Clinical trials: Vitamin C
Systemic Lupus Erythematosus (SLE)
Efficacy of Vitamin C Supplementation on Serum IL-6 Levels and Disease Activity in Systemic Lupus Erythematosus Patients
The study aimed to evaluate the efficacy of vitamin C supplementation compared to placebo towards IL-6 levels and disease activity with the MEX-SLEDAI score in Systemic Lupus Erythematosus (SLE) patients.
- Trial name
- NCT07071220
- Testing
- Vitamin C
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Sriwijaya
Liver Metastases
AvidinOX + [177Lu]DOTA-biotin (or 177Lu-ST2210) Complex in Patients With Liver Metastases From Colorectal Cancer
The purpose of the study is to assess a new treatment for patients with liver tumor metastases from colorectal cancer. The treatment has never been used in humans before.
- Trial name
- NCT02053324
- Testing
- AvidinOX/ST2210
- Where
- 4 sites in Austria, Italy
- Volunteers
- 14 people
- Sponsor
- Alfasigma S.p.A.
Schizophrenia, Schizophreniform Disorders
Treatment of Schizophrenia With an Omega-3 Fatty Acid (EPA) and Antioxidants
The purpose of this trial is to study the effect of adding the omega-3 fatty acid EPA and/or Vitamins E + C to antipsychotic drugs in younger patients with schizophrenia and related psychoses.
- Conditions
- Schizophrenia, Schizophreniform Disorders, Schizoaffective Disorder, Psychotic Disorders
- Trial name
- NCT00419146
- Testing
- Ethyl-eicosapentaenoic acid (EPA), Vitamins E + C
- Where
- Norway
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Hospital, Aker
Aging
The Effects of a High Protein Diet on Microbiota, Gastrointestinal Function and Wellness in Older Women
The purpose of the proposed study is to determine the effects of consuming a high protein diet on fecal microbial communities, gastrointestinal function and symptoms, and general wellness in older adults.
- Trial name
- NCT02445560
- Testing
- Probiotic capsule and Fiber Sachet
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Florida
Sepsis, Septic Shock
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
The global burden of sepsis is substantial with an estimated 15 to 19 million cases per year; the vast majority of these cases occur in low income countries.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Fluid Overload
- Trial name
- NCT03335124
- Testing
- Vitamin C, Hydrocortisone, Thiamine
- Where
- Slovenia
- Volunteers
- 5 people
- Sponsor
- University Medical Centre Ljubljana
Sepsis
Therapy With Hydrocortisone, Ascorbic Acid, Thamine in Patients With Sepsis
In this study , we suggest that the use of combination of Hydrocortisone, Ascorbic Acid, and Thiamine in patient with sepsis may decrease mortality rate and improve the outcome.
- Trial name
- NCT04160676
- Testing
- Hydrocortisone, Ascorbic acid, Thiamine, Normal saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Gastroenteritis
Emergency Department Probiotic Treatment of Pediatric Gastroenteritis
The objective of this study is to determine for previously healthy children who present to a Canadian Emergency Department (ED) with acute gastroenteritis (infection or irritation of the digestive tract); if compared with…
- Trial name
- NCT01853124
- Testing
- Lacidofil
- Where
- 6 sites in Canada
- Volunteers
- 886 people
- Sponsor
- Dr. Stephen Freedman
Stage I Multiple Myeloma, Stage II Multiple Myeloma
Arsenic Trioxide, Ascorbic Acid, Dexamethasone, and Thalidomide in Treating Patients With Multiple Myeloma
RATIONALE: Drugs used in chemotherapy, such as arsenic trioxide and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma, Refractory Plasma Cell Neoplasm
- Trial name
- NCT00112879
- Testing
- arsenic trioxide, ascorbic acid, dexamethasone
- Where
- United States
- Sponsor
- The Cleveland Clinic
Covid19, Corona Virus Infection
Study Designed to Evaluate the Effect of CimetrA in Patients Diagnosed With COVID-19
Multi-center multinational-controlled study in Israel, Brazil, Spain, and South-Africa. 240 adult patients who suffer from moderate COVID-19 infection.
- Trial name
- CimetrA (NCT05037162)
- Testing
- Biochemistry blood test, Hematology blood test, D-Dimer test (coagulation)
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- MGC Pharmaceuticals d.o.o
Hypertriglyceridemia
Vitamin C Administration and Triglycerides Level in Critical Care Patients
Vitamin C (ascorbic acid) is a water-soluble vitamin with antioxidant properties. Previous studies showed that the administration of vitamin C was associated with decreased triglyceride (TG) levels in ambulatory patients…
- Trial name
- NCT06206759
- Testing
- administration of vitamin C
- Where
- Israel
- Volunteers
- 2,000 people
- Sponsor
- Meir Medical Center
Bioavailability of Vitamin C
Comparison of Bioavailability of Liposomal and Traditional Formulation of Vitamin C
The aim of the study was to compare the profiles of vitamin C serum concentration in healthy volunteers after the single oral administration either in a liposomal or traditional formulation.
- Trial name
- NCT05843617
- Testing
- Liposomal Vitamin C, Traditional Vitamin C
- Where
- Poland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AronPharma Sp. z o. o.
Overweight, Obesity
Meta-analyses of the Effect of Liquid Meal Replacements on Cardiometabolic Risk
Obesity is a major risk factor for cardiovascular disease and diabetes. Weight loss is an important therapeutic goal for overweight and obese patients to reduce their risk of developing cardiovascular disease and diabetes.
- Conditions
- Overweight, Obesity, Type 2 Diabetes
- Trial name
- NCT02779790
- Testing
- Liquid Meal Replacements
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Pancreatic Cancer
Ph 2 Trial of Vitamin C & G-FLIP (Low Doses Gemcitabine, 5FU, Leucovorin, Irinotecan, Oxaliplatin) for Pancreatic Cancer
Pancreatic cancer, especially at advanced metastatic stage, is a devastating disease. It is the fourth leading cause of cancer death. Its prognosis is grim - 5-year survival rate being 6%.
- Trial name
- NCT01905150
- Testing
- G-FLIP, G-FLIP-DM, Vitamin C
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Bruckner Oncology
Glioblastoma, GBM
A Phase I Trial of High-Dose Ascorbate in Glioblastoma Multiforme
This is a phase 1 (first in man) study testing the safety of adding high dose ascorbate (vitamin C) to standard radiation and chemotherapy for initial treatment of glioblastoma multiforme (GBM).
- Conditions
- Glioblastoma, GBM, Glioblastoma Multiforme
- Trial name
- NCT01752491
- Testing
- Ascorbate, Temozolomide, Radiation therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Joseph J. Cullen, MD, FACS
Acute Promyelocytic Leukemia
Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia
Acute promyelocytic leukemia (APL) is a rare subtype of acute myeloid leukemia (AML) characterized by consistent clinical, morphologic, and genetic features.
- Trial name
- TUD-APOLLO-064 (NCT02688140)
- Testing
- Arsenic trioxide, Idarubicin, Cytarabine
- Where
- 8 sites in France, Germany and 3 more
- Volunteers
- 133 people
- Sponsor
- Technische Universität Dresden
Sepsis, Severe
Vitamin C, Vitamin B1 and Steroid in Sepsis
A randomized controlled trial to test the synergic modulation effect of vitamin C, thiamine and hydrocortisone in patients with severe sepsis or septic shock.
- Trial name
- NCT04039815
- Testing
- Ascorbic acid-Vitamin B1-Hydrocortisone
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Far Eastern Memorial Hospital
Stroke, Bruises
Prevention and Treatment for Bruises in Patients With Ischemic Stroke
Background Over the past few decades, significant advances have been made in the diagnosis and treatment of strokes. Most studies focus on functional recovery in stroke patients.
- Conditions
- Stroke, Bruises, Skin Lesions
- Trial name
- NCT06823999
- Testing
- Ascorbic acid (Vitamin C)
- Volunteers
- 400 people
- Sponsor
- Chiayi Christian Hospital
Hypercholesterolemia, Vitamin D Deficiency
Effects of Vitamin D on Lipids
The purpose of this study is to examine whether oral vitamin D supplementation in people with inadequate vitamin D concentrations will lower LDL-cholesterol and total cholesterol concentrations.
- Trial name
- NCT00723385
- Testing
- Vitamin D (1000 or 2000 IU/day)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Heart Failure
Does Ascorbic Acid Reduce Sympathoexcitation in CHF?
In CHF central sympathetic activity is increased. ROS formation seems to play a role in this process. This study analyzes the effect of vitamin C as an antioxidant on central sympathetic activity in CHF
- Trial name
- NCT00550121
- Testing
- vitamin C
- Where
- Netherlands
- Sponsor
- Radboud University Medical Center
Micronutrient Status
Micronutrient Dose Response Study in Bangladesh
The recommended daily amounts of vitamins and minerals, referred to as micronutrients, are based on data from high income settings and for healthy populations do not fully correct nutritional deficiencies in undernourished…
- Trial name
- MiNDR (NCT06081114)
- Testing
- Micronutrient Supplement
- Where
- Bangladesh
- Volunteers
- 643 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
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