Clinical trials: Water
Foot Ulcer, Diabetic
A Comparison of an Investigational Dressing to Tegaderm Matrix Wound Dressing in the Management of Diabetic Foot Ulcers
The primary objective is to: Assess the effect of the Non-adherent study dressing to 3M Tegaderm Matrix Dressing with PHI technology on wound healing in patients with a diabetic foot ulcer.
- Trial name
- NCT01013792
- Testing
- Wound Dressing
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Solventum US LLC
Metastatic Melanoma, Metastatic Renal Cell Cancer
Chemotherapy Followed by ESO-1 Lymphocytes and Aldesleukin to Treat Metastatic Cancer
Background: -This study uses an experimental cancer treatment that uses the patient s own lymphocytes (type of white blood cell), which are specially selected and genetically modified to target and destroy their tumor.
- Conditions
- Metastatic Melanoma, Metastatic Renal Cell Cancer, Metastatic Cancer
- Trial name
- NCT00670748
- Testing
- Anti-NY ESO-1 T-cell receptor PBL, aldesleukin, Cyclophosphamide
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Healthy, Elderly
Pharmacokinetics of Centella Asiatica in the Elderly
This study will measure the oral bioavailability and pharmacokinetics of known bioactive compounds from a standardized Centella asiatica water extract (CAW) product (CAP) in cognitively healthy elders.
- Trial name
- NCT03929250
- Testing
- 2g Centella asiatica water extract product, 4g Centella asiatica water extract product
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Alcohol Drinking, Binge Drinking
Alcohol, Behavior, and Brain Imaging
To evaluate the relationship of extraversion to both the acute subjective and behavioral effects of alcohol, and the neural reactivity to the anticipation of reward.
- Conditions
- Alcohol Drinking, Binge Drinking, Drinking Behavior, Substance-Related Disorders
- Trial name
- (DARC) (NCT03930446)
- Testing
- Ethanol
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Breast Cancer, Sentinel Lymph Node
Pain Control for Breast Cancer Patients Receiving Injection of Radioactive Tracer
The purpose of this study is to compare the effectiveness four different pain treatments for the injection of radioactive tracer that women with breast cancer receive for sentinel lymph node biopsies.
- Conditions
- Breast Cancer, Sentinel Lymph Node, Breast Neoplasms, Breast Cancer Female
- Trial name
- NCT04822597
- Testing
- Lidocaine patch, Buzzy(R), Ice pack
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- University of Wisconsin, Madison
Healthy Volunteers
A Study of Prasugrel in Healthy Participants
The purpose of this study is to evaluate the amount of drug available in the body when given to healthy participants as two different formulations with or without a meal.
- Trial name
- NCT01648790
- Testing
- Prasugrel ODT1 - Tablet, Prasugrel ODT2 - Tablet, Prasugrel ODT2 - Suspension
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Volunteers
Bioavailability Study Comparing 10 Mg Amlodipine Besylate Orally Disintegrating Tablet (ODT) And 10 Mg Amlodipine Besylate Tablets
This study is being performed to determine the bioavailability, or extent of absorption into the body, of a 10 mg amlodipine besylate orally disintegrating tablet (ODT) as compared to the bioavailability of a 10 mg amlodipine…
- Trial name
- NCT01138826
- Testing
- Amlodipine - reference, Amlodipine ODT - test
- Where
- India
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Peripheral Artery Disease
Leg Thermotherapy for Intermittent Claudication
This study proposes to evaluate the potential of leg thermotherapy as a non-pharmacological intervention that could improve the mobility and exercise tolerance of patients with intermittent claudication.
- Trial name
- NCT02770547
- Testing
- Low Heat Thermotherapy, High Heat Thermotherapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Indiana University
Child Development
Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology
The goal of this study is to investigate the role of physical pain in the link between childhood adversity and later psychopathology.
- Trial name
- NCT06445712
- Testing
- Parental Support Cold Pressor Task
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Washington University School of Medicine
Dental Caries
Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes
The purpose of this study is to investigate the efficacy of different sodium fluoride (NaF) containing toothpastes in prevention of dental caries.
