Clinical trials: Treatment as usual
Cardiovascular Diseases
Active Choice in the EHR to Promote Statin Therapy
Cardiovascular (CV) events are the leading cause of mortality in the United States. Statins have been demonstrated to be an effective tool for reducing CV events and mortality, but statins are often either not prescribed or…
- Trial name
- NCT03271931
- Testing
- Active choice, Passive choice
- Where
- United States
- Volunteers
- 23,066 people
- Sponsor
- University of Pennsylvania
Chronic Pain, Problematic Opioid Use
Pilot Study of Combined Treatment for Veterans With Chronic Pain & Opiate Misuse
Chronic pain and misuse of opioids is a major public health problem, particularly in military veterans. The major goal of this project is to test the efficacy of an innovative behavioral treatment for chronic pain patients who…
- Trial name
- NCT02423772
- Testing
- Acceptance and Commitment Therapy + Mindfulness-Based Relapse Prevention + Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of New Mexico
Posttraumatic Headache
Multisite Advancement of Research on Chronic Posttraumatic Headache
Posttraumatic headache (PTH) is a common and highly disabling consequence of traumatic brain injury (TBI) in U.S. military service members and veterans.
- Trial name
- NCT05620719
- Testing
- Cognitive Behavioral Therapy for Posttraumatic Headache, Treatment as Usual, Telemedicine-based Cognitive Behavioral Therapy (TCBT)
- Where
- 8 sites in United States
- Volunteers
- 525 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pulmonary Edema, Congestive Heart Failure
DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure
DECONGEST-AHF compares three initial treatments for adults admitted with suspected pulmonary congestion due to acute heart failure: intravenous furosemide, intravenous isosorbide dinitrate, or both medicines together.
- Conditions
- Pulmonary Edema, Congestive Heart Failure, Acute Heart Failure
- Trial name
- DECONGEST-AHF (NCT05276219)
- Testing
- Furosemide Injection, Isosorbide Dinitrate, Furosemide and isosorbide dinitrate
- Where
- 5 sites in Denmark
- Volunteers
- 1,041 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Alcohol-Related Disorders, Substance-Related Disorders
The Women's Recovery Group Study: Stage I Trial
The purpose of this study was to develop a gender-specific 12-session, manual-based relapse prevention group for women with substance use disorders (SUDs).
- Trial name
- NCT00230100
- Testing
- The Women's Recovery Group, mixed-gender Group Drug Counseling
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mclean Hospital
Multiple Primary Lung Cancers
Treatment of EGFR-TKI for Residual Lesions of Multiple Synchronous Ground-glass Opacities
This study is a multi-center, prospective, double-blind randomized controlled clinical trial. The purpose is to evaluate the efficacy and safety of EGFR-TKI on residual GGOs after surgery in patients with multiple primary lung…
- Trial name
- TERMGGO (NCT04982900)
- Testing
- furmonertinib
- Where
- 6 sites in China
- Volunteers
- 138 people
- Sponsor
- Ruijin Hospital
Obstructive Sleep Apnea
Promoting Continuous Positive Airway Pressure (CPAP) Adherence
The proposed research will evaluate new approaches to improving the ability of patients with obstructive sleep apnea (OSA), a breathing disorder during sleep, to use continuous positive airway pressure (CPAP), a medical device…
- Trial name
- NCT01335854
- Testing
- Web-based Access to CPAP Data, Web-based Access to CPAP Data with Financial Incentive
- Where
- 2 sites in United States
- Volunteers
- 135 people
- Sponsor
- University of Pennsylvania
Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis
HLA-B*58:01-Guided Therapy for Gout: Effectiveness, Safety, and Cost-Effectiveness
Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS), are rare but life-threatening complications that…
- Conditions
- Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis, Gout and Hyperuricemia
- Trial name
- HLA-SCREEN (NCT07369622)
- Testing
- HLA-B*58:01 Genotyping, Allopurinol Tablet, Febuxostat
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Haiphong University of Medicine and Pharmacy
Adolescent Depression
A Hybrid Psychological Intervention for Depression in Adolescents
This multi-center, randomized controlled trial was conducted to evaluate the efficacy and long-term effects of a novel hybrid psychological intervention, which combines Resilience Theory with the Satir Model, for adolescents…
- Trial name
- NCT07104851
- Testing
- Resilience-Satir Hybrid Intervention, Treatment as Usual (TAU)
- Where
- China
- Volunteers
- 420 people
- Sponsor
- The First Hospital of Hebei Medical University
Hepatitis C
ED Patient's Perceptions and Acceptability Toward a Novel POC HCV Viral Load Testing
Hepatitis C virus (HCV) infection has become the leading fatal infectious disease in the United States. Approximately 75% of individuals who have been infected with HCV are chronically infected with the virus.
- Trial name
- NCT03767231
- Testing
- Xpert HCV Viral Load Finger-stick Point-of-Care test (Cepheid)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
Schizophrenia
A 2-year Study of Patients With Schizophrenia Who Are Treated With Long-acting Injectable Risperidone.
The purpose of this study is to examine treatment practices of adult schizophrenia patients by their own doctors, and to assess patient outcomes when treated with long-acting risperidone injection over a two-year period of…
- Trial name
- NCT00261430
- Testing
- GAIN Acceptance Approach
- Volunteers
- 650 people
- Sponsor
- Janssen, LP
Diabetes Mellitus
Exubera Large Simple Trial To Evaluate Long-Term Pulmonary And Cardiovascular Safety
The purpose of this study is to evaluate the long-term pulmonary and cardiovascular safety of Exubera in routine clinical practice.
- Trial name
- VOLUME (NCT00359801)
- Testing
- Randomization to Exubera (insulin human [rDNA origin] inhalation powder) or Usual Diabetes Care
- Where
- 197 sites in United States, Germany and 3 more
- Volunteers
- 1,976 people
- Sponsor
- Pfizer
Compliant Behavior, Morbidity;Infant
Financially-Incentives to Improve Provider Compliance
The main objective of this study is to assess whether making health financing streams conditional on provider performance on knowledge assessment can increase provider compliance with under-5 case management guidelines.
- Trial name
- NCT04634019
- Testing
- Financially incentivized knowledge assessments
- Where
- 2 sites in Democratic Republic of the Congo, Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Suicidal Ideation, Suicide Risk
A Text-Based Expressive Writing Program for Adolescents at Risk of Suicide
The goal of this clinical trial is to learn if a structured expressive writing program can help reduce suicidal thoughts in adolescents and young adults who have experienced suicidal thoughts, suicide attempts, or self-harm.
- Conditions
- Suicidal Ideation, Suicide Risk, Self-Injurious Behavior, Adolescent Mental Health
- Trial name
- WRITE-SAFE (NCT07479823)
- Testing
- Structured Expressive Writing Intervention, Treatment as Usual (TAU)
- Volunteers
- 160 people
- Sponsor
- Hallym University Medical Center
Pediatric Cancer, Pediatric Brain Tumor
Playful Sensorimotor Training in Pediatric Brain Tumor Patients
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and clinically relevant side-effect of cancer treatment.
- Conditions
- Pediatric Cancer, Pediatric Brain Tumor, Chemotherapy-induced Peripheral Neuropathy, Sensorimotor Polyneuropathy
- Trial name
- RESET (NCT03334162)
- Testing
- Sensorimotor training
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Basel
HIV/AIDS
Brief Acceptance-Based Retention Intervention for Newly Diagnosed HIV Patients
The overall aim of this program of research is to test a newly developed intervention, Acceptance-Based Behavior Therapy (ABBT), to improve HIV patients' commitment to medical care.
- Trial name
- NCT04201288
- Testing
- Acceptance-Based Behavior Therapy (ABBT), Enhanced-Treatment-as-Usual (ETAU)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Brown University
Mental Health
Study of Mental Health and Relationships
The goal of this clinical trial is to test effects of the Great Life Mentoring (GLM) program on the mental health and adaptive functioning on school-age youth (ages 9-16) from low-income families who are receiving outpatient…
- Trial name
- SMART (NCT06534827)
- Testing
- Great Life Mentoring
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Myocardial Infarction
Post-conditioning to Reduce Infarct Size
When angioplasty (PTCA) and stenting of the blood vessels of the heart is the treatment for a Heart Attack, there is damage to the heart muscle that is caused by the sudden opening of the blood vessels.
- Trial name
- NCT00755469
- Testing
- Post-conditioning
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Minneapolis Heart Institute Foundation
Clinical High Risk Syndrome for Psychosis
PRIME vs Usual Care for Clinical High Risk
The purpose of this study is to determine whether specialty care is superior to usual care in the treatment of patients at clinical high risk for psychosis.
- Trial name
- NCT02960451
- Testing
- PRIME care, Usual care
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Postoperative Respiratory Complication
Preoperative Self-managed Respiratory Therapy for Reduction of Postoperative Pulmonary Complications
Postoperative pulmonary complications (PPCs) are a source of much morbidity and mortality. Rates of PPCs exceed 30% in patients with multiple risk factors.
- Trial name
- PRESMART (NCT03356496)
- Testing
- AirLife 4000 cc incentive spirometry device
- Where
- United States
- Sponsor
- Medical College of Wisconsin
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