Clinical trials: Treatment as usual
HIV Infections, Pregnancy Related
Adaptation of an Intervention Addressing Barriers to PrEP Use Among Pregnant Women in Zimbabwe
The purpose of this study is to develop a multi-level PrEP adherence and persistence intervention as an adaptation of the TENDAI ('grateful' in Shona) program, a problem-solving approach to reduce depression and increase HIV…
- Conditions
- HIV Infections, Pregnancy Related, Depression, Anxiety
- Trial name
- TENDAI4PrEP (NCT06226155)
- Testing
- TENDAI4PrEP, Enhanced treatment as usual
- Where
- Zimbabwe
- Volunteers
- 165 people
- Sponsor
- Massachusetts General Hospital
Low Back Pain
The Benefit of Structured Triage of Patients in the Primary Health Care Seeking Care for Low Back Pain
This study aims to investigate if a low back pain screening tool is helpful for the caregivers to direct the rehabilitation in a more efficient way, at an earlier stage.
- Trial name
- NCT03368521
- Testing
- Back pain screening test
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- FoU Center Spenshult
Acute Coronary Syndrome
Relevance of Plasma PCSK9 Concentration as a Biomarker in Acute Coronary Syndrome.
PCSK9 (Proprotein convertase subtilisin kexin type 9) plays a key role in LDL-cholesterol (LDLC) metabolism by inhibiting LDL receptor (LDLR) at post-transcriptional level.
- Trial name
- PC-SCA-9 (NCT01109706)
- Testing
- biological parameters dosage
- Where
- 2 sites in France
- Volunteers
- 175 people
- Sponsor
- Nantes University Hospital
Frailty
Feasibility of a Multidisciplinary Student-Led Program to Improve Frailty in Nursing Home Residents
BACKGROUND Frailty, regarded as a potentially reversible process and defined as a progressive deterioration of physiological systems and intrinsic capacity, constitutes a key risk factor for disability, dependency and…
- Trial name
- CUIDAFRAIL (NCT07182747)
- Testing
- Nursing students' intervention programme, Standard care from Public Andalusian Health Service
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Almeria
Pneumonia
Randomised Evaluation of COVID-19 Therapy
RECOVERY is a randomised trial of treatments to prevent death in patients hospitalised with pneumonia. The treatments being investigated are: COVID-19: Lopinavir-Ritonavir, Hydroxychloroquine, Corticosteroids, Azithromycin…
- Trial name
- RECOVERY (NCT04381936)
- Testing
- Lopinavir-Ritonavir, Corticosteroid, Hydroxychloroquine
- Where
- 16 sites in Belgium, Estonia and 14 more
- Volunteers
- 70,000 people
- Sponsor
- University of Oxford
Schizophrenia
Improving Medication Adherence Among People With Schizophrenia Through the Use of 2-way Pagers
This study will determine whether using a pager improves medication adherence in people with schizophrenia.
- Trial name
- NCT00392236
- Testing
- 2-way pager, Treatment as usual
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Northwell Health
Atrial Fibrillation, Deep Vein Thrombosis
Weekly Monitoring Strategy of Capillary INR Versus Monthly Monitoring Strategy of Venous INR in Elderly Patients in a Nursing Home.
This primary care study aims to compare the "time in therapeutic range" (TTR) of two strategies for monitoring the international normalized ratio (INR) over 6 months in nursing homes.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Stroke
- Trial name
- INR-CAP (NCT05561244)
- Testing
- Weekly monitoring using the capillary International Normalised Ratio strategy
- Where
- 33 sites in France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Delirium, Intensive Care Unit, Randomised Controlled Trial
The Effects of a Model-based Sensory Stimulation Intervention on Preventing Delirium Among Intensive Care Unit Patients: A Randomised Controlled Trial
Delirium is highly associated with adverse clinical outcomes of intensive care unit (ICU) patients, including increased cognitive impairment, duration of intubation, ICU length of stay, mortality, physical dependence, and health…
- Trial name
- NCT04306016
- Testing
- Sensory stimulation
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Chinese University of Hong Kong
Chronic Obstructive Pulmonary Disease, Health Status
Secondary Prevention of Problems in Health Status in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to determine the effectiveness of an intervention conducted by a pulmonary nurse in patients with COPD.
- Trial name
- NCT00940355
- Testing
- Intervention pulmonary nurse
- Where
- Netherlands
- Volunteers
- 303 people
- Sponsor
- Radboud University Medical Center
Postpartum Depression
Online Peer-Delivered Group CBT for PPD
Mothers and birthing parents (hereafter referred to as mothers) who have recovered from Postpartum Depression and are well now, receive training to teach a 9 week Cognitive Behavioural Therapy (CBT) treatment to mothers who are…
- Trial name
- NCT05044455
- Testing
- Cognitive Behavioural Therapy (CBT)
- Where
- Canada
- Volunteers
- 191 people
- Sponsor
- McMaster University
Suicide, Attempted, Drug Use
Brief New Treatment for Suicide Attempts
Individuals with alcohol or drug use problems who are hospitalized for suicide attempt are at high risk for reattempt. This treatment development study adapts a promising outpatient intervention to prevent suicide reattempt in…
- Conditions
- Suicide, Attempted, Drug Use, Alcohol; Use, Problem
- Trial name
- NCT03300596
- Testing
- Brief intervention to prevent suicide attempt, Enhanced treatment as usual
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Rochester
Emergency Department, Revisit
Development, Validation, and Clinical Trial of a Prediction Tool for High-Risk Emergency Department Revisits
Emergency department (ED) visits have grown tremendously in Taiwan over the past few years, reaching approximately 7 million visits in 2019.
