Clinical trials: Treatment as usual
Chronic Pain, Depression
Comparing Acupuncture, BioModulator, and Transcutaneous Electrical Nerve Stimulation for Symptomatic Treatment of Chronic Pain.
The primary objective of this preliminary study is to compare the Tennant BioModulator with Transcutaneous Electrical Nerve Stimulation (TENS) and Traditional Chinese Acupuncture for the management of chronic pain among injured…
- Conditions
- Chronic Pain, Depression, PTSD Symptoms, Sleep
- Trial name
- NCT01752010
- Testing
- Traditional Chinese Acupuncture, Tennant™ Biomodulator Treatment, Transcutaneous electrical nerve stimulation (TENS) Treatment
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Samueli Institute for Information Biology
Parkinson Disease, Freezing of Gait
Investigating the Neural Signature of Freezing of Gait in Parkinson's Disease
Freezing of Gait (FOG) is a disabling symptom of Parkinson's disease (PD) and a leading cause for falls. Current medical management is inadequate to alleviate FOG so there is need for improved treatments.
- Conditions
- Parkinson Disease, Freezing of Gait, Basal Ganglia Diseases, Brain Disease
- Trial name
- FOG-EEG (NCT06841718)
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- KU Leuven
Shoulder Injuries
Subscapularis Repair Augmentation for Total Shoulder Arthroplasty
The primary purpose of this research is to compare the images obtained by ultrasound between a standard repair of the subscapularis tissue and after repair with a Biobrace.
- Trial name
- NCT05487677
- Testing
- BioBrace Augmentation, Standard Repair with Sutures
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Self-harm, Suicidal Ideation
CaMaPi for Adolescents/Young People With a History of Self-harm and Suicidal Ideation in Jos, Nigeria
Suicide and self-harm are global disease burden that contributes significantly to years of lost life and mortality.
- Trial name
- CaMaPi (NCT06440031)
- Testing
- CaMaPi, TAU
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Hepatitis C
ED Patient's Perceptions and Acceptability Toward a Novel POC HCV Viral Load Testing
Hepatitis C virus (HCV) infection has become the leading fatal infectious disease in the United States. Approximately 75% of individuals who have been infected with HCV are chronically infected with the virus.
- Trial name
- NCT03767231
- Testing
- Xpert HCV Viral Load Finger-stick Point-of-Care test (Cepheid)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
Adolescent Behavior, Lifestyle Modification
A Family-centred Approach Enhancing Cardiovascular Health in Ugandan Adolescents and Their Families
The FaCe-D Study, with funding from the Canadian Institute for Health Research (CIHR) through Global Alliance for Chronic Diseases (GACD) aims to adapt and implement an evidence-based family centred approach (FCA) to prevent…
- Conditions
- Adolescent Behavior, Lifestyle Modification, Cardiovascular Disease Other
- Trial name
- FaCe-D (NCT07265453)
- Testing
- The immediate (treatment) arm, will receive the FaCe-D intervention comprising of 'HOME VISITS, DIET, PHYSICAL ACTIVITY AND HEALTH MESSAGING, Control Arm - standard of care
- Where
- 2 sites in Uganda
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- MRC/UVRI and LSHTM Uganda Research Unit
Type 1 Diabetes
Social Media Use in Adolescent Diabetes Care
The goal of this clinical trial is to evaluate the feasibility of a social media intervention to support diabetes management in adolescents with type 1 diabetes.
- Trial name
- NCT06085339
- Testing
- Social Media
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Children's Hospital
Distress, Psychological, Negative Affect
Nature Exposure Through Virtual Reality (NET-VR) in Older Adults
Daily exposure to nature is associated with improved mood and reduced anxiety symptoms in the overall population. Even brief contact with natural environments can lower stress and restore productivity.However, access to natural…
- Conditions
- Distress, Psychological, Negative Affect, Cognitive Functioning, Older Adults
- Trial name
- NET-VR (NCT07443657)
- Testing
- Nature-Based Virtual Reality Intervention, Waiting list
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Cannabis Use Disorder
A Cannabis E-intervention for Young Cannabis Users With Early Psychosis (iCC)
The concerning lack of research related to technology-based psychological interventions in individuals with psychosis and cannabis use disorder (CUD) led to the design a randomized control trial (RCT) with an innovative mobile…
- Trial name
- iCC (NCT05310981)
- Testing
- iCanChange
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Advance Care Planning, Multimorbidity
ACP in Older Patients With Multimorbidity: a Randomized Pilot
Rationale A recent study into the patient perspective of patients with multiple chronic conditions in the Netherlands underlines the strain multimorbidity can put on people.
