Clinical trials: neoadjuvant therapy, completed
Rectal Cancer
Advanced MR Imaging for Early Biologic Tumor Changes to Neoadjuvant Chemoradiation Treatment for Rectal Cancer
The purpose of this study is to see whether three new types of MRI techniques used during magnetic resonance imaging (MRI) of the pelvis to look at rectal cancer can help doctors to tell if the tumor is getting better in response…
- Trial name
- NCT01830582
- Testing
- Advanced MR Imaging
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Various Advanced Cancer
An Investigational Immuno-therapy Study to Investigate the Safety and Effectiveness of Nivolumab, and Nivolumab Combination Therapy in Virus-associated Tumors
The purpose of this study to investigate the safety and effectiveness of nivolumab, and nivolumab combination therapy, to treat patients who have virus-associated tumors.
- Trial name
- CheckMate358 (NCT02488759)
- Testing
- Nivolumab, Ipilimumab, Relatlimab
- Where
- 40 sites in United States, Belgium and 9 more
- Volunteers
- 578 people
- Sponsor
- Bristol-Myers Squibb
Breast Carcinoma
The Relationship Between the Density of Cancer-Associated Fibroblasts in the Peritumoral Stroma and Clinicopathological Data in Breast Cancer Patients
Research Question: Is there a relationship between the clinical prognosis and pathological data of breast cancer patients and the density of cancer-associated fibroblasts in the peritumoral stroma? Objectives of the Study: 1.
- Trial name
- PERICAFS (NCT06666517)
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines, Immunohistochemistry Analysis, Second Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Hepatocellular Carcinoma
SECOX as Neoadjuvant Therapy in Patients With Locally Advanced HCC
The purpose of this study is to evaluate the resectability after treatment with SECOX (sorafenib, capecitabine, oxaliplatin) as neoadjuvant therapy in patients with locally advanced hepatocellular carcinoma
- Trial name
- NCT03578874
- Testing
- Sorafenib, Capecitabine, Oxaliplatin
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- The University of Hong Kong
Location and Biopsy of Axillary Lymph Nodes
Targeted Biopsy of Carbon Nanoparticles Labelled Axillary Node for CN+ Breast Cancer
To explore the feasibility of target biopsy of carbon nanoparticles labelled lymph node after neoadjuvant systemic therapy for cN+ breast cancer, and evaluate whether it can accurately predict axillary lymph node status after…
- Trial name
- NCT04482803
- Testing
- Carbon nanoparticles suspension injection will be injected into or around the cortex of the clinically assessed positive lymph nodes
- Where
- China
- Volunteers
- 159 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Leukemia, Myeloid, Acute
Lenalidomide in Older Patients With Acute Myeloid Leukemia Without Chromosome 5q Abnormalities
This study is designed to test the safety and efficacy of lenalidomide in older patients (age > 60 years) with untreated acute myeloid leukemia without chromosomal abnormalities involving 5q.
- Trial name
- NCT00546897
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine
Triple-Negative Breast Cancer (TNBC)
Survival Outcomes of Residual Disease in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with a poor prognosis. Although neoadjuvant therapy improves outcomes in patients who achieve a pathological complete response, the…
- Trial name
- ReS-TNBC (NCT07714382)
- Testing
- Chemo-radiotherapy alone, Not applicable- observational study
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Prostate Cancer
Investigating the Effects of AZD2014 Therapy Given Prior to Radical Prostatectomy in Men With High Risk Prostate Cancer
Patients with localised prostate cancer can be treated by radical prostatectomy (prostate gland removal surgery) or radiotherapy.
- Trial name
- CaNCaP02 (NCT02064608)
- Testing
- AZD2014
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Breast Cancer, HER-2 Positive Breast Cancer
Primary Chemotherapy With Anthracycline Followed by Nab-paclitaxel and Trastuzumab
The purpose of this study is to evaluate the efficacy in terms of the pathological complete response (pCR) rate and the efficacy to preoperative administration of Anthracycline-based regimen followed by Nab-paclitaxel and…
- Conditions
- Breast Cancer, HER-2 Positive Breast Cancer, Effects of Chemotherapy
- Trial name
- NCT01432223
- Testing
- Nab-paclitaxel
- Where
- Japan
- Volunteers
- 46 people
- Sponsor
- Osaka Medical College
Treatment Related Cancer
FOLFIRI + Cetuximab + Avelumab RAS Wild-type CRC
Within the proposed single arm multicenter phase-II trial it is intended to investigate the feasi-bility of adding Avelumab to FOLFIRI plus Cetuximab after 4 cycles (2 months) of treatment with FOLFIRI plus Cetuximab.
- Trial name
- NCT05217069
- Testing
- 5-FU, Folinic Acid, Irinotecan
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Carcinoma, Non-Small-Cell Lung
Gemcitabine in Combination With Cisplatin as Neoadjuvant NSCLC Chemotherapy
To evaluate the clinical response rate of neoadjuvant chemotherapy with gemcitabine and cisplatin in patients with operable NSCLC
- Trial name
- NCT00191841
- Testing
- gemcitabine, Cisplatin
- Where
- 4 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Eli Lilly and Company
Breast Cancer
Chemotherapy Monitoring With Breast Computed Tomography (CT)
The purpose of this study is to determine if dedicated breast computed tomography can be used successfully to monitor tumor response in breast cancer patients undergoing neoadjuvant chemotherapy.
- Trial name
- NCT00808041
- Testing
- Dedicated breast computed tomography imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Patients With Locally Advanced Carcinoma of the Stomach and Oesophagogastric Junction
Radiomics-based Models for the Prediction of Pathological Response to Neoadjuvant Therapy in Gastric and Gastroesophageal Cancer
Identifying predictors of response to neoadjuvant therapy in gastric and gastro-oesophageal cancer early in the history of the disease would ensure optimal treatment planning.
- Trial name
- RADI-S (NCT06044961)
- Testing
- CT scan
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer
Neadjuvant Multi-agent Chemotherapy or Letrozole Plus Ribociclib in Luminal B/HER2-negative Breast Cancer.
CORALLEEN is a two-arm, randomized, multicentric study in postmenopausal women with primary HR+/HER2 negative Luminal B breast cancer that will explore if the combination of ribociclib with letrozole offers clinical benefit at…
- Trial name
- CORALLEEN (NCT03248427)
- Testing
- Ribociclib, Letrozole 2.5mg, Doxorubicin
- Where
- 21 sites in Spain
- Volunteers
- 106 people
- Sponsor
- SOLTI Breast Cancer Research Group
Gastric Cardia Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery
This phase Ib/II trial studies the side effects and best way to give pembrolizumab with combination chemotherapy and radiation therapy before surgery and to see how well it works in treating adult patients with gastroesophageal…
- Conditions
- Gastric Cardia Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Stage IB Gastric Cancer AJCC v7, Stage II Gastric Cancer AJCC v7
- Trial name
- NCT02730546
- Testing
- Carboplatin, Computed Tomography, Fluorouracil
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Mayo Clinic
Lymphoma
Bendamustine Hydrochloride and Rituximab With or Without Bortezomib Followed by Rituximab With or Without Lenalidomide in Treating Patients With High-Risk Stage II, Stage III, or Stage IV Follicular Lymphoma
RATIONALE: Drugs used in chemotherapy, such as bendamustine hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01216683
- Testing
- rituximab, Bendamustin, bortezomib
- Where
- 227 sites in United States
- Volunteers
- 289 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Breast Cancer
A Randomized, Phase 2, Neoadjuvant Study of Weekly Paclitaxel With or Without LCL161 in Patients With Triple Negative Breast Cancer
To assess whether adding LCL161 to weekly paclitaxel enhances the efficacy of paclitaxel in women with triple negative breast cancer whose tumors are positive for a defined pattern of gene expression
- Trial name
- NCT01617668
- Testing
- LCL161, paclitaxel
- Where
- 50 sites in United States, Australia and 10 more
- Volunteers
- 209 people
- Sponsor
- Novartis Pharmaceuticals
Chemotherapy Effect
Feasibility and Safety of Neoadjuvant Chemotherapy (FLOT ) for Gastric Cancer Patients in China
Neoadjuvant chemotherapy for advanced-stage gastric cancer is justified by various studies, however, there was not any large scale randomized controlled trial (RCT) to support it until German oncologist introduced a novel…
- Trial name
- NCT03646591
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Ruijin Hospital
Prostate Cancer, Non-metastatic Prostate Cancer
Comparative Health Research Outcomes of NOvel Surgery in Prostate Cancer
Men diagnosed with significant cancer confined to the prostate currently undergo radical therapy directed to the whole prostate (radiotherapy or prostatectomy).
- Conditions
- Prostate Cancer, Non-metastatic Prostate Cancer, Prostate Adenocarcinoma
- Trial name
- IP4-CHRONOS (NCT04049747)
- Testing
- Radical therapy (radiotherapy or prostatectomy [radiotherapy can be external beam or brachytherapy], Focal therapy, Focal therapy after Finasteride 5Mg tablets for 12 weeks
- Where
- 10 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Prostate Cancer
Radiotherapy of the Prostate and the Pelvic Lymph Nodes After Neoadjuvant Antihormonal Treatment
For patients with prostate cancer and a high risk of lymph node involvement or confirmed pelvic lymph node metastases, radiotherapy of the whole pelvis is a treatment option.
- Trial name
- PLATIN (NCT01903408)
- Testing
- Intensity-modulated radiotherapy of the pelvic lymph nodes using SIB
- Where
- Germany
- Volunteers
- 199 people
- Sponsor
- Heidelberg University
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