- Trial name
- NCT00708305
- Testing
- Sodium Fluoride (NaF)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Coronary Artery Disease, Myocardial Ischemia
Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent
The purpose of the study is to demonstrate that Custodiol-HTK is not inferior to cold cardioplegic solution in patients undergoing cardiovascular surgery requiring cardioplegic arrest.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- NCT01681095
- Testing
- Custodiol HTK, Cold Blood Cardioplegia
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Marc Sakwa, MD
Pediatric Obesity
Family-based Lifestyle Intervention Program and Carotenoid Supplementation for Children With Obesity
This is a pilot study of children between the ages of 8 to 11 years of age who are obese and participating in an intense family based intervention with a family-focused multi-component lifestyle intervention.
- Trial name
- NCT02060279
- Testing
- Lifestyle intervention and carotenoid supplements
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nemours Children's Clinic
Hepatic Insufficiency
A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problems
This study is open to adults aged 18 years and older. People without liver problems and people who have mild or moderate liver problems can join the study.
- Trial name
- NCT05661344
- Testing
- BI 1015550
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Lymphoma
Panobinostat (LBH589) Plus Everolimus (RAD001) in Patients With Relapsed and Refractory Lymphoma
Objectives: Primary: Determine the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of the novel combination of everolimus + Panobinostat (LBH589) in a phase-I study in patients with relapsed lymphoma (Hodgkin and…
- Trial name
- NCT00967044
- Testing
- Panobinostat, Everolimus
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
Effect of Irrigation Activation on Periapical Healing
Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions
The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced…
- Trial name
- NCT06204887
- Testing
- Manual dynamic activation, Passive ultrasonic activation, Laser activation
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Type 2 Diabetes
Moderate Alcohol Intake Among Patients With Type 2 Diabetes
Our specific aim is to explore the effect of moderate alcohol intake on parameters of glycemic index and lipid profile among patients with type 2 diabetes.
- Trial name
- NCT00295334
- Testing
- alcohol
- Volunteers
- 109 people
- Sponsor
- Iris Shai
Staphylococcal Vaccine
Safety and Efficacy of SA4Ag Vaccine in Adults Having Elective Open Posterior Spinal Fusion Procedures With Multilevel Instrumentation
The purposes of the clinical trial are to determine whether the SA4Ag vaccine can prevent postoperative Staphylococcus aureus infections in patients who are undergoing elective spinal fusion surgery, and to evaluate the safety of…
- Trial name
- STRIVE (NCT02388165)
- Testing
- Staphylococcus aureus 4-Antigen (SA4Ag) Vaccine
- Where
- 301 sites in United States, Austria and 9 more
- Volunteers
- 3,450 people
- Sponsor
- Pfizer
Anti-biotic Resistance
A Clinical Study to Evaluate if Benzalkonium Chloride (BAK) in a Quinolone Eyedrop Reduces the Likelihood of Developing Resistant Organisms
The purpose of this study is to assess if the presence of BAK in a fluoroquinolone in the study eye affects the development of resistant bacteria on the conjunctiva based upon changes in the surface flora over the course of 2…
- Trial name
- NCT00874887
- Testing
- moxifloxacin 0.5% HCI ophthalmic solution, gatifloxacin ophthalmic solution 0.3%
- Where
- 2 sites in United States, Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Allergan
Head and Neck Cancer
Trial of Induction Chemotherapy With Carboplatin and Paclitaxel, Followed by Concurrent Chemotherapy/Radiation Therapy With ZD1839 (IRESSA), 5-FU, Hydroxyurea, and Twice-Daily Radiation, Followed by Adjuvant ZD1839 Monotherapy in Patients With Locally Advanced Head & Neck Cancer
The purpose of this study is to explore the activity of ZD1839 added to concurrent chemoradiotherapy and as adjuvant monotherapy in patients with locally advanced head and neck cancer.
- Trial name
- NCT01185171
- Testing
- ZD 1839 500mg
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Chicago
Healthy
A Study in Healthy Men to Test Whether Carbamazepine Influences the Amount of Zongertinib in the Blood
The main objective of this trial is to investigate the effect of multiple oral doses of the strong CYP3A inducer carbamazepine on the pharmacokinetics of a single dose of BI 1810631 in plasma.
- Trial name
- NCT06028464
- Testing
- Zongertinib, Carbamazepine
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
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