Clinical trials: ifosfamide
Soft Tissue Sarcoma
Adriamycin and Ifosfamide Combined With Sintilimab
The aim of this study was to explore the efficacy and safety of adriamycin and ifosfamide combined with sintilimab versus chemotherapy in the treatment of advanced or unresectable soft tissue sarcoma.
- Trial name
- NCT04589754
- Testing
- Sintilimab plus chemotherapy, Adriamycin-based chemotherapy
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Sun Yat-sen University
Childhood Acute Lymphoblastic Leukemia in Remission, Recurrent Childhood Acute Lymphoblastic Leukemia
Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia
This phase II trial is studying how well combination chemotherapy with or without donor peripheral stem cell transplant works in treating children with acute lymphoblastic leukemia.
- Trial name
- NCT00022737
- Testing
- filgrastim, asparaginase, cyclophosphamide
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- National Cancer Institute (NCI)
Lymphoma
Three Different Therapy Regimens in Treating Patients With Previously Untreated Hodgkin Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving drugs in different combinations may kill more cancer cells.
- Trial name
- NCT00920153
- Testing
- bleomycin sulfate, ABVD regimen, carmustine
- Where
- France
- Volunteers
- 442 people
- Sponsor
- French Innovative Leukemia Organisation
Lymphoma
Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell or bone marrow transplantation may allow the doctor to give…
- Trial name
- NCT00006373
- Testing
- etoposide, ifosfamide, topotecan hydrochloride
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Rhabdomyosarcoma
Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy
This study will treat participants with newly diagnosed, low, intermediate and high risk rhabdomyosarcoma (RMS) using multi-modality risk-adapted therapy with standard or intensified dose chemotherapy, radiation and surgical…
- Trial name
- NCT01871766
- Testing
- Vincristine, Dactinomycin, Cyclophosphamide
- Where
- 4 sites in United States
- Volunteers
- 115 people
- Sponsor
- St. Jude Children's Research Hospital
Ovarian Cancer, Sarcoma
Chemotherapy in Treating Patients With Advanced Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002526
- Testing
- filgrastim, doxorubicin hydrochloride, ifosfamide
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Cancer Institute
Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
This phase II trial studies how well combination chemotherapy works in treating patients with newly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back…
- Conditions
- Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor, Stage II Kidney Wilms Tumor, Stage III Kidney Wilms Tumor
- Trial name
- NCT04322318
- Testing
- Biopsy Procedure, Biospecimen Collection, Bone Scan
- Where
- 205 sites in United States, Australia and 4 more
- Volunteers
- 256 people
- Sponsor
- Children's Oncology Group
Non-Hodgkin's Lymphoma, Hodgkin's Disease
Efficacy Study of Outpatient Therapy for Lymphoma
This is a Phase II trial evaluating the efficacy (overall response rate) of a risk-adjusted outpatient based approach to lymphoma salvage therapy with vinorelbine, gemcitabine and pegfilgrastim and/or gemcitabine, ifosfamide…
- Trial name
- NCT00163761
- Testing
- gemcitabine, vinorelbine, ifosfamide, filgastrim, gemcitabine, vinorelbine, filgastrim
- Where
- 10 sites in Australia
- Volunteers
- 90 people
- Sponsor
- Bayside Health
Spindle Cell Sarcoma of Bone, Osteosarcoma
European Study in Bone Sarcoma Patients Over 40 Years
The study is a first step of a process to establish the standard chemotherapy treatment with the aim to improve outcome for patients with these rare tumours. For this reason the study will be non-controlled clinical trial.
- Trial name
- EUROBOSS (NCT02986503)
- Testing
- Doxorubicin+cisplatin+ifosfamide, Doxorubicin+cisplatin+ifosfamide+methotrexate
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 100 people
- Sponsor
- Italian Sarcoma Group
Hodgkin Lymphoma
IGEV Followed by Autologous Transplantation for Refractory or Relapsed Hodgkin Lymphoma
The aim of study is to prove IGEV regimen followed by autologous stem cell transplantation as salvage treatment in patients with refractory or relapsed Hodgkin lymphoma is effective.
