Clinical trials: Vinorelbine
Carcinoma, Non-Small -Cell Lung
A Phase III Study With THIO + Cemiplimab vs Chemotherapy as 3rd Line Treatment in Advanced/Metastatic NSCLC
THIO is a first-in-class small molecule telomere targeting agent, in development for the treatment of non-small cell lung cancer (NSCLC) in combination with cemiplimab (LIBTAYO®).
- Trial name
- NCT06908304
- Testing
- 6-Thio-2'-Deoxyguanosine, Cemiplimab, Docetaxel
- Where
- 15 sites in Poland, Romania and 2 more
- Volunteers
- 300 people
- Sponsor
- Maia Biotechnology
Non-small-cell Lung Cancer
Neoadjuvant Therapy of Icotinib in Epidermal Growth Factor Receptor Mutated NSCLC Patients
The purpose of this study is to evaluate the overall response rate and disease free survival for IIIAN2 non-small-cell lung cancer patients with EGFR 19 or 21 exon mutation.
- Trial name
- NCT01843647
- Testing
- Icotinib, Chemotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Betta Pharmaceuticals Co., Ltd.
Lymphoma
Combination Chemotherapy in Treating Patients With Relapsed or Refractory Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00006029
- Testing
- gemcitabine hydrochloride, pegylated liposomal doxorubicin hydrochloride, vinorelbine tartrate
- Where
- 76 sites in United States, Puerto Rico
- Volunteers
- 91 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Advanced Breast Cancer
Trastuzumab + Alpelisib +/- Fulvestrant vs Trastuzumab + CT in PIK3CA-mutated HER2+ Advanced BC (ALPHABET)
Randomized phase III trial of trastuzumab + Alpelisib +/- fulvestrant versus trastuzumab + chemotherapy in patients with PIK3CA mutated previously treated HER2+ Advanced Breast cancer.
- Trial name
- ALPHABET (NCT05063786)
- Testing
- Trastuzumab, Alpelisib, Fulvestrant
- Where
- 106 sites in Austria, France and 4 more
- Volunteers
- 27 people
- Sponsor
- Spanish Breast Cancer Research Group
Lung Neoplasm Malignant
Oral Navelbine and Cisplatin Followed by Metronomic Oral Navelbine in Non-Small Cell Lung Cancer
This is an open-label, multi-center clinical trial, aims to evaluate the efficacy and safety of combination of oral Navelbine and Cisplatin followed by metronomic oral Navelbine in Patients with advanced Non-Small Cell Lung…
- Trial name
- NCT02985203
- Testing
- Vinorelbine Oral
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Guangdong Association of Clinical Trials
Breast Cancer
A Study to Evaluate Vinorelbine Plus Capecitabine Combined With Trastuzumab for HER2 Positive Patients Following Neoadjuvant Chemotherapy
This study aims to evaluate vinorelbine plus capecitabine combined with trastuzumab versus trastuzumab alone as the adjuvant Treatment of HER2 positive patients following neoadjuvant chemotherapy
- Trial name
- NCT04302441
- Testing
- Vinorelbine, Capecitabine
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Fudan University
Carcinoma, Non-Small-Cell Lung
Combination of Weekly Chest Radiotherapy and Oral Navelbine for the Palliation of Advanced Non Small Cell Lung Cancer: A Phase I Study
The study is designed for subjects whose cancer is too advanced and therefore cannot be operated with the goal of completely removing the cancer.
- Trial name
- NCT00256815
- Testing
- chemotherapy, Radiation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Clinical Oncology Research Associates
Breast Cancer Metastatic
A Study to Evaluate the Efficacy and Safety of TSL-1502 Capsules in Breast Cancer Patients With Germline BRCA Mutations
This research study is evaluating the efficacy and safety of TSL-1502 capsules in patients with breast cancer, will be included HER2-negative locally advanced or metastatic breast cancer patients with germline BRCA mutations.
- Trial name
- NCT05420779
- Testing
- TSL-1502 capsules(low dose), TSL-1502 capsules(high dose), Investigator's choice of chemotherapy
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.
Carcinoma, Non-Small-Cell Lung
Erlotinib and Standard Platinum-Based Chemotherapy for Newly Diagnosed, Advanced Non-Small Cell Carcinoma of the Lung
This study was conducted to compare the activities of erlotinib to that of intravenous, platinum-based therapy in the treatment of non-small cell lung cancer (NSCLC).
- Trial name
- NCT00391586
- Testing
- Erlotinib, Platinum-based chemotherapy
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- New Mexico Cancer Research Alliance
Prostate Cancer
Mitoxantrone, Etoposide, and Vinorelbine As Second-Line Therapy in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy
RATIONALE: Drugs used in chemotherapy, such as mitoxantrone, etoposide, and vinorelbine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00627354
- Testing
- etoposide, mitoxantrone hydrochloride, prednisone
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Groupe D'Etude des Tumeurs Uro-Genitales
Breast Cancer
Addition of Aromatase at the Navelbine in Pretreated Metastatic Breast Cancer.
