Clinical trials: pharmacological study, completed
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Corpus Uteri, Lung Cancer
Aerosolized Liposomal Camptothecin in Patients With Metastatic or Recurrent Cancer of the Endometrium or the Lung
To determine the concentration of 9-nitrocamptothecin (9NC) in the alveolar fluid over time. 1.2. To determine the arterial concentration of 9NC administered by inhalation in comparison to venous and urine concentrations. 1.3.
- Trial name
- NCT00277082
- Testing
- 9-NC in aerosol reservoir
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of New Mexico
Inflammatory Bowel Disease
Study Assessing Risk Factors for Abdominal Pain in Children With Inflammatory Bowel Disease
To characterize persistent abdominal pain in children with inflammatory bowel disease (IBD) by examining factors such as disease type, activity and location, psychosocial factors, and genetics.
- Trial name
- NCT02984059
- Testing
- Genomic DNA, RNA analysis, Microbiome
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Connecticut Children's Medical Center
Breast Cancer, Chemotherapy-Induced Peripheral Neuropathy
TENS, Compression, and Cryotherapy for Paclitaxel-Induced Peripheral Neuropathy in Women With Breast Cancer
This single-center, four-arm, parallel-group randomized controlled trial evaluates transcutaneous electrical nerve stimulation (TENS), compression, and cryotherapy for the management of chemotherapy-induced peripheral neuropathy…
- Trial name
- NCT07817979
- Testing
- Transcutaneous Electrical Nerve Stimulation, Cryotherapy, Compression Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Cumhuriyet University
Type 2 Diabetes
Necessity for Lipid Lowering Therapy in Type 2 Diabetes Patients
Purpose: To assess prior need for lipid lowering therapy in patients with type 2 diabetes. Background/Hypothesis: At present, lipid lowering therapy, usually with a HMG-CoA reductase inhibitor or "statin", is recommended therapy…
- Trial name
- NCT00639080
- Testing
- Stop lipid lowering therapy (statin)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Endocrine Research Society
Unspecified Adult Solid Tumor, Protocol Specific
SB939 in Treating Patients With Locally Advanced or Metastatic Solid Tumors
RATIONALE: SB939 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying the side effects and best dose of SB939 in treating patients with locally…
- Trial name
- NCT00504296
- Testing
- HDAC inhibitor SB939, immunoenzyme technique, immunohistochemistry staining method
- Where
- 2 sites in Canada
- Volunteers
- 39 people
- Sponsor
- NCIC Clinical Trials Group
Metastatic Osteosarcoma, Recurrent Osteosarcoma
Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma
This phase II trial studies how well denosumab works in treating patients with osteosarcoma that has come back (recurrent) or does not respond to treatment (refractory).
- Conditions
- Metastatic Osteosarcoma, Recurrent Osteosarcoma, Refractory Osteosarcoma, Stage IV Osteosarcoma AJCC v7
- Trial name
- NCT02470091
- Testing
- Denosumab, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 141 sites in United States, Canada and 1 more
- Volunteers
- 56 people
- Sponsor
- Children's Oncology Group
Frailty
Designing a Multicomponent Intervention for Improving Frailty. A Pilot Study in the Basque Country
This pilot study tested whether a new program for older adults with frailty could realistically be carried out in primary health care.
