess the possible difference between two intensive treatment programs: a classic "Hand and Arm Bimanual Intensive Therapy Including Lower Extremities" (HABIT-ILE)…
- Trial name
- HABITILEhome (NCT05727111)
- Testing
- Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) implemented at the patient home, Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE), Follow-up Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) at the patient's home
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
Borderline Personality Disorder
Cognitive Reappraisal Training for Borderline Personality
Previous work by the study group convinced the study team to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based…
- Trial name
- BPD (NCT04967222)
- Testing
- Cognitive Reappraisal by Distancing, Control Downregulate Condition
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypertension
Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduction in vascular oxidative…
- Trial name
- NCT01501929
- Testing
- Metoprolol succinate, Nebivolol, Non-invasive measurement of Cardiac Output (CO)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Child Abuse, Child Maltreatment
A Randomized Controlled Study of Safer Kids: A Manualized Intervention to Prevent Child Abuse
One of the most important responsibilities for the social services is to investigate suspected child abuse and to offer suitable intervention for the families.
- Trial name
- NCT04163367
- Testing
- Safer Kids, Intervention as usual (IAU)
- Where
- 30 sites in Sweden
- Volunteers
- 112 people
- Sponsor
- Karolinska Institutet
Adolescent Well-Being, Mental Disorders, Severe
Adolescents' Well-being in Community-based Treatment Versus Residential Treatment
This is a quasi-experimental longitudinal study to compare the outcomes of youth in a Psychiatric Residential Treatment Facility (PRTF) compared to youth in the community-based Child-Focused Assertive Community Treatment Team…
- Trial name
- NCT06498427
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Outcome Referrals, Inc.
Attention Deficit Hyperactivity Disorder
CBT for Adult Inmates With ADHD
Background Recent literature suggests that ADHD is a risk factor for the development of antisocial behavior that is more severe and persistent than in community and other psychiatric populations.
- Trial name
- NCT06080373
- Testing
- PROBECO, Formulation-based cognitive behavioral therapy
- Volunteers
- 111 people
- Sponsor
- Universidad Europea de Valencia
Arthroscopic Rotator Cuff Repair
Rotator Cuff Repair With Magnesium Pin
Rotator cuff tears are one of the most common conditions encountered in orthopaedic practice leading to significant shoulder pain and functional deficit. The incidence of rotator cuff tears increases with age and previous trauma.
- Trial name
- NCT06292754
- Testing
- magnesium pin in additional to the suture anchor, routine suture anchor
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Critical Illness, Communication
Time Limited Trials to Reduce Non-Beneficial Intensive Care Unit Treatments
Overutilization of intensive care unit (ICU) treatments among patients with advanced medical illnesses and poor prognosis places them at risk for prolonged suffering with minimal anticipated benefit.
- Trial name
- NCT04181294
- Testing
- Family meetings using time limited trials as default ICU communication and care planning approach, Usual practice
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Chronic Kidney Diseases
Assessing Bone Calcium Content in Children With Kidney Disease Treated With Two Different Medicines
This is an open label, time series trial. The trial is likely to be single centre (additional sites will only be opened if necessary) and will involve 25 children with chronic kidney disease (stage 3b, 4-5) or on dialysis.
- Trial name
- CAL-BAL (NCT04120922)
- Testing
- calcium carbonate, sevelamer carbonate
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University College, London
Osteosarcoma
ICONIC: Improving Outcomes Through Collaboration in OsteosarComa
There has been little improvement in outcome for patients with osteosarcoma (OS) over the last 20 years. There have been only a few clinical trials of new treatments and no major new therapies introduced recently.
- Trial name
- ICONIC (NCT04132895)
- Testing
- observational only, no interventions are prescribed in protocol.
- Where
- 22 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University College, London
Depression
Dance Movement Therapy in the Treatment of Depressed Patients: A Randomised Controlled Trial
This multi-centre research investigates the effects of dance movement therapy (DMT) on participants diagnosed with depression. In total, 109 persons participated in the study in various locations in Finland.
- Trial name
- NCT04421651
- Testing
- Dance Movement Therapy group
- Volunteers
- 109 people
- Sponsor
- University of Jyvaskyla
Metastatic Lung Adenocarcinoma, Metastatic Lung Non-Small Cell Carcinoma
Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer
This study evaluates the side effects of pembrolizumab with or without chemotherapy in treating patients with stage IV non-small cell lung cancer that has come back after a period of improvement (recurrent) and may have spread…
- Conditions
- Metastatic Lung Adenocarcinoma, Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Adenocarcinoma, Recurrent Lung Non-Small Cell Carcinoma
- Trial name
- NCT04533451
- Testing
- Pembrolizumab, Pemetrexed, Carboplatin
- Where
- 505 sites in United States
- Volunteers
- 101 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Schizophrenia
Dance/Movement Therapy for Bone Mineral Density in Schizophrenia
Fractures are common accidents for long-term hospitalized patients with schizophrenia (SZ) in psychiatric hospitals, and once they occur, patients usually endure the pain of fractures for a long time.
- Trial name
- NCT05716802
- Testing
- dance/movement therapy, treatment as usual
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hebei Province Veterans Hospital
Functional Independence, Respiratory Insufficiency
More Air - Better Performance - Faster Recovery
The objective of this study is to investigate i) the effect of 3 weeks IMT to adults post-stroke to maximal inspiratory pressure (MIP) and ii) the effects of 3 weeks IMT to the degree of dependency in activities of daily living…
- Trial name
- IMT (NCT04686019)
- Testing
- Inspiratory muscle training (IMT)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Central Jutland Regional Hospital
Suicidal Behavior
Brief Intervention and Contact Program Main Trial
Suicide is a significant public health concern and causes approximately 1.5% of all deaths in the general population in Canada. Research shows that for individuals with comorbid psychiatric illness and suicidal behaviour, the…
- Trial name
- BIC (NCT05656781)
- Testing
- Brief Intervention and Contact (BIC) based on Word Health Organization (WHO)
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Developmental Language Disorder and Language Impairment, Anxiety Disorders and Symptoms
Reducing Anxiety Problems Among Children Indicated to Have Developmental Language Disorder
This study aims to pilot a world-first intervention, a mental health intervention augmented for children indicated with developmental language disorder (DLD).
- Trial name
- RAP-iDLD (NCT05552365)
- Testing
- Adapted Cognitive Behavioural, Treatment as Usual
- Where
- Singapore
- Volunteers
- 9 people
- Sponsor
- Nanyang Technological University
Chronic Low-back Pain (cLBP)
Combining Brain Stimulation and Physiotherapy for the Management of Chronic Low Back Pain
Chronic low back pain (CLBP) is a major health challenge in Canada, leading to substantial disability and socioeconomic burden, particularly among Veterans. In military Veterans, LBP is the most common chronic pain condition.
- Trial name
- NCT06999772
- Testing
- Active rTMS, Psychologically-informed physiotherapy (PiP), Usual physiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 96 people
- Sponsor
- Laval University
Cognitive Therapy, Depression, Postpartum
RCT of Automated Conversational Agent vs. Treatment as Usual for the Management of Perinatal Mood
The purpose of this study is to investigate the efficacy of an evidence-based smartphone application (app) for the management of mood compared to treatment as usual alone among 135 women who have been discharged post-delivery…
- Conditions
- Cognitive Therapy, Depression, Postpartum, Mental Health, Depression
- Trial name
- NCT03646539
- Testing
- Use of smartphone application (app), Treatment as usual
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Stanford University
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