Clinical trials: pharmacological study, completed
Phase 1 First-in-human Study Involving Healthy Subjects
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TNX-1500 in Healthy Subjects
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TNX-1500 in Healthy Subjects
- Trial name
- NCT07473752
- Testing
- TNX-1500, Keyhole Limpet Hemocyanin (KLH)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Tonix Pharmaceuticals, Inc.
Vitamin D Deficiency
Vitamin Deficiency in Immigrants, a Treatment Study
The purpose of this study is to determine the efficacy of different doses of vitamin D in persons, immigrated to Sweden from Middle East or Africa, with decreased S vitamin D.
- Trial name
- VIDI2 (NCT01419119)
- Testing
- Cholecalciferol high dose at Vitamin D deficiency, Cholecalciferol median dose at Vitamin D insufficiency, Cholecalciferol low dose at Vitamin D deficiency
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Umeå University
Bacterial Infections
Dose-finding, Pharmacokinetics, and Safety of VABOMERE in Pediatric Subjects With Bacterial Infections
A single dose infusion of Vabomere (meropenem-vaborbactam) is being tested for dose-finding, pharmacokinetics, safety, and tolerability in pediatric subjects from birth to less than 18 years of age with serious bacterial…
- Trial name
- TANGOKIDS (NCT02687906)
- Testing
- Vabomere
- Where
- 9 sites in United States
- Volunteers
- 39 people
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, LLC)
Basal-Like Breast Carcinoma, BRCA1 Mutation Carrier
Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy
This phase I trial studies the side effects and best dose of veliparib in treating patients with malignant solid tumors that do not respond to previous therapy.
- Conditions
- Basal-Like Breast Carcinoma, BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Breast Carcinoma
- Trial name
- NCT00892736
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Veliparib
- Where
- 7 sites in United States
- Volunteers
- 98 people
- Sponsor
- National Cancer Institute (NCI)
Asthma
Single-Dose Clinical Pharmacology Study in Asthmatic Adolescent and Adult Patients
This clinical pharmacology want to investigate the systemic availability of BDP/B17MP (active metabolite of BDP) and formoterol after single oral inhalation of CHF 1535 100/6 pMDI with and without spacer device (AeroChamber…
- Trial name
- ADO pMDI (NCT01803087)
- Testing
- Test treatments CHF 1535 100/6 pMDI (Foster®) TEST1, CHF 1535 100/6 pMDI (Foster®) using AeroChamber Plus™ (TEST 2)., BDP pMDI 100 µg (Qvar®) plus formoterol fumarate pMDI 6 µg (Atimos®) (REF)
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Hematuria, Bladder Cancer
A Trial of a Modified Cystoscopy Method to Reduce Pain Perception
The goal of this project is to improve patient experience of cystoscopy using a non-pharmacologic modification of procedure. Cystoscopy is a common outpatient procedure for urology patients and is usually performed without…
- Conditions
- Hematuria, Bladder Cancer, Bladder Disease
- Trial name
- NCT03257293
- Testing
- Modified Cystoscopy, Routine Cystoscopy
- Where
- Canada
- Volunteers
- 93 people
- Sponsor
- Western University, Canada
Unspecified Adult Solid Tumor, Protocol Specific
A Dose Finding Phase I Trial of the Combination of Topotecan and PS-341, a Novel Proteasome Inhibitor, in Advanced Malignancies
Drugs used in chemotherapy such as topotecan use different ways to stop tumor cells from dividing so they stop growing or die. Bortezomib may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth.
- Trial name
- NCT00068484
- Testing
- topotecan hydrochloride, bortezomib, pharmacological study
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Bipolar Disorder, Major Depression
Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
The purpose of the study is to find out what parts of the brain have increased or decreased activity and connectivity in individuals who have bipolar disorder, major depression, or no history of mood disorder.
- Trial name
- NCT01811147
- Testing
- Selective Serotonin Reuptake Inhibitor (SSRI)
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Chagas Disease, Lactation
Study of Benznidazole Transfer Into Breastmilk in Lactating Women With Chagas Disease
The investigators propose to study the transfer of benznidazole into breastmilk from the blood of lactating women who receive the drug for the treatment of Chagas disease.
