Clinical trials: Varenicline
Smoking Cessation
Randomized Study Comparing the Efficacy and Safety of Varenicline Tartrate to Placebo in Smoking Cessation When Subjects Are Allowed to Set Their Own Quit Date
The hypothesis is that varenicline will be effective (compared with placebo) for smoking cessation when subjects are allowed to set their own quit date within the first 5 weeks of treatment.
- Trial name
- NCT00691483
- Testing
- varenicline
- Where
- 33 sites in United States, Argentina and 12 more
- Volunteers
- 659 people
- Sponsor
- Pfizer
Cigarette Smoking
Tailored Tobacco Quitline for Rural Veterans
The proposed work is designed to help increase access to tobacco cessation services among rural veterans and to develop more effective treatment services that better address comorbid issues commonly experienced by rural smokers.
- Trial name
- NCT01592695
- Testing
- Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Dry Eye Disease
Evaluation of Tear Film Quality and Stability in Subjects With Dry Eye Disease Using OC-01 (Varenicline Solution) Nasal Spray 0.03 mg as Compared to Vehicle Control Nasal Spray
A randomized, controlled, double-masked, investigator-initiated trial to evaluate tear film quality and stability in subjects with dry eye disease using OC-01 (varenicline solution) nasal spray 0.03 mg as compared to vehicle…
- Trial name
- TSUNAMI (NCT05514041)
- Testing
- Varenicline solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stephenson Eye Associates
Tobacco Use Cessation, Smoking Cessation
Implementation of HIT-Enhanced Tobacco Treatment for Hospitalized Smokers
This study will implement and test the effectiveness and cost-effectiveness of a tobacco cessation intervention (Academic Detailing + Integrated Tobacco Order Set - AD + ITOS) for adults admitted to the hospital.
- Conditions
- Tobacco Use Cessation, Smoking Cessation, Smoking, Tobacco Use Disorder
- Trial name
- NCT01691105
- Testing
- AD + Integrated Tobacco Order Set
- Where
- United States
- Volunteers
- 1,044 people
- Sponsor
- Yale University
Tobacco Use Disorder
Varenicline or Nicotine Patch in Promoting Smoking Cessation Among Current Smokers
This pilot clinical trial studies varenicline or nicotine patch in promoting smoking cessation among current smokers. Varenicline or nicotine patch may help people stop smoking
- Trial name
- NCT01771627
- Testing
- varenicline, nicotine patch
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Roswell Park Cancer Institute
Vaping, Nicotine Dependence
Varenicline for Nicotine Vaping Cessation in Adolescents
The study will test the hypothesis that varenicline, when added to behavioral and texting support for vaping cessation, will improve vaping abstinence rates in adolescents dependent on vaped nicotine over placebo plus behavioral…
- Trial name
- ViVA (NCT05367492)
- Testing
- Double Blind Varenicline, QuitVaping, This Is Quitting
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Tobacco Cessation
A Stepped Care Approach to Treating Tobacco Use in Rural Veterans
Tobacco use remains prevalent among Veterans. Although effective smoking cessation interventions exist, long-term term quit rates remain sub-optimal.
- Trial name
- Stepped Care (NCT04501016)
- Testing
- Tailored behavioral counseling, Tobacco cessation pharmacotherapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Healthy, Non-Smoking
Evaluation of Varenicline Safety, Tolerability, Pharmacokinetics and Pro-Cognitive Effects in Healthy Elderly Non-Smoking Subjects
1. Characterize the tolerability and safety of repeated doses of varenicline in healthy non-smoking elderly subjects. 2. Describe the steady state pharmacokinetics of varenicline in healthy non-smoking elderly subjects. 3.
- Trial name
- NCT00694044
- Testing
- varenicline
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pfizer
Smoking, Acute Coronary Syndrome
Safety and Efficacy of the Novel Selective Nicotinic Receptor Partial Agonist, CHANTIX (Varenicline) in Patients With Acute Coronary Syndrome
Assess the role of a nicotine antagonist in helping patients presenting to hospital with acute coronary syndrome to stop smoking.
