Clinical trials: ifosfamide
Pancreatic Cancer
Mitomycin C and Ifosfamide in Treating Patients With Metastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as mitomycin C and ifosfamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- PACT-11 (NCT00967291)
- Testing
- ifosfamide, mitomycin C
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS San Raffaele
B-cell Non-Hodgkin's Lymphoma
JS203 Combination Regimens in B-Cell Non-Hodgkin's Lymphoma
To evaluate the preliminary efficacy of JS203 combined with standard regimens in patients with B-cell Non-Hodgkin's lymphoma
- Trial name
- NCT07081022
- Testing
- JS203 in combination with gemcitabine and oxaliplatin, JS203 in combination with ifosfamide, carboplatin and etoposide, JS203 in combination with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Pleomorphic Rhabdomyosarcoma, Stage IIB Adult Soft Tissue Sarcoma AJCC v7
Sorafenib Tosylate, Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With High-Risk Stage IIB-IV Soft Tissue Sarcoma
This phase II trial studies how well sorafenib tosylate, combination chemotherapy, radiation therapy, and surgery work in treating patients with high-risk stage IIB-IV soft tissue sarcoma.
- Conditions
- Pleomorphic Rhabdomyosarcoma, Stage IIB Adult Soft Tissue Sarcoma AJCC v7, Stage III Adult Soft Tissue Sarcoma AJCC v7, Stage IV Adult Soft Tissue Sarcoma AJCC v7
- Trial name
- NCT02050919
- Testing
- Epirubicin Hydrochloride, External Beam Radiation Therapy, Ifosfamide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- OHSU Knight Cancer Institute
Recurrent Burkitt Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 Rearrangements
Testing the Addition of a New Anti-Cancer Drug, Glofitamab to Usual Chemotherapy for Burkitt and Double Hit Lymphoma
This phase II/III trial tests adding glofitamab to standard of care chemoimmunotherapy in patients with Burkitt and high grade (double hit) B- cell lymphomas that are newly diagnosed, that has come back after a period of…
- Conditions
- Recurrent Burkitt Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 Rearrangements, Refractory Burkitt Lymphoma, Refractory High Grade B-Cell Lymphoma With MYC and BCL2 Rearrangements
- Trial name
- NCT07724457
- Testing
- Biospecimen Collection, Bone Marrow Biopsy, Carboplatin
- Volunteers
- 271 people
- Sponsor
- National Cancer Institute (NCI)
Neuroblastoma
Combination Chemotherapy, Monoclonal Antibody, and Natural Killer Cells in Treating Young Patients With Recurrent or Refractory Neuroblastoma
This is a safety / feasibility trial evaluating the combination of a humanized anti-GD2 antibody (HU14.18K322A) manufactured at the Children's GMP, LLC at St.
- Trial name
- NCT01576692
- Testing
- Humanized anti-GD2 antibody, Chemotherapy, Cytokines
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- St. Jude Children's Research Hospital
Non-Hodgkin's Lymphoma, Hematopoietic Stem Cell Mobilization
Comparison Study of EAP and Disease-Specific Chemotherapy Regimens in Hematopoietic Stem Cell Mobilization for Lymphoma
This study utilizes a prospective, multicenter, randomized two-arm design to evaluate the efficacy and safety of the etoposide, cytarabine, and pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF)…
- Trial name
- NCT06520163
- Testing
- Etoposide, Cytarabine, PEG-rhG-CSF
- Where
- 17 sites in China
- Volunteers
- 99 people
- Sponsor
- The Affiliated People's Hospital of Ningbo University
Primary Central Nervous System Lymphoma
IBER Salvage Treatment Followed by Ibrutinib Maintenance for Relapsed or Refractory PCNSL
This is a multicenter, single-arm, prospective phase II study to evaluate the efficacy and safety of a novel combination regimen for relapsed/refractory PCNSL.
- Trial name
- NCT04066920
- Testing
- IBER salvage chemotherapy followed by ibrutinib maintenance therapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Deok-Hwan Yang
Cancer
Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as thrombopoietin and G-CSF may increase the number of immune cells found in…
- Trial name
- NCT00003597
- Testing
- recombinant human thrombopoietin, carboplatin, etoposide
- Where
- 24 sites in United States, Australia
- Volunteers
- 16 people
- Sponsor
- Children's Oncology Group
CIC-Rearranged Sarcoma, Metastatic Ewing Sarcoma
Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body
This phase II/III trial compares the effect of vincristine, irinotecan, and regorafenib (VIrR) in combination with vincristine, doxorubicin, cyclophosphamide (VDC), ifosfamide and etoposide (IE) to usual treatment with VDC/IE for…
- Conditions
- CIC-Rearranged Sarcoma, Metastatic Ewing Sarcoma, Metastatic High Grade Sarcoma, Metastatic Undifferentiated Round Cell Sarcoma
- Trial name
- NCT06820957
- Testing
- Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration
- Where
- 8 sites in United States
- Volunteers
- 2 people
- Sponsor
- Children's Oncology Group
Pulmonary Dysfunction
Early Pulmonary Dysfunction in Childhood Cancer Patients
This longitudinal, prospective, multicentre study is to monitor lung function prospectively in childhood cancer patients after diagnosis.
