Clinical trials: Vancomycin, completed
Corneal Perforation, Exposure Keratitis
The Role of OmniLenz® in the Treatment of Small Corneal Perforations Secondary to Exposure Keratitis in ICU Patients
Case series of 5 ICU patients in Farwaniya Hospital who developed exposure keratitis and a subsequent small corneal perforation between April 2022 and April 2024.
- Conditions
- Corneal Perforation, Exposure Keratitis, Infectious Keratitis
- Trial name
- NCT06539663
- Testing
- OmniLenz®
- Where
- Kuwait
- Volunteers
- 5 people
- Sponsor
- Farwaniya Hospital
Clostridium Difficile Infection
Does Fidaxomicin Therapy Reduce Spread of Clostridium Difficile?
This study evaluates whether patients with Clostridium difficile infection (CDI) who are treated with fidaxomicin have less contamination of their skin and surrounding environment with spores of C.
- Trial name
- NCT02461901
- Testing
- Environmental sampling, Skin swab sampling, Fecal sampling
- Where
- 3 sites in United Kingdom
- Volunteers
- 203 people
- Sponsor
- Professor Mark Wilcox
Influenza
Safety of Synbiotics as Adjuvant to Influenza Vaccine in Elderly
Probiotics are viable commensal microorganisms that promote the establishment of beneficial microflora. Animal and human studies demonstrate that probiotics can enhance body's immune response to stimuli.
- Trial name
- NCT01304771
- Testing
- Synbiotic AKSB
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Bacterial Skin and Skin Structure Infection
Retrospective Effectiveness Study of Dalbavancin and Other Standard of Care of the Same Class in Patients With ABSSSI
The aim of this study is to collect the data on the effectiveness of dalbavancin in terms of save of hospitalization days on patients treated between June 2017 and June 2019 in two countries (Italy and Greece) vs the other…
- Trial name
- REDS (NCT04298463)
- Testing
- Xydalba, vancomycin, teicoplanin or daptomycin
- Where
- 16 sites in Greece, Italy
- Volunteers
- 184 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Spinal Fusion Acquired
Intrawound Vancomycin Powder in Spinal Fusion Surgery
Vancomycin powder (for solution for Infusion) will be investigated (off-label usage) in spinal fusion surgery. The powder will be locally administered into to the wound cavity before wound closure.
- Trial name
- iVRCT (NCT02631408)
- Testing
- Vancomycin
- Where
- Austria
- Volunteers
- 308 people
- Sponsor
- Orthopedic Hospital Vienna Speising
Pneumonia, Methicillin-Resistant Staphylococcus Aureus
Trial of MRSA Polymerase Chain Reaction for Pneumonia
The purpose of this study is to conduct a randomized clinical trial to compare an antibiotic strategy based on a novel diagnostic test, polymerase chain reaction (PCR) to usual care, in critically ill adults with pneumonia…
- Trial name
- NCT02660554
- Testing
- Polymerase Chain Reaction (PCR)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Northwestern University
Skin and Soft Tissue Infections
Evaluating the Use of Large-dose, Extended Interval Vancomycin Intravenous Administration for Skin and Soft Tissue Infections
Our hypothesis is that large-dose, extended-interval vancomycin (30 mg/kg IV q24h) administration provides non-inferior clinical efficacy and microbiological efficacy to standard vancomycin (15 mg/kg IV q12h) administration for…
- Trial name
- VOD (NCT01037192)
- Testing
- vancomycin
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Fraser Health
Bacterial Infections
Prospective Study to Optimize Vancomycin Dosing in Children and Adults Using Computer Software
We will compare the percentage of patients having therapeutic vancomycin serum concentrations after current standard dosing, after dosing with our software. We will also include therapeutic outcomes and costs in the analysis.
- Trial name
- NCT01932034
- Testing
- BestDose Computer Software
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- Children's Hospital Los Angeles
Prosthetic Joint Infection
The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures
Total joint replacement is a common clinical practice for patients suffering from disabling arthritis, since it provides significant pain relief and functional recovering.
- Trial name
- NCT02413034
- Testing
- Cefazolin, Control group
- Volunteers
- 28 people
- Sponsor
- Parc de Salut Mar
Multidrug Resistant Bacterial Infection, Enterobacteriaceae Infections
PMT for MDRO Decolonization
This is a randomized, open label, comparative Phase II trial being conducted to determine whether fecal microbiota transplant using Penn Microbiome Therapy (PMT) products helps standard therapy eradicate antibiotic-resistant…
- Conditions
- Multidrug Resistant Bacterial Infection, Enterobacteriaceae Infections, Pseudomonas Aeruginosa, VRE Infection
- Trial name
- NCT05632315
- Testing
- PMT
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Pennsylvania
Nephrotoxicity
Vancomycin-Associated Nephrotoxicity
The primary goal of this study is to determine if there is an association between greater exposure to vancomycin and the development of nephrotoxicity.
- Trial name
- NCT01216540
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University at Buffalo
Healthy Adults
Dietary Supplement With and Without a Probiotic and/or Antibiotic
Complex oligosaccharides can alter the gut microbiome by aiding in the growth of certain organisms, and possibly, inhibiting others. The synergy with a probiotic may enhance gastrointestinal colonization.
- Trial name
- NCT05141903
- Testing
- Antibiotic, HMO Concentrate, Probiotic
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Prolacta Bioscience
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
Post Operative Surgical Site Infection
Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter Randomized, Controlled Trial (VANCO)
The Vancomycin Study is a multi-center, prospective randomized controlled trial that will compare the proportion of deep surgical site infections within 6 months in patients treated with local Vancomycin powder compared to those…
- Trial name
- VANCO (NCT02227446)
- Testing
- Vancomycin antibiotic powder
- Where
- United States
- Volunteers
- 1,036 people
- Sponsor
- Major Extremity Trauma Research Consortium
Congenital Heart Diseases, Aortic Valve Disorder
Pre-operative Prophylaxis With Vancomycin and Cefazolin in Pediatric Cardiovascular Surgery Patients
The investigators hope to learn 1) if the addition of prophylaxis with vancomycin will decrease the rate of cefazolin non-susceptible surgical site infections (SSI), in high risk population 2) to develop better understanding of…
- Trial name
- NCT01619982
- Testing
- Cefazolin 25 mg/kg body weight and Vancomycin hydrochloride, Cefazolin 30 mg/kg body weight
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stanford University
Infection
Reduction of Nosocomial Vancomycin -Resistant Enterococci (VRE) Colonization and Infection by Active Surveillance and Intervention of Infection Control
Vancomycin -resistant enterococci(VRE) has emerged as one of the most common nosocomial pathogen of health-care associated infection since 1988.
- Trial name
- NCT01201031
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University WanFang Hospital
Complicated Skin and Soft Tissue Infection
Evaluation of Ceftaroline Fosamil Versus Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections
The purpose of this study is to evaluate the effects of Ceftaroline Fosamil versus Vancomycin plus Aztreonam in treatment of patients with complicated bacterial skin and soft tissue infections.
- Trial name
- NCT01499277
- Testing
- Ceftaroline fosamil, Vancomycin, Aztreonam
- Where
- 91 sites in United States, Argentina and 26 more
- Volunteers
- 802 people
- Sponsor
- Pfizer
Bacterial Conjunctivitis
Safety and Efficacy of Vancomycin Ophthalmic Ointment in Patients With Moderate to Severe Bacterial Conjunctivitis
This is a Phase 3 study to evaluate the safety and efficacy of a vancomycin hydrochloride ophthalmic ointment dosed 4 times daily for 7 days compared to placebo (vehicle) in patients with moderate to severed Gram-positive…
- Trial name
- NCT02432807
- Testing
- Vancomycin 1.1%
- Where
- 16 sites in United States
- Volunteers
- 303 people
- Sponsor
- Kurobe LLC
Skin Structures and Soft Tissue Infections
Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-1
This is a multicenter, randomized, double-blind study of the efficacy and safety of iclaprim compared to vancomycin for the treatment of skin and skin structure infections.
- Trial name
- REVIVE-1 (NCT02600611)
- Testing
- iclaprim, vancomycin
- Where
- 56 sites in United States, Bulgaria and 8 more
- Volunteers
- 600 people
- Sponsor
- Motif Bio
Streptococcal Sepsis, Hematologic Malignancies
Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation
This is a randomized 2-arm study to compare two different times of giving the drug vancomycin. Half of the patients will begin vancomycin two days before a bone marrow transplant.
- Trial name
- NCT00138112
- Testing
- Empirical Vancomycin, Prophylactic Vancomycin
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Memorial Sloan Kettering Cancer Center