Clinical trials: Varenicline
Cigarette Smoking, Smoking Behaviors
A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
This is a research study to find out if treatment decision making can be improved for smokers who find it difficult to quit with medications.
- Conditions
- Cigarette Smoking, Smoking Behaviors, Treatment
- Trial name
- ADAPT (NCT06118502)
- Testing
- Switching to a different medication, Continued use of the same medication, Switching to a harm reduction tobacco product
- Where
- United States
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Schizophrenia, Cigarette Smoking
Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors
This is a 8-week double-blind placebo controlled parallel group study of the efficacy of varenicline (Chantix) for smoking cessation in schizophrenic patients, and its effect on cognitive function in patients with…
- Trial name
- NCT00802919
- Testing
- Varenicline
- Where
- 4 sites in United States, China and 1 more
- Volunteers
- 93 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Smoking Cessation
Combining Varenicline and Guanfacine for Smoking Cessation
The novel design of this study combines a laboratory paradigm to evaluate stress-induced smoking behavior and smoking-related reinforcement, followed by a 12-week treatment phase to evaluate clinical outcomes.
- Trial name
- NCT04198116
- Testing
- Varenicline, Guanfacine ER
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking, HIV Infections
Smoking Cessation Using Motivational Therapy and Varenicline
People that are infected with HIV appear to be especially susceptible to the adverse effects of cigarette smoking. The purpose of this study is to determine if quitting smoking by using a specialized smoking cessation treatment…
- Trial name
- NCT00701896
- Testing
- Varenicline tartrate, Nicotine Replacement Therapy, Biological Control
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Philip Diaz
Smoking Cessation
A Study Evaluating the Absorption Of Varenicline Through The Skin Following Once Daily Application Of A Patch For 14 Days
This study will evaluate the steady-state pharmacokinetics, safety and tolerability of a varenicline patch applied once daily to the skin for 14 days.
- Trial name
- NCT01234142
- Testing
- varenicline free base patch
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pfizer
Craving, Smoking
Effects of Varenicline on Smoking Lapse in Smokers With and Without Schizophrenia
The objective of this study is to determine the mechanisms by which varenicline, an effective smoking cessation treatment, protects against relapse.
- Conditions
- Craving, Smoking, Schizophrenia
- Trial name
- NCT01850953
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking, Tobacco Use Disorder
Chantix & Bupropion for Smoking Cessation
The overarching goal of this line of research is to increase smoking abstinence rates using a combination of existing pharmacotherapies.
- Trial name
- ChanBan (NCT00587769)
- Testing
- Bupropion SR & Varenicline
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson's Disease
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease Experiments 1 & 2 - Proj #3
Varying oral doses of Varenicline (VCN), starting with very low doses, will be administered to participants with Parkinson's Disease (PD) or healthy controls without PD for several days.
- Trial name
- UdallP3 (NCT02933372)
- Testing
- Varenicline
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Coronary Heart Disease
Risk Reduction in Coronary Heart Disease
Study hypothesis: Multifactorial risk reduction in coronary heart disease can reduce the risk of new coronary heart disease and death
- Trial name
- SPREK! (NCT00679237)
- Testing
- smoking cessation, betablocker, diuretics, ACEI, ARB,, statins, ezetimibe
- Where
- Norway
- Volunteers
- 1,600 people
- Sponsor
- Sorlandet Hospital HF
Tobacco Dependence, Smoking Cessation
Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence
The addition of tDCS as an adjunct to pharmacotherapy is a novel approach but one that is grounded in a growing evidence-base.The primary objective of this research is to provide preliminary evidence of the effectiveness of tDCS…
- Conditions
- Tobacco Dependence, Smoking Cessation, Tobacco Smoking, Tobacco Use Disorder
- Trial name
- NCT03841292
- Testing
- Varenicline, Active tDCS
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Centre for Addiction and Mental Health
Coronary Heart Disease
Varenicline Versus Transdermal Nicotine Patch for Smoking Cessation in Patients With Coronary Heart Disease
The purpose of this study is to determine if a new drug, varenicline, for smoking cessation is more effective than the standard nicotine replacement therapy aide currently used, "the patch" among smokers hospitalized with…
- Trial name
- NCT00959972
- Testing
- Varenicline, Transdermal Nicotine Patch
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Pulmonary Disease, Chronic Obstructive, Asthma
Smoking Cessation Intervention in Respiratory Inpatients
Prospective, open-label, parallel-group, 52-week trial comparing varenicline in combination with behavioral support with one session of behavioral support alone.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma, Community Acquired Pneumonia
- Trial name
- NCT02922387
- Testing
- Varenicline, Behavioral support
- Volunteers
- 101 people
- Sponsor
- General Hospital of Kavala
Cocaine Dependence
Human Behavioral Pharmacology Laboratory Study of Varenicline's Impact on Cocaine Reinforcement
Cocaine use, abuse and dependence is a public health problem that is directly responsible for hundreds of billions of dollars in health care expenditures per year.
- Trial name
- NCT01143857
- Testing
- Varenicline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jennifer Plebani
Smoking Cessation
A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo and Zyban for Smoking Cessation
The primary purpose of this study is to evaluate the safety and efficacy of varenicline given for a twelve week treatment period in comparison with placebo and Zyban for smoking cessation.
- Trial name
- NCT00143364
- Testing
- varenicline (CP-526,555)
- Where
- 15 sites in United States
- Volunteers
- 1,005 people
- Sponsor
- Pfizer
Tobacco Use, Tobacco Use Cessation
Metabolism-informed Care for Smoking Cessation
Nicotine mediates smoking's addictive effects in the brain. The ratio of 3-hydroxycotinine to cotinine, known as the nicotine metabolite ratio, or NMR, is a genetically- informed biomarker reflecting hepatic CYP2A6 activity and…
- Trial name
- NCT03227679
- Testing
- Nicotine Metabolite Ratio, Varenicline, Bupropion
- Volunteers
- 82 people
- Sponsor
- Vanderbilt University Medical Center
Smoking
Smoking Cessation Program in the Preadmission Clinic: The Use of a Teachable Moment
The Objective of this study is to introduce a practically feasible multifaceted intervention in the preadmission clinic to help reduce smoking in preoperative surgical patients.
- Trial name
- NCT01243203
- Testing
- Champix
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Vaping, Nicotine Dependence
Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents
The Investigators propose a randomized, placebo-controlled trial to test the hypothesis that varenicline added to group behavioral and texting support will be well tolerated and improve vaping cessation rates among nicotine…
- Trial name
- Pilot (NCT04602494)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Smoking Behavior, Smoking Lapse Behavior
Efficacy and Safety of NicVAX® Co-administered With Varenicline (Champix®)
The purpose of this study is to evaluate the efficacy and safety of NicVAX co-administered with varenicline as an aid in smoking cessation over a one-year period in smokers who want to quit smoking.
- Conditions
- Smoking Behavior, Smoking Lapse Behavior, Smoking Relapse Behavior
- Trial name
- NCT00995033
- Testing
- NicVAX vaccine, Varenicline
- Where
- 2 sites in Netherlands
- Volunteers
- 558 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease
Influence of Varenicline on the Antiplatelet Action of Clopidogrel
The purpose of this study is to investigate the effects of steady-state varenicline on the antiplatelet action of clopidogrel in patients with coronary artery disease.
- Trial name
- VACL (NCT01308671)
- Testing
- Varenicline, Counseling and psychosocial support
- Where
- China
- Volunteers
- 198 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
Smoking Cessation
Sympathovagal Balance in Smoking Cessation
This study has the following primary aim: the main objective of this study is to investigate the effects of smoking cessation during quit attempts on sympathovagal balance.
- Trial name
- NCT01474265
- Testing
- Varenicline, Nicorette TX
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH