Clinical trials: Water
Alcohol Use Disorder
The Efficacy of Probiotics for the Treatment of Alcohol Use Disorder Among Adult Males
This two-armed, parallel-group, double-blind, multi-center randomized control trial (RCT) aims to evaluate the efficacy of probiotic supplement compared with placebo in ameliorating alcohol craving and severity of alcohol use…
- Trial name
- NCT05830708
- Testing
- Lactobacillus sp. probiotic
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Sepsis
Study of Early Enteral Dextrose in Sepsis
This study is a prospective single-center randomized double-blinded placebo-controlled clinical trial testing the effects of early enteral dextrose as a therapeutic agent in critically ill patients with sepsis.
- Trial name
- SEEDS (NCT03454087)
- Testing
- Enteral Dextrose Infusion, Free Water Infusion
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Pittsburgh
MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis
Fructose is a Metabolic and Inflammatory Pathogenic Factor in Metabolic Dysfunction-associated Steatohepatitis (MASH)
MASLD (Metabolic dysfunction-associated steatotic liver disease) is a condition where fat builds up in the liver. It is the most common cause of liver disease worldwide.
- Conditions
- MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, Steatosis of Liver
- Trial name
- FLOURISH (NCT07013916)
- Testing
- fructose, glucose
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Obesity
Oral Glucosestimulation After Gastric Bypass Surgery
The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in morbidly obese patients after Roux-en-Y-gastric-Bypass.
- Trial name
- NCT01851616
- Testing
- 25g of glucose in 200ml tap water, given orally (plus 50 mg 13C-sodium acetate), 10g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- University Hospital, Basel, Switzerland
Effect of Irrigation Activation on Periapical Healing
Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions
The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced…
- Trial name
- NCT06204887
- Testing
- Manual dynamic activation, Passive ultrasonic activation, Laser activation
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Narcolepsy
Patient Narcoleptic Treated With BF2.649 (Pitolisant) in add-on to Sodium Oxybate (HARMONY IV)
This is a multicentric international phase III, double blind randomized study assessing efficacy and safety in parallel group of BF2.649 (pitolisant) compared to placebo in add-on to sodium oxybate of narcoleptic patients with…
- Trial name
- HARMONY IV (NCT01789398)
- Testing
- BF2.649
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Bioprojet
Cerebrovascular Accidents
Effect of Combined Therapy on Neglect Syndrome in Stroke Patients
The purpose of the current study is to evaluate motor and neglect recovery of stroke patients produced by CIT using kinematic and oculomotor assessment, together with conventional clinical measures.
- Trial name
- NCT00784706
- Testing
- EP, CIT, conventional therapy
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
COVID-19, Fatigue
Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence
The pandemic caused by SARS-CoV-2 infection has resulted, in addition to the well-known acute symptoms, in the emergence of persistent, diffuse and heterogeneous symptoms referred to as persistent COVID.
- Conditions
- COVID-19, Fatigue, Distress Respiratory Syndrome, Cognitive Dysfunction
- Trial name
- DICOPERIA (NCT05629793)
- Testing
- Experimental tests
- Where
- 7 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Menstrual Pain
Effectiveness of PEA Compared to Placebo on Acute Menstrual Pain
This is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed Palmitoylethanolamide (PEA) compared to placebo on menstrual pain in otherwise healthy participants 18 years and over.
- Trial name
- NCT05810116
- Testing
- Levagen+, Microcrystalline cellulose
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- RDC Clinical Pty Ltd
Pulmonary Fibrosis
Exhaled Breath Analysis Using eNose Technology as a Biomarker for Diagnosis and Disease Progression in Fibrotic ILD
The ILDnose study a multinational, multicenter, prospective, longitudinal study in outpatients with pulmonary fibrosis. The aim is to assess the accuracy of eNose technology as diagnostic tool for diagnosis and differentiation…
- Trial name
- ILDnose (NCT04680832)
- Testing
- Electronic nose
- Where
- 5 sites in Australia, France and 3 more
- Volunteers
- 600 people
- Sponsor
- Erasmus Medical Center
Premature Ejaculation
FTIH Study With GSK958108
This study is the first administration of GSK958108 to man. The study will evaluate the safety, tolerability and pharmacokinetics of single ascending doses of GSK958108 and evaluate the effect of food on GSK958108 pharmacokinetics
- Trial name
- NCT00664365
- Testing
- GSK958108
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Ventilator Associated Pneumonia
Oral Care Interventions and Ventilator Associated Pneumonia in Critically Ill Children
This experimental study aims to verify the influence of the oral hygiene performance with chlorhexidine digluconate 0.12% in the development of VAP in children.
