Clinical trials: Varenicline
Nicotine Dependence, Smoking
Varenicline for Smoking Cessation in Heavy Drinking Smokers
The purpose of this study is to determine whether extended pretreatment with varenicline (Chantix) is more efficacious for smoking cessation than standard pretreatment, how well varenicline is tolerated in heavy drinking smokers…
- Conditions
- Nicotine Dependence, Smoking, Heavy Drinking
- Trial name
- NCT00860028
- Testing
- Extended Varenicline Pretreatment, Short-term Varenicline Pretreatment
- Volunteers
- 30 people
- Sponsor
- Yale University
HIV, AIDS
Effectiveness of a Smoking Cessation Algorithm Integrated Into HIV Primary Care
To determine the efficacy of an algorithm designed to recommend smoking cessation-related pharmacotherapy options to the primary care providers of smokers living with HIV/AIDS.
- Conditions
- HIV, AIDS, Smoking Cessation
- Trial name
- NCT03670316
- Testing
- Algorithm Treatment, Quitline only
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- University of Alabama at Birmingham
Cigarette Smoking
Effects of Smoking Environments on Craving and Smoking (CameraCue2.0)
The goal of this study is to evaluate the effects of varenicline versus nicotine replacement versus placebo on personal smoking environment cue (PSE) reactivity.
- Trial name
- NCT02551692
- Testing
- Nicotine Patch, Varenicline
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Duke University
Nicotine Dependence
Concurrent Bupropion / Varenicline for Smoking Cessation
This study focuses on the first step in developing an algorithm for maximizing quit-smoking success based on an adaptive approach, which changes treatment from the initial nicotine replacement therapy (NRT) when that treatment…
- Trial name
- ConNic4 (NCT01303861)
- Testing
- Varenicline, Bupropion, Nicotine patches
- Where
- 4 sites in United States
- Volunteers
- 702 people
- Sponsor
- Duke University
Smoking, Smoking Cessation
Tobacco Treatment Outreach to Reduce Disparities for Primary Care Populations
The objectives of this project are to develop and evaluate a multi-level approach to tobacco treatment for low-SES and minority patients.
- Trial name
- NCT01156610
- Testing
- Tobacco Treatment
- Where
- 2 sites in United States
- Volunteers
- 706 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Pain, Opioid Dependence
Pilot Study of Varenicline to Treat Opioid Dependence
The objective of this proposal is to explore the potential of varenicline as a pharmacotherapeutic agent for opioid dependence and addiction.
- Trial name
- NCT01436474
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Alcohol Dependence, Cocaine Dependence
Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving
This is a Phase II within-subjects double-blind placebo-controlled human laboratory study. The purpose of the study is to determine the efficacy of varenicline (Chantix) for reducing cue-induced cocaine and alcohol craving.
- Trial name
- NCT01151813
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Smoking Cessation
A Phase I Study to Evaluate the Pharmacokinetics of Multiple Doses of Varenicline in Healthy Adolescent Smokers
This study will investigate the multiple dose pharmacokinetics, safety, and tolerability of two dose strengths of varenicline in adolescents aged 12 to 16 years who regularly smoke at least three cigarettes per day.
- Trial name
- NCT00463918
- Testing
- varenicline
- Where
- 16 sites in United States, United Kingdom
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Pfizer
Smoking Cessation
A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo and Zyban for Smoking Cessation
The primary purpose of this study is to evaluate the safety and efficacy of varenicline given for a twelve week treatment period in comparison with placebo and Zyban for smoking cessation.
- Trial name
- NCT00143364
- Testing
- varenicline (CP-526,555)
- Where
- 15 sites in United States
- Volunteers
- 1,005 people
- Sponsor
- Pfizer
Alcohol Reactivity
Effect of Varenicline on Fixed-Dose Alcohol Administration in Participants With Alcohol Use Disorders
The purpose of this study is the examine the effect of varenicline on cognition to a high dose (0.08 g/dL) of alcohol (vs. placebo alcohol) over the ascending and descending limb of the blood alcohol curve.
- Trial name
- NCT01000987
- Testing
- varenicline
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Yale University
Smoking Cessation, Harm Reduction
Combination of E-cigarettes and Varenicline for Tobacco Harm Reduction
This open-label study will explore the impact of varenicline on the process of switching from combustible cigarettes (CC) to an e-cigarette.
- Trial name
- EVAR (NCT04210180)
- Testing
- Varenicline, e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Pulmonary Disease, Chronic Obstructive, Asthma
Smoking Cessation Intervention in Respiratory Inpatients
Prospective, open-label, parallel-group, 52-week trial comparing varenicline in combination with behavioral support with one session of behavioral support alone.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma, Community Acquired Pneumonia
- Trial name
- NCT02922387
- Testing
- Varenicline, Behavioral support
- Volunteers
- 101 people
- Sponsor
- General Hospital of Kavala
Smoking Cessation, Smoking Behaviors
Varenicline Light Smoking Pilot
The goal of this study is to assess varenicline vs. placebo for its effect on decreasing cue reactivity in light and intermittent smokers.
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking
- Trial name
- NCT04089982
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Schizophrenia
Effects of Varenicline on Plasticity in Schizophrenia
This laboratory pilot study will explore the effects of varenicline tartrate on long-term potentiation (LTP)-like mechanisms of (1) the motor cortex and (2) the dorsolateral prefrontal cortex (DLPFC) and working memory in…
- Trial name
- VAR-PAS (NCT01934023)
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Addiction, Craving
Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder
The proposed project will include enrollment of 200 daily tobacco cigarette users, ages 22+, from the San Diego community. Participants will be assessed on the VR Nicotine Cue Exposure paradigm then randomized (stratified on age…
- Trial name
- VR (NCT06582888)
- Testing
- Varenicline Tartrate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego
Smoking, Smoking Cessation
Connect to Quit for Smoking
The purpose of this research study is to examine the effectiveness of an intervention designed to reduce smoking in low income veterans within a regional United States Veterans Administration(VA) health care system.
- Trial name
- CTQ (NCT01299896)
- Testing
- Coordinated Care, Usual Care
- Where
- United States
- Volunteers
- 633 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Neurotrophic Keratopathy
Phase 2 Clinical Trial to Evaluate OC-01 Nasal Spray in Subjects With Neurotrophic Keratopathy
The objective of this study is to evaluate the safety and effectiveness of OC-01 (varenicline) nasal spray as compared to placebo nasal spray for mean change from baseline in corneal fluorescein staining in subjects with Stage 1…
- Trial name
- NCT04957758
- Testing
- OC-01 (varenicline) nasal spray 1.2 mg/ml
- Where
- 31 sites in United States
- Volunteers
- 113 people
- Sponsor
- Oyster Point Pharma, Inc.
Nicotine Dependence, Cigarettes
Penn State TXT2Quit Study
This study is evaluating the feasibility and short term smoking cessation outcomes of an automated smoking cessation intervention delivered via mobile phone text messaging as an adjunct to Varenicline in a primary care setting.
- Trial name
- NCT02367391
- Testing
- Motivational Text Messages, Control
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Dry Eye
OC-01 (Varenicline) Nasal Spray and Dry Eye Signs and Symptoms in Daily Disposable Contact Lens Wearers
This study is a single center, prospective, randomized, controlled, double-masked, two-arm investigator-initiated study to investigate the efficacy of OC-01 (varenicline) nasal spray on the signs and symptoms of dry eye disease…
- Trial name
- NCT05161208
- Testing
- OC-01 (varenicline 0.6mg/ml) Nasal Spray
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Center for Ophthalmic and Vision Research, LLC
Nicotine Dependence, Cigarette Smoking
New Approaches to Smoking Cessation in Heavy Drinkers
The purpose of this study is to develop and test an integrated cognitive-behavioral intervention for smoking and alcohol among heavy drinking smokers.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Alcohol Consumption, Heavy Drinking
- Trial name
- NCT02151591
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University