Clinical trials: Varenicline
Substance Use Disorder
Varenicline Treatment for Cannabis Use Disorder
Marijuana is the most commonly used illicit drug. There is high demand for effective interventions for cannabis use disorder, yet few specific treatments for have been developed.
- Trial name
- NCT02892110
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Medical University of South Carolina
Cigarette Smoking
Contingency Management and Pharmacotherapy for Smoking Cessation
In total, 70 smokers will be randomized to: standard of care smoking cessation medication varenicline alone (an FDA-approved smoking cessation medication) or varenicline plus contingency management (CM) (a behavioral procedure…
- Trial name
- Donaghue (NCT00683280)
- Testing
- contingency management, Standard of Care
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- UConn Health
Asthma
Smoking Young Asthmatics: Change of Inflammation During Tobacco Cessation and Steroid Treatment
This is a study describing changes in inflammation of the airways in asthmatics before and after smoking cessation and steroid treatment.
- Trial name
- NCT02233231
- Testing
- Varenicline
- Volunteers
- 52 people
- Sponsor
- Vibeke Backer
Nicotine Dependence
Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt
Study of varenicline 2.0 mg/day treatment for 2 weeks with smoking test done in laboratory on Day 8 and a 1 week quit attempt from Day 8-14.
- Trial name
- VarenSmoke (NCT00571805)
- Testing
- varencline
- Where
- United States
- Sponsor
- NYU Langone Health
Veterans, Tobacco Use Disorder
Varenicline for Smoking Reduction in Veterans Not Ready To Quit
In order to reduce the prevalence of cigarette smoking among Veterans, it is vital that healthcare providers offer effective tobacco treatment to all Veterans who smoke, including those not ready to make a quit attempt.
- Conditions
- Veterans, Tobacco Use Disorder, Cigarette Smoking, Tobacco Dependence
- Trial name
- NCT06966362
- Testing
- Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation
Randomized trial to evaluate whether zonisamide can enhance varenicline-induced smoking cessation.
- Trial name
- 1207 (NCT01685996)
- Testing
- zonisamide
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Johns Hopkins University
Smoking Cessation
A Pilot Study Of Smoking Cessation Treatment Including Varenicline In Patients Scheduled For Planned Surgery
It is possible to offer smoking cessation treatment including varenicline to patients scheduled for elective surgery. This study will evaluate whether or not this will enable some patients to quit smoking for up to 4 weeks prior…
- Trial name
- NCT00889720
- Testing
- Varenicline
- Where
- 2 sites in France, Italy
- Volunteers
- 16 people
- Sponsor
- Pfizer
Tobacco Smoking
EVarQuit: Extended Pre-quit Varenicline to Assist in Quitting Smoking
Varenicline is the most effective smoking cessation therapy available. Nevertheless, most smokers using varenicline relapse within the first few months after quitting.
- Trial name
- EVarQuit (NCT03262662)
- Testing
- Varenicline, Brief smoking cessation counseling
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Smoking Cessation, Substance-Related Disorders
Smoking Cessation Treatment for Methadone Maintenance Patients
Patients in substance abuse treatment smoke four times more than non-substance abusers, and suffer high rates of tobacco-related disease and death.
- Trial name
- NCT01027754
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Albert Einstein College of Medicine
Smoking Cessation
Extended Treatment for Smoking Cessation
Adult smokers (21-65) and adolescent smokers (18 - 21) years of age residing in Alameda and Santa Clara counties will serve as the target population for this study.
- Trial name
- NCT01330043
- Testing
- Bupropion, Nicotine patch, Varenicline
- Where
- United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Stanford University
Smoking
Endothelial Function and Autonomic Regulation After Short-term Smoking Cessation: Varenicline Versus Placebo
The purpose of this study is to evaluate endothelial function and autonomic regulation (for example, heart rate and blood pressure) in smokers before and after short-term smoking cessation.
- Trial name
- NCT00673595
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking Cessation, Tobacco Dependence
De-nicotinised Cigarettes Study
The aim of this study is to determine if using a behavioural replacement for smoking (de-nicotinised cigarettes; DNCs), in addition to standard treatment during the first two weeks after the target quit date, can reduce urges to…
- Trial name
- Denic (NCT01250301)
- Testing
- De-nicotinised cigarettes + standard treatment, Standard Treatment
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Smoking Cessation, Electronic Cigarette Use
The Avenues Study: Dual Use Cessation
The overarching goal of this research is to determine the most effective approach for helping dual users of cigarettes and electronic nicotine delivery systems (ENDS) quit smoking.
- Trial name
- NCT06474299
- Testing
- Varenicline, Nicotine patch, Dual Focused Cessation Counseling
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Wisconsin, Madison
HIV, Smoking Cessation
The Canadian HIV Quit Smoking Trial: Tackling the Co-morbidities of Depression and Cardiovascular Disease in HIV+ Smokers
The objectives of this trial are: Primary objectives: 1. To determine among HIV+ individuals whether varenicline or NRT is more effective at helping individuals remain abstinent from smoking tobacco. 2.
- Trial name
- CANQUIT (NCT01800019)
- Testing
- Nicotine Replacement Therapy (NRT), Varenicline, HIV Tailored Quit Smoking Counseling
- Where
- Canada
- Volunteers
- 256 people
- Sponsor
- Ottawa Hospital Research Institute
Methamphetamine Dependence, Substance Abuse
Varenicline vs Placebo for the Treatment of Methamphetamine Dependence
Methamphetamine (MA) abuse is the fastest growing drug problem in the United States and is responsible for significant public health complications, including HIV infection.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- RAVEN (NCT01011829)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Schizophrenia, Schizoaffective Disorder
Varenicline Adjunctive Treatment in Schizophrenia
The principal aim of the project is to conduct an off-label adjunctive clinical trial evaluating varenicline as a treatment for core neurobiological and clinical deficits in schizophrenia, in addition to evaluating for smoking…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- NCT00492349
- Testing
- Varenicline
- Where
- 3 sites in United States
- Volunteers
- 91 people
- Sponsor
- University of Maryland, Baltimore
Smoking Cessation
Understanding Disparities in Quitting in African American and White Smokers
The purpose of this study is to describe the differences in quitting smoking between African Americans (AA) and White smokers treated with varenicline.
- Trial name
- NCT01836276
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 449 people
- Sponsor
- Nikki Nollen, PhD, MA
Irritable Bowel Syndrome
A Study of Varenicline in the Treatment of Visceral Sensation
The purpose of this study is to evaluate the effect of varenicline on rectal sensation, based on ascending method of limits and on graded rapid phasic distensions in participants with non-constipation IBS and chronic abdominal…
- Trial name
- NCT06854406
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Breast Cancer, Tobacco Dependence
Tobacco Dependence in Breast Cancer Patients Trial of Varenicline (Chantix)
Breast cancer patients who smoke, are at greater risk for treatment complications. The purpose of this study is to see if the researchers can find ways to help patients who have breast cancer quit smoking.
- Trial name
- NCT01532232
- Testing
- varenicline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Smoking Cessation
Assessment of Safety and Efficacy of Varenicline in Patients That Wish to Stop Smoking
The primary objective of this protocol is to evaluate 12 weeks of treatment of varenicline compared to placebo for smoking cessation.
- Trial name
- NCT00594204
- Testing
- varenicline tartrate (CP-526, 555-18)
- Where
- 42 sites in Brazil, Colombia and 9 more
- Volunteers
- 593 people
- Sponsor
- Pfizer