Clinical trials: Treatment as usual
Opioid-use Disorder
PRimary Care Opioid Use Disorders Treatment (PROUD) Trial
Effective treatment for opioid use disorders (OUDs) requires medications. Two medications for treating OUDs-buprenorphine and injectable naltrexone-can be prescribed in primary care (PC).
- Trial name
- PROUD (NCT03407638)
- Testing
- PROUD Intervention
- Where
- 6 sites in United States
- Volunteers
- 377,373 people
- Sponsor
- Kaiser Permanente
Opioid Use Disorder, Chronic Pain
Stepped Care for Patients to Optimize Whole Recovery
This is a prospective, randomized clinical trial of 204 patients with opioid use disorder (OUD) and chronic pain (CP) to test the effectiveness of treatment as usual compared with Stepped Care for Patients to Optimize Whole…
- Trial name
- SC-POWR (NCT05155163)
- Testing
- SC-POWR
- Where
- 2 sites in United States
- Volunteers
- 204 people
- Sponsor
- Yale University
Diabetic Kidney Disease
Using a Diabetic Kidney Disease (DKD) Registry to Treat to Multiple Targets (TMT)
In this quality improvement program (DKD-TMT), patients will be recruited from multiple sites across Asia, with each site recruiting at least 300 type 2 diabetic patients with Diabetic Kidney Disease (DKD).
- Trial name
- DKD-TMT (NCT02176278)
- Testing
- Telephone Reminder, Doctor-Nurse Follow Up, Personalized Risk Report for Patient Empowerment
- Where
- 11 sites in China, Hong Kong and 5 more
- Volunteers
- 2,400 people
- Sponsor
- Asia Diabetes Foundation
Infectious Diseases
Prescription Support System for Antimicrobial Use in Belgian Primary Care
Inappropriate antibiotic prescribing in primary care remains an important contributor to antimicrobial resistance. Despite the availability of evidence-based clinical guidelines, antibiotics are still frequently prescribed for…
- Trial name
- PaSSo (NCT07347015)
- Testing
- Prescription Support System (PSS)
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- KU Leuven
Depression
Maternal Depression Treatment in HIV
Cluster randomized controlled trial to compare the effects of task-shifted, evidence-based depression care vs. usual care on adherence to each step of the prevention of mother-to-child-transmission (PMTCT) care cascade at 8…
- Trial name
- M-DEPTH (NCT03892915)
- Testing
- evidence-based depression treatment
- Where
- Uganda
- Volunteers
- 391 people
- Sponsor
- RAND
Delirium, Critical Illness
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients
Delirium is one of the most common manifestations of cerebral dysfunction in severely ill patients. The international guidelines for the prevention of delirium in intensive care recommend the daily application of environmental…
- Trial name
- Clodex (NCT04758936)
- Testing
- Clonidine, Dexmedetomidine
- Where
- 3 sites in Belgium
- Volunteers
- 50 people
- Sponsor
- Erasme University Hospital
Ulcerative Colitis Acute
Upadacitinib Combined With Corticosteroids vs Corticosteroid Monotherapy Induction for Inpatients and Outpatients With Acute Severe Ulcerative Colitis
This trial is being conducted to learn more about the optimal sequence of various medications in the management of acute severe ulcerative colitis (ASUC).
- Trial name
- ACUTE (NCT07258771)
- Testing
- Oral Upadacitinib, Intravenous Methylprednisolone, Oral prednisolone Taper
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Berinstein, Jeffrey
Lipodystrophy, Partial
Tirzepatide for Partial Lipodystrophy Treatment: A New Horizon in 2024
This study aims to see if the clinical use of Tirzepatide in patients with lipodystrophy (a rare disorder associated with abnormal loss of the body's fat tissue) may lead to improved diabetes mellitus control and lowering of…
- Trial name
- TILT-2024 (NCT07091734)
- Testing
- Tirzepatide, Usual care medications
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan
Smoking, Lung Cancer
Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)
This trial studies how well a centralized care strategy works in improving the quality of smoking cessation and shared decision making among patients who smoke and are considering lung cancer screening.
- Trial name
- NCT04200534
- Testing
- Best Practice, Nicotine Patch, Quality-of-Life Assessment
- Where
- 3 sites in United States
- Volunteers
- 358 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cardiovascular Diseases
Psychosomatic Risk Screening
Mental health problems are common in terms of lifetime prevalence and often occur in combination with chronic physical illnesses.
- Trial name
- NCT06651164
- Testing
- psychosocial risk screening
- Where
- Germany
- Volunteers
- 142 people
- Sponsor
- Heidelberg University
ICD
Nursing Interventions Following Sudden Cardiac Arrest
Determine the benefits of implantable cardioverter defibrillator (ICD) patients participating in a structured, 8-week educational telephone intervention delivered by expert cardiovascular nurses post-ICD.
- Trial name
- NCT04462887
- Testing
- Nursing intervention program
- Volunteers
- 168 people
- Sponsor
- University of Washington
Multiple Sclerosis
A RCT of Telephone-supported ACT in MS
This study will investigate the feasibility of running a randomised controlled trial (RCT) of a psychotherapy called "Acceptance and Commitment Therapy (ACT)", delivered in a self-help format with additional telephone support…
- Trial name
- NCT02596633
- Testing
- Telephone-support Acceptance and Commitment Therapy (ACT)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Ankle (Ligaments); Instability (Old Injury), Ankle Sprain
A Study on Reducing Opioid Use After Ankle Arthroscopy
Study Title Effect of a Postoperative Multimodal Analgesic Protocol Predominantly Based on Non-Opioid Medications vs Opioid-Based Analgesia on Pain After Ankle Arthroscopy: A Noninferiority Randomized Clinical Trial Purpose This…
- Conditions
- Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect, Opioid Analgesia
- Trial name
- NCT07154433
- Testing
- Opioid Analgesic Regimen, Non-opioid analgesic regimen
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer Early Stage Breast Cancer (Stage 1-3), HR Positive/HER2 Low Breast Cancer
Chemotherapy With or Without Adebrelimab and T-DXh as Neoadjuvant Therapy for HR+/HER2 Low Early Stage Breast Cancer
The goal of this clinical trial is to learn if add SHR-A1811 and/or Adebrelimab on standard chemotherapy could further improve the pCR rate in HR+/HER2 low early stage breast cancer patients.
- Trial name
- NCT07317778
- Testing
- SHR-A1811, Adebrelimab (PD-L1 inhibitor), Taxane Chemotherapy
- Where
- China
- Volunteers
- 249 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Cognitive Decline, Cancer
Combined Model of Online Remote Interventions for Cancer-Related Cognitive Impairment
Cancer survival rates have increased dramatically in recent years. However, many survivors report cognitive decline following treatment, which significantly impairs their quality of life.
- Trial name
- CRCI (NCT04210778)
- Testing
- Cognitive orientation to daily occupational performance (CO-OP), Computerized Cognitive Training (BrainHQ, posit science)
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Acute Exacerbation of COPD
Use of MULTIplex PCR, Procalcitonin, and Sputum Appearance to Reduce Duration of Antibiotic Therapy During Severe COPD EXAcerbation: A Controlled, Randomized, Open-label, Parallel-Group, Multicenter Trial
COPD is a common chronic disease. Its natural course is characterized by Acute exacerbations (AE). This may require hospitalization or even ICU/RESUSCITATION admission.
- Trial name
- MULTI-EXA (NCT05280132)
- Testing
- Personalized antibiotic treatment, Usual antibiotic treatment
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pleural Effusion, Pneumothorax
Ballooned Intercostal Drain Trial
This study is designed to assess whether a new type of chest drain reduces the number of drains that fall out of or are accidentally removed from the chest cavity (usually requiring another drain to be inserted), without causing…
- Trial name
- NCT03000504
- Testing
- Ballooned intercostal drain
- Where
- 3 sites in United Kingdom
- Volunteers
- 178 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Knee Osteoarthritis
Risk Assessment and Management Program (RAMP) on Knee Osteoarthritis in Primary Care
The goal of this clinical trial is to determine the clinical effectiveness of a Chronic Care Model (CCM) named Risk Assessment and Management Program on Knee OA (RAMP-Knee OA) in adults with knee Osteoarthritis (Knee OA) at 52…
- Trial name
- NCT06283147
- Testing
- Risk assessment and Management Programme - Knee Osteoarthritis
- Where
- Hong Kong
- Volunteers
- 228 people
- Sponsor
- Chinese University of Hong Kong
Memory Deficits, Electroconvulsive Therapy
Cognitive Training for Memory Deficits Associated With Electroconvulsive Therapy
Although electroconvulsive therapy (ECT) remains the most effective treatment for people with severe depression, patients may experience a significant degree of persistent and/or permanent memory problems following ECT.
- Trial name
- NCT01876758
- Testing
- Cognitive Intervention: Memory Training, Comparable general mental stimulation
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- New York State Psychiatric Institute
Knee Osteoarthritis, Meniscus Tear
Effects of Kinesiotaping and Physiotherapy in Grade 2 Osteoarthritis Following Degenerative Meniscal Tears
Degenerative meniscal tears are a common cause of osteoarthritis commonly diagnosed in football players and are considered a major risk factor for the development of knee osteoarthritis.
- Trial name
- NCT06227078
- Testing
- Kinesiotaping
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- Gopal Nambi
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