Clinical trials: immunohistochemistry staining method, completed
Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer
Decitabine, Vaccine Therapy, and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer
This phase I trial is studying the side effects and best dose of decitabine when given together with pegylated liposomal doxorubicin hydrochloride and vaccine therapy in treating patients with recurrent ovarian epithelial cancer…
- Conditions
- Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Primary Peritoneal Cavity Cancer
- Trial name
- NCT01673217
- Testing
- decitabine, NY-ESO-1 peptide vaccine, pegylated liposomal doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Roswell Park Cancer Institute
Obesity
Gastric Mucosal Mast Cells, Macrophages and Microvessels in Obesity
This comparative cross-sectional study compared tryptase-positive mast cells, CD68-positive macrophages, and CD31-positive microvessels in the gastric mucosa of 31 patients with obesity undergoing sleeve gastrectomy and 33…
- Trial name
- NCT07448896
- Testing
- Sleeve gastrectomy, Diagnostic upper gastrointestinal endoscopy with biopsy
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Cervical Cancer, Fallopian Tube Cancer
Gefitinib in Treating Patients With Cervical Cancer
RATIONALE: Biological therapies such as gefitinib may interfere with the growth of the tumor cells and slow the growth of cervical cancer.
- Conditions
- Cervical Cancer, Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00049556
- Testing
- gefitinib, immunohistochemistry staining method, surface-enhanced laser desorption/ionization-time of flight mass spectrometry
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Oral Lichen Planus, Vitamin D Deficiency
Vitamin D Deficiency As a Risk Factor for the Development and Malignant Transformation of Oral Lichen Planus
To examine how a lack of vitamin D may increase the risk of developing oral lichen planus and its malignant progression while accounting for sex, food habits, sunlight, socioeconomic level, and psychological variables.
- Trial name
- NCT06033105
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Mitochondrial Diseases, Developmental Delay Disorder
Reference Values of Intraepidermal Nerve Fiber Density in Children and Small Fiber Neuropathy in Neurodevelopmental Disorders
Background: Small-Fiber-Neuropathy describes the degeneration of mildly or unmyelinated nerve fibers and causes neuropathic pain and autonomic dysfunction.
- Conditions
- Mitochondrial Diseases, Developmental Delay Disorder, Small Fiber Neuropathy, Cerebral Palsy
- Trial name
- SFN_children (NCT05645874)
- Testing
- Skin biopsy
- Where
- Germany
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Sarcoma
Biomarker in Tumor Tissue Samples From Patients With Rhabdomyosarcoma
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01365962
- Testing
- gene expression analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Volunteers
- 60 people
- Sponsor
- Children's Oncology Group
Prostate Cancer
GM-CSF Before Surgery in Treating Patients With Localized Prostate Cancer
RATIONALE: Colony-stimulating factors, such as GM-CSF, may help the body build an effective immune response to kill tumor cells. Giving GM-CSF before surgery may be an effective treatment for localized prostate cancer.
- Trial name
- NCT00305669
- Testing
- sargramostim, immunohistochemistry staining method, immunological diagnostic method
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Soft Tissue Sarcoma
Biomarker Differences in Samples From Patients With Undifferentiated Sarcomas
This clinical trial studies biomarker differences in samples from patients with undifferentiated sarcomas. Studying biomarker in tissue samples from patients with cancer in the laboratory may help doctors identify and learn more…
- Trial name
- NCT01802125
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Children's Oncology Group
Neuroblastoma
Beta-Glucan and Monoclonal Antibody 3F8 in Treating Patients With Metastatic Neuroblastoma
RATIONALE: Beta-glucan may stimulate the immune system and stop tumor cells from growing. Monoclonal antibodies, such as 3F8, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00492167
- Testing
- beta-glucan, monoclonal antibody 3F8, immunohistochemistry staining method
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Solid Tumor
Effects of Epidermal Growth Factor Receptor Inhibitor Therapy in the Skin of Cancer Patients
RATIONALE: Studying samples of tissue and blood in the laboratory from patients with cancer receiving epidermal growth factor receptor (EGFR) inhibitors may help doctors understand the effects of EGFR inhibitor therapy in the…
- Trial name
- NCT00483457
- Testing
- enzyme inhibitor therapy, protein expression analysis, immunohistochemistry staining method
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Breast Cancer
Vorinostat in Treating Women With Ductal Carcinoma in Situ of the Breast
RATIONALE: Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This clinical trial is studying how well vorinostat works in treating women with ductal carcinoma in situ…
- Trial name
- NCT00788112
- Testing
- vorinostat, protein expression analysis, immunohistochemistry staining method
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, San Francisco
Odontogenic Cysts, Odontogenic Tumors
Evaluation of the Expression and Prognostic Role of Tumor Stem Cell Marker SOX2 in Odontogenic Cysts and Tumors
The pathogenesis of odontogenic lesions remains unclear; however, a probable explanation may involve the existence of tumor stem cells (TSCs), which are thought to generate both benign and malignant tumors.
