Clinical trials: Treatment as usual
Major Depressive Disorder
Application of the Web-based Acceptance and Commitment Therapy for Depression
PROSPECTIVE INTERVENTION STUDY; EFFICACY OF WEB-BASED ACCEPTANCE AND COMMITMENT THERAPY
- Trial name
- ACTION (NCT06293781)
- Testing
- Web-based ACT, Treatment as usual
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Gachon University
Adolescent Behavior, Lifestyle Modification
A Family-centred Approach Enhancing Cardiovascular Health in Ugandan Adolescents and Their Families
The FaCe-D Study, with funding from the Canadian Institute for Health Research (CIHR) through Global Alliance for Chronic Diseases (GACD) aims to adapt and implement an evidence-based family centred approach (FCA) to prevent…
- Conditions
- Adolescent Behavior, Lifestyle Modification, Cardiovascular Disease Other
- Trial name
- FaCe-D (NCT07265453)
- Testing
- The immediate (treatment) arm, will receive the FaCe-D intervention comprising of 'HOME VISITS, DIET, PHYSICAL ACTIVITY AND HEALTH MESSAGING, Control Arm - standard of care
- Where
- 2 sites in Uganda
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- MRC/UVRI and LSHTM Uganda Research Unit
Breast Cancer
Effect of GM1 in Prevention of Taxanes Induced Neurotoxicity in Operable Breast Cancer
Background: Taxane plays a key role in the treatment of breast cancer and taxane-induced peripheral neuropathy (TIPN) is a dose-limiting adverse effect leading to treatment discontinuation.
- Trial name
- NCT02468739
- Testing
- Ganglioside-monosialic acid
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Sun Yat-sen University
Depression, Anxiety
E-health Cognitive Behavioral Therapy in Women Treated by in Vitro Fertilization (IVF)
Yearly, 15,000 Dutch in vitro fertilization (IVF) cycles are performed for subfertility with a pregnancy rate of 26%. A failed cycle has great emotional impact; 20-25% of the women has relevant forms of depression/anxiety even…
- Conditions
- Depression, Anxiety, Infertility
- Trial name
- NCT01283607
- Testing
- Digicoach
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- University Medical Center Nijmegen
Delirium
Computer-assisted Cognitive Stimulation Treatment for Delirium
The objectives of our study are to determine whether people with delirium in a subacute care unit improve after one week with non-pharmacological therapies based on improving sleep schedules, mobility, and cognitive stimulation…
- Trial name
- Delitract (NCT07563244)
- Testing
- Specific computer-based cognitive stimulation intervention, Usual care intervention
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Major Depressive Disorder
Pharmacologic Treatment Augmentation in Chronic Depression
To enroll in this clinical trial, prospective participants must meet stringent criteria. The participants need to fall within the age range of 18 to 64 and exhibit chronic depression at therapy resistance stage 2.
- Trial name
- Ket+CBASP (NCT06410599)
- Testing
- Ketamine, CBASP, TAU
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Obsessive-compulsive Disorder, Social Phobia
Brief Behavioral Treatment for Anxiety in Young Children
Behaviorally and cognitive-behaviorally based therapeutic techniques (BT; CBT) that incorporate exposure therapy useful for treatment of anxiety disorders among typically developing children.
- Conditions
- Obsessive-compulsive Disorder, Social Phobia, Generalized Anxiety Disorder, Specific Phobia
- Trial name
- PLET (NCT02051192)
- Testing
- Parent-Led Exposure Therapy, Treatment As Usual
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of South Florida
Depressive Disorder, Depression
Detection and Treatment of Depression in Patients Admitted to the General Hospital
Depression is a common disorder among patients with a somatic illness admitted to the general hospital. Patients with depression do worse in terms of their somatic symptoms or functioning that those without depression.
- Trial name
- NCT00521911
- Testing
- Cognitive Behavioural Therapy
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Opioid-use Disorder, Opioid-Related Disorders
Harnessing Placebo Effects in Methadone Treatment
More than 2 million individuals in the United States have an Opioid Use Disorder (OUD). Methadone maintenance treatment is the gold standard of medication-assisted treatment for OUD, but high-dose methadone is associated with…
- Trial name
- NCT02941809
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- University of Maryland, Baltimore
Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease
SGLT2 Inhibitors on Coronary Atherosclerosis Progression Via Perivascular Adipose Tissue in Diabetes
This study is a multicenter, randomized controlled trial to test whether an SGLT2 inhibitor (dapagliflozin), a type of diabetes medication, can slow down or even reverse the progression of coronary atherosclerosis (plaque buildup…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease, Atherosclerosis
- Trial name
- SCOPE (NCT07614230)
- Testing
- Dapagliflozin (DAPA), Standard Care (Treatment as Usual)
- Where
- 2 sites in China
- Volunteers
- 144 people
- Sponsor
- Junjie Yang
Eating Disorders
Multi-Family Group Therapy for Adult Eating Disorders
Eating Disorders are a debilitating and serious mental illness. This illness is associated with medical complications, psychological and social impairment.
