Clinical trials: polymerase chain reaction
Acne Vulgaris
Gene Polymorphisms, Skin Barrier, and Inflammation in Acne
This study investigated the relationship between Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) gene polymorphisms and acne pathogenesis.
- Trial name
- NCT07069075
- Testing
- MMP-2 Gene Polymorphism (rs243865) Analysis, TIMP-2 Gene Polymorphism (rs8179090) Analysis
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hong Zhang
Neuroblastoma
A Pilot Study on ALK Gene Mutations in Neuroblastoma
Neuroblastoma (NB) originates from the sympathetic nervous system and is one of the most common cancers in infants and children.
- Trial name
- NCT01986595
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Breast Cancer
Biomarkers in Women Receiving Chemotherapy & Celecoxib for Stage II or Stage III Breast Cancer Removable by Surgery
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00665457
- Testing
- filgrastim, capecitabine, celecoxib
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Nebraska
Keratoconus
Myofibroblastic Transformation Secondary to Epithelial-stromal Interactions in the Keratoconus
Keratoconus is characterized by a thinning of the cornea, which causes a decrease in visual acuity due to astigmatism. Publications suggest that keratoconus is linked to chronic inflammation (increase in pro-inflammatory…
- Trial name
- MYKE (NCT03990740)
- Testing
- Corneal sampling
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Dental Caries, Gingivitis
Interdental Microbiota Among Adolescents
Adolescence remains a period during which tooth decay is still very active. There are few epidemiological studies in adolescents, and the majority of them were young people aged 15 and under.
- Trial name
- MIARC (NCT03700840)
- Testing
- Interdental brushes
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université Montpellier
Disseminated Neuroblastoma, Localized Resectable Neuroblastoma
Study of DNA in Blood Samples From Patients With Neuroblastoma
This research trial studies is deoxyribonucleic acid (DNA) in blood samples from patients with neuroblastoma. Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that…
- Conditions
- Disseminated Neuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Recurrent Neuroblastoma
- Trial name
- NCT00898391
- Testing
- laboratory biomarker analysis, polymerase chain reaction, polyacrylamide gel electrophoresis
- Where
- United States
- Volunteers
- 329 people
- Sponsor
- Children's Oncology Group
Leber Hereditary Optic Neuropathy
Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year
The goal of this clinical trial is to assess the efficacy and safety of GS010 gene therapy - (lenadogene nolparvovec) in subjects with LHON due to the G11778A ND4 mitochondrial mutation with a vision loss up to one year.
- Trial name
- REFLECT (NCT03293524)
- Testing
- GS010
- Where
- 13 sites in United States, Belgium and 5 more
- Volunteers
- 98 people
- Sponsor
- GenSight Biologics
Covid19
Gazelle COVID-19 Test Clinical Accuracy Protocol
Gazelle COVID-19 is a fluorescent lateral flow immunoassay and accompanying Reader intended for the qualitative detection of nucleocapsid antigen from SARS-CoV-2 in nasal swab specimens from individuals who are suspected of…
- Trial name
- NCT04987918
- Testing
- Applied Biosystems TaqPath COVID- 19 Combo Kit
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Hemex Health
Helicobacter Pylori Infection
Fecal Molecular Susceptibility-guided Hp Rescue Therapy
The goal of this clinical trial is to evaluate the eradication efficacy and health economic benefits of individualized regimens guided by fecal molecular susceptibility testing with 7-day and 14-day courses in the rescue…
- Trial name
- NCT07405697
- Testing
- 7-day fecal molecular susceptibility-guided therapy, 14-day fecal molecular susceptibility-guided therapy
- Where
- 4 sites in China
- Volunteers
- 290 people
- Sponsor
- Shanghai Zhongshan Hospital
Central Nervous System Infection
Lymphocytic Herpesviruses and Cerebrospinal Fluid Polymerase Chain Reaction (PCR)
Enterovirus and herpes simplex viruses 1 and 2 are the main causative agents of central nervous system infections. Instead, the role of lymphocytic herpesviruses in the etiology of central nervous system (CNS) infections is not…
- Trial name
- NCT01438879
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- PaijatHame Central Hospital
Head and Neck Cancer
DNA Analysis of Tumor Tissue Samples From Patients With Human Papilloma Virus-Associated Cancer of the Oropharynx
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897988
- Testing
- gene expression analysis, mutation analysis, polyacrylamide gel electrophoresis
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Periodontitis, Halitosis
Adjunctive Effect of Photodynamic Therapy on Halitosis
The present study aims to evaluate bad breath in patients undergoing gingival treatment combined with tongue scraping and laser and to assess its potential benefits for both periodontal and microbiological condition.
- Trial name
- NCT06764342
- Testing
- Full-mouth scaling combined with antimicrobial photodynamic therapy, full-mouth scaling
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Pneumonia, Bacterial Pneumonia
Multiplex Polymerase Chain Reaction in Postoperative Pneumonia After Thoracic Surgery
Background: In thoracic surgery, postoperative pneumonia (POP) is the leading cause of postoperative morbidity and mortality. The clinical diagnosis of POP is difficult and conventional microbiological diagnostic tests perform…
- Trial name
- POP-PCR (NCT03752320)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer
Biomarkers in Tissue Samples From Patients With Breast Cancer Treated With Bevacizumab
RATIONALE: DNA analysis of tumor tissue may help doctors predict how well patients will respond to treatment. PURPOSE: This research study is studying biomarkers in tissue samples from patients with breast cancer treated with…
- Trial name
- NCT01156168
- Testing
- DNA analysis, gene expression analysis, polymorphism analysis
- Volunteers
- 363 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Immune System Diseases
Retroviral Insertion Site Methodology Study
Adenosine deaminase (ADA) is an enzyme involved in the development and functioning of the immune system. Deficiency of ADA results in severe combined immunodeficiency (SCID), a fatal inherited immune disorder.
- Trial name
- NCT03311074
- Testing
- Strimvelis
- Sponsor
- Fondazione Telethon
Malaria
Malaria Infection Diagnosed by Polymerase Chain Reaction (PCR) as a Means of Evaluating Pre-erythrocytic Candidate Malaria Vaccines
The ability to test candidate pre-erythrocytic stage malaria vaccines, using a well-established sporozoite challenge model, in a field setting with group sizes of tens rather than hundreds of volunteers would greatly facilitate…
- Trial name
- NCT00121823
- Testing
- FP9 ME-TRAP, MVA ME-TRAP
- Where
- The Gambia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Breast Cancer
Studying Blood and DNA Samples From Patients With Breast Cancer Treated With Chemotherapy With or Without Trastuzumab
RATIONALE: Studying samples of blood and DNA in the laboratory from patients who received chemotherapy with or without trastuzumab may help doctors learn more about the effects of trastuzumab on cells.
- Trial name
- NCT01562288
- Testing
- DNA analysis, gene expression analysis, polymerase chain reaction
- Volunteers
- 1,576 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Head and Neck Cancer
Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer That Cannot Be Removed By Surgery
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00646659
- Testing
- cetuximab, carboplatin, cisplatin
- Where
- Belgium
- Volunteers
- 47 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Appendicitis Acute
Polymerase Chain Reaction (PCR) and Cultivation of the Peritoneal Fluid at Operation for Appendicitis and Postoperative Enteral Antibiotic Treatment
Patients diagnosed with acute appendicitis receives antibiotics during the operation, and only patients where the surgeon suspects a complicated appendicitis with spread inflammation to the abdominal cavity receive antibiotics…
- Trial name
- PACPAT (NCT04713527)
- Testing
- Cultivation and PCR within 24 hours, Enteral antibiotics
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Southern Denmark
COVID-19, Myocarditis
Support for the Resumption of Training of High-level Athletes Post-epidemic COVID-19
As of March 2020, COVID-19 has become a global pandemic, halting athletic competition worldwide. Reports from China show a high prevalence of cardiac involvement in patients with severe SARS-CoV-2 infection.
- Trial name
- ASCCOVID19 (NCT04936503)
- Testing
- Resting electrocardiogram, Stress test, Cardiac echocardiography
- Where
- 21 sites in France
- Volunteers
- 984 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux