Clinical trials: Water, completed
Peripheral Artery Disease, Diabetes Mellitus
Cocoa Flavanols and Painfree Walking Distance
To characterize potential vascular long-term effects of flavanols in patients with peripheral artery occlusive disease (PAOD), a placebo-controlled double-blinded randomized control study will be performed in 62 patients…
- Trial name
- NCT01064583
- Testing
- cocoa
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Postoperative Ileus, Caffeine
Can Coffee/Caffeine Improve Post-Operative Gastrointestinal Recovery
Disruption of the normal gastrointestinal (GI) motility is a well-known consequence of major surgery. The pathophysiology behind this phenomenon is not fully understood but involves the autonomic nervous system as well as a…
- Trial name
- NCT04547868
- Testing
- Coffee, Decaffeinated Coffee, Warm water
- Where
- 3 sites in Canada
- Volunteers
- 174 people
- Sponsor
- Sunnybrook Health Sciences Centre
Heart Failure
Dietary Supplementation in Heart Failure
A single-center, double-blind, placebo-controlled, cross-over study pilot study comparing R Drink vs. placebo in 60 heart failure patients. Half of the participants will also have diabetes mellitus.
- Trial name
- R-DRINK (NCT03980574)
- Testing
- R Drink
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ohio State University
Healthy
Dietary Influence on Serotonin in Cognitive and Emotional Functioning in Women
The purpose of this study is to determine whether a chronic dose of a tryptophan-rich protein drink (lumiVida™) can improve cognitive function, emotional processing and sleep in middle-aged women.
- Trial name
- P2B_UK (NCT02172859)
- Testing
- lumiVida™
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Dental Anxiety, Pain
Effectiveness of Hand/Eyes/Mouth Behavior Management Technique During Local Anesthesia in Preschool Children
This will be a randomized, controlled, parallel-group clinical trial. The aim of this studio will be to evaluate the effectiveness of "Hands/Eyes/mouth" behavior management technique versus a conventional technique (covering the…
- Conditions
- Dental Anxiety, Pain, Infant Behavior, Heart Rate and Rhythm Disorders
- Trial name
- NCT02591797
- Testing
- inferior alveolar and lingual nerve block procedure
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Cardenal Herrera University
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Effects of Long-lasting Bicarbonate-Sulfate-Calcium-Magnesium Water Intake on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Outcome
Background: Fonte Essenziale®, a mineral water rich in bicarbonate, sulphate, calcium, and magnesium, has shown potential in modulating the gut-liver axis and microbiota in hepatic steatosis.
- Trial name
- FonteESSEMASLD (NCT07211113)
- Testing
- Fonte Essenziale® mineral water
- Where
- Italy
- Volunteers
- 87 people
- Sponsor
- University of Campania Luigi Vanvitelli
Colon Polyp
The Colon Endoscopic Bubble Scale (CEBuS); Validation Study
Colonoscopy is currently accepted as the gold standard in screening, surveillance and prevention for colorectal cancer (CRC), and therefore, its quality is a major priority.
- Trial name
- CEBuS (NCT04378088)
- Testing
- Validation of CEBuS
- Where
- Portugal
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Healthy Volunteers
Effect of Calcium 500 mg and Vitamin D3 1000 IU Chewable Tablet on Intestinal Calcium Absorption
The purpose of this study is to demonstrate that the intestinal absorption of calcium from a novel calcium carbonate-vitamin D3 chewable tablet formulation (calcium 500 milligrams (mg) and vitamin D3 1000 International Units…
- Trial name
- NCT02338713
- Testing
- Calcichew D3, Noncarbonated Water
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Takeda
Constipation, Slow Transit Constipation
YQD Combined With Plant Lactobacillus for Slow Transit Constipation
Slow transit constipation (STC) is a common and difficult-to-treat subtype of chronic constipation, characterized by reduced colonic motility and delayed stool passage.
- Trial name
- YQD-LAC-STC (NCT07757061)
- Testing
- YQD (Yìqì Jiànpí Decoction), Plant-derived Lactobacillus, Mosapride Citrate
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First People's Hospital Of Lin'an District, Hangzhou
Healthy Volunteers, Bioequivalence Study
Bioequivalence Study of Klaribact (Clarithromycin) 500 mg, Film Coated Tablet
This is An Open Label, Randomized, Single Dose, Two Way Cross over, Two Period, Two Treatment, Two Sequence Bioequivalence Study to compare the rate and extent of absorption of Klaribact FC Tablet (Clarithromycin 500 mg) with…
- Trial name
- BE (NCT05436769)
- Testing
- Klaribact 500 mg Clarithromycin Tablet, Klaricid 500 mg Clarithromycin Tablet
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Heart Failure
New Model of Care in Heart Failure
Heart failure (HF) is characterized by high mortality, poor quality of life and frequent hospitalizations. The effectiveness of out-patient care for HF patients is unsatisfactory.
- Trial name
- AMULET (NCT03476590)
- Testing
- new model of ambulatory care with use of of non-invasive vital signs assessment and telemedicine
- Where
- Poland
- Volunteers
- 605 people
- Sponsor
- Military Institute od Medicine National Research Institute
Snakebite, Envenoming, Snake
Broad-spectrum Rapid Antidote: Varespladib IV to Oral Trial for Snakebite (BRAVIO)
This is a multicenter,randomized,double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability and efficacy of a continuous rate infusion (CRI) of IV varespladib followed by transition to the oral…
- Trial name
- BRAVIO (NCT05717062)
- Testing
- Varespladib intravenous form, varespladib-methyl- oral form
- Where
- 10 sites in United States
- Volunteers
- 140 people
- Sponsor
- Ophirex, Inc.
Spinal Cord Injury Cervical
Access-H20 Faucet for Spinal Cord Injury
The Phase I SBIR objective is to design, develop \& demonstrate feasibility of Access-H2OTM, a sensor driven smart faucet to enable and empower independent drinking and grooming for individuals impacted by spinal cord injury…
- Trial name
- NCT06159946
- Testing
- Access-H2O faucet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Old Dominion University
Pharmacokinetic Study in Healthy Volunteers
Impact of OCT1 and CYP2D6 Genotypes on Pharmacokinetics of Berberine in Healthy Volunteers
This study should investigate the differences of berberine pharmacokinetic parameters in three cohorts of healthy volunteers with distinct genotypes of the organic cation transporter 1 (OCT1) gene and the cytochrome P450 2D6…
- Trial name
- BERKI-1 (NCT05463003)
- Testing
- Berberine
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Respiratory Tract Infections
Impact of Probiotic Use on Immune Cell Function in Children
Probiotics are microorganisms that are believed to provide health benefits when consumed. The term probiotic is currently used to name ingested microorganisms associated with beneficial effects to humans and animals.
- Trial name
- NCT02687503
- Testing
- Probiotic
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of Wisconsin, Madison
Knee Osteoarthritis, Osteoarthritis
Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis
This study is designed to evaluate the effects of intra-articular injections of polyacrylamide hydrogel (Arthrosamid®) in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease of the Knee
- Trial name
- HYDRO-KNEE (NCT07193368)
- Testing
- Polyacrylamide hydrogel 2.5% intra-articular injection
- Where
- Turkey (Türkiye)
- Volunteers
- 387 people
- Sponsor
- Feza Korkusuz MD
Healthy Volunteers
3-Way Crossover Study to Compare the PK (Pharmokinetics) and to Evaluate the Effect of Food on the Bioavailability
This is a single center, Phase 1, randomized, open-label, single-dose, 3 treatment, 3-period, 6-sequence, crossover study designed to compare the PK of SMP-100 dissolved in water for oral administration with SMP-100 tablets under…
- Trial name
- NCT05029518
- Testing
- SMP-100
- Where
- Australia
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Chengdu SciMount Pharmatech Co., Ltd.
HIV
Condom Performance in a Longitudinal Enhanced Assessment of User Experiences
This study will enroll 252 men who have sex with men (MSM) and 252 men who have sex with women (MSW) in a double-blind, three-way randomized crossover trial with conditions of fitted, thin, and standard condoms.
- Trial name
- C-PLEASURE (NCT02753842)
- Testing
- 5 Fitted Condoms, 5 Thin Condoms, 5 Standard Condoms
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Global Protection Corp.
Healthy
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of PUR3100 in Health Adults
A Double Dummy, Double-blind Study to Assess the Safety, Tolerability, and Pharmacokinetics of PUR3100 in Healthy Adults
- Trial name
- NCT05351086
- Testing
- PUR3100, Dihydroergotamine (D.H.E 45)
- Where
- Australia
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Pulmatrix Inc.
Brain Cancer, Brain Tumors
Fluorescence-guided Resection of Malignant Gliomas With 5-Aminolevulinic Acid
The aim of the study "Fluorescence-guided resection of malignant gliomas with 5-Aminolevulinic acid (5-ALA) vs. conventional resection" is to determine how accurately contrast agent-accumulating tumour can be removed by primary…
- Conditions
- Brain Cancer, Brain Tumors, Cancer of Brain, Primary Brain Tumors
- Trial name
- NCT00241670
- Testing
- 5-aminolevulinic acid (5-ALA)
- Volunteers
- 415 people
- Sponsor
- medac GmbH
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