- Trial name
- MFGT (NCT02106728)
- Testing
- Multi-Family Therapy, Supportive Family Therapy
- Where
- Canada
- Volunteers
- 117 people
- Sponsor
- Gina Dimitropoulos
COVID-19
Effect of Daily Oral Administration of Food Supplement NLC-V in Patients Diagnosed With COVID-19
This study is designed to evaluate the safety and efficacy of NLC-V in patients diagnosed with COVID-19.
- Trial name
- NCT05226767
- Testing
- NLC-V
- Where
- Israel
- Volunteers
- 31 people
- Sponsor
- Todos Medical, Ltd.
Pain, Shoulder, Post Operative Pain
The Role of Neurofeedback Training and Pain Management in Post-operative Shoulder Rehabilitation
The primary aim is to compare the efficacy of neurofeedback training (NFT) and pain management protocol (PMP) in pain reduction, restoration of shoulder function, and improved cognitive performance as the post-operative…
- Trial name
- NCT05948007
- Testing
- Neurofeedback training, Pain management protocol
- Sponsor
- Chang Gung Memorial Hospital
Diabetes Mellitus, Type 2
Remote Study Collecting Blood Glucose Values and Activity Data in Patients With Type 2 Diabetes on Different Treatments
Earlier protocol ID was NN1250-4630, protocol ID is changed to NN1535-7774. The purpose of this study is to collect blood glucose values and activity data in patients with type 2 diabetes for approximately 12 weeks using…
- Trial name
- NCT04809311
- Testing
- Oral antidiabetetic drugs, Basal insulin, Glucagon-like peptide-1 (GLP-1)
- Where
- Denmark
- Volunteers
- 156 people
- Sponsor
- Novo Nordisk A/S
Suicide Prevention
Suicide Prevention for Substance Using Youth Experiencing Homelessness
Suicide is the leading cause of death among YEH and most youth do not access services that may be available to them. Therefore, this study seeks to address this gap in the research literature with the goal to identify an…
- Trial name
- NCT05994612
- Testing
- Cognitive Therapy for Suicide Prevention, Services as Usual
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Mental Disorders
Efficacy of the Recovery Workbook as a Psychoeducational Tool for Facilitating Recovery
The present study will determine if Spaniol and colleague's (1994) Recovery Workbook group intervention is an effective clinical tool to move a person with SMI along in their journey of recovery.
- Trial name
- NCT00375167
- Testing
- Recovery Workbook Training (psychoeducational training), ACT as usual
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Queen's University
Depression
Managing Cancer and Living Meaningfully (CALM): A Study to Evaluate the Effectiveness of a Psychological Intervention for Cancer Patients
The purpose of this study is to test the effectiveness of a brief manualized individual psychotherapy, called Managing Cancer and Living Meaningfully (CALM), to reduce distress and promote psychological well-being in patients…
- Trial name
- CALM (NCT01506492)
- Testing
- CALM
- Where
- Canada
- Volunteers
- 305 people
- Sponsor
- University Health Network, Toronto
Allogeneic Hematopoietic Stem Cell Transplantation Recipient
High Dose Vitamin A in Preventing Gastrointestinal GVHD in Participants Undergoing Donor Stem Cell Transplant
This phase I trial studies the side effects and how well high dose vitamin A works in preventing gastrointestinal graft versus host disease (GVHD) in participants undergoing donor stem cell transplant.
- Trial name
- NCT03719092
- Testing
- Vitamin A Compound, Best Practice
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Depressive Symptoms, Anxiety
Effectiveness of a Guided Mobile App Intervention for Depression and Anxiety in University Students (PROMES-U Study)
Background: Symptoms of depression and anxiety are prevalent among Spanish university students. Minimally guided online interventions have shown promise in reducing symptomatology and preventing increased mental distress.
- Trial name
- PROMES-U (NCT06078007)
- Testing
- MyMoodCoach
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- University of the Balearic Islands
Child Behavior Problem, Parent-Child Relations
Pilot of Enhanced Child Adult Relationship Enhancement in Pediatric Primary Care
The purpose of this study is to evaluate the efficacy of the enhanced PriCARE intervention in improving parenting capacity, decreasing child behavior problems, and reducing risk of child maltreatment at several primary care…
- Trial name
- PriCARE (NCT04110236)
- Testing
- PriCARE, Positive Discipline Module
- Where
- 2 sites in United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
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