- Trial name
- LACTBENZ (NCT01547533)
- Where
- Argentina
- Volunteers
- 10 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Labor Pain
The Effect of Lower Back Massage on Perceived Labor Pain
The aim of the study was to assesment the change in pain scores with lower back massage, a non-pharmacological method, on perceived labor pain in the early active phase of the first stage of labor.
- Trial name
- NCT05222867
- Testing
- lower back massage
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma
MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma
This phase I trial studies the side effects and best dose of MORAb-004 in treating young patients with recurrent or refractory solid tumors or lymphoma.
- Conditions
- Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Childhood Burkitt Lymphoma
- Trial name
- NCT01748721
- Testing
- anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis
- Where
- 20 sites in United States
- Volunteers
- 27 people
- Sponsor
- Morphotek
Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific
Phenylbutyrate in Treating Patients With Refractory Solid Tumors or Lymphoma
Phase I trial to study the effectivenes of phenylbutyrate in treating adults with refractory solid tumor or lymphoma. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00002909
- Testing
- chemotherapy, oral sodium phenylbutyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Anesthesia, Liver Transplant
Closed-loop Anaesthesia for Liver Transplantation: a Pilot Study
Automated titration of propofol and remifentanil guided by the bispectral index (BIS) has been used for numerous surgical procedures.
- Trial name
- THConcentr (NCT03357900)
- Testing
- Automated titration of propofol and remifentanil
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hopital Foch
Brain and Central Nervous System Tumors
ABT-888, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
RATIONALE: ABT-888 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00770471
- Testing
- temozolomide, veliparib, DNA methylation analysis
- Where
- 11 sites in United States
- Volunteers
- 24 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Diabetes Mellitus, Type 2
Use of Incretins in Diabetic Patients
Observational, retrospective study, conducted in diabetic patients aimed to evaluate the effects on the glyco-metabolic control and on cardiovascular events of different DPP-4 inhibitors.
- Trial name
- NCT03486964
- Testing
- DPP-4 inhibitors
- Where
- Italy
- Volunteers
- 2,234 people
- Sponsor
- University of Pavia
Hyperuricemia With or Without Gout
Study of FYU-981 in Hyperuricemic Outpatients With or Without Gout (Effect on Two Hyperuricemic Types)
To investigate the pharmacodynamics and safety of FYU-981 administered orally once a day for 14 weeks, to uric acid-overproduction type or uric acid-underexcretion type of male hyperuricemic outpatients with or without gout.
- Trial name
- NCT03375632
- Testing
- FYU-981
- Where
- Japan
- Volunteers
- 26 people
- Sponsor
- Mochida Pharmaceutical Company, Ltd.
Preeclampsia
Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS)
Preeclampsia is one of the most common complications of pregnancy and is characterized by high blood pressure and protein in the urine. This can cause problems in the second half of pregnancy for both the mother and fetus.
- Trial name
- CAPPS (NCT00135707)
- Testing
- Dietary Supplement/Vitamins
- Where
- 16 sites in United States
- Volunteers
- 10,154 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Erythroid Leukemia
Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies
This phase I/II trial studies the side effects and best dose of donor natural killer cells when given together with donor stem cell transplant and to see how well they work in treating patients with myeloid malignancies that are…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Erythroid Leukemia, Acute Megakaryoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- NCT01823198
- Testing
- Aldesleukin, Allogeneic CD56-positive CD3-negative Natural Killer Cells, Allogeneic Hematopoietic Stem Cell Transplantation
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- M.D. Anderson Cancer Center
Hepatic Complications, Lymphoma
Temsirolimus in Treating Patients With Metastatic Solid Tumor or Lymphoma That Cannot Be Removed By Surgery Who Have Different Levels of Liver Function
This phase I trial is studying the side effects and best dose of temsirolimus in treating patients with metastatic solid tumor or lymphoma that cannot be removed by surgery who have different levels of liver function.
- Conditions
- Hepatic Complications, Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00275093
- Testing
- temsirolimus, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Artery Bypass Surgery, Valve Surgery
Observational Study to Investigate the Effects of Training on the Administration of Cardioplexol™
This is a multi-center, open label, single group, observational study designed to evaluate the effects of a Cardioplexol™ preparation and administration training program proposed to cardiac surgeons and cardiotechnicians…
- Trial name
- NCT03823521
- Testing
- Cardioplegia Solution
- Where
- 6 sites in Austria, Germany
- Volunteers
- 171 people
- Sponsor
- Swiss Cardio Technologies AG
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.