Clinical trials: Varenicline
Smoking Cessation
Study on the Model of Smoking Cessation Intervention and Service Ability Improvement
This is a observation non-randomized control trial, and a follow-up study on the smoking cessation.
- Trial name
- NCT01935505
- Testing
- Consulting, Nicotine patch, Telephone intervention
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Smoking Cessation
A Multi-National Study To Assess How Effective And Safe The Smoking Cessation Medicine Varenicline Is In Smokers Who Have Already Tried Varenicline In The Past As A Prescription Medicine From Their Usual Healthcare Provider
The main purpose of this study is to compare the effectiveness and safety of the re-treatment of smokers with varenicline with placebo for smoking cessation during the last 4 weeks of a 12 week course of treatment.
- Trial name
- NCT01244061
- Testing
- Varenicline
- Where
- 37 sites in United States, Australia and 6 more
- Volunteers
- 498 people
- Sponsor
- Pfizer
Smoking Cessation
Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders
This study is being conducted to assess varenicline and bupropion as aids to smoking cessation treatment in subjects with and without an established diagnosis of major psychiatric disorder and to characterize the neuropsychiatric…
- Trial name
- EAGLES (NCT01456936)
- Testing
- varenicline tartrate, bupropion hydrochloride, Nicotine Replacement Therapy Patch
- Where
- 156 sites in United States, Argentina and 14 more
- Volunteers
- 8,144 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tobacco Dependence
Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1
Schizophrenia is associated with high rates of cigarette smoking and associated morbidity and mortality. In this study, smokers with schizophrenia will complete a baseline session and then randomized to varenicline (VAR) or…
- Trial name
- NCT03507127
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brown University
Mental Illness
Trial of Integrated Smoking Cessation, Exercise and Weight Management in Serious Mental Illness: TRIUMPH
This study will determine whether an 18-month practical tobacco smoking cessation program integrating weight management counseling and exercise will be superior to treatment as usual in achieving prolonged smoking abstinence in…
- Trial name
- TRIUMPH (NCT02424188)
- Testing
- TRIIUMPH Intervention
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Johns Hopkins University
HIV/AIDS, Smoking
Mobile Health Interventions for Medication Adherence Among PLWH
Cigarette smoking remains highly prevalent among persons living with HIV (PLWH). Quitting smoking can have important health benefits for this population. However, PLWH have historically had a difficult time quitting smoking.
- Conditions
- HIV/AIDS, Smoking, Smoking Cessation, HIV
- Trial name
- HIVSMART (NCT04191278)
- Testing
- Varenicline, Mobile phone application, Contingency management
- Sponsor
- Duke University
HIV/AIDS, Nicotine Dependence
Optimizing Tobacco Use Treatment for PLWHA
The advent of anti-retroviral therapy (ART) for people living with HIV/AIDS (PLWHA) substantially improved life expectancy but has also led to the critical need to address modifiable risk factors associated with cancer and…
- Trial name
- HTO (NCT04176172)
- Testing
- Varenicline, Nicotine patch, Standard treatment
- Where
- 2 sites in United States
- Volunteers
- 340 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Tobacco Use Cessation, Psychiatric Disorders
Varenicline for Smoking Cessation in Hospitalized Patients With Psychiatric Disorders
Varenicline increases smoking abstinence rates compared to bupropion, nicotine patch or placebo in outpatients with psychiatric disorders.
- Trial name
- NCT03809897
- Testing
- Varenicline, Nicotine patch
- Where
- 4 sites in Spain
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Smoking Cessation
A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction
This study will determine whether varenicline is safe and helps people to quit smoking through reduction when they are not willing/able to make an abrupt quit attempt.
- Trial name
- NCT01370356
- Testing
- Varenicline Tartrate
- Where
- 65 sites in United States, Australia and 8 more
- Volunteers
- 1,510 people
- Sponsor
- Pfizer
Pancreatitis, Chronic, Pancreatitis, Acute
Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis
The purpose of this research is to assess the effectiveness of two treatment strategies for smoking cessation in patients with acute recurrent pancreatitis or chronic pancreatitis who smoke cigarettes.
