Clinical trials: Treatment as usual
Optic, Atrophy, Hereditary, Leber
Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE)
The goal of this clinical trial is to assess the effectiveness of GS010, a gene therapy, in improving the visual outcome in participants with Leber Hereditary Optic Neuropathy (LHON) due to the G11778A ND4 mitochondrial mutation…
- Trial name
- REVERSE (NCT02652780)
- Testing
- GS010
- Where
- 7 sites in United States, France and 3 more
- Volunteers
- 37 people
- Sponsor
- GenSight Biologics
Thyroid Cancer, Graves Disease
Personalized Treatment in Thyroid Disorders
The Collar Therapy Indicator (CoTI) (A device that is placed in collar around the neck resembling a turtle neck sweater collar with a wire and recording box) has been shown in a single small previously published experience to…
- Trial name
- NCT03517579
- Testing
- Cervical Collar Therapy Indicator (COTI)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Motivation for Physical Activity
A Multi-professional Team Intervention on Physical Activity Referrals in Primary Care Patients With Cardiovascular Risk Factors-the Dalby Lifestyle Intervention Cohort (DALICO) Study
Background The present study protocol describes the trial design of a primary care intervention cohort study, which examines whether an extended, multi-professional physical activity referral (PAR) intervention is more effective…
- Trial name
- DALICO (NCT01187576)
- Testing
- Multi-professional team intervention with PAR, lifestyle brochure, Ordinary recommendations on health behaviours, lifestyle brochure
- Where
- Sweden
- Sponsor
- Region Skane
Depression, Anxiety
Developing and Testing of Culturally Adapted Cognitive Behavior Therapy (CaCBT) for Pashto Speaking Pakistanis and Afghans
CBT for common mental disorders has a strong evidence base in both the USA and the UK. There are wider cultural and linguistic differences between Non Pashtun and Pashtun population of Pakistan and Afghanistan and there is…
- Trial name
- NCT02797691
- Testing
- CaCBT, Medication/ Psychotherapy
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Peshawar Medical College
Esophageal Carcinoma, Lung Carcinoma
Yoga Program for Improving the Quality of Life in Couples Coping With Cancer
This clinical trial seeks to learn if a yoga program can improve physical performance, quality of life and symptom burden in cancer patients who are undergoing radiation therapy, and their partners.
- Conditions
- Esophageal Carcinoma, Lung Carcinoma, Malignant Head and Neck Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT04607590
- Testing
- Best Practice, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Depression
Computer-Assisted Cognitive-Behavioral Therapy for Adolescent Depression
Background: Most adolescents suffering depression are treated in primary care clinics. Cognitive-behavior therapy (CBT) is effective in the treatment of adolescent depression.
- Trial name
- YPSA-M (NCT01862913)
- Testing
- Computer-assisted cognitive-behavioral therapy, Usual care treatment
- Where
- Chile
- Volunteers
- 216 people
- Sponsor
- University of Chile
Obesity
To Investigate the Safety, Tolerability and Pharmacodynamics of GSK2890457 in Healthy Volunteers and Subjects With Type 2 Diabetes
This study is the first administration of GSK2890457 in humans. The study will be conducted in 3 parts: - Part A (conducted at a single investigative site) will determine the safety and tolerability of GSK2890457 alone in healthy…
- Trial name
- NCT01725126
- Testing
- GSK2890457, Metformin, Liraglutide
- Where
- 3 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Mental Disorders
A Randomized Controlled Trial of Mental Health Peer-Led Education
This randomized controlled trial tests the efficacy of a mental health peer-led educational intervention called BRIDGES (Building Recovery of Individual Dreams and Goals through Education and Support).
- Trial name
- BRIDGES (NCT01297985)
- Testing
- BRIDGES Peer-Led Education
- Where
- United States
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Scleroderma, Systemic Sclerosis
Scleroderma Patient-centered Intervention Network (SPIN) Hand Program
The Scleroderma Patient-centered Intervention Network (SPIN) is an organization established by researchers, health care providers, and people living with scleroderma (systemic sclerosis or SSc) from Canada, the USA, and Europe.
- Trial name
- SPIN-HAND (NCT03419208)
- Testing
- SPIN-HAND Program
- Where
- Canada
- Volunteers
- 466 people
- Sponsor
- Lady Davis Institute
Obesity, Poverty
Promoting Healthy Development With the Recipe 4 Success Intervention
10-session home visit intervention conducted within Early Head Start and designed to reduce low-income toddler's obesity risk and improve their self-regulation skills and parents' sensitivity.
