Clinical trials: neoadjuvant therapy, completed
Pancreatic Cancer
Neoadjuvant Chemoradiation in Patients With Borderline Resectable Pancreatic Cancer
Previous reports suggest benefit of neoadjuvant chemoradiation treatment for borderline resectable pancreas cancer. This study is a multicenter prospective randomized phase II/III study of neoadjuvant chemoradiation with…
- Trial name
- NCT01458717
- Testing
- Neoadjuvant chemoradiation, Upfront surgery
- Where
- 5 sites in South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
Doxorubicin and Cyclophosphamide (AC) Followed by Weekly Docetaxel as Neoadjuvant Treatment of Breast Cancer Patients
Treatment consists of 4 AC cycles followed by 2 weekly docetaxel cycles (12 infusions). The pathological complete response rate obtained in previous studies is around 12%.
- Trial name
- NCT00129376
- Testing
- Doxorubicin, Cyclophosphamide, Docetaxel
- Where
- 6 sites in Spain
- Volunteers
- 63 people
- Sponsor
- Spanish Breast Cancer Research Group
Renal Transplantation
Safety and Efficacy Study of Rituximab in Renal Transplantation
Current strategies for the medical management of transplant patients are largely focused on the prevention and treatment of T-lymphocyte mediated processes.
- Trial name
- NCT00255593
- Testing
- rituximab
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Karolinska University Hospital
Triple Negative Breast Cancer
Induction Preoperative Chemotherapy for Patients With Locally Advanced Triple Negative Breast Cancer
The purpose of this study is to increase survival of patients with locally advanced triple-negative breast cancer using two consequent induction preoperative chemotherapy regimens.
- Trial name
- NCT01969032
- Testing
- Paclitaxel, Carboplatinum, Doxorubicin, Endoxan, Capecitabine
- Where
- Russia
- Volunteers
- 41 people
- Sponsor
- Russian Academy of Medical Sciences
Fatigue, Breast Cancer
Wide Spectrum Micronutrients Supplementation in Patients With Cancer Related Fatigue During Neoadjuvant and Adjuvant Chemotherapy
The goal of this clinical trial is to test the effect of the administration of APPORTAL® in addition to the SoC (recommended physical exercise), in patients with breast cancer, suffering from fatigue during neoadjuvant and…
- Trial name
- NCT06137833
- Testing
- APPOPRTAL®
- Where
- 5 sites in Italy
- Volunteers
- 92 people
- Sponsor
- Pharmanutra S.p.a.
Non Small Cell Lung Cancer, Lung Cancer
Phase II Lung Metcore - Preoperative Metformin for Lung Cancer
This is a phase II single centre open label single arm pre-operative window of metformin treatment in stage I-IIIa Non small cell lung cancer.
- Trial name
- Metcore (NCT03086733)
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Non-Small Cell Lung Cancer
A Study of Thymidylate Synthase Expression in Patients With Non-Small Cell Lung Cancer
Thymidylate synthase (TS) is a substance the body produces naturally. The purpose of this research is to determine if there is a link between TS production and how well patients respond to treatment of non-squamous non-small cell…
- Trial name
- NCT00887549
- Testing
- pemetrexed, cisplatin
- Where
- 14 sites in Ireland, United Kingdom
- Volunteers
- 70 people
- Sponsor
- Eli Lilly and Company
Breast Cancer
Neoadjuvant TDM1 With Lapatinib and Abraxane Compared With Trastuzumab Plus Pertuzumab With Paclitaxel
This is a randomized, open label Phase II neoadjuvant study comparing the efficacy and safety of trastuzumab emtansine (T-DM1) plus lapatinib (L)followed by abraxane (A) versus trastuzumab plus pertuzumab followed by paclitaxel…
- Trial name
- TEAL (NCT02073487)
- Testing
- T-DM1, Trastuzumab, Lapatinib
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- The Methodist Hospital Research Institute
Pancreatic Cancer, Neoadjuvant
An Exploration of Candidates for Neoadjuvant Treatment in Resectable Pancreatic Cancer
An Exploration of Candidates for Neoadjuvant Treatment in Resectable Pancreatic Cancer
- Trial name
- NCT06129812
- Testing
- Neoadjuvant treatment
- Volunteers
- 1,132 people
- Sponsor
- Seoul National University Hospital
Triple Negative Breast Neoplasms, Triple Negative Breast Cancer
Triple-negative Breast Cancer: a New Perspective on Biomarkers
A single-institutional cohort to determine the prevalence of new immunohistochemical panel in advanced triple-negative submitted to neoadjuvant chemotherapy and its association with response and survival.
- Trial name
- TNBCbrazil (NCT03539965)
- Where
- Brazil
- Volunteers
- 239 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Acute Lymphoblastic Leukemia, Hodgkin Disease
Imaging of Chemotherapy-induced Morphological and Functional Lung Changes in Childhood ALL and HD
With increasing cure rates of childhood cancer there is growing recognition of late effects of treatments. However, there is a lack of non-invasive and child-friendly procedures that can indicate possible late damage.
- Conditions
- Acute Lymphoblastic Leukemia, Hodgkin Disease, Allogeneic Stem Cell Transplantation
- Trial name
- MinimALL (NCT06093334)
- Testing
- Low-field magnetic resonance imaging, Cardiopulmonary testing, Pulmonary testing
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Resectable Pancreatic Ductal Adenocarcinoma
A Phase II Study of Neoadjuvant FOLFIRINOX
The primary objective of this study is to evaluate the rate of pathologic complete response to neoadjuvant FOLFIRINOX in patients with resectable pancreatic cancer using a tissue collection component.
- Trial name
- NCT02178709
- Testing
- FOLFIRINOX
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Indiana University
Chemotherapy-induced Peripheral Neuropathy, Breast Cancer
Symptoms Associated with Chemotherapy-Induced Peripheral Neuropathy
Breast cancer remains the most frequent type of cancer globally. Nevertheless, the increased rate of disease-free survival of breast cancer brought the specific need of managing of short and long-term side effects of multimodal…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Breast Cancer, Breast Cancer Female
- Trial name
- NCT06352567
- Testing
- European Organization for Research and Treatment of Cancer-Chemotherapy Induced Peripheral Neuropathy (EORTC-CIPN20) questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Izmir Bakircay University
Pancreatic Cancer
Evaluation of Survival Prognostic Factors for Patients With Exocrine Pancreatic Cancer Resectable or Potentially Resectable
This study aims to collect clinical, biological and quality of life data from patients with a borderline or resectable pancreatic cancer.
- Trial name
- Pancreas-CGE (NCT02818907)
- Testing
- Additional biological samples
- Where
- 8 sites in France
- Volunteers
- 290 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Colorectal Cancer, Liver Metastases
Cetuximab in Neoadjuvant Treatment of Non-Resectable Colorectal Liver Metastases (CELIM)
General Objectives: To test the feasibility of neoadjuvant treatment with cetuximab/chemotherapy followed by liver resection To determine the optimal combination (cetuximab/FOLFOX versus cetuximab/FOLFIRI) for further trials in…
- Trial name
- NCT00153998
- Testing
- Cetuximab, Liver resection, Cetuximab and FOLFIRI
- Where
- 21 sites in Austria, Germany
- Volunteers
- 135 people
- Sponsor
- Technische Universität Dresden
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
S0219, Combination Chemotherapy Followed By Observation or Surgery in Patients With Stage II or Stage III Cancer of the Urothelium
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells and decrease the need for surgery.
- Conditions
- Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer
- Trial name
- NCT00045630
- Testing
- carboplatin, gemcitabine, paclitaxel
- Where
- 128 sites in United States
- Volunteers
- 77 people
- Sponsor
- SWOG Cancer Research Network
Resectable Pancreatic Cancer
Study of Gemcitabine and Abraxane to Treat Potentially Operable Pancreatic Cancer
The main purpose of this research study is to evaluate whether Abraxane and gemcitabine are effective in treating patients with operable pancreatic cancer.
- Trial name
- NCT01298011
- Testing
- Gemcitabine and Abraxane
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Pancreatic Cancer Research Team
Bladder Cancer, Bladder Cancer Stage I
The Impact of Neoadjuvant Chemotherapy on Survival Outcomes in Patients With Variant Histologies Bladder Cancer Who Underwent Radical Cystectomy
The World Health Organization 2016 bladder tumor classification reported that the diagnosis of variant histology has increased from 6% to 33% in the last 2 decades, and there is an increasing interest in investigating the effects…
- Conditions
- Bladder Cancer, Bladder Cancer Stage I, Bladder Cancer Stage II
- Trial name
- NCT06358599
- Testing
- Cisplatin
- Where
- Turkey (Türkiye)
- Volunteers
- 221 people
- Sponsor
- Ankara Etlik City Hospital
Hematologic Neoplasms
Modified Stem Cell Transplant Procedure to Treat Patients With Blood and Immune System Cancers
This study will investigate the safety and effectiveness of a modified stem cell transplant procedure for treating cancers of the blood and immune system.
- Trial name
- NCT00051311
- Testing
- Stem cell transplantation, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Docetaxel, Doxorubicin and Cyclophosphamide Versus Vinorelbine and Capecitabine in Patients Not Sufficiently / Sufficiently Responding as Preoperative Treatment of Locally Advanced or Operable Primary Breast Cancer
Primary objective of the study in patients without a sufficient sonographic response (i.e. iNC) to 2 cycles of TAC as preoperative treatment of operable (T>/= 2cm, N0-2,M0) primary breast cancer: To determine the response rate…
- Trial name
- GeparTrio (NCT00544765)
- Testing
- TAC, NX
- Volunteers
- 2,014 people
- Sponsor
- GBG Forschungs GmbH
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