- Conditions
- Pancreatitis, Chronic, Pancreatitis, Acute, Recurrent Acute Pancreatitis, Smoking (Tobacco) Addiction
- Trial name
- NCT07171112
- Testing
- Standard Varenicline Dosing (1 mg BID), Bupropion 150 mg twice daily, Increased Varenicline Dosing (1mg TID)
- Where
- United States
- Sponsor
- Mayo Clinic
Dry Eye Disease
Efficacy of OC-01 Nasal Spray on Goblet Cell and Meibomian Gland Stimulation
The objective of this study is to evaluate the safety and effectiveness of OC-01 Nasal Spray as compared to placebo in simulating Goblet Cell and Meibomian Gland function in adult subjects with DED.
- Trial name
- NCT03688802
- Testing
- OC-01 (varenicline) nasal spray
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Oyster Point Pharma, Inc.
Smoking Cessation
Varenicline for Treatment of E-cigarette Dependence
Varenicline is used to treat tobacco use dependence. It helps reduce cravings for tobacco use and decreases the pleasurable effects of cigarettes and other tobacco products.
- Trial name
- NCT05541497
- Testing
- Varenicline Tartrate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Healthy
A Clinical Study to Evaluate the Pharmacokinetics, Safety and Tolerability of HIP1502
The clinical trial aims to assess the pharmacokinetics, safety and tolerability of HIP1502 in healthy male subjects.
- Trial name
- NCT04018378
- Testing
- varenicline tartrate 1mg (HGP1604, R) - varenicline oxalate 1mg (HIP1502, T), RT, varenicline oxalate 1mg (HIP1502, T) - varenicline tartrate 1mg (HGP1604, R), TR
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Cognition in Schizophrenia
Study of the Effects of Mecamylamine and Varenicline in Schizophrenia
We are conducting this study to find out if blocking or partially stimulating the effects of nicotine in the brain can affect memory and concentration. Nicotine is the addictive drug found in tobacco products.
- Trial name
- NCT00455650
- Testing
- Mecamylamine, Varenicline
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Drug Addiction
Effect of Varenicline on Tobacco Addiction and on Abstinence-induced Cognitive Impairment
Background: Varenicline (Chantix ) is a drug that is approved by the Food and Drug Administration (FDA) to help people stop smoking.
- Trial name
- NCT01309685
- Testing
- Varenicline
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder, Hiv
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2
This study seeks to determine the feasibility, acceptability, and preliminary efficacy of an intervention consisting of off-label use of a medication with strong efficacy data for alcohol use disorder (AUD) with medical…
- Conditions
- Alcohol Use Disorder, Hiv, Tobacco Use Disorder
- Trial name
- HARP (NCT06006143)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Cancer, Surgical Procedure, Unspecified
PAPRIKA - Patients Empowerment for Major Surgery Preparation @Home
PAPRIKA establishes a technologically enabled and personalized prehabilitation and follow-up after surgical intervention program for patients undergoing elective major surgery Program creates close collaboration between the…
- Trial name
- PAPRIKA (NCT04295668)
- Testing
- Usual care, Prehabilitation
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital Clinic of Barcelona
Smoking
Varenicline for Light Smokers
The purpose of this study is to determine if varenicline is effective in treating tobacco dependence in adults who smoke 5-10 cigarettes per day.
- Trial name
- ChanLight (NCT01639560)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Use, Tobacco Use Cessation
Metabolism-informed Care for Smoking Cessation
Nicotine mediates smoking's addictive effects in the brain. The ratio of 3-hydroxycotinine to cotinine, known as the nicotine metabolite ratio, or NMR, is a genetically- informed biomarker reflecting hepatic CYP2A6 activity and…
- Trial name
- NCT03227679
- Testing
- Nicotine Metabolite Ratio, Varenicline, Bupropion
- Volunteers
- 82 people
- Sponsor
- Vanderbilt University Medical Center
Nicotine Dependence, Cigarettes
Translational Neuropsychopharmacology Research of Nicotine Addiction
This study will examine the effects of combining Varenicline (VRN) and N-acetylcysteine (NAC) on neural circuitry function and treating nicotine addiction.
- Trial name
- NCT02723162
- Testing
- Varenicline (VRN), N-Acetylcysteine (NAC)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina