Clinical trials: Varenicline
Smoking Cessation, Substance-Related Disorders
Smoking Cessation Treatment for Methadone Maintenance Patients
Patients in substance abuse treatment smoke four times more than non-substance abusers, and suffer high rates of tobacco-related disease and death.
- Trial name
- NCT01027754
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Albert Einstein College of Medicine
Smoking Cessation, Smoking Behaviors
Varenicline Light Smoking Pilot
The goal of this study is to assess varenicline vs. placebo for its effect on decreasing cue reactivity in light and intermittent smokers.
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking
- Trial name
- NCT04089982
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Tobacco Use Disorder, Smoking Cessation
Pharmacogenetics, Emotional Reactivity and Smoking
The goals of this placebo-controlled randomized clinical trial were to evaluate the differences in emotional reactivity (peak startle response to affective stimuli) during a cessation attempt among smokers treated with bupropion…
- Trial name
- NCT00507728
- Testing
- Bupropion, Varenicline, Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 646 people
- Sponsor
- M.D. Anderson Cancer Center
Nicotine Dependence
Varenicline (Chantix) Treatment for Waterpipe Smoking Cessation
The lack of proven waterpipe smoking cessation interventions makes it important to explore interventions proven effective for cigarette smoking cessation.
- Trial name
- NCT02575183
- Testing
- Varinecline (Chantix), Behavioral Therapy
- Where
- 2 sites in Lebanon
- Volunteers
- 152 people
- Sponsor
- American University of Beirut Medical Center
Tobacco Use Disorder, Medication Adherence
Varenicline Smoking Cessation Treatment for Methadone Maintenance Patients
This randomized trial will evaluate whether varenicline directly observed therapy provided at a methadone clinic is more efficacious than self-administered varenicline for promoting smoking cessation and enhancing adherence.
- Trial name
- NCT01378858
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Albert Einstein College of Medicine
Parkinson's Disease
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease Experiments 1 & 2 - Proj #3
Varying oral doses of Varenicline (VCN), starting with very low doses, will be administered to participants with Parkinson's Disease (PD) or healthy controls without PD for several days.
- Trial name
- UdallP3 (NCT02933372)
- Testing
- Varenicline
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson's Disease
Crossover Target Engagement Study of Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease (Project #3 - Experiment 3 [UdallP3E3])
With an appropriate oral dose of Varenicline (VCN) identified from experiments 1 \& 2 of the study (see NCT02933372), the investigators will administer VCN to Parkinson Disease (PD) participants to determine if VCN improves…
- Trial name
- UdallP3E3 (NCT04403399)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Smoking, HIV Infections
Smoking Cessation Using Motivational Therapy and Varenicline
People that are infected with HIV appear to be especially susceptible to the adverse effects of cigarette smoking. The purpose of this study is to determine if quitting smoking by using a specialized smoking cessation treatment…
- Trial name
- NCT00701896
- Testing
- Varenicline tartrate, Nicotine Replacement Therapy, Biological Control
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Philip Diaz
HIV Infection, Alcohol Use
Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV)
This study is a randomized controlled trial (RCT) to compare the effects of varenicline, cytisine, and nicotine replacement therapy (NRT) to reduce: 1) alcohol use and craving, 2) smoking; and 3) inflammation and risk for…
- Conditions
- HIV Infection, Alcohol Use, Smoking
- Trial name
- St PETER HIV (NCT02797587)
- Testing
- Varenicline, Cytisine, Nicotine Replacement Therapy
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Boston Medical Center
Medication Adherence
Balanced Placebo Design With Varenicline: Pharmacological and Expectancy Effects on Medication Adherence
The current study will use the double-blind balanced placebo design to examine differences between expectancies versus the pharmacological effects of varenicline medication administered for two weeks to cigarette smokers.
- Trial name
- NCT03538808
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Smoking Cessation, Tobacco Dependence
Translating Extinction Research to Improve Pharmacotherapy for Tobacco Dependence
The purpose of this Pilot feasibility study is to find out the effect of different behavioral treatments along with different duration of a drug called varenicline, on smoking behavior and quitting smoking.
- Trial name
- NCT02202499
- Testing
- Varenicline, Counseling and Support Materials, Laboratory Assessments
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Nicotine Dependence, Nicotine Withdrawal
Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence
The objective of this proposal is to elucidate effects of bupropion SR + varenicline on smoking-cessation related processes in early abstinence using a human laboratory model.
- Trial name
- ChanBan (NCT00749658)
- Testing
- Bupropion, Varenicline
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking Cessation, Pharmacokinetics
A Clinical Trial to Compare Pharmacokinetics of the "CDFF0318" and "Champix Tab. 1mg"
A Phase 1 Clinical Trial to Compare and Evaluate Safety and Pharmacokinetic Characteristics after Administration of the "CDFF0318" and "Champix Tab. 1mg (Varenicline tartrate)" in Healthy Male Volunteers
- Trial name
- NCT04631874
- Testing
- CDFF0318, Champix
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- CTC Bio, Inc.
Nicotine Dependence
Maintaining Nonsmoking
The research is based on a chronic disorder model of cigarette smoking which suggests that long-term treatment targeted to prevent relapse may be useful.
- Trial name
- NCT01162239
- Testing
- Varenicline, Initial Individual counseling, Check-ins with medical staff
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking, Smoking Cessation
Hollings Cancer Center Varenicline Sampling Study
The purpose of this study is to learn what happens when people are given a free, 4-week, sample of varenicline, a smoking cessation medication.
- Conditions
- Smoking, Smoking Cessation, Smoking, Tobacco, Smoking, Cigarette
- Trial name
- NCT03742154
- Testing
- Varenicline 0.5 MG
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical University of South Carolina
Tobacco Use Disorder
Varenicline or Nicotine Patch in Promoting Smoking Cessation Among Current Smokers
This pilot clinical trial studies varenicline or nicotine patch in promoting smoking cessation among current smokers. Varenicline or nicotine patch may help people stop smoking
- Trial name
- NCT01771627
- Testing
- varenicline, nicotine patch
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Roswell Park Cancer Institute
Smoking Cessation
Genetically Informed Smoking Cessation Trial
The investigators' goal is to identify the most appropriate smoking cessation treatments for smokers based on genetic information. Smokers try to quit smoking but relapses are common.
- Trial name
- GISC (NCT02351167)
- Testing
- Combination NRT (Nicotine patch, Nicotine lozenge), Varenicline, Intensive smoking counseling
- Where
- United States
- Volunteers
- 822 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Smoking Cessation, Smoking
A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers
The overall purpose of this research is two-fold. First, the two smoking cessation medication treatments with the strongest evidence of effectiveness have never been directly compared.
- Conditions
- Smoking Cessation, Smoking, Nicotine Dependence
- Trial name
- NHLBI-RO1 (NCT01553084)
- Testing
- Varenicline, Nicotine lozenge, Nicotine Patch
- Where
- 2 sites in United States
- Volunteers
- 1,086 people
- Sponsor
- University of Wisconsin, Madison
Alcohol Dependence, Cocaine Dependence
Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving
This is a Phase II within-subjects double-blind placebo-controlled human laboratory study. The purpose of the study is to determine the efficacy of varenicline (Chantix) for reducing cue-induced cocaine and alcohol craving.
- Trial name
- NCT01151813
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Smoking Cessation, Opioid Related Disorders
Smoking Cessation & Opioid Dependence Treatment Integration
The primary purpose of this study was to examine the feasibility of integrating a smoking cessation intervention for cigarette smokers enrolled in an outpatient program for opioid dependence.
- Trial name
- NCT02854800
- Testing
- varenicline
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- West Virginia University