Clinical trials: Water
Heart Defects, Congenital
Effects of Perioperative Nesiritide or Milrinone Infusion on Recovery From Fontan Surgery
The staged surgical pathway to treat children with single ventricle heart defects culminates with the Fontan operation. In this procedure, systemic venous return is rerouted directly to the pulmonary arteries, which serves to…
- Trial name
- NCT00543309
- Testing
- nesiritide, milrinone
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- John M Costello
Postmenopausal Symptoms
Pharmacokinetic Evaluation of Brisdelle™ (Formerly Known as Mesafem) Following Single & Repeat Oral Administration in Healthy Postmenopausal Women
The purpose of this study is to assess the pharmacokinetics (absorption, breakdown and elimination from the body), safety and tolerability of Brisdelle (paroxetine mesylate) Capsules 7.5 mg when given as a single dose and…
- Trial name
- N30-005 (NCT01829919)
- Testing
- Brisdelle (paroxetine mesylate)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Noven Therapeutics
Denture Cleansers
Oral and Dermal Tolerability Clinical Study of an Experimental Denture Wipe
The purpose of this two-phase study was to evaluate the oral and dermal tolerance of an experimental, non-rinse denture cleansing wipe after 7 and 14 days of use.
- Trial name
- NCT03478644
- Testing
- Experimental Denture Wipe, Tap Water
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pain
A Study of TRV130 for the Treatment of Pain After Abdominoplasty
The primary objective is to evaluate the analgesic efficacy of IV TRV130 compared with placebo in patients with acute postoperative pain following abdominoplasty.
- Trial name
- NCT02335294
- Testing
- TRV130, Morphine
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Trevena Inc.
Kerosene Pneumonitis
Antibiotic Efficacy in Pneumonitis Following Paraffin (Kerosene) Ingestion in Children
Paraffin (kerosene) ingestion in the developing world accounts for a large number of visits to healthcare facilities, especially amongst children.
- Trial name
- NCT01253980
- Testing
- Amoxicillin
- Where
- South Africa
- Volunteers
- 74 people
- Sponsor
- University of Cape Town
Healthy Adult Male
Bioequivalence Study of Brexpiprazole Orally Disintegrating Tablets (ODT) 2mg
To investigate the bioequivalence of brexpiprazole ODT 2 mg and brexpiprazole conventional tablet 2 mg
- Trial name
- NCT03902574
- Testing
- Brexpiprazole ODT 2mg with water, Brexpiprazole ODT 2mg without water, Brexpiprazole conventional tablet 2mg
- Where
- Japan
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Phantom Limb Pain
Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
When a limb is traumatically severed, pain perceived in the part of the body that no longer exists often develops. This is called "phantom limb" pain, and is different from "stump" pain, which is pain within the part of the limb…
- Trial name
- DoD-PLP-Tx (NCT01824082)
- Testing
- Perineural infusion [continuous peripheral nerve block(s)]
- Where
- 4 sites in United States
- Volunteers
- 144 people
- Sponsor
- University of California, San Diego
PreDiabetes, Neuropathy
Heat Shock Therapy to Improve Mitochondrial Function in Neuropathy
Sensory dysfunction as a result of peripheral nerve damage is a significant problem that leads to reduced quality of life for patients.
- Trial name
- HOTFUN (NCT05070741)
- Testing
- Heat Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Kansas Medical Center
Growth and Development
To Investigate the Impact of a Nutritional Supplement on Bone Turnover Markers in Indian Healthy Premenopausal Women (25- 45 Years) After 6 Months of Intervention
To investigate the effect of nutritional supplement on bone turnover markers (which are sensitive and respond quickly to nutrition or drug intervention) in Indian healthy premenopausal women after 6 months of intervention.
- Trial name
- NCT03155269
- Testing
- Fortified Beverage Powder, Non fortified beverage Powder
- Where
- India
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Ventilator-associated Pneumonia
Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates
The goal of this pilot study is to test the hypothesis that mechanically ventilated infants receiving Biotene OralBalance® gel for oral care would have a reduced intubation time compared to infants receiving oral care placebo.
- Trial name
- NCT01314742
- Testing
- Biotene OralBalance® gel, Sterile Water moisten cotton tipped applicator
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
Infections, Bacterial
To Assess Bioavailability, Food Effect and Pharmacokinetics of Gepotidacin Tablets: A Phase I, Single-Dose, 2 Part Study in Healthy Subjects.
This study is divided in 2 parts. Part 1a is being conducted to evaluate the safety, tolerability, and relative bioavailability of the 2 free base tablet formulations (roller compacted [RC] and high shear wet granulation [HSWG])…
- Trial name
- NCT02853435
- Testing
- Gepotidacin RC Tablet, Gepotidacin HSWG Tablet, Gepotidacin Capsule
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Advanced Solid Tumors, Recurrent Solid Tumors
ONO-4538 Phase I Study in Patients With Solid Tumor
The objective of the study is to investigate the pharmacokinetics of ONO-4538 administered to Korean patients with advanced or recurrent solid tumors who are refractory or intolerant to standard therapy or for whom no appropriate…
- Trial name
- NCT02261285
- Testing
- ONO-4538
- Where
- 5 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Infertility, Female
Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF
The purpose of this study is to investigate the effect of G-CSF on endometrial thickness in women who have failed reaching minimal endometrial thickness by standard treatments, to assess how many reach embryo transfer and what…
- Trial name
- NCT01202643
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Head Lice Infestation
Ovicidal Efficacy and Safety of Abametapir Lotion 0.74% Administered for the Treatment of Head Lice Infestation
The purpose of the study was to evaluate ovicidal efficacy of a single application of abametapir lotion 0.74% w/w intended for the treatment of head lice.
- Trial name
- NCT02097485
- Testing
- Abametapir Lotion 0.74% w/w, Vehicle Lotion
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Coronary Artery Disease, Atherosclerosis
Rilonacept to Improve Artery Function in Patients With Atherosclerosis
This study will determine whether an experimental drug called Rilonacept can improve artery function in patients with atherosclerosis, a disease in which fatty deposits in arteries cause the vessels to stiffen, impeding blood…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00417417
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Incontinence-associated Dermatitis
Evaluation of Skin Cleansers and Skin Protectants in Management of Incontinence-associated Dermatitis
The aim of this study is to evaluate the efficacy of two different skin care regimens (3M Cavilon Advanced Skin Protectant with 3M No-Rinse Cleanser and Coloplast Conveen Critic Barrier with Easi-Cleanser) against standard care…
- Trial name
- NCT04625426
- Testing
- 3M Cavilon No-Rinse Skin Cleanser and 3M Cavilon Advanced Skin Protectant, Conveen EasiCleanse and Conveen Critic Barrier, Standard cleansing and Conveen Critic Barrier
- Where
- Singapore
- Volunteers
- 86 people
- Sponsor
- Tan Tock Seng Hospital
Anaesthesia
Comparison Between the I-gel and the LMA-Unique
Airway management is one of the basic topics in anesthetic practice. Use of endotracheal intubation and face mask are standard methods to maintain an open airway widely adopted for many years.
- Trial name
- NCT02163486
- Testing
- Group U (UNIQUE), I-GEL
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Dokuz Eylul University
Atelectasis
Does High Intraoperative Inspired Oxygen Reduce Postoperative Arterial Oxygen Saturation?
The purpose of this study is to determine whether breathing high levels of oxygen during surgery affects oxygen levels after surgery.
- Trial name
- NCT00715741
- Testing
- FiO2 (fraction of inspired oxygen) 0.3 plus PEEP (positive end expiratory pressure) 3 -5 cm water, FiO2 0.3 without PEEP, FiO2 >0.9 with 3-5 cm water PEEP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Constipation, Post-Op Complication
Does a Preoperative Bowel Regimen Change Time to First Bowel Movement After Robotic Sacral Colpopexy
The hypothesis is that starting a bowel regimen with Polyethylene Glycol prior to robotic assisted sacrocolpopexy will decrease time to first bowel movement after surgery.
- Trial name
- NCT04197869
- Testing
- Polyethylene Glycol Powder
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Northwell Health
HIV Infections
Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine
The purpose of this study is to evaluate the safety and immune response to an HIV clade C vaccine and to an MF59- or alum-adjuvanted clade C Env protein in healthy, HIV-uninfected adults.
- Trial name
- HVTN107 (NCT03284710)
- Testing
- ALVAC-HIV (vCP2438), Bivalent Subtype C gp120/MF59, Bivalent Subtype C gp120 admixed with Al(OH)3 Suspension
- Where
- 6 sites in Mozambique, South Africa and 1 more
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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