Clinical trials: Water, completed
Dental Caries
Effectiveness of SDF With Different Post-treatment Protocols in Arresting Dental Caries
To compare the effectiveness of the semi-annual application of 38% SDF with two post-treatment protocols in arresting dental caries in preschool children
- Trial name
- NCT05655286
- Testing
- 38% SDF treatment, not to rinse for at least 30 minutes after SDF treatment, rinse mouth immediately after SDF treatment
- Where
- China
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Healthy
Dietary Influence on Serotonin in Cognitive and Emotional Functioning in Women
The purpose of this study is to determine whether a chronic dose of a tryptophan-rich protein drink (lumiVida™) can improve cognitive function, emotional processing and sleep in middle-aged women.
- Trial name
- P2B_UK (NCT02172859)
- Testing
- lumiVida™
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Periodontitis, Chronic Periodontitis (Disorder)
Photodynamic Therapy as an Adjunct to Non-Surgical Periodontal Therapy in Stage II Periodontitis
Gum disease (periodontitis) affects millions of people worldwide and can lead to tooth loss if untreated. The standard treatment is a deep cleaning procedure called non-surgical periodontal therapy (NSPT), where a dentist removes…
- Trial name
- aPDT-NSPT (NCT07609888)
- Testing
- Non-Surgical Periodontal Therapy (NSPT), Antimicrobial Photodynamic Therapy (aPDT) with Indocyanine Green and 810 nm Diode Laser
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Gulf Medical University
Rheumatoid Arthritis
Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4
Olokizumab (OKZ) has been shown to reverse the inhibitory effect of IL-6 on the activity of Cytochrome P450 (CYP450) isozymes CYP1A2, CYP2B6, CYP2C9, CYP2C19, and CYP3A4/5 in vitro.
- Trial name
- NCT04246762
- Testing
- Olokizumab, Omeprazole, Caffeine
- Where
- 2 sites in Bulgaria, Moldova
- Volunteers
- 17 people
- Sponsor
- R-Pharm International, LLC
Pain
Misoprostol Versus Uterine Striating by Bladder Filling for Pain Relief During Office Hysteroscopy
The aim of this study is to compare the effectiveness of misoprostol versus uterine straightening by bladder filling for pain relief in menopausal patients undergoing office hysteroscopy.
- Trial name
- NCT02328495
- Testing
- Misoprostol, Bladder Filling
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Cairo University
Surgery, Cardiac Disease
Self-Affirmation for Managing Anxiety and Perceived Discomfort in Open-Heart Surgery
This study adopted a randomized controlled pretest-posttest follow-up research design. The study was conducted at a public training and research hospital (Istanbul, Turkey) specialized in thoracic and cardiovascular surgery.
- Trial name
- NCT05487430
- Testing
- Positive Self-Affirmation
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- University of Vic - Central University of Catalonia
Foot Dermatoses
Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1%
The main objective of this study is to compare subject adherence and satisfaction for two modes of treatment toenails infection (Onychomycosis) with Loceryl Nail Lacquer (Loceryl NL) and a Fungal Nail Treatment Set containing…
- Trial name
- OPEN (NCT02705664)
- Testing
- Loceryl Nail Lacquer, Urea Ointment, Bifonazole Cream
- Where
- Iceland
- Volunteers
- 22 people
- Sponsor
- Galderma R&D
Health Risk Behaviors
Nitrate INFORMER Water Study
Nitrate is a controversial component of vegetables, meat, and drinking water. The now well-established benefits of nitrate, through the enterosalivary nitrate-nitrite-nitric oxide (NO) pathway, on cardiovascular risk factors and…
- Trial name
- NCT05710341
- Testing
- Water with added nitrate, Water without added nitrate
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Edith Cowan University
Urinary Tract Infections
Clinical Trial of L. Reuteri in Urinary Tract Infections in Non Pregnant Women
RCT to evaluate the safety and efficacy of Lactobacillus reuteri DSM 16666 \& Lactobacillus reuteri DSM 17938 to significantly modify the frequency of clinical or bacteriological cure in women with non complicated acute cystitis…
- Trial name
- UTIReuteri (NCT03019172)
- Testing
- Lactobacillus reuteri
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Innovacion y Desarrollo de Estrategias en Salud
Bioequivalence, Diabetes Mellitus, Type 2
Bioequivalence Study of Sitagliptin Hydrochloride / Metformin Hydrochloride Extended-release Film Coated Tablets 50 mg /500 mg (FDC) in Healthy Adult Male and Female Subjects Under Fasting Conditions.
The objective of this study was to evaluate and compare the bioavailability and therefore to assess the bioequivalence of two different formulations of sitagliptin/metformin extended release tablets after a single oral dose…
- Trial name
- NCT06124495
- Testing
- Sitagliptin/Metformin HCl 50/500 mg extended release film-coated tablet
- Where
- Mexico
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Galenicum Health
Tuberculosis
Safety and Immunogenicity of Nyaditum Resae® Probiotic to Protect From Tuberculosis
This is a double-blind, masked, compared with placebo clinical trial in healthy volunteers with or without tuberculosis infection.
- Trial name
- NCT02076139
- Testing
- Nyaditum resae® 10e4, Nyaditum resae® 10e5, Distilled water
- Where
- Spain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Manresana de Micobacteriologia, SL
Type 2 Diabetes Mellitus
Dietary Intervention Modifies Gut Microbiota in Type 2 Diabetes.
Aim: To study the effect of a dietary intervention with functional foods on gut microbiota in subjects with type 2 diabetes Materials and methods: Patients with type 2 diabetes were enrolled in a double-blind, parallel-arm…
- Trial name
- NCT03421301
- Testing
- dietary portfolio
- Volunteers
- 81 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Necator Americanus Infection
Immunisation, Treatment and Controlled Human Hookworm Infection
24 healthy volunteers will be immunized with three times 50 L3 larvae or placebo followed by treatment with albendazol and subsequently challenged with twice 50 L3 larvae.
- Trial name
- ITCHHI (NCT03702530)
- Testing
- 3x 50 L3 larvae immunisation with albendazole treatment, 2x 50 L3 larvae infection
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Dehydration in Children
Hydration Intervention in Children
The investigators are conducting this research study to determine learn how daily habits and fluid choices impact children's health, sleep, cognitive function and mood.
- Trial name
- NCT04265300
- Testing
- Creative Roots
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Neuroendocrine Tumors, Progesterone Receptor Positive Tumor
Study of Tamoxifen in Well Differentiated Neuroendocrine Tumors and Hormone Receptor Positive Expression
This is a single-arm, unicentric, single-stage clinical study of tamoxifen for patients with well differentiated neuroendocrine tumors and radiological progression with positive (> 1 percent) HR (estrogen and / or progesterone)…
- Conditions
- Neuroendocrine Tumors, Progesterone Receptor Positive Tumor, Estrogen Receptor Positive Tumor
- Trial name
- HORMONET (NCT03870399)
- Testing
- Tamoxifen
- Where
- 2 sites in United States, Brazil
- Volunteers
- 23 people
- Sponsor
- AC Camargo Cancer Center
Cervical Cancer, Oropharyngeal Cancer
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers
Background: The human papillomavirus (HPV) can cause a number of cancers, including cervical and throat cancers. The National Cancer Institute (NCI) Surgery Branch has developed an experimental therapy that involves taking white…
- Conditions
- Cervical Cancer, Oropharyngeal Cancer, Vaginal Cancer, Anal Cancer
- Trial name
- NCT01585428
- Testing
- Fludarabine, Cyclophosphamide, Young TIL
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Hookah Smoking
Effects of Hookah Smoking on Blood Flow to the Heart, Muscle and Skin
This is a pilot study on acute effects of Hookah smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking is known to transiently increase blood pressure and heart rate while decreasing heart…
- Trial name
- NCT02147665
- Testing
- Hookah smoking
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Healthy, Hyperalgesia
Positron Emission Tomography to Measure Pain and Pain Control
This study will examine how the brain processes pain signals and how the different parts of the brain work with each other in response to painful stimuli.
- Conditions
- Healthy, Hyperalgesia, Pain, Peripheral Nervous System Disease
- Trial name
- NCT00001307
- Testing
- Oxygen-15 Water, Capsaicin
- Where
- United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Abscesses, Furunculosis
The Natural History of Community-Associated MRSA Infections and Decolonization Strategies
The purpose of this study is to determine the natural history of community-associated Staphylococcus aureus infections in both adult and pediatric patients by monitoring the rate of recurrent infections in those colonized with S.
- Conditions
- Abscesses, Furunculosis, Staphylococcus Aureus, Staphylococcal Skin Infections
- Trial name
- StLStaRS (NCT00513799)
- Testing
- Mupirocin ointment, Chlorhexidine showers, Bleach baths (dilute)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Nursing Care, Oral Care
The Effect of Preoperative Oral Care Procedures on Postoperative Thirst Discomfort
Aim: To determine the effect of an oral care procedure using cold distilled water, initiated in the preoperative period, on the level of discomfort associated with thirst in patients undergoing lung resection.
- Conditions
- Nursing Care, Oral Care, Thirst, Postoperative Care
- Trial name
- NCT07913932
- Testing
- Oral Care
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Trakya University
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