Clinical trials: Vehicle, completed
Type 2 Diabetes Mellitus
Xenin-25: Novel Regulator of Insulin Secretion and Beta-cell Function
An intestinal hormone called Glucose-dependent Insulinotropic Polypeptide (GIP) is released into the blood immediately after ingestion of a meal and plays an important role in regulating blood sugar levels.
- Trial name
- NCT00949663
- Testing
- Glucose-dependent Insulinotropic Polypeptide (GIP), Xenin-25, Glucose-dependent Insulinotropic Polypeptide plus Xenin-25
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Heart Failure, Hypertension
Effects of Different Forms of a Natural Heart Hormone on Blood Pressure and Fluid Balance in Healthy Volunteers
The human heart produces hormones that help regulate blood pressure and fluid balance in the body. One of these hormones is atrial natriuretic peptide (ANP).
- Conditions
- Heart Failure, Hypertension, Kidney Failure
- Trial name
- NCT07606183
- Testing
- Infusion of two different cardiac peptides plus vehicle
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Peter Fruergaard Andersen
Allergic Conjunctivitis
The INVIGORATE 2 Trial: A Clinical Trial to Assess the Efficacy and Safety of Subjects With Seasonal Allergic Conjunctivitis
The INVIGORATE 2 Trial: A single-center, randomized, double-masked, crossover design, vehicle-controlled, Phase 3 clinical trial to assess the efficacy and safety of reproxalap ophthalmic solution (0.25%) compared to vehicle in…
- Trial name
- NCT05234554
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Vehicle Ophthalmic Solution
- Where
- Canada
- Volunteers
- 131 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Slowing the Progression of Myopia in Children
The Safety and Efficacy of HR19034 in Children With Myopia
The study is being conducted to evaluate the efficacy, and safety of HR19034 Eye Drops. To explore the reasonable dosage of HR19034 for slowing the progression of myopia in children
- Trial name
- NCT07844356
- Testing
- HR19034
- Where
- China
- Volunteers
- 509 people
- Sponsor
- Chengdu Suncadia Medicine Co., Ltd.
Plaque Psoriasis, Psoriasis
Enstilar® Foam in the Treatment of Chronic Plaque Psoriasis in Patients With Skin of Color
This will be a single-center, randomized, double-blinded, vehicle-controlled clinical study to determine the efficacy of Enstilar® foam, a combination of calcipotriene and betamethasone dipropionate 0.005%/0.064%, in the…
- Trial name
- NCT03506477
- Testing
- Enstilar® foam, Vehicle foam
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
COVID-19, Pharmacokinetics
Safety and Acceptability of Q GRFT Nasal Spray for COVID-19 Prophylaxis
This is a phase I randomized, placebo-controlled, single site to assess the local and systemic safety of intranasal Q-Griffithsin (Q-GRFT) after 14 doses in approximately 45 adult participants.
- Conditions
- COVID-19, Pharmacokinetics, Safety
- Trial name
- NCT05180500
- Testing
- Q-Griffithsin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sharon Hillier
Acne
Exploratory Study to Evaluate the Efficacy and Safety of CD07223 Gel in Subjects With Acne
The purpose of the study is to evaluate the efficacy of CD07223 1.5% Gel and 0.5% gel in reducing inflammatory, non-inflammatory, and total acne lesion counts after 6 weeks of twice daily applications.
- Trial name
- NCT01106807
- Testing
- Epiduo vehicle gel, CD07223, Epiduo (adapalene and benzoyl peroxide) 0.1%/2.5% gel
- Where
- 9 sites in United States
- Volunteers
- 73 people
- Sponsor
- Galderma R&D
Motor Vehicle Accidents, TBI (Traumatic Brain Injury)
Concussion in Motor Vehicle Accidents: The Concussion Identification Index
The primary goal of this study is to provide clinicians with a brief, patient self-administer instrument yielding a single composite score that reliably correlates with objective findings on standardized neurocognitive assessment…
- Conditions
- Motor Vehicle Accidents, TBI (Traumatic Brain Injury), Brain Contusion, Brain Injuries
- Trial name
- CIDI (NCT02858544)
- Testing
- The Concussion Identification Index, ImPACT
- Where
- United States
- Volunteers
- 1,790 people
- Sponsor
- Clionsky Neuro Systems Inc.
Dry Eye Disease
Safety and Efficacy of Licaminlimab Ophthalmic Solution for the Treatment of Dry Eye Disease
The goal of this clinical trial is to learn about licaminlimab (OCS-02) in the treatment of dry eye disease. The main question it aims to answer is if licaminlimab ophthalmic solution is more effective than vehicle in treating…
- Trial name
- RELIEF (NCT05896670)
- Testing
- licaminlimab, vehicle of OCS-02, Artificial tears
- Where
- 5 sites in United States
- Volunteers
- 122 people
- Sponsor
- Oculis
Bacterial Conjunctivitis
Efficacy and Safety of Auriclosene (NVC-422) in the Treatment of Bacterial Conjunctivitis
The purpose of this study is to evaluate the microbiological and clinical efficacy of Auriclosene compared to its vehicle for bacterial conjunctivitis.
- Trial name
- BACTOvation™ (NCT01877694)
- Testing
- Auriclosene Solution 0.3%, Auriclosene Vehicle
- Where
- 21 sites in United States
- Volunteers
- 217 people
- Sponsor
- NovaBay Pharmaceuticals, Inc.
Dermatitis
Study of the Safety and Efficacy of Tacrolimus Ointment in Treating Chronic Allergic Contact Dermatitis
A study of subjects with a known nickel allergy comparing Tacrolimus to placebo, both associated with nickel patches to determine the safety and efficacy of treating Chronic Allergic Contact Dermatitis with Tacrolimus Ointment
- Trial name
- NCT00667056
- Testing
- tacrolimus ointment
- Where
- 10 sites in United States
- Volunteers
- 98 people
- Sponsor
- Astellas Pharma Inc
Acne
A Pilot Study to Investigate Filiation Between Primary and Secondary Lesions in Acne Patients
Exploratory, international, multi-centre, randomized, investigator blinded study in acne
- Trial name
- NCT01688531
- Testing
- CD0271 0.1%/CD1579 2.5% gel, CD0271 0.1%/CD1579 2.5% gel vehicle
- Where
- 3 sites in Canada, France
- Volunteers
- 38 people
- Sponsor
- Galderma R&D
Hyperinsulinemic Hypoglycemia
Glucagon Ready to Use (RTU) in Subjects With Hyperinsulinemic Hypoglycemia After Bariatric Surgery
This is a double-blind, placebo-controlled Phase 2 study to assess the efficacy, safety and tolerability of Glucagon RTU when administered to subjects with a history of bariatric surgery during episodes of post-postprandial…
- Trial name
- NCT03770637
- Testing
- Glucagon RTU
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Xeris Pharmaceuticals
Presbyopia
Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With Presbyopia
The objectives of this study are: To evaluate the efficacy of Nyxol + Pilocarpine to improve DCNVA in subjects with presbyopia
- Trial name
- NCT04675151
- Testing
- Phentolamine Ophthalmic Solution 0.75%, Pilocarpine
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Opus Genetics, Inc
Actinic Keratosis (AK)
A Study to Evaluate Two Concentrations of DFD-07 Cream, in Subjects With Actinic Keratosis (AK) of the Face and/or Scalp Over a 12-week Treatment Period
Once or twice daily 12 week treatment in patients with Actinic Keratosis randomized to treatment in one of four arms.
- Trial name
- NCT03116698
- Testing
- Low dose DFD07 once daily, High dose DFD07 once daily, High dose DFD07 twice daily
- Where
- 20 sites in United States
- Volunteers
- 240 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Psoriasis
A Phase I Study to Assess Novel Cream in a Psoriasis Plaque Test
The purpose of this study is to investigate dose-response relationship, antipsoriatic efficacy and safety of different concentrations of topical formulations with AN2728 in subjects with psoriasis vulgaris.
- Trial name
- NCT00763204
- Testing
- AN2728 Cream, 2%, AN2728 Cream, 1%, AN2728 Cream, 0.3%
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Pfizer
Inflammation, Pain
Efficacy and Safety of RX-10045 Ophthalmic Solution for Ocular Inflammation and Pain in Cataract Surgery
The primary objective of this study is to assess the efficacy and safety of 2 concentrations of RX-10045 ophthalmic solution, 0.05% and 0.1%, compared to placebo for the treatment of ocular inflammation and pain in subjects…
- Conditions
- Inflammation, Pain, Cataract
- Trial name
- NCT02329743
- Testing
- RX-10045
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- A.T. Resolve SARL
Perennial Allergic Rhinitis
Safety of PATANASE Nasal Spray in Patients With Perennial Allergic Rhinitis
The purpose of this study was to assess local nasal adverse effects, as well as systemic effects, of PATANASE nasal spray when compared with Patanase Vehicle, pH 3.7 and Patanase Vehicle, pH 7.0 in patients with perennial…
- Trial name
- NCT00789555
- Testing
- Olopatadine hydrochloride 0.6% nasal spray (PATANASE), Olopatadine nasal spray vehicle, pH 3.7, Olopatadine nasal spray vehicle, pH 7.0
- Where
- United States
- Volunteers
- 1,260 people
- Sponsor
- Alcon Research
Pruritus
Topical Aprepitant in Prurigo Patients
Topical Aprepitant in Prurigo Patients - An Exploratory Phase IIa Trial With Topically Applied Aprepitant in Patients With Prurigo
- Trial name
- iTAPP (NCT01963793)
- Testing
- Aprepitant
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- LEO Pharma
Atopic Dermatitis
Effect of Pimecrolimus Cream on Cathelicidin Levels in Subjects With Eczema
The purpose of this study is to determine the effect of topical pimecrolimus on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with eczema.
- Trial name
- NCT00946478
- Testing
- Pimecrolimus, Vehicle cream
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
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