- Conditions
- Advance Care Planning, Multimorbidity, Old Age; Debility, Health Economics
- Trial name
- NCT04856202
- Testing
- Advance Care Planning interview
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Migraine, Migraine Disorders
Healthy Living Partnerships for Veterans With Migraine
This pilot study, modeled upon the successful and empirically validated HELP Prevent Diabetes Intervention, incorporates a migraine education component describing the links between lifestyle behaviors and migraine activity (e.g.…
- Conditions
- Migraine, Migraine Disorders, Migraine With Aura, Migraine Without Aura
- Trial name
- HELP-VM (NCT04373330)
- Testing
- Intensive Lifestyle Intervention
- Sponsor
- Wake Forest University Health Sciences
Down Syndrome, Healthy Aging
Group-based Resistance Training for Adults With Down Syndrome
The investigators are interested in Resistance Training as a physical exercise intervention for adults with Down syndrome. Resistance Training (or RT for short) is a popular form of physical exercise, which focuses on improving…
- Conditions
- Down Syndrome, Healthy Aging, Resistance Training
- Trial name
- NCT07347912
- Testing
- Resistance Training, Services as Usual Control Group
- Where
- Ireland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Saint John of God Intellectual Disability Services - Dublin South East
Non-suicidal Self-injury (NSSI)
Blended Unified Protocol for Chinese Adolescents With Non-Suicidal Self-Injury: A Randomized Controlled Trial
This study is an open-label, randomized controlled trial evaluating the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A) in reducing non-suicidal self-injury (NSSI) among…
- Trial name
- NCT07110181
- Testing
- a blended version of the Unified Protocol for Adolescents (UP-A), Standard psychiatric treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jian-Jun Ou
Kidney Transplant Rejection
Impact of the Microbiota on the Likelihood of Renal Graft Rejection
Identification of a bacterial signature in the blood or stool that may be associated with acute rejection in patients treated with Nulojix during their first year of transplant.
- Trial name
- MERRLIN (NCT04736381)
- Testing
- Belatacept Injection [Nulojix]
- Where
- 10 sites in France
- Volunteers
- 70 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
ADHD, Sleep
Sleep IntervEntion as Symptom Treatment for ADHD
Up to 72% of adolescents with ADHD portray sleep problems. The most common sleep difficulties in adolescents with ADHD are initial insomnia, nocturnal awakenings, non-restorative or restless sleep.
- Conditions
- ADHD, Sleep, Adolescents, CBT
- Trial name
- SIESTA (NCT04723719)
- Testing
- SIESTA, Treatment as usual for ADHD
- Where
- Belgium
- Volunteers
- 92 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obsessive-Compulsive Disorder, Obsessive-compulsive Disorders and Symptoms
Cognitive Bias Modification for OCD
This study will conduct the development and preliminary evaluation of Cognitive Bias Modification for Interpretation (CBM-I) and Approach Avoidance Training (AAT) as augmentations to treatment as usual for OCD and related…
- Trial name
- NCT03799419
- Testing
- Cognitive bias modification for interpretation bias, Psychoeducation, Approach avoidance training
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Mclean Hospital
Psychotic Disorders
Group Training for Social Skills in Psychosis
The purpose of this study is to assess the feasibility of a social skills training group for people with psychosis.
- Trial name
- GRASP (NCT02181777)
- Testing
- GRASP, Standard care
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- King's College London
Pain
Evaluating Lanolin for the Treatment of Nipple Pain Among Breastfeeding Women
The purpose of this study is to evaluate the effectiveness of lanolin for the treatment of painful/damaged nipples among breastfeeding women, and to evaluate if the use of lanolin has an effect on breastfeeding outcomes such as…
- Trial name
- LanP (NCT01420419)
- Testing
- Lanolin, Standard (usual) in-hospital and community postpartum care
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University of Toronto
Preterm Birth, Early Intervention
Movement Imitation Therapy for Preterm Babies (MIT-PB) - A Pilot Study
Background: Very preterm babies are at high risk for developmental disorders. Prechtl's General Movements (GMs) Assessment is a valuable and reliable tool in infants until three months corrected age for predicting their further…
- Conditions
- Preterm Birth, Early Intervention, General Movements
- Trial name
- NCT07449312
- Testing
- Movement Imitation Therapy for Preterm Babies (MIT-PB), Usual care Physiotherapy
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Monkeypox
Efficacy/Effectiveness, Safety, and Immunogenicity of LC16m8 Mpox Vaccine in Colombia
Background: Mpox is a zoonotic disease caused by the mpox virus (MPXV). It has been endemic in West and Central African countries.
- Trial name
- MPOX-COL (NCT06223919)
- Testing
- LC16m8
- Where
- 3 sites in Colombia
- Volunteers
- 8,686 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
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