Clinical trials: Varenicline
Tobacco Dependence, Smoking Cessation
Combination of Nicotine Replacement Therapy (NRT) and Varenicline to Increase Cessation of Tobacco (CONVICT Study)
Varenicline and nicotine replacement therapy (NRT) are both effective smoking cessation treatments. Anecdotally smokers who are finding their quit attempt difficult have reported benefiting from adding NRT to varenicline.
- Trial name
- CONVICT (NCT01184664)
- Testing
- Nicotine Patch, Varenicline
- Where
- 2 sites in United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Spinocerebellar Ataxia Type 3
Study to Determine the Safety and Tolerability of Varenicline (Chantix®) in Treating Spinocerebellar Ataxia Type 3
Spinocerebellar ataxia (SCA) is a group of inherited disorders characterized by cerebellar degeneration leading to imbalance, incoordination, speech difficulties and problems with walking.
- Trial name
- NCT00992771
- Testing
- varenicline
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of South Florida
Tobacco Use Disorder
Smoking Termination Opportunity for inPatients
The Smoking Termination Opportunity for inPatients, (STOP) project is designed to capture the opportunity that is provided by admission for acute smoking related illness, to assist patients through withdrawal by use of a…
- Trial name
- STOP (NCT01141855)
- Testing
- Champix, Counselling alone
- Where
- 3 sites in Australia
- Volunteers
- 392 people
- Sponsor
- The Queen Elizabeth Hospital
Smoking Cessation
Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation
No published studies to date have evaluated the combined impact of varenicline and oral nicotine replacement therapy (NRT) on smoking cessation in a randomized trial.
- Trial name
- COMBOII (NCT07099638)
- Testing
- Varenicline (VAR), Nicotine lozenge (NRT), Smartphone intervention with adherence components (COMBO-A)
- Where
- United States
- Volunteers
- 496 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cocaine Dependence
A Phase II Trial of Varenicline for the Treatment of Cocaine Dependence
This is a double-blind placebo-controlled clinical trial (n = 156) of varenicline for the treatment of cocaine dependence that utilizes contingency management to promote treatment attendance.
- Trial name
- NCT01680887
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pennsylvania
Smoking Cessation, Hiv
Botswana Smoking and Abstinence Reinforcement Trial
Many people living with HIV in southern Africa, specifically Botswana use tobacco products. Using tobacco makes some of the effects of HIV worse and even causes excess deaths.
- Trial name
- BSMART (NCT05694637)
- Testing
- Screening, Brief Intervention and Referral to Treatment (SBIRT) intervention consisting of the 5As, (Ask, Advise, Assess, Assist, Arrange), Varenicline
- Where
- 15 sites in Botswana
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Smoking Cessation
Individualizing Pharmacotherapy for African American Smokers
Improving cessation outcomes for African American smokers through the use of novel, empirically-based strategies is a national health priority.
- Trial name
- NCT03897439
- Testing
- Nicotine patch, Varenicline Tartrate, Bupropion
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Smoking
Menominee Stop Tobacco Abuse Renew Tradition Study
The purpose of this community-based study is to evaluate the effectiveness of a culturally-tailored smoking cessation treatment for American Indian (AI) smokers as compared to standard evidence-based cessation treatment (not…
- Trial name
- START (NCT01083654)
- Testing
- Standard Treatment Counseling, Culturally-Tailored Treatment
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Wisconsin, Madison
Smoking Cessation
Extended (6-Week) Varenicline Preloading: Does it Facilitate Smoking Reduction and Cessation?
SUMMARY Rationale: Worldwide, cigarette smoking carries a high mortality. Since the available cessation programs are not effective for all smokers, new strategies are necessary for tobacco control.
- Trial name
- NCT02634281
- Testing
- Varenicline
- Where
- Israel
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Smoking Behavior, Smoking Lapse Behavior
Efficacy and Safety of NicVAX® Co-administered With Varenicline (Champix®)
The purpose of this study is to evaluate the efficacy and safety of NicVAX co-administered with varenicline as an aid in smoking cessation over a one-year period in smokers who want to quit smoking.
- Conditions
- Smoking Behavior, Smoking Lapse Behavior, Smoking Relapse Behavior
- Trial name
- NCT00995033
- Testing
- NicVAX vaccine, Varenicline
- Where
- 2 sites in Netherlands
- Volunteers
- 558 people
- Sponsor
- Maastricht University Medical Center
Nicotine Dependence
Effects of Chantix on Relapse Prevention for Smoking Cessation
The goal of the proposed study is to validate an experimental paradigm to assess medication effects on smoking relapse following a brief (3-day) monitored period of smoking abstinence and a programmed cigarette lapse.
- Trial name
- NCT00948649
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Additional, Effective Methods to Stop Smoking
Smoke-Free Living Study
The goal of this study is to provide you with an effective treatment for reducing the physical and emotional stress that can occur during the early phase of being without cigarettes.
- Trial name
- NCT00832806
- Testing
- Extended IVR (integrated voice response technology), Varenicline (Champix), IVR treatment
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Acute Coronary Syndrome
Evaluation of Varenicline (Champix) in Smoking Cessation for Patients Post-Acute Coronary Syndrome (EVITA) Trial
The EVITA study is a clinical trial that will test the effect of varenicline (Champix™), a new drug used to help people quit smoking, in patients who have suffered a heart attack.
- Trial name
- EVITA (NCT00794573)
- Testing
- varenicline
- Where
- 4 sites in Canada
- Volunteers
- 302 people
- Sponsor
- Mark Eisenberg
Nicotine Dependence
Varenicline for Adolescent Smoking Cessation
This is a placebo-controlled smoking cessation treatment study for adolescents ages 14-21. After assessment and inclusion into the study, participants will be randomized to receive a 12-week double blind course of varenicline or…
- Trial name
- NCT01509547
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Medical University of South Carolina
Smoking Cessation
Assessing Neuropsychiatric Symptoms Including Depression, Anxiety, Irritability, and Suicidal Thoughts or Behavior in Subjects Quitting Smoking on Varenicline Tartrate or Placebo
Study objective is to compare neuropsychiatric adverse events in subjects treated with varenicline or placebo in a controlled setting where both groups are experiencing nicotine withdrawal.
- Trial name
- NCT00749944
- Testing
- varenicline
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Pfizer
Schizophrenia, Schizoaffective
Safety and Tolerability of Varenicline in Schizophrenia (SATOVA)
This is a 15 week trial to determine (1) the safety and tolerability of varenicline when used for smoking cessation/reduction in individuals with schizophrenia; (2) if treatment with varenicline affects the symptoms of…
- Conditions
- Schizophrenia, Schizoaffective, Psychosis
- Trial name
- NCT00702793
- Testing
- Varenicline
- Sponsor
- University of British Columbia
Smoking, Smoking Cessation
Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network
The goal of this clinical trial is to compare the reach and effectiveness of the Refer2Quit intervention for increasing tobacco use treatment and quit rates among household members who smoke versus a treatment as usual group.
- Conditions
- Smoking, Smoking Cessation, Second Hand Tobacco Smoke
- Trial name
- NCT06582693
- Testing
- Refer2Quit
- Where
- United States
- Volunteers
- 3,200 people
- Sponsor
- Children's Hospital of Philadelphia
Cigarette Smoking-Related Carcinoma
Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial
This phase IV trial investigates how to personalize treatments (such as medications and/or counseling) for quitting smoking based on the unique character traits of participants.
- Trial name
- NCT04604509
- Testing
- Bupropion Hydrochloride Controlled-release, Nicotine Replacement, Questionnaire Administration
- Where
- United States
- Volunteers
- 2,010 people
- Sponsor
- M.D. Anderson Cancer Center
Smoking Cessation
A 52-Week Placebo-Controlled Study Evaluating the Safety of Varenicline
The primary purpose of this study is to obtain safety information on cigarette smokers treated with 52 weeks of varenicline regardless of smoking status.
- Trial name
- NCT00143299
- Testing
- varenicline (CP-526,555)
- Where
- 9 sites in United States, Australia
- Volunteers
- 375 people
- Sponsor
- Pfizer
Methamphetamine Dependence, Methamphetamine Abuse
Varenicline as a Treatment for Methamphetamine Dependence
The primary purpose of the study is to determine the effects of treatment with varenicline (1 and 2 mg daily), compared to treatment with placebo, on methamphetamine-induced craving and subjective effects in…
- Conditions
- Methamphetamine Dependence, Methamphetamine Abuse, Substance Abuse
- Trial name
- Varenicline (NCT01571167)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine