Clinical trials: pharmacological study, completed
Cognitively Normal Older Adults, Hypertension
Risk Reduction for Alzheimer's Disease
Physical inactivity, high blood pressure and dyslipidemia are risk factors for Alzheimer's disease (AD) and vascular dementia. Importantly, these risk factors are modifiable with lifestyle changes, pharmacological treatment, or…
- Conditions
- Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Alzheimer's Disease
- Trial name
- rrAD (NCT02913664)
- Testing
- Angiotensin II receptor blocker (ARB, losartan) and calcium channel blocker (CCB, amlodipine), Aerobic Exercise Training, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 513 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Neoplasm
Regional Anesthesia and Partial Mastectomy
Pectoralis nerves plane block (PECS) first described by Blanco in 2011 has become part of postoperative pain management in breast surgery, thoracic surgery and thoracic trauma.
- Trial name
- NCT04824599
- Testing
- PECS II, Local anesthetic infiltration, Subcutaneus local anesthetic infiltration
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karlstad Central Hospital
Alpha1-Antitrypsin Deficiency
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency
The purpose of this study is to evaluate the safety and tolerability of 72 milligrams per kilogram (mg/kg) and 180 mg/kg Alpha-1 15%, administered as a single-dose subcutaneous (SC) infusion and subsequently as weekly SC…
- Trial name
- NCT04722887
- Testing
- Alpha-1 15%, Liquid Alpha1-Proteinase Inhibitor (Human)
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- Grifols Therapeutics LLC
Primary Dysmenorrhea
Primary Dysmenorrhea and Mobilization.
72 women diagnosed with primary dysmenorrhea were included in the study and divided into four groups. the first group received treatment with a mobilization approach, the second group received motor imagery-focused exercises and…
- Trial name
- NCT07314021
- Testing
- FEMOB, MOPEXE, Conventional Treatment group
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medipol University
Child Malnutrition, Malnutrition in Children
Emollient Therapy for Severe Acute Malnutrition
The investigators hypothesize that the absorption of topically applied EFA-containing emollient (SSO) into the skin and thence into the bloodstream in children with SAM will improve skin barrier function and accelerate weight…
- Conditions
- Child Malnutrition, Malnutrition in Children, Malnutrition
- Trial name
- NCT02616289
- Testing
- Topical emollient (Sun Flower seed oil)
- Where
- Bangladesh
- Volunteers
- 212 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Allergic Conjunctivitis
Evaluation of Efficacy of Ophthalmic Solution in Seasonal Allergic Conjunctivitis
The purpose of this summary is to evaluate the efficacy and safety of R89674 0.025% ophthalmic solution compared with placebo or an active control in subjects with seasonal allergic conjunctivitis
- Trial name
- NCT00364091
- Testing
- R89674 0.025% ophthalmic solution
- Where
- 6 sites in United States
- Volunteers
- 365 people
- Sponsor
- Vistakon Pharmaceuticals
Advanced Breast Cancer
Study of Efficacy and Safety of LEE011 in Men and Postmenopausal Women With Advanced Breast Cancer.
The main aim of this study was to evaluate the efficacy and safety of adding ribociclib to fulvestrant in men and postmenopausal women with hormone receptor positive (HR+), HER2-negative advanced breast cancer.
- Trial name
- MONALEESA-3 (NCT02422615)
- Testing
- Ribociclib, Fulvestrant
- Where
- 174 sites in United States, Australia and 28 more
- Volunteers
- 726 people
- Sponsor
- Novartis Pharmaceuticals
Colonoscopy
Virtual Reality Alternative to Pharmacological Sedation During Colonoscopy
Colonoscopy patients will be fitted with a virtual reality head-mounted display, and virtual experiences will be initiated prior to colonoscope insertion. Colonoscopy will be initiated without standard sedatives and narcotics.
- Trial name
- NCT04349150
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hepatic Complications, Malignant Neoplasm
Bortezomib in Treating Patients With Advanced Cancer and Liver Dysfunction
Bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for their growth. This phase I trial is studying the side effects and best dose of bortezomib in treating patients with advanced cancer and liver…
- Trial name
- NCT00091117
- Testing
- bortezomib, pharmacological study
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Hypogonadism
Oral Testosterone for the Treatment of Hypogonadism
Low testosterone is a condition that occurs when the body is unable to produce sufficient quantities of testosterone. The medical name for low testosterone is hypogonadism. Hypogonadism can be caused by many factors.
- Trial name
- NCT01717768
- Testing
- TSX-002
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- TesoRx Pharma, LLC
Unspecified Adult Solid Tumor, Protocol Specific
SJG-136 in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery
This phase I trial studies the side effects and best dose of SJG-136 in treating patients with solid tumors that are metastatic or cannot be removed by surgery.
- Trial name
- NCT00121290
- Testing
- SJG-136, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Cancer Institute (NCI)
Tobacco Use Cessation
Study of the Effectiveness of a Virtual Reality Treatment in the Management of Smoking Cessation
Tobacco is an addiction with serious consequences: somatic, psychiatric... The number of requests for treatment for tobacco addiction is gradually increasing from year to year, but conventional treatments have limited…
- Trial name
- 3DSmoke (NCT04610931)
- Testing
- Virtual Reality-Enhanced Cognitive Behavioral Therapy (VR-CBT), cognitive behavior therapy
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Clermont-Ferrand
Unspecified Adult Solid Tumor, Protocol Specific
1-Methyl-D-Tryptophan in Treating Patients With Metastatic or Refractory Solid Tumors That Cannot Be Removed By Surgery
This phase I trial is studying the side effects and best dose of 1-methyl-D-tryptophan in treating patients with metastatic or refractory solid tumors that cannot be removed by surgery.
- Trial name
- NCT00567931
- Testing
- 1-methyl-d-tryptophan, pharmacological study, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Artery Disease, Coronary Artery Stenosis
Nationwide Cohort Study of Antiplatelet Agents as Primary Prevention
There is no specific recommendation regarding pharmacologic treatment as primary prevention for patients with intermediate coronary artery stenosis whose revascularization was deferred based on negative fractional flow reserve…
- Trial name
- NHIS (NCT06281041)
- Testing
- Antiplatelet Agents
- Where
- South Korea
- Volunteers
- 4,657 people
- Sponsor
- Samsung Medical Center
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q)
Selinexor and Chemotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
This phase I trial studies the side effects and best dose of selinexor when given together with etoposide with or without mitoxantrone hydrochloride and cytarabine in treating patients with acute myeloid leukemia that has…
- Conditions
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Trial name
- NCT02299518
- Testing
- mitoxantrone hydrochloride, etoposide, cytarabine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Alice Mims
Atrial Fibrillation Paroxysmal
Refralon Versus Amiodarone for Cardioversion of Paroxysmal Fibrillation and Atrial Flutter
Patients hospitalized with paroxysmal atrial fibrillation and flutter to restore sinus rhythm will be randomized into two groups: one will be cardioversion with refralon and the other with amiodarone
- Trial name
- NCT05445297
- Testing
- Pharmacological cardioversion with Amiodarone, Pharmacological cardioversion with Refralon
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Endometriosis
A Study To Investigate How The Body Handles Multiple Doses Of PF-0243873 And To Investigate The Effect Of PF-02413873 On Sex Hormone Levels In Healthy Young Women
The study will investigate how well multiple doses of PF-02413873 are tolerated by healthy young women, how the body handles multiple doses of PF-02413873 and which effect PF-02413873 has on sex hormones in healthy young women
- Trial name
- NCT00800618
- Testing
- PF-02413873 100 mg QD, PF-02413873 1500 mg QD, PF-02413873 20 mg QD
- Where
- 4 sites in United States, Belgium
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Pfizer
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery
This phase I trial is studying the side effects and best dose of resveratrol in treating patients with colorectal cancer that can be removed by surgery.
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Stage I Colon Cancer, Stage I Rectal Cancer
- Trial name
- NCT00433576
- Testing
- resveratrol, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Carpal Tunnel Syndrome
Comparison of Injection Techniques in Carpal Tunnel Syndrome
The aim of this study is to compare the effects of ultrasound-guided hydrodissection with 5% dextrose and perineural corticosteroid injection on the clinical parameters of carpal tunnel syndrome, as well as to evaluate the…
- Trial name
- NCT07105540
- Testing
- 5% Dextrose, Betamethasone and local anesthetic
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Ankara Etlik City Hospital
Anticoagulants and Bleeding Disorders
MAC Project, Monitoring of AntiCoagulant Therapies (MAC)
MAC Project is a prospective cohort, multicenter, observational, no-profit study aimed to prospectively collect reliable real-life clinical information in unselected VTE or NVAF patients treated with any DOAC, during a…
- Trial name
- MAC (NCT04329390)
- Testing
- Anticoagulant drugs
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Quovadis Associazione
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