- Trial name
- NCT07637890
- Testing
- Multi-component intervention: physical exercise, polypharmacy review and nutritional care
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Biogipuzkoa Health Research Institute
Upper Airway Obstruction
Phamacological Reversal of Airway Instability During Sedation
The investigators are attempting to demonstrate a decrease in the frequency and severity of sedation-induced respiratory arrhythmias(central and obstructive apneas) with pharmacological pre-treatment in this pilot project and…
- Trial name
- PHYSO (NCT01171118)
- Testing
- Physostigmine, Oxygen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Brain and Central Nervous System Tumors
Epothilone ZK-219477 in Treating Patients With Recurrent Glioblastoma
RATIONALE: Drugs used in chemotherapy, such as epothilone ZK-219477, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00424060
- Testing
- sagopilone, fluorescence in situ hybridization, gene expression analysis
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Medication Adherence
Improving Adherence to Pharmacological Treatment
The overall goal of this study was to implement and evaluate the effects of a systems-based and pharmacist-mediated program designed to improve adherence for patients with known coronary heart disease (CHD) to lipid-lowering…
- Trial name
- PACT (NCT00848224)
- Testing
- systems-based and pharmacist-mediated program
- Where
- United States
- Volunteers
- 689 people
- Sponsor
- University of Massachusetts, Worcester
Advanced Malignant Solid Neoplasm, Hepatocellular Carcinoma
Viral Therapy in Treating Patient With Refractory Liver Cancer or Advanced Solid Tumors
This phase I trial studies the best dose and side effects of recombinant vesicular stomatitis virus expressing interferon beta in treating patients with liver cancer or solid tumors with lesions that have spread to other parts of…
- Trial name
- NCT01628640
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Colorectal Cancer, Refractory Colorectal Cancer
Fruquintinib in Refractory Metastatic Colorectal Cancer: A Real-world Study
Fruquintinib is an oral tyrosine kinase inhibitor (TKI), which improves progression-free survival (PFS) and overall survival (OS) in patients with refractory metastatic colorectal cancer (mCRC).
- Conditions
- Colorectal Cancer, Refractory Colorectal Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT06202417
- Testing
- Fruquintinib
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Fudan University
Neoplasms, Cancer
Study of VGX-100 Administered Alone and Co-administered With Bevacizumab in Adult Subjects With Advanced Solid Tumors
This is a non-randomized, multi-dose, first-in-human, multicenter, two arm (Arm A: VGX-100 alone; Arm B: VGX-100 co-administered with bevacizumab), open label, dose escalation study in subjects with advanced or metastatic solid…
- Trial name
- NCT01514123
- Testing
- VGX-100, Bevacizumab
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Circadian Technologies Ltd.
Gambling, Pathological
Computer-based Training (Retraining) for People With Gambling Problems
The study examines the efficacy and acceptance of a computer-based training program for individuals with problematic or pathological gambling behavior.
- Trial name
- Retraining (NCT03460288)
- Testing
- Retraining (AAT)
- Where
- Germany
- Volunteers
- 141 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Rheumatoid Arthritis
A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants
This open-label, single arm, Phase 3b study will evaluate the efficacy of tocilizumab (RoActemra), administered as monotherapy or in combination with methotrexate and/or other DMARDs, in participants with moderate to severe…
- Trial name
- NCT01941940
- Testing
- Tocilizumab, DMARDs
- Where
- 49 sites in Italy
- Volunteers
- 227 people
- Sponsor
- Hoffmann-La Roche
Glaucoma, Ocular Hypertension
Efficacy and Tolerability of Xalatan in Patients
Efficacy data was not collected or analyzed. This study did assess safety and tolerability of Xalatan.
- Trial name
- A6111128 (NCT00950690)
- Testing
- Xalatan 0.005% eye drops
- Where
- 3 sites in Egypt, Saudi Arabia and 1 more
- Volunteers
- 1,289 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Postmenopausal Symptoms, Aging
Cholinergic Health After Menopause (CHAMP)
Women are at increased risk for Alzheimer's disease (AD). Notably at menopause, some women experience a change in cognition. However, not all women experience negative effects of menopause on cognition.
- Conditions
- Postmenopausal Symptoms, Aging, Alzheimer Disease
- Trial name
- CHAMP (NCT04129060)
- Testing
- Cholinergic antagonist
- Where
- 2 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma
STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain
This phase I trial studies the side effects and best dose of STAT3 inhibitor WP1066 in treating patients with malignant glioma that has come back or melanoma that has spread to the brain and is growing, spreading, or getting…
- Conditions
- Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Recurrent Brain Neoplasm, Recurrent Glioblastoma
- Trial name
- NCT01904123
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, STAT3 Inhibitor WP1066
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Coronary Artery Disease
Active Detection of the Extension of Atherothrombosis in High Risk Coronary Patients
Coronary artery disease is the first cause of death related to atherothrombosis.
- Trial name
- AMERICA (NCT00445835)
- Testing
- Arterial doppler for screening asymptomatic and significant extracoronary arterial stenoses in all arterial beds, Conservative arm
- Where
- France
- Volunteers
- 526 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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