- Trial name
- NCT03976089
- Testing
- Recipe 4 Success, Treatment as Usual Early Head Start
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Depression, Postpartum, Malnutrition, Child
Decreasing Stunting by Reducing Maternal Depression in Uganda: A Cluster Randomized Controlled Trial (CRCT) for Improved Nutrition Outcomes
The project seeks to test the integration of Interpersonal Psychotherapy for Groups within Care Group projects and investigate whether the treatment of maternal depression with Interpersonal Psychotherapy for Groups improves the…
- Trial name
- NCT03573713
- Testing
- Care Groups, IPT-G
- Where
- Uganda
- Volunteers
- 1,248 people
- Sponsor
- Food for the Hungry
To Assess the Reduction in the Viral Load of SARS-CoV-2 in Patients Receiving Ivermectin Compared to Those Receiving Standard Care
Evaluation of the Impact of the Administration of Single Dose of Ivermectin in the Early Phase of COVID-19
The action of ivermectin in vitro on the viral replication of SARS-CoV-2 was demonstrated and published by an Australian team in June 2020.
- Trial name
- IVERCoV (NCT05040724)
- Testing
- Ivermectin
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Raincy Montfermeil Hospital Group
Stress, Cancer Diagnosis
Building Resiliency Among Caregivers of Curvivors and Metavivors
The main purpose of this research study is to assess the feasibility and participants' satisfaction of the Stress Management and Resiliency - Relaxation Response Resiliency Program (SMART-3RP) and compare this treatment with…
- Conditions
- Stress, Cancer Diagnosis, Distress, Emotional
- Trial name
- ForTe (NCT05702723)
- Testing
- Smart-3RP, Enhanced Usual Care
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Massachusetts General Hospital
Multiple Sclerosis
Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis
Multiple sclerosis (MS) is among the most prevalent autoimmune diseases among young and middle-aged adults. Up to 65% of MS patients experience objective cognitive impairment including problems with information processing speed…
- Trial name
- NCT03889327
- Testing
- Neuropsychological Feedback & Psychoeducation (Cognition), Psychoeducation (Health)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Missouri, Kansas City
Dementia
Improving Wellbeing and Health for Care Home Residents During COVID-19
More than 400,000 people in the UK live in care homes. These individuals are particularly vulnerable to COVID-19; many are frail and the majority have concurrent physical health problems and dementia.
- Trial name
- COVIDWHELD (NCT04590469)
- Testing
- COVID WHELD
- Where
- United Kingdom
- Sponsor
- University of Exeter
Chemotherapy-induced Peripheral Neuropathy
Whole-body Vibration Training to Reduce the Symptoms of Chemotherapy-induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and clinically meaningful side effect of cancer treatment.
- Trial name
- VANISH (NCT03032718)
- Testing
- Whole-body vibration training
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- University of Basel
Smoking, Acute Coronary Syndrome
Smoking Cessation for Patients With Acute Coronary Syndrome (ACS)
The aim of the present study is to assess if a personal care program of smokers hospitalised for acute coronary syndrome can change the smoking habits as compared with similar patients in conventional care program at 6 months.
- Trial name
- PATPAC (NCT00987597)
- Testing
- Technique of in-vivo exposure (cigarette) and mental image exposure (craving), conventional follow-up
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood Purification, Dual-cannula
Blood Purification Therapy With Dual-cannula in Jugular-femoral Venous
Acute kidney failure (AKI) is one of the most important causes of morbidity and mortality for critical ill patients. The use of blood purification treatment such as renal replacement therapy (CRRT) and plasma exchange has…
- Conditions
- Blood Purification, Dual-cannula, Vena Cava Disconnection
- Trial name
- NCT05510713
- Testing
- Hemodialysis Catheter
- Volunteers
- 50 people
- Sponsor
- Shanghai Zhongshan Hospital
Microbiota
Clinical Trial to Assess the Effects of Topical Lotions on Changes in the Skin Microbiome and Associations With Itch
This was a multi-center, 14-day clinical use study with a 7-day regression period, being conducted to assess the changes in the skin microbiome with two moisturizers in female and male subjects 16-50 years of age with mild to…
- Trial name
- NCT03673059
- Testing
- OTC Eczema Moisturizer Regimen, Cosmetic Moisturizer Regimen
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Johnson & Johnson Consumer Products Company Division of Johnson & Johnson Consumer Companies, Inc.
Vernal Keratoconjunctivitis
Tacrolimus Eye Drops in Treatment of Vernal Keratoconjunctivitis
The purpose of the study is to evaluate efficacy and safety of topical Tacrolimus eye drops in different concentrations in treatment of vernal keratoconjunctivitis (VKC) comparing it with Steroid based usual topical regimen
- Trial name
- NCT07138742
- Testing
- Steroid eye drops, Tacrolimus eye drops
- Volunteers
- 90 people
- Sponsor
- Sohag University
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