Clinical trials: Treatment as usual
Breast Cancer
Effectiveness of an eHealth Self-management Support Program for Persistent Pain After Breast Cancer Treatment
The scientific goals of the project are: 1. The primary scientific objective of the study is to determine the effectiveness of an eHealth self-management support program for persistent pain after breast cancer treatment compared…
- Trial name
- PECAN (NCT06308029)
- Testing
- eHealth self-management support program, Face-to-face rehabilitation program
- Where
- 2 sites in Belgium
- Volunteers
- 270 people
- Sponsor
- Universiteit Antwerpen
Anxiety Disorders, Depression
Early Intervention Coping Kids (TIM) Follow up Study
The project objectives are to investigate if a preventive intervention targeting anxious and sad children aged 8 to 12 years has haf the anticipated long-term effects, 5 years after receiving the intervention.
- Trial name
- FOPPT4 (NCT05766072)
- Testing
- EMOTION Kids coping with anxiety and depression (Mestrende barn in Norwegian)
- Where
- Norway
- Volunteers
- 217 people
- Sponsor
- University of Oslo
Severe Mental Disorder
A Naturalistic Controlled Trial of Individual Placement and Control in Bodø
The investigators aim to test the effectiveness of Individual Placement and Support (IPS) on 1. employment, 2. welfare dependency, and 3. public-sector health care utilization.
- Trial name
- IPSBODO (NCT04179877)
- Testing
- IPS
- Where
- Norway
- Volunteers
- 77,000 people
- Sponsor
- Norwegian Institute of Public Health
Pregnancy Preterm, Neonatal Hypoglycemia
Euglycemia After Antenatal Late Preterm Steroids, the E-ALPS Study
Annually in the U.S 300,000 neonates are born late preterm, defined as 34 weeks 0 days - 36 weeks 6 days. The Antenatal Late Preterm Steroids (ALPS) Trial demonstrated that maternal treatment with betamethasone in the late…
- Conditions
- Pregnancy Preterm, Neonatal Hypoglycemia, Hyperglycemia Drug Induced
- Trial name
- E-ALPS (NCT03076775)
- Testing
- Maternal glycemic control
- Where
- 2 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Adrenal Hyperplasia, Congenital
Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal Hyperplasia
The conventional glucocorticoid replacement therapy in congenital adrenal hyperplasia (CAH) renders the cortisol levels unphysiological, which may cause symptoms and long-term complications.
- Trial name
- CAH (NCT01771328)
- Testing
- Hydrocortisone, Cortisone acetate
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Haukeland University Hospital
Post-operative Pain, Opioid Use
QL vs LAI for Palatoplasty
This study will consist of patients ages 6-18 who are undergoing a surgery on the hard or soft palate of the mouth (palatoplasty), with removal of bone from the front of the hip (anterior iliac bone graft harvesting).
- Conditions
- Post-operative Pain, Opioid Use, Cleft Palate
- Trial name
- NCT06420336
- Testing
- Quadratus lumborum block, Local anesthetic infiltration
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Mastectomy Related Lymphedema, Lymphedema of Upper Limb
Testing an Intervention to Foster Hope for Cancer Survivors With Lymphedema
The specific objectives and research questions of the proposed study are: 1. a. Administer a group rehabilitation intervention to address loss and foster hope in 30 participants with upper and lower limb SLC --15 in an…
- Conditions
- Mastectomy Related Lymphedema, Lymphedema of Upper Limb, Lymphedema of Lower Extremity
- Trial name
- NCT02453295
- Testing
- Intervention Group
- Volunteers
- 60 people
- Sponsor
- University of Ottawa
Adult, HIV Infections
Adherence Toolkit for Managing Nonadherence to HIV Medications in Indonesia
The goal of this usability study and a cluster randomised controlled trial is to investigate the effectiveness of an adherence toolkit as a decision support tool to improve adherence to antiretroviral therapy.
- Trial name
- NCT05996081
- Testing
- Adherence toolkit
- Where
- Indonesia
- Volunteers
- 400 people
- Sponsor
- University of Groningen
Being Referred for Child Protection Services
Evaluating the Mentalization-based Treatment Lighthouse Parenting Programme: Protocol of a Feasibility and Acceptability Quasi-Experimental Study
The goal of this study is to learn whether it is practical and acceptable to deliver the Lighthouse Parenting Programme and to carry out the planned research procedures with caregivers involved with Child Protection Services.
- Trial name
- NCT07448870
- Testing
- Lighthouse Parenting Programme, Treatment-as-usual (TAU)
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Universidade do Porto
Pleural Biphasic Mesothelioma, Pleural Epithelioid Mesothelioma
Testing the Addition of Targeted Radiation Therapy to Surgery and the Usual Chemotherapy Treatment (Pemetrexed and Cisplatin [or Carboplatin]) for Stage I-IIIA Malignant Pleural Mesothelioma
This trial studies how well the addition of targeted radiation therapy to surgery and the usual chemotherapy treatment works for the treatment of stage I-IIIA malignant pleural mesothelioma.
- Conditions
- Pleural Biphasic Mesothelioma, Pleural Epithelioid Mesothelioma, Stage I Pleural Malignant Mesothelioma AJCC v8, Stage IA Pleural Malignant Mesothelioma AJCC v8
- Trial name
- NCT04158141
- Testing
- Carboplatin, Cisplatin, Decortication
- Where
- 12 sites in United States
- Volunteers
- 16 people
- Sponsor
- NRG Oncology
Oral Health, Parkinson Disease
Preliminary Study of the Quality of the Oral Flora in Parkinson's Patients
This is a prospective interventional clinical study whose main objective is to determine the impact of oral hygiene guidance on the oral health status of patients with Parkinson disease
- Trial name
- PARKIDENT (NCT03827551)
- Testing
- Delivery of oral hygiene advices
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Knee Osteoarthritis, Physical Performance Parameters
Knee Osteoarthritis in Elderly People - Gait Analysis
The investigators perform a prospective controlled study and assess gait parameters in bilateral knee osteoarthritis (KOA) elderly patients with wireless system - BTS G-WALK, pre- and post-rehabilitation program.
- Conditions
- Knee Osteoarthritis, Physical Performance Parameters, Ultrasound, Quality of Life (QOL)
- Trial name
- NCT07093229
- Testing
- Ultrasound exam of quadriceps muscles (left/right) and gait analysis, Electrotherapy measures: transcutaneous nerve stimulation, ultrasound and low intensity laser; each one daily , applied on both lower limbs, for 10 days. Kinetic measures daily, Gait training
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Diana Kamal
Anxiety Disorders, Generalized Anxiety Disorder
Mindful Self-Compassion for Anxiety Disorders and Depression
The study will compare 8-week Mindful Self-Compassion training, compared to a control group that does not receive the intervention, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders…
- Conditions
- Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Social Phobia
- Trial name
- NCT05671419
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Georgetown University
Autism Spectrum Disorder
Efficacy of a Comprehensive School-based Intervention for High-functioning Children With Autism Spectrum Disorder
This study was a 4-year efficacy trial (cluster randomized trial) of a comprehensive school-based intervention (CSBI) for high-functioning elementary students with autism spectrum disorder (HFASD).
- Trial name
- NCT03338530
- Testing
- Comprehensive School-Based Intervention
- Volunteers
- 103 people
- Sponsor
- Canisius College
Adnexal Torsion
Role of Preoperative D-dimer Levels in the Diagnosis of Adnexal Torsion
Adnexal torsion is the fifth most common gynecologic emergency. Thirty percent of all cases of adnexal torsion occur in females younger than 20 years.
- Trial name
- NCT06324565
- Testing
- D-Dimer test
- Where
- 9 sites in Austria, Italy and 1 more
- Volunteers
- 130 people
- Sponsor
- IRCCS Burlo Garofolo
Sarcoma
Radiographic Evaluation of Tumor Biology During Neoadjuvant Radiotherapy for Sarcoma
This is a single arm study in which patients will undergo MRI studies at 3 non-SOC timepoints (end of weeks 1, 3, and 5) while receiving SOC RT for their soft tissue sarcoma.
- Trial name
- NCT07487870
- Testing
- MRI
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Andrew Frankart
Osteoporosis, Postmenopausal
MAGnesium Effect With ANtiosteoporotic Drugs
Randomized pilot clinical trial to demonstrate superiority of bisphosphonate-magnesium combination over bisphosphonates alone in postmenopausal osteoporosis in slowing bone remodeling as assessed by C-terminal telopeptide of bone…
- Trial name
- MAGELLAN (NCT05328154)
- Testing
- Follow-up of patients with postmenopausal osteoporosis, with or without fractures, requiring initiation of injectable bisphosphonate therapy as part of their usual care, Follow-up of patients with postmenopausal osteoporosis, fractured or not, requiring initiation of injectable bisphosphonate therapy as part of care with magnesium supplementation
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
Preterm Birth
Environmental Enrichment Intervention and Brain Development in Preterm Infants
This study aims to evaluate the effects of a structured environmental enrichment (EE)-based early developmental intervention on brain, motor, and cognitive outcomes in preterm infants.
- Trial name
- PRE-ENV (NCT07343505)
- Testing
- Standard Developmental Care, Environmental Enrichment-Based Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Eskisehir Osmangazi University
Treatment 1:Dialectical Behavior Therapy (DBT), Treatment as Usual
Efficacy of "DBT-LIVE", an Identity Skills Training Program, for Borderline Personality Disorder.
The main objective of this project is to adapt and evaluate the LIVE Skill module in the Spanish population. LIVE Skill is a psychological intervention protocol specifically designed to address identity disturbances in…
- Trial name
- NCT07684872
- Testing
- DBT LIVE, TAU
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- Universidad Europea de Valencia
Autism Spectrum Disorder
Integrated Life Skill Training and Executive Function Strategies in Children With ASD
The goal of this clinical trial is to test if using what is called executive function strategies like strategies for improving self-regulation ,strategies for improving planning and problem solving work well when applied within…
- Trial name
- ASD (NCT05829577)
- Testing
- Executive Function Strategies and Training, Daily Life skill training, Sensory Integration /Processing training
- Where
- Qatar
- Volunteers
- 92 people
- Sponsor
- Hamad General Hospital
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