- Trial name
- NCT01333605
- Testing
- IGEV
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Fudan University
B-cell Lymphoma Recurrent, B-cell Lymphoma Refractory
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma
Secondary involvement of the central nervous system (CNS), such as CNS relapse after treatment or progression during treatment, is a rare but deadly occurrence in patients with B-cell non-Hodgkin lymphoma (NHL), particularly in…
- Conditions
- B-cell Lymphoma Recurrent, B-cell Lymphoma Refractory, CNS Metastases
- Trial name
- SIENA (NCT06552559)
- Testing
- Selinexor
- Where
- 2 sites in South Korea
- Volunteers
- 37 people
- Sponsor
- Samsung Medical Center
Lung Cancer
High-Dose Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003284
- Testing
- filgrastim, carboplatin, etoposide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Herbert Irving Comprehensive Cancer Center
Osteosarcoma, Survival
Comparison of MAPI+Camrelizumab Versus API+Apatinib Versus MAPI in Patients With a Poor Response to Preoperative Chemotherapy for Newly Diagnosed High-grade Osteosarcoma
Treatment strategies for high-grade osteosarcoma with multidrug chemotherapy and resection result in 3-year event-free survival of 60-70%.
- Conditions
- Osteosarcoma, Survival, Chemotherapy Effect, Toxicity, Drug
- Trial name
- MAPAC (NCT04351308)
- Testing
- MAPI chemotherapy, Apatinib Mesylate, Camrelizumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Refractory Nasopharyngeal Carcinoma
Ifosfamide and Doxorubicin in Patients With Refractory Nasopharyngeal Carcinoma
This research is to test the effectiveness and toxicity of both Ifosfamide and Doxorubicin. It also aims to explore the relationship between EBV DNA and clinical response in patients with advanced naso-pharyngeal cancer which has…
- Trial name
- NCT00484601
- Testing
- Ifosfamide, Doxorubicin
- Where
- Singapore
- Volunteers
- 9 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Carcinoma, Non-Small-Cell Lung
Phase II Study of Durvalumab ,Doxorubicin, and Ifosfamide in Pulmonary Sarcomatoid Carcinoma
To evaluate the efficacy and safety of durvalumab in combination with doxorubicin and ifosfamide in patients with PSC.
- Trial name
- NCT04224337
- Testing
- Durvalumab + doxorubicin + ifosfamide
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Seoul National University Hospital
Osteosarcoma, Ewing Sarcoma
Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma
Ewing sarcoma (EWS) and osteosarcoma primarily affect adolescents and young adults. Common treatments include chemotherapy, surgery and radiation, however, there have been few recent advancements in the standard of care.
- Trial name
- NCT07321912
- Testing
- Eflornithine, Topotecan, Cyclophosphamide
- Where
- 3 sites in United States
- Volunteers
- 406 people
- Sponsor
- Milton S. Hershey Medical Center
Osteosarcoma
A Study of Sulfatinib on Relapsed or Refractory Drug Resistant Osteosarcoma
This is a phase 1/2 study evaluating safety, tolerability, and efficacy of Sulfatinib in combination with chemotherapy (ifosfamide and etoposide) in children and adolescents with refractory or relapsed osteosarcoma ( combination…
- Trial name
- NCT05590572
- Testing
- Sulfatinib, Etoposide, Isophosphamide
- Where
- 5 sites in China, South Korea
- Volunteers
- 148 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma
Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug with surgery and/or radiation therapy may kill more tumor cells.
- Trial name
- NCT00002898
- Testing
- dactinomycin, carboplatin, cyclophosphamide
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Societe Internationale d'Oncologie Pediatrique
Sarcoma
Whole-Body Hyperthermia Plus Chemotherapy in Treating Patients With Advanced Sarcoma
RATIONALE: Hyperthermia therapy kills tumor cells by heating them to several degrees above body temperature. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00002974
- Testing
- carboplatin, etoposide, ifosfamide
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Wisconsin, Madison
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Combination Chemotherapy Following Surgery in Treating Patients With Urinary Tract Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00028860
- Testing
- filgrastim, carboplatin, gemcitabine hydrochloride
- Where
- United States
- Sponsor
- Tulane University Health Sciences Center