Clinical trials: Zoledronic acid
Breast Cancer
Comparison Study of Letrozole Alone or Letrozole With Zoledronic Acid in Early Breast Cancer, Neoadjuvant Therapy
This study is to measure the extent of tumor shrinkage when Letrozole and Zoledronic Acid are given before surgery to newly diagnosed post-menopausal women with early breast cancer
- Trial name
- NCT00247650
- Testing
- Zoledronic Acid; Letrozole
- Where
- 10 sites in Canada
- Volunteers
- 190 people
- Sponsor
- Novartis
HIV Infections, Osteopenia
Bisphosphonate Therapy for HIV-Infected Adults With Decreased Bone Mineral Density
Bisphosphonates are a type of drug used to prevent and treat bone loss. The purpose of this study is to determine if zoledronate, an investigational bisphosphonate, can improve bone mineral density (BMD) in HIV-infected adults.
- Conditions
- HIV Infections, Osteopenia, Osteoporosis
- Trial name
- NCT00102908
- Testing
- Zoledronate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sarcopenia in Elderly
RANKL Inhibition to Combat Sarcopenia in Hip Fracture Patients
The objective of this study is to conduct a pragmatic, randomized, double-blind, active-controlled trial to assess the efficacy of receptor activator of nuclear factor-kB ligand (RANKL) inhibition in the treatment of sarcopenia…
- Trial name
- NCT07056478
- Testing
- Denosumab (Prolia), Zoledronic acide (Aclasta)
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Metastatic Breast Cancer
Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients
to evaluate whether bone marker can provide the valuable predictor of skeletal complications and whether regular assessing of NTX(N-telopeptide of type I collagen) and osteocalcin can be useful in advanced breast cancer patients…
- Trial name
- NCT00912938
- Testing
- zoledronic acid
- Where
- South Korea
- Volunteers
- 237 people
- Sponsor
- Korean Breast Cancer Study Group
Epithelial Ovarian, Fallopian Tube
TAME: A Pilot Study of Weekly Paclitaxel, Bevacizumab, and Tumor Associated Macrophage Targeted Therapy (Zoledronic Acid) in Women With Recurrent, Platinum-resistant, Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer
This is a randomized pilot trial of weekly paclitaxel and bevacizumab with or without zoledronic acid in women with platinum-resistant epithelial ovarian cancer with 1-2 prior regimens for recurrence.
- Conditions
- Epithelial Ovarian, Fallopian Tube, Primary Peritoneal Cancer
- Trial name
- NCT05053750
- Testing
- Paclitaxel/Bev (control), Paclitaxel/Bev + ZA (experimental)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer Prostate
Study to Assess Efficacy and Safety of Zoledronic Acid and the Value of Markers of Bone Resorption in the Prediction of Bone Metastases and Cancer Treatment-induced Bone Loss (CTIBL) in Patients With Prostate Cancer on Hormone Therapy
The objective of the study is to investigate whether blood markers can be used to predict the development of bone metastases and to assess the efficacy and safety of zoledronic acid in cancer treatment induced bone loss.
- Trial name
- NCT00172055
- Testing
- Zoledronic acid
- Where
- 19 sites in Belgium
- Volunteers
- 218 people
- Sponsor
- Novartis Pharmaceuticals
Hip Fractures, Osteoporosis
A Study to Improve the Collaboration Between Primary and Secondary Health Care on the Treatment of Osteoporosis After a Hip Fracture.
This is a study to improve the collaboration between primary and secondary health care on the treatment of osteoporosis after a hip fracture.
- Conditions
- Hip Fractures, Osteoporosis, Zoledronic Acid, Ambulant Nurse
- Trial name
- NCT05904353
- Testing
- Ambulant nurse-assisted administration of zoledronic acid, Usual care
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University Hospital, Akershus
Thalassemia Majors (Beta-Thalassemia Major), Osteoporosis
Denosumab Versus Zoledronic Acid in Thalassemia-Induced Osteoporosis
This study is to compare the two medications Denosumab and Zoledronic Acid For Patients With Beta Thalassemia Major Induced Osteoporosis.
- Trial name
- DOHA (NCT03040765)
- Testing
- Denosumab 60 MG/ML Prefilled Syringe, Zoledronic Acid 5Mg/Bag 100Ml Inj
- Where
- Qatar
- Volunteers
- 17 people
- Sponsor
- Hamad Medical Corporation
Sickle Cell Disease
Phase 1 Study of Zoledronic Acid in Sickle Cell Disease
The long-term goal of this study is to learn if Zoledronic Acid can prevent or reduce pain in sickle cell disease. The goal of this study is to learn about the safety of Zoledronic Acid in persons with sickle cell disease who…
- Trial name
- NCT00639392
- Testing
- Zoledronic Acid
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Spinal Cord Injury
Zoledronic Acid in Acute Spinal Cord Injury
Maintenance of bone mass following spinal cord injury (SCI) is essential to fracture prevention and the associated morbidity of bed rest and further secondary complications.
- Trial name
- NCT01642901
- Testing
- Zoledronic acid, normal saline 0.9%
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Thomas Jefferson University
Osteoporosis
Preserving Geriatric Muscle With an Osteoporosis Medication
Our goal is to demonstrate efficacy of the novel agent Denosumab to improve or preserve muscle health, strength, mobility and function in frail older adults.
- Trial name
- NCT06118905
- Testing
- Denosumab 60 MG/ML, Zoledronic Acid 5Mg/Bag 100Ml Infusion
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Chrissy Kistler
Primary Osteoarthritis
Effect of Zoledronic Acid in Primary Knee Osteoarthritis
We try to find out the effect of zoledronic acid over pain of primary knee osteoarthritis and also functional status in a period of 6 months.
- Trial name
- NCT06051344
- Testing
- Zoledronic acid
- Where
- Bangladesh
- Volunteers
- 92 people
- Sponsor
- Toufiqe-E-Ealahi
Myeloid Leukemia, Chronic
Imatinib Mesylate and Zoledronic Acid in Patients With Chronic Myeloid Leukaemia in Cytogenetic Response Without Molecular Response
Imatinib mesylate is standard treatment of Chronic myeloid leukaemia, complete cytogenetic response is obtained in most of cases but molecular response concerned only a small part of the patients.
- Trial name
- AFR22 (NCT00210119)
- Testing
- Glivec
- Where
- 7 sites in France
- Volunteers
- 19 people
- Sponsor
- Institut Bergonié
Giant Cell Tumor of Bone
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location.
- Trial name
- NCT03295981
- Testing
- Zoledronic Acid
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Avascular Necrosis of Femoral Head
Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head
The purpose of this study is to test the effect of zoledronic acid over 2 years in preventing early collapse and progression of joint dome depression (≥ 2 mm by X-ray) of the femoral head in patients with large (> 30%: criteria…
- Trial name
- EZAPCOFH (NCT00939900)
- Testing
- zoledronic acid (aclasta)
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Seoul National University Bundang Hospital
Multiple Myeloma Bone Disease
A Study to Assess BHQ880 in Combination With Zoledronic Acid in Relapsed or Refractory Myeloma Patients
This study has two portions, a phase I portion and a phase II portion. The purpose of the phase I portion is to assess the maximum-tolerated dose (MTD) and to characterize dose limiting toxicity (DLT) of escalating doses of…
- Trial name
- NCT00741377
- Testing
- BHQ880, Zoledronic acid
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Hip Fractures, Osteoporosis
Zoledronate Early to Hip Fracture Patients - Safe and Effective?
To prevent hip fracture patients for having another fracture, secondary fracture preventing medication should be given as soon as possible.
- Trial name
- ZEBRA (NCT05025293)
- Testing
- Zoledronic Acid 5Mg/Bag 100Ml Inj, sodium chloride
- Where
- Norway
- Volunteers
- 228 people
- Sponsor
- Lene Bergendal Solberg
Osteoporosis
Study to Investigate the Efficacy and Safety After Administration of Daewoong Zoledronic Acid for the Purpose of Treatment or Prevention of Osteoporosis
This study is a non-interventional observational study. On the baseline (Visit 1), we collect demographic data from all participating subjects according to their daily medical conditions, prescribe drugs and collect validity and…
- Trial name
- NCT05614778
- Testing
- Zoledronic Acid injection, 5mg/100mL
- Where
- South Korea
- Volunteers
- 2,881 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Paget's Disease of Bone
Safety and Efficacy Trial With Zoledronic Acid for the Treatment of Paget's Disease of Bone, Including an Extended Observation Period
The primary objective of this core study was to show non-inferiority of zoledronic acid to risedronate, with respect to the proportion of patients who achieved therapeutic response.
- Trial name
- NCT00103740
- Testing
- zoledronic acid, Risedronate, Calcium and vitamin D supplements
- Where
- 41 sites in United States, Australia and 8 more
- Volunteers
- 185 people
- Sponsor
- Novartis Pharmaceuticals
Non-small Cell Lung Cancer, Bone Metastases
Screening Non Small Cell Lung Cancer With Bone Metastasis and Efficacy and Safety Research of Receiving Bisphosphonates
A multicenter Prospective Study to assess the screening methods, parameter of NTX and the efficacy and safety of zoledronic acid treatment in addition to anti-tumor therapy in patients of non-small cell cancer with bone…
- Trial name
- BLEST (NCT00765687)
- Testing
- bisphosphates
- Where
- China
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University