- Trial name
- NCT07909096
- Testing
- ED-HIKRS, Usual Care
- Volunteers
- 4,010 people
- Sponsor
- National Taiwan University Hospital
Chronic Pain, Nociplastic Pain
Multimodal Lifestyle Approach for Chronic Pain With Nociplastic Pain Features
This single-center, single-arm pilot feasibility study aims to examine the feasibility and preliminary effectiveness of an intervention program using a pain education booklet based on a multimodal lifestyle approach for patients…
- Trial name
- MLA-MM (NCT07693062)
- Testing
- Multimodal Lifestyle Approach Using a Pain Education Booklet
- Where
- 2 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Prefectural University of Hiroshima
Psychological Distress, Quality of Life
The Effectiveness of Culturally Adapted Cognitive Behavioral Intervention Among COVID-19 Survivors
The effectiveness study for Culturally-Adapted Cognitive Behavioral Intervention (CA-CBI) will be conducted with individuals infected with and recovered from Coronavirus disease (COVID-19) to measure if this intervention is…
- Conditions
- Psychological Distress, Quality of Life, Depressive Symptoms, Anxiety
- Trial name
- NCT04949061
- Testing
- Culturally Adapted Cognitive Behavioral Intervention (CA-CBI), Enhanced Treatment as Usual (ETA-U)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Koç University
Neoplasms, CNS Neoplasms
Interdisciplinary Rehabilitation of Patients With Glioma During Anti-cancer Treatment
The results of the present RCT study will add to the growing body of literature investigating the potential role of exercise as a supportive therapeutic intervention for patient with glioma.
- Trial name
- NCT02221986
- Testing
- Interdisciplinary rehabilitation
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Odense University Hospital
Obesity, Overweight
Balance: A Pragmatic Trial of a Digital Health Intervention to Prevent Weight Gain in Primary Care
Up to 50% of obese patients are not interested in, or ready for, weight loss. Clinical practice guidelines clearly recommend that these patients avoid gaining weight.
- Conditions
- Obesity, Overweight, Overnutrition, Nutrition Disorders
- Trial name
- D0479 (NCT03003403)
- Testing
- Intervention Program
- Where
- United States
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Duke University
Pediatric Cancer
Multisite Implementation of COMPRENDO
COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring…
- Trial name
- COMPRENDO (NCT06055296)
- Testing
- COMPRENDO Peer Navigation Intervention
- Where
- 4 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pressure Ulcer
Peripheral Tissue Perfusion and Oxygenation in Areas at Risk of Press Ulcer (POTER-OIL)
The study objectives will be: Primary objectives: 1. To determine the effects on oxygenation and tissue perfusion of applying HFA (Hyperoxygenated Fatty Acids) or EVOO (Extra Virgin Olive Oil) to the heels of healthy subjects…
- Trial name
- POTER-OIL (NCT05144646)
- Testing
- MEPENTOL® AND FARMAOLIVA® IN HEALTHY WITH INTRASUBJECT CONTROL, MEPENTOL® AND FARMAOLIVA® IN PATIENTS WITH INTRASUBJECT CONTROL
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- JOSE MIGUEL MORALES ASENCIO
Early-onset Schizophrenia, Psychotic Disorders
Computerized Cognitive Remediation Therapy in Adolescents With a First Psychotic Episode
Cognitive deficits (CD) are considered one of the essential characteristics in psychotic disorders and occur throughout the course of the disease, being a key characteristic in the evolution of the disease and in the…
- Conditions
- Early-onset Schizophrenia, Psychotic Disorders, Cognitive Remediation Therapy, Cognition
- Trial name
- CCRT2019 (NCT05405946)
- Testing
- Computerized Cognitive Remediation Therapy, Treatment as Usual
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundació Sant Joan de Déu
Cerebral Palsy
Implementation of a HABIT-ILE Intervention at Home for Children With Bilateral Cerebral Palsy
Intensive interventions based on the principles of motor skill learning, like Hand-Arm Bimanual Therapy Including Lower Extremities (HABIT-ILE), have demonstrated excellent effectiveness in improving motor function and daily life…
- Trial name
- HABITILEhome (NCT05740605)
- Testing
- Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE), Hand-Arm Bimanual Intensive Therapy Including Lower Extremities at home, Follow-up Hand-Arm Bimanual Intensive Therapy Including Lower Extremities
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
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