- Trial name
- NCT01083407
- Testing
- 0.12% Chlorhexidine Digluconate, Toothbrushing
- Volunteers
- 146 people
- Sponsor
- Federal University of São Paulo
Refractory Granulomatous Lobular Mastitis
Surgical Intervention for Refractory Granulomatous Lobular Mastitis
Granulomatous lobular mastitis (GLM) belongs to a group of benign diseases, which is mainly treated with glucocorticoids and surgical treatment.
- Trial name
- NCT04637711
- Testing
- Focus clearing + whole breast exploration and washing + one-stage micro plastic surgery No Intervention: Extensive lesion excision
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Wuhan University
Indicated for Pelvic Radiotherapy, Vaginal Rehabilitation, and Alleviation of Late Toxic Reactions in the Vagina
Vaginal Function Exercisers and Vaginal Dilation Irrigation Drug Administration Tubes Are Used for Vaginal Rehabilitation Therapy in Pelvic Radiotherapy
Gynecological pelvic tumors primarily include ovarian cancer, cervical cancer, and endometrial cancer. Radiotherapy (RT) is one of the key treatment modalities for gynecological tumors.
- Trial name
- Exerciser (NCT07473271)
- Testing
- Vaginal exerciser and vaginal dilator with irrigation tube
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Peking Union Medical College Hospital
Electric Impedance, Pharmacokinetics
Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients
Bioelectrical impedance analysis is studied as a bedside tool to estimate capillary leak in order to guide dosing of hydrophilic antimicrobials.
- Conditions
- Electric Impedance, Pharmacokinetics, Capillary Leak Syndrome
- Trial name
- NCT03410771
- Testing
- Monitor antibiotic exposure (PK profile), Bioelectrical impedance analysis to measure body composition
- Where
- Belgium
- Volunteers
- 68 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Severe Sepsis
Extravascular Lung Water Index in Severe Sepsis
To investigate whether extravascular lung water index (EVLI) is an independent predictor for multiorgan dysfunction syndrome (MODS) in patients with severe sepsis and to determine if increased EVLI may serve as an predictor for…
- Trial name
- EVLI in sepsis (NCT00986271)
- Testing
- EVLI was determinated by PiCCO plus system.
- Volunteers
- 67 people
- Sponsor
- Chang Gung Memorial Hospital
Pharmacokinetic Study in Healthy Volunteers
Evaluation of Solanidine as an Exogenous Biomarker to Phenotype CYP2D6 Activity in Humans
This study investigates the evaluation of solanidine as an exogenous biomarker to phenotype CYP2D6-activity in humans. Participants will be classified by their CYP2D6 genotype into poor metabolizers (PM), low intermediate…
- Trial name
- SOLA-1 (NCT07817030)
- Testing
- Yohimbine, Consumption of a defined potato-rich meal
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Pharmacokinetic
Investigation How CG5503 is Taken up and Excreted From the Body After 2 Minutes Intravenous Infusion With and Without Oral Co-administration of Charcoal
This was a Phase I study in 12 healthy male participants to compare the pharmacokinetic properties of CG5503 (how it is taken up and excreted from the body) after 2 minutes intravenous (i.v.) infusion with and without oral…
- Trial name
- NCT03951987
- Testing
- 4 ml CG5503, 5 g charcoal powder
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Chronic Kidney Disease
Impact of Increased Water Intake in Chronic Kidney Disease
The investigators have designed a randomized controlled trial to test whether increased water intake slows renal decline in patients with Stage-III Chronic Kidney Disease.
- Trial name
- WIT (NCT01766687)
- Testing
- Hydration
- Where
- Canada
- Volunteers
- 822 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Dental Caries
A Study to Evaluate the Cariostatic Efficacy of Nano Silver Fluoride (NSF) vs. Silver Diamine Fluoride (SDF) in Children
This study, titled "A Randomized Controlled Trial to Evaluate the Cariostatic Efficacy of Nano Silver Fluoride (NSF) vs. Silver Diamine Fluoride (SDF) in Children" (Study Number: ATSU-YI-NSF 2025), is sponsored by Young…
- Trial name
- NCT07861321
- Testing
- Nano Silver Fluoride / NSF
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- A.T. Still University of Health Sciences
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