Clinical trials: Vitamin C
Cholera, Vibrio Infections
Safety and Immunogenicity of Single Dose Choleragarde® in HIV-Seropositive Adults
The purpose of this study is to assess the safety and immunogenicity of Peru-15 (CholeraGarde®) vaccine in HIV seropositive adult population of Bangkok Thailand
- Conditions
- Cholera, Vibrio Infections, Diarrhea
- Trial name
- NCT00741637
- Testing
- CholeraGarde®
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- International Vaccine Institute
Septic, Acute Respiratory Distress Syndrome
Lessening Organ Dysfunction With VITamin C in Septic ARDS
The primary objective of the study aims to compare the effect of high-dose intravenous vitamin C vs. placebo on a composite of death or persistent organ dysfunction - defined as continued dependency on mechanical ventilation, new…
- Trial name
- LOVIT ARDS (NCT04404387)
- Testing
- Administration of vitamin C
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Immune System Diseases
Impact of HLNatural Immune Supplement on Colds
According to the Centers of Disease Control and Prevention (CDC) adults will have an average of 2-3 colds per year. Most colds will last approximately 7-10 days.
- Trial name
- NCT04103099
- Testing
- HLNatural Immune
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Hawthorne Effect Inc.
Peripheral Artery Disease
Effect of Neo40 on PAD
Reduced nitric oxide (NO) availability is a hallmark of a number of cardiovascular diseases (CVD) including peripheral artery disease (PAD).
- Trial name
- NCT02934438
- Testing
- Neo40
- Volunteers
- 30 people
- Sponsor
- HumanN
Females, Males
The Effects of Vitamin C on Acute-Exercise in Postmenopausal Females
This study is looking at whether vitamin C can help improve oxidative stress and blood vessel health in females after menopause.
- Conditions
- Females, Males, Menopause, Sedentary
- Trial name
- PM-VitC (NCT07109115)
- Testing
- Vitamin C (Ascorbic Acid)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Virginia
COVID - 19
Vitamin E Supplementation As Adjunctive Therapy To Lower Inflammation In COVID-19 Patients
Since the first reported case of the novel coronavirus (SARS-CoV-2) in humans at the end of 2019 in Wuhan, the virus had infected approximately 100 million individuals.
- Trial name
- VITEC (NCT07412574)
- Testing
- Patients were randomly assigned, under a double-blind design, α-Tocopherol group (n = 22)
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Universidad Veracruzana
Diabetic Retinopathy
Combined Antioxidant Therapy on Oxidative Stress, Mitochondrial Dysfunction Markers in Diabetic Retinopathy
The present study aims to support previous research on antioxidant therapy effects in diabetic retinopathy outcome. The investigators intend to assess 180 patients with diabetic retinopathy in different stages (moderate, severe…
- Trial name
- NCT03702374
- Testing
- Combined antioxidant therapy
- Where
- Mexico
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Colonoscopy
2L Oral Bi-PegLyte Versus 2L Oral MoviPrep Regimen for Outpatient Colonic Preparation
This study is a randomized, controlled, single centre, endoscopist-blinded non-inferiority trial. The purpose of our study is to determine if using a 2-litre mixture in combination with vitamin C is better than using 2 litres of…
- Trial name
- NCT01865916
- Testing
- Polyethylene Glycol (PEG) and 15 mg Bisacodyl, Polyethylene Glycol (PEG) + ascorbic acid
- Where
- Canada
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetes, Fatty Liver
Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women
Background: Vitamin E is an antioxidant that reduces the damaging effects of oxygen in the body. Most American men (90%) and women (96%) do not get enough vitamin E from their diets; however, the amount of vitamin E needed by the…
- Conditions
- Diabetes, Fatty Liver, Obesity, Healthy Volunteers
- Trial name
- NCT00862433
- Testing
- Alpha tocopherol, Vitamin E, Vitamin C
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Congenital Heart Disease (CHD)
Impact of Vitamin C Supplementation on Hospital Outcomes in Children Undergoing Corrective Heart Surgery for Congenital Heart Diseases
Vitamin C will be given before admission in the immediate preoperative preceding 7 days (the dose 30 -45 mg per day ) in oral drops preparations Inflammatory markers including CRP , TLC ,PNI , GPS NLR will be checked on admission…
- Trial name
- RCT (NCT06789640)
- Testing
- Vitamin C
- Volunteers
- 20 people
- Sponsor
- Cairo University
Iron Deficiency Anemia of Pregnancy
Adiposity and Iron Requirements in Pregnancy
This study aims to explore how body fat influences the response to either 25 or 50 mg of daily iron supplements during pregnancy.
- Trial name
- ADIPREG (NCT06425796)
- Testing
- Adiposity and Iron Requirements in Pregnancy (ADIPREG)
- Where
- 3 sites in United Kingdom
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Orthodontic Relapse
THE EFFECT OF VITAMIN C ON POST-ORTHODONTIC TREATMENT RELAPSE
The aim of this study is to evaluate and compare the effect of locally injected and orally administered (systemic) Vitamin C on post-orthodontic treatment relapse
- Trial name
- NCT06146296
- Testing
- Local Vitamin C injection, Oral Vitamin C supplement
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Nourhan M.Aly
Aging, Metabolism
Practicality of Intermittent Fasting and Its Effect on Markers of Aging and Oxidative Stress
Healthy volunteers will be recruited to participate in a ten-week double-blinded crossover trial. The trial will consist of two, three-week periods of intermittent fasting, where subjects receive either antioxidant…
- Trial name
- NCT02132091
- Testing
- Intermittent Fasting, 400 IU Vitamin E, 1000 mg Vitamin C
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Hepatitis C
Add Vitamin D With Standard of Care for Chronic Hepatitis C Patients
Standard therapy for chronic hepatitis C virus (HCV) is (Peg/RBV) combination therapy obtaining sustained virologic response (SVR) in 77% of naïve patients with genotype 1-3 Studies rarely address the issues of improving host…
- Trial name
- Addwin (NCT01439776)
- Testing
- Vit D
- Where
- 13 sites in South Korea
- Volunteers
- 180 people
- Sponsor
- Hanyang University
Septic Shock, Ascorbic Acid Deficiency
Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.
This is a retrospective chart review that will measure the impact on outcomes in septic shock patients who were resuscitated with a novel combination of medicines called iHAT (intravenous hydrocortisone -ascorbic acid-thiamine).
- Trial name
- NCT03913468
- Testing
- Intravenous Ascorbic Acid
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- University of Wisconsin, Madison
Gestational Diabetes
MTHFR Mutation and Concentration of B12,Folic Acid,Homocysteine and HS CRP in the Blood of Pregnant Women With GDM.
Research hypothesis: pregnant women with gestational diabetes have elevated serum CRP values and homocysteine compared to pregnant women with normal glucose metabolism Elevated CRP and homocysteine values are associated with…
- Trial name
- NCT04952324
- Testing
- Blood sampling and determination of MTHFR mutation,vitamin B12, folic acid, homocystein and HS CRP
- Where
- 2 sites in Bosnia and Herzegovina
- Volunteers
- 100 people
- Sponsor
- University of Mostar
Covid19
RCT,Double Blind, Placebo to Evaluate the Effect of Zinc and Ascorbic Acid Supplementation in COVID-19 Positive Hospitalized Patients in BSMMU
The first COVID-19 case was identified on March 7, 2020. Since then, 4127 deaths of the total 3,40583 confirmed cases are reported in Bangladesh of August 26, 2020.
- Trial name
- NCT04558424
- Testing
- zinc gluconate and ascorbic acid
- Where
- Bangladesh
- Volunteers
- 50 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Oxidative Stress, Cell-derived Microparticles
Pik Lenin High Altitude Research Expedition 2009
Exposure to hypobaric hypoxia demands maximum effort of the body and can lead to high altitude illnesses. Recently, there is rising interest on coagulation activation during trekking and mountaineering in higher regions and on…
- Trial name
- PLHARE (NCT01571687)
- Testing
- antioxidant supplements
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Aging, Inflammation
Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation
This study focuses on whether high cardiorespiratory fitness in older adults has a protective effect on the vascular response to acute inflammation in comparison to low-fit older and young adults.
- Trial name
- NCT03889158
- Testing
- Typhoid Vaccine, Ascorbic Acid
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Healthy, Hyperlipidemias
Effect of Goji Berry Consumption on Biochemical Parameters
Goji Berry as a functional food have been shown to reduce risk of hyperlipidemia, type 2 diabetes, etc. However, human studies are limited in this area.
- Trial name
- NCT06190587
- Testing
- Goji Berry
- Where
- Cyprus
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
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