- Trial name
- NCT06833840
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
Breast Cancer
Window of Opportunity Trial, PARP Inhibitor Rucaparib Affect on PD-L1 Expression in Triple Negative Breast Tumors
This is a single arm window of opportunity trial conducted in patients with early stage triple negative breast tumors to evaluate if treatment with a Poly(ADP-ribose) polymerase (PARP) inhibitor will increase expression of…
- Trial name
- NCT03911453
- Testing
- Rucaparib
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Head and Neck Squamous Cell Carcinoma
PBI-MST-01(NCT04541108) Substudy TAK-02: Intratumoral Microdosing of TAK-676 in HNSCC
This is a multi-center, open-label Phase 0 substudy designed to study the localized pharmacodynamics (PD) of TAK-676 alone or in combination with Carboplatin, 5-FU, or Paclitaxel within the tumor microenvironment (TME) when…
- Trial name
- NCT06062602
- Testing
- TAK-676, Carboplatin, 5-FU
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Presage Biosciences
Lip and Oral Cavity Squamous Cell Carcinoma, Oral Cavity Verrucous Carcinoma
Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions
This randomized phase II trial studies how well vandetanib works in preventing head and neck cancer in patients with precancerous head and neck lesions. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Conditions
- Lip and Oral Cavity Squamous Cell Carcinoma, Oral Cavity Verrucous Carcinoma, Precancerous Condition
- Trial name
- NCT01414426
- Testing
- vandetanib, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Thyroid Cancer
Three-pronged Centralized Molecular Analysis to Optimize Detection of NTRK1,2,3 Fusions in Thyroid Cancer
This multi-center study aims at NTRK fusion testing of all patients with advanced thyroid cancer (any histotype and regardless of stage).
- Trial name
- NTRK (NCT05796258)
- Testing
- NTRK fusion assessment
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Regina Elena Cancer Institute
Neuroblastoma
Biomarkers in Blood and Tissue Samples From Patients With Newly Diagnosed Neuroblastoma
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01387724
- Testing
- RNA analysis, polymerase chain reaction, protein expression analysis
- Volunteers
- 300 people
- Sponsor
- Children's Oncology Group
Photodamaged Skin
Effect of Topical Agents With Various Antioxidant Containts on Photodamage Skin Induced
Ultraviolet (UV) irradiation of the skin leads to acute inflammatory reactions such as erythema, sunburn, and chronic reactions, including premature skin aging and skin tumors.
- Trial name
- NCT06170346
- Testing
- Antioxidants, Vehicle
- Where
- Indonesia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Head and Neck Cancer
Biomarkers of Response in Blood and Tumor Tissue Samples From Patients With Unresectable Stage IV Squamous Cell Cancer of the Head and Neck Previously Treated With Cetuximab, Cisplatin, and Radiation Therapy
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01194635
- Testing
- fluorescence in situ hybridization, gene expression analysis, polymerase chain reaction
- Volunteers
- 69 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Chronic Myeloproliferative Disorders, Fanconi Anemia
Research Study in Healthy Volunteers of Patients With Fanconi Anemia, Myeloproliferative Disorders, or Myeloma
RATIONALE: Analyzing tissue and blood samples from healthy volunteers or patients with Fanconi anemia, myelodysplasia, myeloproliferative disorders, or myeloma in the laboratory may help doctors learn more about the causes of…
- Conditions
- Chronic Myeloproliferative Disorders, Fanconi Anemia, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00900055
- Testing
- microarray analysis, polyacrylamide gel electrophoresis, polymerase chain reaction
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute