Clinical trials: pharmacological study, completed
Rheumatoid Arthritis
An Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients Completing Treatment in Tocilizumab Core Studies
This single-arm study evaluated the long-term efficacy and safety of tocilizumab in participants who had completed treatment in the tocilizumab core studies (NCT00106522 [Roche protocol WA18062], NCT00106574 [Roche protocol…
- Trial name
- NCT00720798
- Testing
- Tocilizumab, Disease-modifying anti-rheumatic drugs, Non-steroidal anti-inflammatory drugs
- Where
- 295 sites in United States, Argentina and 32 more
- Volunteers
- 2,067 people
- Sponsor
- Hoffmann-La Roche
Healthy Volunteers
A Study to Evaluate Effects of CC-99677 on the Pharmacokinetics of an Oral Contraceptive in Healthy Female Participants
The purpose of this study is to evaluate the effect of CC-99677 coadministration on the pharmacokinetics (PK) of an oral contraceptive (OC).
- Trial name
- NCT04718636
- Testing
- Oral Contraceptive (Ortho Tri-Cyclen or its generic equivalent), CC-99677
- Where
- 3 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Celgene
Mild Cognitive Impairment
Filipino Multicomponent Intervention to Maintain Cognitive Performance in High Risk Population (FINOMAIN)
FINOMAIN is a community-based, cluster randomized controlled trial (cRCT) of dance intervention INDAK and standardized vascular care.
- Trial name
- FINOMAIN (NCT04301544)
- Testing
- INDAK (Improving Neurocognition through Dance and Kinesthetics), Nutrition Counseling, Standardized Vascular Care
- Where
- Philippines
- Volunteers
- 72 people
- Sponsor
- St. Luke's Medical Center, Philippines
Procedural Pain, Procedural Anxiety
Effects of Rain Stick and Musical Egg on Pain, Fear and Anxiety
This research will be conducted in a pre-test-post-test parallel group randomized controlled experimental study model to determine the effects of rain stick and musical egg applied during blood collection on pain, fear and…
- Conditions
- Procedural Pain, Procedural Anxiety, Fear Needles
- Trial name
- NCT06983093
- Testing
- Rain Stick, Musical Egg
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hakkari Universitesi
Contraception
EC PK in Women With Normal and Obese BMI
A well-designed pharmacokinetics (PK) study may identify the physiologic basis for observed differences in levonorgestrel emergency contraception (LNG-EC) and ulipristal acetate emergency contraception (UPA-EC) failure rates in…
- Trial name
- NCT02689804
- Testing
- LNG-EC, UPA-EC
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Columbia University
TBI (Traumatic Brain Injury)
Pharmacological Intervention in Depression After Traumatic Brain Injury
The purpose of this study is to determine if treatment with venlafaxine reduces symptoms of depression in persons with traumatic brain injury.
- Trial name
- NCT00205491
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer
R-(-)-Gossypol Acetic Acid in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer
This phase II trial is studying how well R-(-)-gossypol acetic acid works in treating patients with recurrent extensive-stage small cell lung cancer.
- Trial name
- NCT00773955
- Testing
- R-(-)-gossypol acetic acid, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Non Epileptic Seizures, Functional Neurological Symptom Disorder
Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures
The objective of this study is to determine the effects of the ketogenic diet on the frequency of non-epileptic seizures in patients with functional neurological symptoms disorder compared to a healthy diet.
- Conditions
- Non Epileptic Seizures, Functional Neurological Symptom Disorder, Conversion Disorder, Ketogenic Dieting
- Trial name
- NCT05219006
- Testing
- ketogenic dieting, healthy dieting
- Where
- Mexico
- Volunteers
- 17 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm
PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of PI3Kbeta inhibitor AZD8186 when given together with docetaxel in treating patients with solid tumors with PTEN or PIK3CB mutations that have spread to other places in…
- Conditions
- Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Prostate Carcinoma, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT03218826
- Testing
- Docetaxel, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 8 sites in United States
- Volunteers
- 23 people
- Sponsor
- National Cancer Institute (NCI)
Polymyalgia Rheumatica
A Study to Evaluate the Efficacy of Tocilizumab as a Remission-Induction and Glucocorticoid-Sparing Regimen in Subjects With New-Onset Polymyalgia Rheumatica (PMR- SPARE)
The purpose of this study is to assess the efficacy of a tocilizumab-based regimen compared with placebo on top of rapidly tapered glucocorticoid treatment in a double- blind, controlled fashion, focussing on glucocorticoid-free…
- Trial name
- NCT03263715
- Testing
- Tocilizumab Prefilled Syringe [Actemra], Glucocorticoids
- Where
- 3 sites in Austria
- Volunteers
- 39 people
- Sponsor
- Medical University of Vienna
Adult Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm
Azacitidine and Oxaliplatin In Treating Patients With Advanced Cancers Relapsed or Refractory to Any Platinum Therapy
This phase I clinical trial studies the side effects and the best dose of azacitidine and oxaliplatin in treating patients with advanced cancers that do not respond to treatment or have returned after any platinum therapy.