- Trial name
- SWISS-Pearl (NCT05427136)
- Testing
- Lung function measurements, Breath Analysis, Magnetic resonance imaging (MRI)
- Where
- 5 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- University Children's Hospital Basel
Diffuse Large B-cell-lymphoma
Venetoclax Plus R-ICE Chemotherapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma
The purpose of this study is to determine the correct dose and safety of adding a new cancer drug, venetoclax, to a standard combination of chemotherapy drugs as a second treatment for relapsed/refractory DLBCL.
- Trial name
- NCT03064867
- Testing
- Venetoclax, Rituximab, Ifosfamide
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- Molly Gallogly
Ovarian Cancer, Testicular Germ Cell Tumor
Combination Chemotherapy in Treating Patients With Germ Cell Tumors That Have Not Responded to Previous Cisplatin
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002559
- Testing
- filgrastim, cisplatin, ifosfamide
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sarcoma, Oral Mucositis
Evaluate PKs and Efficacy Assessment of Palifermin in Patients With Sarcoma
Primary: 1. To evaluate the preliminary efficacy of palifermin in reducing the incidence and severity of oral mucositis (OM) in patients with sarcoma receiving multicycle chemotherapy. 2.
- Trial name
- NCT00267046
- Testing
- Palifermin, Adriamycin (Doxorubicin), Ifosfamide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- M.D. Anderson Cancer Center
Diffuse Large B-cell Lymphoma
Rituximab, Ifosfamide, Carboplatin, and Etoposide (RICE) Followed by Gallium Nitrate, Rituximab and Dexamethasone (GARD) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma
The purpose of this study is to find out what effects, good and/or bad; rituximab, ifosfamide, carboplatin and etoposide (RICE) followed by gallium nitrate, rituximab and dexamethasone (GARD) have on diffuse large B cell…
- Trial name
- NCT00836173
- Testing
- RICE, GaRD Treatment
- Where
- United States
- Sponsor
- Loyola University
Leukemia, Acute Lymphoblastic
Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL)
B-precursor ALL is an aggressive malignant disease. Therapy is usually stratified according to risk characteristics to ensure that appropriate treatment is administered to patients with high-risk of relapse.
- Trial name
- NCT02393859
- Testing
- Blinatumomab, Dexamethasone, Vincrisitne
- Where
- 103 sites in Argentina, Australia and 22 more
- Volunteers
- 111 people
- Sponsor
- Amgen
Lymphoma
Concurrent Chemotherapy and Radiation Therapy for Newly Diagnosed Nasal NK Cell Lymphoma
The goal of this clinical research study is to learn if radiation therapy and chemotherapy can help control Stage 1 and/or 2 NK cell lymphoma. The safety of the radiation and chemotherapy combination will also be studied.
- Trial name
- NCT02106988
- Testing
- Radiation Therapy, Dexamethasone, Etoposide phosphate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
Nasal and Nasal-type NK/T-cell Lymphoma
Treatment of Natural Killer/T Cell Lymphoma-I/II
The purpose of this study is to evaluate the efficacy and safety of DDGP regiment (gemcitabine，pegaspargase,cisplatin,dexamethasone) for patients with newly diagnosed stage I/II Natural Killer (NK)/T Cell Lymphoma.
- Trial name
- CTTNKTL-I/II (NCT01501136)
- Testing
- DDGP(cisplatin,dexamethasone,gemcitabine,pegaspargase), VIPD（cisplatin，Etoposide，Ifosfamide， dexamethasone，Mesna）, gemcitabine,pegaspargase,cisplatin,dexamethasone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Mingzhi Zhang
Neuroblastoma
Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00017225
- Testing
- filgrastim, carboplatin, cisplatin
- Where
- 94 sites in Germany, Netherlands and 1 more
- Sponsor
- German Society for Pediatric Oncology and Hematology GPOH gGmbH
Germ Cell Tumor
High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors
This is a prospective, single-center, non-randomized phase II study. Patients with germ cell tumors of gonadal and extragonadal localization who have progressed after prior platinum-containing first-line chemotherapy will receive…
- Trial name
- GERMAN (NCT06418789)
- Testing
- High-dose chemotherapy (TI- 2 cycles, CE- 3 cycles )
- Where
- Russia
- Volunteers
- 25 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Devic's Disease
Hematopoietic Stem Cell Transplant in Devic's Disease
This study is designed to examine whether treating Devic's disease patients with high dose cyclophosphamide together with rabbit antithymocyte globulin (rATG)/rituximab (drugs which reduce the function of the immune system)…
- Trial name
- NCT00787722
- Testing
- Hematopoietic Stem Cell Transplantation, Cyclophosphamide, G-CSF
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Northwestern University