- Trial name
- NCT01170338
- Testing
- Varenicline 100 mg by mouth twice daily, control
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Newark Beth Israel Medical Center
Alcoholism
Varenicline for Alcohol Dependence
The primary objective of this study is to assess the efficacy of varenicline in reducing the proportion of heavy drinking days during the last 8 weeks of treatment in subjects with alcohol dependence confirmed by Diagnostic and…
- Trial name
- NCIG 003 (NCT01146613)
- Testing
- Varenicline
- Where
- 7 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Nicotine Dependence
Impact of Varenicline on Blood-Oxygen-Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Activation on Smokers
The purpose of this study is to evaluate the impact of varenicline treatment on cue induced craving to smoking using brain imaging.
- Trial name
- GRAND (NCT00934024)
- Testing
- varenicline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Attention Deficit/Hyperactivity Disorder, Smoking Cessation
Chantix in Adult Smokers With Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this research study is to learn about the efficacy of a medication called varenicline (Chantix) in treating ADHD in adults and in reducing cigarette smoking in adults with ADHD.
- Trial name
- NCT00907218
- Testing
- Varenicline (Chantix)
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Current Smoker, Head and Neck Squamous Cell Carcinoma
Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy
This pilot randomized clinical trial studies how well bupropion hydrochloride works compared with patient's choice for quitting smoking in patients with squamous cell head and neck cancer undergoing radiation therapy with or…
- Conditions
- Current Smoker, Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma
- Trial name
- NCT02582008
- Testing
- Bupropion Hydrochloride, Laboratory Biomarker Analysis, Nicotine Replacement
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Wake Forest University Health Sciences
Nicotine Dependence
Study of Varenicline (Champix) for Smoking Cessation/Reduction in Patients With Bipolar Disorder
Bipolar Disorder is a chronic relapsing mental disorder characterized by periods of elevated, expansive and irritable mood, often alternating with periods of significant clinical depression.
- Trial name
- NCT01093937
- Testing
- varenicline
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence, Nicotine Withdrawal
Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence
The objective of this proposal is to elucidate effects of bupropion SR + varenicline on smoking-cessation related processes in early abstinence using a human laboratory model.
- Trial name
- ChanBan (NCT00749658)
- Testing
- Bupropion, Varenicline
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking Cessation, Smoking Reduction
Preoperative Smoking Cessation in Patients Undergoing Surgery
Background: At present, effectively implementing smoking cessation programs in the health care system constitutes a major challenge. A unique opportunity to initiate smoking cessation focuses on smokers scheduled for surgery.
- Conditions
- Smoking Cessation, Smoking Reduction, Surgery--Complications, Surgery
- Trial name
- PORTICO (NCT05192837)
- Testing
- Intensive preoperative smoking cessation counselling
- Where
- Switzerland
- Volunteers
- 251 people
- Sponsor
- Luzerner Kantonsspital
Tobacco Use Disorder, Weight Gain
Lorcaserin for Preventing Weight Gain Among Smokers
This will be an open label clinical trial with all subjects receiving both lorcaserin and varenicline with a primary aim of reducing post cessation weight gain.
- Trial name
- NCT02393547
- Testing
- Varenicline, Lorcaserin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking Cessation, Smoking, Cigarette
Randomized Trial of Electronic Cigarettes With or Without Nicotine in Smoking Cessation.
Background: Electronic cigarettes (EC) mainly containing nicotine (88-95 % of users) are widely and growingly used worldwide. It is estimated that there were 1.7 million daily users in France in 2016.
- Conditions
- Smoking Cessation, Smoking, Cigarette, Electronic Cigarette
- Trial name
- ECSMOKE (NCT03630614)
- Testing
- Electronic cigarette without nicotine (ECwN) plus active varenicline tablets
- Where
- France
- Volunteers
- 650 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Smoking Cessation, Pharmacokinetics
A Clinical Trial to Compare Pharmacokinetics of the "CDFF0318" and "Champix Tab. 1mg"
A Phase 1 Clinical Trial to Compare and Evaluate Safety and Pharmacokinetic Characteristics after Administration of the "CDFF0318" and "Champix Tab. 1mg (Varenicline tartrate)" in Healthy Male Volunteers
- Trial name
- NCT04631874
- Testing
- CDFF0318, Champix
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- CTC Bio, Inc.
Nicotine Dependence
Varenicline (Chantix) Treatment for Waterpipe Smoking Cessation
The lack of proven waterpipe smoking cessation interventions makes it important to explore interventions proven effective for cigarette smoking cessation.
- Trial name
- NCT02575183
- Testing
- Varinecline (Chantix), Behavioral Therapy
- Where
- 2 sites in Lebanon
- Volunteers
- 152 people
- Sponsor
- American University of Beirut Medical Center