- Trial name
- NCT01039155
- Testing
- Azacitidine, Laboratory Biomarker Analysis, Oxaliplatin
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Cancer Institute (NCI)
Gliosarcoma, Recurrent Glioblastoma
NU-0129 in Treating Patients With Recurrent Glioblastoma or Gliosarcoma Undergoing Surgery
The purpose of this research study is to evaluate the safety of the study drug, NU-0129, based on Spherical Nucleic Acid (SNA) platform when infused in patients with recurrent glioblastoma multiforme or gliosarcoma.
- Trial name
- NCT03020017
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Targeted Molecular Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Northwestern University
Hematuria, Bladder Cancer
A Trial of a Modified Cystoscopy Method to Reduce Pain Perception
The goal of this project is to improve patient experience of cystoscopy using a non-pharmacologic modification of procedure. Cystoscopy is a common outpatient procedure for urology patients and is usually performed without…
- Conditions
- Hematuria, Bladder Cancer, Bladder Disease
- Trial name
- NCT03257293
- Testing
- Modified Cystoscopy, Routine Cystoscopy
- Where
- Canada
- Volunteers
- 93 people
- Sponsor
- Western University, Canada
Recurrent Osteosarcoma
Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma
This phase II trial studies how well eribulin mesylate works in treating patients with osteosarcoma that has come back after treatment (recurrent) or has not responded to treatment (refractory).
- Trial name
- NCT02097238
- Testing
- Eribulin Mesylate, Pharmacological Study
- Where
- 119 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
Patients With Severe Chronic Kidney Disease Being Evaluated With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson
Attenuation of the Side Effect Profile of Regadenoson: Study With Aminophylline in Patients With Severe Kidney Disease Undergoing Myocardial Perfusion Imaging
The routine administration of 75 mg of intravenous aminophylline in patients with severe chronic kidney disease undergoing a nuclear stress test with regadenoson (Lexiscan®) can reduce or eliminate the incidence of diarrhea and…
- Trial name
- ASSUAGE-CKD (NCT01336140)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Rush University Medical Center
Substance Abuse, Anxiety
Auricular Acupuncture in Substance Abuse: Effects on Anxiety, Sleep, Drug Use.
Background. A common alternative treatment for substance abuse is ear acupuncture. The aim of the study was to evaluate the short and long-term effect of auricular acupuncture on anxiety, sleep, drug use and addiction treatment…
- Conditions
- Substance Abuse, Anxiety, Sleep
- Trial name
- NCT02604706
- Testing
- NADA Acupuncture, LP acupuncture, Relaxation
- Where
- Sweden
- Volunteers
- 280 people
- Sponsor
- Örebro Läns Landsting
Hypercholesterolaemia
An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia
Primary Objective: To evaluate the effect of alirocumab on low-density lipoprotein cholesterol (LDL-C) levels after 8 weeks of treatment in heterozygous familial hypercholesterolemia (heFH) participants aged of 8 to 17 years…
- Trial name
- ODYSSEY KIDS (NCT02890992)
- Testing
- alirocumab SAR236553 (REGN727), statins, ezetimibe
- Where
- 16 sites in United States, Canada and 8 more
- Volunteers
- 42 people
- Sponsor
- Sanofi
Glaucoma, Ocular Hypertension
Safety and Efficacy Study of Brimonidine/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension
This study evaluates the safety and efficacy of brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution compared with concurrent brimonidine 0.2% and timolol ophthalmic solutions
- Trial name
- NCT00652106
- Testing
- 0.2% brimonidine/0.5% timolol fixed combination ophthalmic solution, Concurrent brimonidine 0.2% and Timolol 0.5% ophthalmic solution, Brimonidine 0.2% ophthalmic solution
- Where
- United States
- Volunteers
- 432 people
- Sponsor
- Allergan
Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma
Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma
This phase I/II trial studies the side effects and best dose of panobinostat and everolimus when given together and to see how well they work in treating patients with multiple myeloma, non-Hodgkin lymphoma, or Hodgkin lymphoma…
- Conditions
- Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, B-cell Adult Acute Lymphoblastic Leukemia
- Trial name
- NCT00918333
- Testing
- panobinostat, everolimus, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 124 people
- Sponsor
- Mayo Clinic
Macular Hole, Retinal Detachment
Effect of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy
The purpose of this study is to see if glaucoma eye drops (dorzolamide-timolol) have any effect on the duration of an intraocular gas bubble following pars plana vitrectomy.
- Trial name
- NCT01257698
- Testing
- Dorzolamide 2%-timolol 0.5% topical eyedrops
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mid Atlantic Retina
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.