The CHEOPS study aims to confirm the clinical benefit of a combination of an anti-aromatase and metronomic chemotherapy treatment
- Trial name
- CHEOPS (NCT02585388)
- Testing
- Vinorelbine, Letrozole, Anastrozole
- Where
- 47 sites in France
- Volunteers
- 120 people
- Sponsor
- ARCAGY/ GINECO GROUP
Lung Cancer
S0027: Vinorelbine Followed by Docetaxel in Treating Patients With Advanced Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of vinorelbine followed by docetaxel in treating patients…
- Trial name
- NCT00026156
- Testing
- docetaxel, vinorelbine tartrate
- Where
- 96 sites in United States
- Volunteers
- 125 people
- Sponsor
- SWOG Cancer Research Network
Recurrent Non-Small Cell Lung Carcinoma, Stage IV Non-Small Cell Lung Cancer
Vinorelbine Tartrate and Paclitaxel in Treating Older Patients With Advanced Non-Small Cell Lung Cancer
This phase II trial studies the side effects and how well vinorelbine tartrate and paclitaxel works in treating older patients with non-small cell lung cancer that has spread to other placed in the body.
- Trial name
- NCT00602797
- Testing
- Paclitaxel, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Metastatic Melanoma
Docetaxel and Vinorelbine Plus Sargramostim in Metastatic Malignant Melanoma
This is a Phase II Evaluation of Docetaxel and Vinorelbine Plus Sargramostim in subjects who have metastatic melanoma which has advanced beyond the point at which local therapies such as surgery or radiation therapy would be…
- Trial name
- NCT00256282
- Testing
- Vinorelbine, Docetaxel, Sargramostim
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- John P. Fruehauf
Salivary Gland Cancer, Adenoid Cystic Carcinoma of the Salivary Gland
Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers
This research study is studying the effect of different drugs as possible treatments for salivary and other head and neck cancers/ The name of the study intervention involved in this study is: -- implantable microdevice
- Conditions
- Salivary Gland Cancer, Adenoid Cystic Carcinoma of the Salivary Gland, Squamous Cell Carcinoma of Head and Neck, Head and Neck Cancer
- Trial name
- NCT05553782
- Testing
- Implantable Microdevice (IMD)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Breast Neoplasms
Afatinib (BIBW2992) in HER2 (Human Epidermal Growth Factor Receptor 2)-Overexpressing Inflammatory Breast Cancer
The general aim of this study is to investigate the efficacy and safety of afatinib alone and in combination with weekly vinorelbine (in patients who progress on afatinib monotherapy within this trial) as treatment in patients…
- Trial name
- NCT01325428
- Testing
- Afatinib once daily (OD), Vinorelbine Weekly
- Where
- 16 sites in United States, Australia and 5 more
- Volunteers
- 26 people
- Sponsor
- Boehringer Ingelheim
Cancer
Dose-escalation Study of Intravenous Liposomal Vinorelbine Tartrate Injection in Patients With Advanced Malignancy
This is a phase I/IIa, Open label, Dose-escalation Study Investigating the Safety, Tolerability, and Pharmacokinetics of Intravenous Liposomal Vinorelbine Tartrate Injection in Patients with Advanced Malignancy.
- Trial name
- NCT02925000
- Testing
- TLC178
- Where
- 3 sites in United States, Taiwan
- Volunteers
- 46 people
- Sponsor
- Taiwan Liposome Company
Breast Cancer, Triple Negative Breast Cancer
Efficacy and Safety of PD-L1 Monoclonal Antibody Combined With Metronomic VEX in Advanced Triple-negative Breast Cancer
In recent years, immune therapy has significantly altered the treatment landscape for various malignant tumors, including breast cancer.
- Trial name
- NCT06229067
- Testing
- Adebrelimab, Vinorelbine, Cyclophosphamide (tablet)
- Volunteers
- 182 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Non-small Cell Lung Cancer
Cetuximab and Vinorelbine in Elderly Subjects With Lung Cancer
The purpose of this study is it to determine how well patients with non-small cell lung cancer respond to cetuximab plus vinorelbine.
- Trial name
- NCT00165334
- Testing
- Cetuximab, Vinorelbine (Navelbine)
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Dana-Farber Cancer Institute
Metastatic Breast Cancer
Detect V / CHEVENDO (Chemo vs. Endo)
Chemo- versus endocrine therapy in combination with dual HER2-targeted therapy of Herceptin® (trastuzumab) and Perjeta® (pertuzumab) plus Kisqali® (ribociclib) in patients with HER2 positive and hormone-receptor positive…
- Trial name
- NCT02344472
- Testing
- pertuzumab, Trastuzumab, Capecitabine
- Where
- Germany
- Volunteers
- 271 people
- Sponsor
- Prof. Wolfgang Janni