Clinical trials: Varenicline
Tobacco Use Disorder
Varenicline-Aided Cigarette Reduction in Smokers Not Ready to Quit
The investigators will randomize smokers to receive 1) Varenicline + smoking cessation/reduction counseling or 2) Placebo pill + smoking cessation/reduction counseling.
- Trial name
- NCT01308736
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Drinking
Do Treatments for Smoking Cessation Affect Alcohol Drinking?
The purpose of this study is to examine the effect of smoking cessation medications on alcohol drinking. Effect of 2mg/day, 1mg/day, placebo varenicline was evaluated.
- Trial name
- NCT00580645
- Testing
- varenicline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Methamphetamine Dependence, Substance Abuse
Varenicline for Methamphetamine Dependence
Methamphetamine (MA) dependence is a source of continuing danger for both individuals and society. While there are some behavioral treatments, they are not always effective.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- NCT01365819
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, Los Angeles
Smoking Cessation
Combining Varenicline and Guanfacine for Smoking Cessation
The novel design of this study combines a laboratory paradigm to evaluate stress-induced smoking behavior and smoking-related reinforcement, followed by a 12-week treatment phase to evaluate clinical outcomes.
- Trial name
- NCT04198116
- Testing
- Varenicline, Guanfacine ER
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder, Medication Adherence
Varenicline Smoking Cessation Treatment for Methadone Maintenance Patients
This randomized trial will evaluate whether varenicline directly observed therapy provided at a methadone clinic is more efficacious than self-administered varenicline for promoting smoking cessation and enhancing adherence.
- Trial name
- NCT01378858
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Albert Einstein College of Medicine
Smoking Cessation, Stress
Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment
This open-label study will evaluate hydroxyzine, a first-generation antihistamine, combined with varenicline, to help smokers abstain from smoking during a 12-week trial period by diminishing the nausea, stress, anxiety, and…
- Conditions
- Smoking Cessation, Stress, Sleep Disturbance, Nausea
- Trial name
- HAVE (NCT04188106)
- Testing
- Varenicline Pill, Hydroxyzine Pill
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Smoking
Metabolism Informed Smoking Treatment: The MIST RCT
This phase 3 randomized controlled trial will test Metabolism-Informed Smoking Treatment (MIST), a precision approach to smoking treatment that biologically tailors medication selection to nicotine metabolism.
- Trial name
- NCT04590404
- Testing
- Post-discharge automated phone calls (IVR) with option to connect with a tobacco coach., Nicotine Replacement Therapy, Varenicline
- Where
- United States
- Volunteers
- 606 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Smoking Cessation
Integrating Tobacco Treatment Into Cancer Care: A Randomized Controlled Comparative Effectiveness Trial
There are currently over 11 million cancer survivors in the U.S. and survival rates are increasing. Unfortunately, 10-30% of cancer patients are current smokers at the time of diagnosis, and many of these patients have elevated…
- Trial name
- NCT01871506
- Testing
- Standard Care (SC), Intensive Counseling (IC)
- Where
- 3 sites in United States
- Volunteers
- 303 people
- Sponsor
- Massachusetts General Hospital
Nicotine Dependence
Varenicline for the Treatment of Smokeless Tobacco
Varenicline (Chantix™, Pfizer) is a novel selective nicotinic receptor partial agonist with specificity for the α4β2 nicotine acetylcholine receptor that has demonstrated remarkable efficacy for increasing long-term tobacco…
- Trial name
- CHANCHEW (NCT00813917)
- Testing
- varenicline
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking Cessation
Smoking Cessation for American Indians
American Indians and Alaska Natives (AI/ANs) have the highest smoking rates of the major racial/ethnic groups in the United States, approaching 40% to 50%.1-3 In addition, this underserved population has very low smoking…
- Trial name
- NCT01106456
- Testing
- All Nations Breath of Life (ANBL), Nontailored program (NT), Pharmacotherapy
- Where
- 2 sites in United States
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- Won Choi, PhD, MPH
Smoking
Varenicline and Bupropion for Smoking Cessation
This study provides an opportunity to combine varenicline and bupropion SR and capitalize on the potential additive benefit. The investigators hypothesize that this will further increase long-term (≥ 6 months) smoking abstinence…
- Trial name
- CHANBAN (NCT00935818)
- Testing
- Varenicline, bupropion SR
- Where
- 3 sites in United States
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking Cessation
Evaluation of a Tailored Smoking Cessation Treatment Algorithm Based on Initial Treatment Response and Genotype
Nicotine replacement therapy (NRT) is a well-tolerated and efficacious smoking cessation treatment, and yet many smokers fail to quit using NRT.
- Trial name
- ConNic3 (NCT00894166)
- Testing
- Nicotine Patches, Nicotine patches, then bupropion & nicotine patches (Pre-Quit), Nicotine patches, then varenicline (Pre-Quit)
- Where
- United States
- Volunteers
- 606 people
- Sponsor
- Duke University
Smoking Cessation
Drug Use Investigation Of Varenicline (Regulatory Post Marketing Commitment Plan)
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)factors…
- Trial name
- NCT00772941
- Testing
- Varenicline
- Volunteers
- 3,939 people
- Sponsor
- Pfizer
Schizophrenia, Schizoaffective Disorder
A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar Disorder
Varenicline (Chantix) is a smoking cessation treatment that was approved in 2006 by the FDA for treatment of nicotine dependence and may be particularly beneficial in smokers with schizophrenia or bipolar disorder.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Smoking
- Trial name
- SCRP (NCT00621777)
- Testing
- Varenicline
- Where
- 10 sites in United States
- Volunteers
- 247 people
- Sponsor
- Massachusetts General Hospital
Vaping, Nicotine Dependence
Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents
The Investigators propose a randomized, placebo-controlled trial to test the hypothesis that varenicline added to group behavioral and texting support will be well tolerated and improve vaping cessation rates among nicotine…
- Trial name
- Pilot (NCT04602494)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Cigarette Smoking, Nicotine Dependence
Treatment of Smoking Among Individuals With PTSD
This study will examine the effect of combining prolonged exposure, a cognitive-behavioral treatment program for post-traumatic stress disorder (PTSD) with medication (varenicline) and counseling treatments for smoking cessation.
- Conditions
- Cigarette Smoking, Nicotine Dependence, Post-traumatic Stress Disorder, Tobacco Use Disorder
- Trial name
- NCT00937235
- Testing
- Varenicline, Medication Management Counseling, Prolonged Exposure
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pennsylvania
Smoking Cessation
Varenicline for Treatment of E-cigarette Dependence
Varenicline is used to treat tobacco use dependence. It helps reduce cravings for tobacco use and decreases the pleasurable effects of cigarettes and other tobacco products.
- Trial name
- NCT05541497
- Testing
- Varenicline Tartrate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Nicotine Dependence
Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity
This is a brief smoking cessation trial in women, comparing transdermal nicotine patch (TNP) versus varenicline.
- Trial name
- NCT00664755
- Testing
- varenicline, transdermal nicotine patch
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina