Clinical trials: Vitamin C
Gastric Cancer
IV Ascorbic Acid in Advanced Gastric Cancer
Linus Pauling and Dr Ewan Cameron have published two retrospective studies about using high dose vitamin C to treat cancer patients forty years ago.
- Trial name
- NCT03015675
- Testing
- ascorbic acid, mFOLFOX6
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Respiratory Tract Diseases, Influenza (Pandemic)
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of hospitalised…
- Conditions
- Respiratory Tract Diseases, Influenza (Pandemic), Influenza, Community Acquired Pneumonia
- Trial name
- REMAP-CAP (NCT02735707)
- Testing
- Ceftriaxone + Macrolide, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam + Macrolide
- Where
- 408 sites in United States, Australia and 27 more
- Volunteers
- 20,000 people
- Sponsor
- UMC Utrecht
Glioblastoma
MEDICO-ECONOMIC EVALUATION OF SURGERY GUIDED BY FLUORESCENCE FOR THE OPTIMIZATION OF RESECTION OF GLIOBLASTOMAS
Glioblastoma is the most frequent primary malignant brain tumor in adults (3,000 new cases per year) and is characterized by a poor prognosis (median survival 12 months).
- Trial name
- RESECT (NCT01811121)
- Testing
- 5-aminolévulinique acid (5-ALA)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Hospices Civils de Lyon
Complex Regional Pain Syndrome I of Lower Limb
"Liposomal Encapsulated Vitamin C in Complex Regional Pain Syndrome"
Abstract: Complex regional pain syndrome (CRPS) is a significant complication in operated osteoarticular pathology and may adversely affect patient's quality of life. Vitamin C is an anti-oxidant and a neuro-modulating agent.
- Trial name
- NCT04204200
- Testing
- liposomal vitamin C, standard vitamin C
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier de Ham
Exercise-induced Bronchospasm
Vitamin C & Exercise Induced Bronchoconstriction (EIB)
The purpose of this research is to assess the association between diet and pulmonary function during standardized EIB testing. Determine the effect of Vitamin C supplementation on airway inflammatory markers and…
- Trial name
- NCT03610932
- Testing
- Vitamin C
- Where
- United States
- Sponsor
- University of Kansas Medical Center
Urinary Tract Infections
Vitamin C and Hiprex in rUTI
A single centre proof of concept study to assess whether Vitamin C improves the efficacy of Methenamine Hippurate (Hiprex®) in the prophylaxis of recurrent urinary tract infections (rUTIs) in women
- Trial name
- NCT06710899
- Testing
- Methenamine Hippurate 1g BD, Methenamine Hippurate 1g BD + Vitamin C 1g BD
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University Hospitals of North Midlands NHS Trust
Catheter-Associated Urinary Tract Infection
Vitamin C Effectiveness in Preventing Urinary Tract Infections After Gynecological Surgeries
Double-blind placebo-controlled randomized trial aiming to assess the role of Vitamin C supplementation in the prevention of catheter-associated urinary tract infections in women undergoing elective gynecological surgeries.
- Trial name
- NCT05913180
- Testing
- Ascorbic Acid 1000 MG
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- American University of Beirut Medical Center
COVID-19
Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients
The efficacy of natural foods such as freeze-dried mare's milk (Saumal) in post-COVID syndrome therapy has not been studied. The literature review has shown that researchers have focused more on evidence-based medications and…
- Trial name
- NCT05970861
- Testing
- Freeze-dried Mare Milk (Saumal)
- Where
- Kazakhstan
- Volunteers
- 75 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Polycystic Ovary Syndrome
Oral Contraceptive and Cardiovascular Risk in PCOS
Oral contraceptive therapy is routinely used for the treatment of menstrual disturbances of patients with polycystic ovary syndrome (PCOS).
- Trial name
- NCT00593294
- Testing
- Physical exercise, OC - Drospirenone plus Ethynylestradiol, Vitamin, polyvitamins tablets
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federico II University
Peripheral Vascular Diseases
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1
The purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with…
- Trial name
- NCT04916327
- Testing
- Antioxidant
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Skin Health
The Influence of Probiotics in a Drinkable Yogurt on Skin Health
The aim of this study is to test if probiotics administered to healthy female subjects in a dairy format have any skin health benefits.
- Trial name
- NCT00864188
- Testing
- no bacterial strains, One probiotic strain - Lactobacillus paracasei NCC2461, Two standard yogurt fermenting bacterial strains - Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus
- Where
- Germany
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Overweight, Obesity
Anti-inflammatory Dietary Intervention in Overweight and Obese Adolescents
The number of overweight and obese children has increased in Ireland at a greater rate than worldwide trends. The poor eating patterns that drive adolescent obesity leads to an increase in the number of unhealthy inflammatory…
- Trial name
- NCT01665742
- Testing
- Supplement containing fish oil, vitamin C, alpha-tocopherol, green tea extract and lycopene
- Where
- 3 sites in Ireland
- Volunteers
- 58 people
- Sponsor
- University College Dublin
Ovarian Reserve
Antioxidants vs. Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve
Two group of patients were selected. Group 1 represents 46 patients that received ovarian-biostimulation monthly for three months. Group 2 represents 32 patients that received antioxidant therapy daily for 3 months.
- Trial name
- NCT03621683
- Testing
- blood rich plasma platelets, Antioxidant therapy
- Where
- Venezuela
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Lucy Coleman
Pancreatic Neoplasms
Gemcitabine, Ascorbate, Radiation Therapy for Pancreatic Cancer, Phase I
This is a phase 1 (first in man) study testing the safety of adding high dose ascorbate (vitamin C) to standard radiation and chemotherapy for treatment of pancreatic cancer.
- Trial name
- NCT01852890
- Testing
- Ascorbate, Gemcitabine, Radiation therapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Joseph J. Cullen
Hemorrhage
An Observational Cohort Study to Investigate the Risk of Thromboembolic Events in Patients Receiving Kcentra® or Plasma to Reverse Vitamin K Antagonist (VKA) Therapy in the Setting of Acute Major Bleeding
This observational cohort study is designed to obtain product safety information from the routine clinical setting within large, diverse, community-based populations.
- Trial name
- NCT02319460
- Testing
- Kcentra®, Plasma
- Where
- United States
- Volunteers
- 2,238 people
- Sponsor
- CSL Behring
Nutrient Pharmacokinetics
Vitamin Gum Pharmacokinetics
The present study will investigate the oral release and systemic pharmacokinetics of a panel water- and fat-soluble vitamins from two commercially-produced chewing gum formulations. Vitaball, Inc. (Ft.
- Trial name
- NCT03230396
- Testing
- Vitamingum Sport, Vitamingum Immunity
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Penn State University
Necator Americanus Infection
Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections
Mebendazole tablets which are produced by most pharmaceutical manufacturers, including the State Pharmaceutical Manufacturing Corporation (SPMC) of Sri Lanka, contain a mixture of polymorphs A and C.
- Trial name
- NCT01350271
- Testing
- Mebendazole polymorph A and C 500 mg, Mebendazole polymorph C
- Where
- 2 sites in Sri Lanka
- Volunteers
- 214 people
- Sponsor
- University of Kelaniya
Melasma
Efficacy of Melanostop Peeling for Improvement of Melasma
Participants with face melasma will receive 4 Melanostop peel treatments containing 20% azelaic acid, 10% resorcinol and 6% phytic acid. Peels will be performed at 2-week interval.
- Trial name
- VIMEL (NCT03826277)
- Testing
- Melanostop peel
- Where
- Slovenia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Cystic Fibrosis
Study of Docosahexanoic Acid in Patients With Cystic Fibrosis (CF)
Patients with Cystic Fibrosis have increased oxidative stress and impaired antioxidant systems. Under certain conditions, docosahexaenoic acid (DHA) intake may have a favorable role in reducing redox status.
- Trial name
- OMEGAMUCO (NCT02690857)
- Testing
- Docosahexaenoic acid, Sunflower Oil
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Gestational Weight Gain, Diet, Food, and Nutrition
Nutri-CAP: Nutrition for Children, Adolescent Girls, and Pregnant Women in Slums of Dhaka City
The objective of the research project is to establish an evidence-based sustainable nutrition service delivery platform for optimizing pregnancy weight gain, increasing dietary diversity of adolescent girls, and ensuring proper…
- Conditions
- Gestational Weight Gain, Diet, Food, and Nutrition, Undernutrition, Health Behavior
- Trial name
- NCT05311436
- Testing
- Experimental - Intensive nutrition counselling for pregnant, adolescent and under2 children
- Where
- Bangladesh
- Volunteers
- 3,278 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
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