Clinical trials: gene expression analysis, completed
Head and Neck Cancer
DNA Analysis of Tumor Tissue Samples From Patients With Human Papilloma Virus-Associated Cancer of the Oropharynx
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897988
- Testing
- gene expression analysis, mutation analysis, polyacrylamide gel electrophoresis
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Periodontitis
Gene Expression Profiles in Chronic Periodontitis
Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis.
- Trial name
- NCT02467283
- Testing
- Genom-based whole-genome transcriptomic
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Prostate Cancer
Study of Tissue and Blood Samples From Patients With Recurrent Prostate Cancer Who Received Lapatinib on Clinical Trial ECOG-E5803
RATIONALE: Studying samples of tumor tissue and blood in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897351
- Testing
- mutation analysis, polymorphism analysis, protein expression analysis
- Volunteers
- 37 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Intestinal Infectious Diseases, Neuroinfections
Differential Diagnostics of Etiology of Acute Infections
Method for diagnostics of the origin of infections (bacterial vs viral) based on the identification of activation markers of blood neutrophils and monocytes will be developed.
- Trial name
- NCT03161951
- Volunteers
- 169 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Chronic Hepatitis C, Obesity
Microarray Analysis of IFN-Induced Gene Expression in Obese and Non-Obese Patients With Chronic Hepatitis C
The response rate to interferon-based anti-viral therapy for chronic hepatitis C is lower in patients who are obese. However, it is not clear whether this is related to suboptimal dosing of the medication or alterated response in…
- Trial name
- NCT00322179
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Palo Alto Veterans Institute for Research
Saliva, Dental Crown
Interleukin-2 (IL-2), Interleukin-5 (IL-5) and Interleukin-17 (IL-17) Levels of Patients With Stainless Steel Crowns
The aim of this study is to investigate whether nickel hypersensitivity following stainless steel crown treatment in children aged 3-9 leads to an increase in IL-2, IL-5, and IL-17 levels by analyzing saliva samples.
- Conditions
- Saliva, Dental Crown, Nickel Sensitivity
- Trial name
- NCT06439095
- Testing
- Salivary Collection, Ph and ion level measurement of saliva
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Yuzuncu Yil University
Autism Spectrum Disorder
Culturally Adapted Play-Based Behavioural Intervention for Autism
This study compared Culturally Adapted Play-Based Behavioural Intervention (PPBI) and Applied Behaviour Analysis (ABA) for children with Autism Spectrum Disorder (ASD) in semi-rural Tamil Nadu through a double-blinded randomized…
- Trial name
- NCT06859541
- Testing
- Culturally Adapted Play-Based Behavioural Intervention, Applied Behaviour Analysis
- Where
- India
- Volunteers
- 56 people
- Sponsor
- Saveetha University
Kidney Cancer
Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors
RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer.
- Trial name
- NCT01544569
- Testing
- DNA analysis, fluorescence in situ hybridization, gene expression analysis
- Volunteers
- 50 people
- Sponsor
- Children's Oncology Group
Sarcoma
Biomarker in Tumor Tissue Samples From Patients With Rhabdomyosarcoma
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01365962
- Testing
- gene expression analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Volunteers
- 60 people
- Sponsor
- Children's Oncology Group
Leukemia, Lymphoma
Gene Expression in Samples From Patients With T-Cell Acute Lymphoblastic Leukemia
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
- Trial name
- NCT01520246
- Testing
- gene expression analysis, laboratory biomarker analysis
- Volunteers
- 20 people
- Sponsor
- Children's Oncology Group
Breast Cancer
Assessment of Candidate Protein Expression in Breast Cancer Specimens
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00918892
- Testing
- gene expression analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Case Comprehensive Cancer Center
Unspecified Adult Solid Tumor, Protocol Specific
Cisplatin and Everolimus in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00423865
- Testing
- cisplatin, everolimus, gene expression analysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Leukemia
Biomarker Study of Chemotherapy Resistance and Outcomes in Samples From Older Patients With Acute Myeloid Leukemia
RATIONALE: Studying blood samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01421875
- Testing
- DNA methylation analysis, RNA analysis, gene expression analysis
- Volunteers
- 257 people
- Sponsor
- Eastern Cooperative Oncology Group
Atopic Dermatitis, Psoriasis
Analysis of Response of Subjects With Atopic Dermatitis or Psoriasis to Oral Vitamin D3
This study will examine whether administration of oral Vitamin D3 given over 21 days will change the antimicrobial peptide expression in the skin or saliva of subjects with Atopic Dermatitis (AD).
- Trial name
- NCT00789880
- Testing
- Vitamin D3
- Where
- 3 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malignant Melanoma
Vaccination With Tumor mRNA in Metastatic Melanoma - Fixed Combination Versus Individual Selection of Targeted Antigens
The purpose of the vaccination protocol is to induce specific immune responses against melanoma associated antigens by intradermal injections of mRNA coding for the corresponding antigen.
- Trial name
- NCT00204516
- Testing
- mRNA coding for melanoma associated antigens, GM-CSF
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- University Hospital Tuebingen
Leukemia, Lymphoma
Pentostatin, Cyclophosphamide, Rituximab, and Mitoxantrone in Treating Patients With Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Cancer
RATIONALE: Pentostatin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cyclophosphamide and mitoxantrone, work in different ways to stop the growth…
- Trial name
- NCT00546377
- Testing
- filgrastim, pegfilgrastim, rituximab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Biomarkers in Tissue Samples From Patients With Ductal Breast Carcinoma in Situ
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01132560
- Testing
- RNA analysis, gene expression analysis, reverse transcriptase-polymerase chain reaction
- Volunteers
- 500 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Breast Cancer
Nipple Aspiration, Ductal Lavage, and Duct Endoscopy in Screening Women at Moderate-to-High Risk of Developing Breast Cancer
RATIONALE: Screening tests, such as nipple aspiration, ductal lavage, and breast duct endoscopy, may help doctors detect cancer cells early and plan more effective treatment for breast cancer.
- Trial name
- NCT00081003
- Testing
- gene expression analysis, protein expression analysis, cytology specimen collection procedure
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Lung Cancer
Study of 18F-Fluoro-PEG6-IPQA
The goal of this clinical research study is to learn if an imaging solution called 18F-PEG6-IPQA can help to find tumors when used in positron emission tomography (PET) scans.
- Trial name
- NCT01320059
- Testing
- 18F-PEG6-IPQA, Positron emission tomography (PET)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Cancer
Gene Expression Profiles in Predicting Survival of Patients With Head and Neck Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897052
- Testing
- microarray analysis, laboratory biomarker analysis
- Volunteers
- 29 people
- Sponsor
- Vanderbilt-Ingram Cancer Center